clofibrate has been researched along with Liver Neoplasms in 38 studies
angiokapsul: contains clofibrate & insoitolnicotinate
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Glutathione S-transferase placental (GST-P)-negative hepatocellular altered foci (HAF), hepatocellular adenoma (HCA), and hepatocellular carcinoma (HCC) were generated by two initiation-promotion models with N-nitrosodiethylamine (NDEN) and peroxisome proliferators, Wy-14,643 and clofibrate." | 3.72 | alpha(2)-Macroglobulin: a novel cytochemical marker characterizing preneoplastic and neoplastic rat liver lesions negative for hitherto established cytochemical markers. ( Fukushima, S; Kikuchi, K; Kushida, M; Mikami, N; Morimura, K; Oeda, K; Okuno, Y; Ozaki, K; Saito, K; Sukata, T; Sumida, K; Uwagawa, S, 2004) |
| " It is suggested that the liver lesions of this woman may be related to long-term administration of hypolipidemic drug clofibrate for hypercholesteremia and the lesions could be one of the precursor changes of human hepatocellular carcinoma." | 3.66 | Adenoma with multiple hyperplastic nodules in noncirrhotic liver possibly related to long-term administration of a hypolipidemic drug. ( Mori, H; Sugie, S; Takahashi, M; Tanaka, T, 1982) |
| "Perfluorooctanoic acid (PFOA) is a potent hepatocarcinogen and peroxisome proliferator (PP) in rodents." | 1.35 | Genomic profiling reveals an alternate mechanism for hepatic tumor promotion by perfluorooctanoic acid in rainbow trout. ( Benninghoff, AD; Carpenter, HM; Hendricks, JD; Orner, GA; Pereira, CB; Tilton, SC; Williams, DE, 2008) |
| "Clofibrate treatment, however, resulted in a significant decrease in both parameters (p<0." | 1.34 | Role of cytosolic liver fatty acid binding protein in hepatocellular oxidative stress: effect of dexamethasone and clofibrate treatment. ( Burczynski, FJ; Gong, Y; Jiang, P; Rajaraman, G; Wang, GQ; Yan, J, 2007) |
| "Within the scope of the Rat Liver Foci Bioassay the model carcinogens N-nitrosomorpholine (NNM), 2-acetylaminoflouren (2-AAF), phenobarbital (PB), and clofibrate (CF) were analyzed concerning their potency and dose-response relationship to induce foci of altered hepatocytes (FAHs), which are known to be precursor lesions of liver adenoma and carcinoma." | 1.34 | Comparison of mode of action of four hepatocarcinogens: a model-based approach. ( Bannasch, P; Groos, J; Kopp-Schneider, A; Schwarz, M, 2007) |
| "When overexpressed in rat hepatoma cells (H4IIE) using a recombinant adenovirus, the mutated PPARalpha receptor antagonized the clofibrate-induced L-CPT I gene expression, whereas it did not affect LCFA-induced L-CPT I." | 1.33 | Fatty acids induce L-CPT I gene expression through a PPARalpha-independent mechanism in rat hepatoma cells. ( Burnol, AF; Caüzac, M; Diradourian, C; Girard, J; Le May, C; Pégorier, JP; Perdereau, D, 2005) |
| "A transformed human hepatoma cell line was examined to determine if it was an appropriate model system for studying the mechanism of action of two peroxisome proliferators that lower blood lipids." | 1.29 | Inverse relationship between peroxisomal and mitochondrial beta-oxidation in HepG2 cells treated with dehydroepiandrosterone and clofibric acid. ( Chance, DS; McIntosh, MK; Wu, SM, 1995) |
| "Fenofibrate was compared to clofibrate to investigate whether their relative effects on lipoprotein production in Hep G2 cells were comparable to their relative effects on plasma lipoproteins." | 1.28 | Modulation of lipoprotein production in Hep G2 cells by fenofibrate and clofibrate. ( Goldberg, DM; Hahn, SE, 1992) |
| "In clofibrate-treated rats, the tumor cells showed a slight increase in the size of microbodies and in catalase activity; however, the tumor microbodies did not increase in number." | 1.25 | Response of microbodies in Morris hepatoma 9618A to clofibrate. ( Gotoh, M; Itabashi, M; Mochizuki, Y; Morris, HP; Tsukada, H, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (39.47) | 18.7374 |
| 1990's | 13 (34.21) | 18.2507 |
| 2000's | 7 (18.42) | 29.6817 |
| 2010's | 3 (7.89) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jendralla, H | 1 |
| Granzer, E | 1 |
| von Kerekjarto, B | 1 |
| Krause, R | 1 |
| Schacht, U | 1 |
| Baader, E | 1 |
| Bartmann, W | 1 |
| Beck, G | 1 |
| Bergmann, A | 1 |
| Kesseler, K | 1 |
| Ji, Z | 1 |
| Settivari, RS | 1 |
| LeBaron, MJ | 1 |
| Tilton, SC | 1 |
| Orner, GA | 1 |
| Benninghoff, AD | 1 |
| Carpenter, HM | 1 |
| Hendricks, JD | 1 |
| Pereira, CB | 1 |
| Williams, DE | 1 |
| Penna, F | 1 |
| Reffo, P | 1 |
| Muzio, G | 2 |
| Canuto, RA | 2 |
| Baccino, FM | 1 |
| Bonelli, G | 1 |
| Costelli, P | 1 |
| Maggiora, M | 1 |
| Oraldi, M | 1 |
| Yan, J | 2 |
| Gong, Y | 3 |
| Wang, G | 1 |
| Burczynski, FJ | 2 |
| Sukata, T | 1 |
| Uwagawa, S | 1 |
| Ozaki, K | 1 |
| Sumida, K | 1 |
| Kikuchi, K | 1 |
| Kushida, M | 1 |
| Saito, K | 1 |
| Morimura, K | 1 |
| Oeda, K | 1 |
| Okuno, Y | 1 |
| Mikami, N | 1 |
| Fukushima, S | 1 |
| Le May, C | 1 |
| Caüzac, M | 1 |
| Diradourian, C | 1 |
| Perdereau, D | 1 |
| Girard, J | 1 |
| Burnol, AF | 1 |
| Pégorier, JP | 1 |
| Rajaraman, G | 1 |
| Wang, GQ | 1 |
| Jiang, P | 1 |
| Groos, J | 1 |
| Bannasch, P | 1 |
| Schwarz, M | 1 |
| Kopp-Schneider, A | 1 |
| Tanaka, N | 1 |
| Moriya, K | 1 |
| Kiyosawa, K | 1 |
| Koike, K | 1 |
| Gonzalez, FJ | 1 |
| Aoyama, T | 1 |
| Mori, H | 1 |
| Tanaka, T | 1 |
| Sugie, S | 1 |
| Takahashi, M | 1 |
| Heller, F | 1 |
| Pourbaix, S | 1 |
| Rao, MS | 4 |
| Lalwani, ND | 1 |
| Watanabe, TK | 1 |
| Reddy, JK | 5 |
| Mochizuki, Y | 5 |
| Furukawa, K | 1 |
| Sawada, N | 1 |
| Sakai, M | 1 |
| Matsushima-Hibiya, Y | 1 |
| Nishizawa, M | 1 |
| Nishi, S | 1 |
| Tamura, H | 1 |
| Chance, DS | 1 |
| Wu, SM | 1 |
| McIntosh, MK | 1 |
| Watanabe, T | 1 |
| Hasegawa, R | 1 |
| Yoshida, T | 1 |
| Mizoguchi, Y | 1 |
| Futakuchi, M | 1 |
| Kim, DJ | 2 |
| Cui, L | 1 |
| Ito, N | 1 |
| Chen, L | 1 |
| Hardwick, JP | 1 |
| Bell, DR | 1 |
| Williams, GM | 1 |
| Perrone, C | 1 |
| Lee, KK | 1 |
| Hong, JT | 1 |
| Tsukada, H | 4 |
| Itabashi, M | 2 |
| Gotoh, M | 2 |
| Morris, HP | 1 |
| Goto, M | 1 |
| Hahn, SE | 1 |
| Goldberg, DM | 1 |
| Nilsson, R | 1 |
| Beije, B | 1 |
| Préat, V | 1 |
| Erixon, K | 1 |
| Ramel, C | 1 |
| Yeldandi, AV | 1 |
| Subbarao, V | 1 |
| Rajan, A | 1 |
| Nagini, S | 1 |
| Nagarajan, B | 1 |
| Hertz, R | 1 |
| Arnon, J | 1 |
| Hoter, A | 1 |
| Shouval, D | 1 |
| Bar-Tana, J | 1 |
| Gupta, RC | 1 |
| Goel, SK | 1 |
| Earley, K | 1 |
| Singh, B | 1 |
| Reddy, J | 2 |
| Svoboda, D | 2 |
5 reviews available for clofibrate and Liver Neoplasms
| Article | Year |
|---|---|
[Peroxisomes and hypolipidemic agents ].
Topics: Animals; Clofibrate; Cricetinae; Energy Metabolism; Female; Humans; Hydrogen Peroxide; Hypolipidemic | 1982 |
[Peroxisome proliferators and hepatocarcinogenesis].
Topics: Cell Division; Clofibrate; Humans; Liver; Liver Neoplasms; Microbodies; Oxidative Stress; Receptors, | 1995 |
[Significance of cellular signal transduction system in peroxisome proliferation].
Topics: Animals; Calcium; Calcium Channel Blockers; Cell Communication; Clofibrate; Enzyme Induction; Liver | 1994 |
Mechanism-based risk assessment of peroxisome proliferating rodent hepatocarcinogens.
Topics: Animals; Carcinogens; Cell Division; Clofibrate; DNA Damage; Dose-Response Relationship, Drug; Human | 1996 |
Hepatocarcinogenesis of peroxisome proliferators.
Topics: Animals; Carcinogens; Cell Division; Clofibrate; DNA Damage; Humans; Hypolipidemic Agents; Liver Neo | 1996 |
33 other studies available for clofibrate and Liver Neoplasms
| Article | Year |
|---|---|
Synthesis and biological activity of new HMG-CoA reductase inhibitors. 3. Lactones of 6-phenoxy-3,5-dihydroxyhexanoic acids.
Topics: Animals; Anticholesteremic Agents; Caproates; Carcinoma, Hepatocellular; Cholesterol; Dogs; Humans; | 1991 |
Pilot studies evaluating the nongenotoxic rodent carcinogens phenobarbital and clofibrate in the rat Pig-a assay.
Topics: Animals; Biological Assay; Carcinogens; Clofibrate; Glycosylphosphatidylinositols; Liver; Liver Neop | 2019 |
Genomic profiling reveals an alternate mechanism for hepatic tumor promotion by perfluorooctanoic acid in rainbow trout.
Topics: Aflatoxin B1; Animals; Caprylates; Carcinogenicity Tests; Clofibrate; Cluster Analysis; Dehydroepian | 2008 |
Mechanisms of clofibrate-induced apoptosis in Yoshida AH-130 hepatoma cells.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Caspase 8; Caspase | 2009 |
Involvement of PPARα and PPARγ in apoptosis and proliferation of human hepatocarcinoma HepG2 cells.
Topics: Apoptosis; bcl-Associated Death Protein; Carcinoma, Hepatocellular; Cell Cycle; Cell Proliferation; | 2010 |
Regulation of liver fatty acid binding protein expression by clofibrate in hepatoma cells.
Topics: Anilides; Animals; Carcinoma, Hepatocellular; Catalase; Cell Line, Tumor; Clofibrate; Fatty Acid-Bin | 2010 |
alpha(2)-Macroglobulin: a novel cytochemical marker characterizing preneoplastic and neoplastic rat liver lesions negative for hitherto established cytochemical markers.
Topics: Adenoma; Alkylating Agents; alpha-Macroglobulins; Animals; Anticholesteremic Agents; Biomarkers, Tum | 2004 |
Fatty acids induce L-CPT I gene expression through a PPARalpha-independent mechanism in rat hepatoma cells.
Topics: Adenoviridae; Animals; Carcinoma, Hepatocellular; Carnitine O-Palmitoyltransferase; Cell Line, Tumor | 2005 |
Role of cytosolic liver fatty acid binding protein in hepatocellular oxidative stress: effect of dexamethasone and clofibrate treatment.
Topics: Carcinoma, Hepatocellular; Catalase; Cell Hypoxia; Clofibrate; Cytosol; Dexamethasone; Fatty Acid-Bi | 2007 |
Comparison of mode of action of four hepatocarcinogens: a model-based approach.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Clofibrate; Diethylnitrosamine; Female; Liver Neoplasms | 2007 |
PPARalpha activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Clofibrate; DNA Damage; Fatty Acids; Fatty L | 2008 |
Adenoma with multiple hyperplastic nodules in noncirrhotic liver possibly related to long-term administration of a hypolipidemic drug.
Topics: Aged; Carcinoma, Hepatocellular; Clofibrate; Female; Humans; Hypercholesterolemia; Hyperplasia; Hype | 1982 |
Inhibitory effect of antioxidants ethoxyquin and 2(3)-tert-butyl-4-hydroxyanisole on hepatic tumorigenesis in rats fed ciprofibrate, a peroxisome proliferator.
Topics: Animals; Anisoles; Antioxidants; Body Weight; Butylated Hydroxyanisole; Carcinogens; Clofibrate; Clo | 1984 |
Effects of various concentrations of ethyl-alpha-p-chlorophenoxyisobutyrate (clofibrate) on diethylnitrosamine-induced hepatic tumorigenesis in the rat.
Topics: Animals; Body Weight; Clofibrate; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, | 1982 |
Suppression of rat glutathione transferase P expression by peroxisome proliferators: interaction between Jun and peroxisome proliferator-activated receptor alpha.
Topics: Animals; Base Sequence; Clofibrate; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; G | 1995 |
Inverse relationship between peroxisomal and mitochondrial beta-oxidation in HepG2 cells treated with dehydroepiandrosterone and clofibric acid.
Topics: Analysis of Variance; Biomarkers; Carcinoma, Hepatocellular; Carnitine O-Palmitoyltransferase; Catal | 1995 |
Phenotypic alteration of hepatocellular foci in rats treated with clofibrate and phenobarbital.
Topics: Animals; Clofibrate; Glutathione Transferase; Liver Neoplasms; Liver Neoplasms, Experimental; Male; | 1994 |
Identification of a new P450 subfamily, CYP4F1, expressed in rat hepatic tumors.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Amino Acid Sequence; Animals; Antisense Elements (Genetics); Ba | 1993 |
A knockout for risk assessment.
Topics: Animals; Clofibrate; Liver; Liver Neoplasms; Mice; Mice, Knockout; Microbodies; Receptors, Cytoplasm | 1995 |
Differential effects of nongenotoxic and genotoxic carcinogens on the preneoplastic lesions in the rat liver.
Topics: Administration, Oral; Animals; Body Weight; Carcinogens; Cell Count; Clofibrate; Diethylnitrosamine; | 1998 |
Response of microbodies in Morris hepatoma 9618A to clofibrate.
Topics: Animals; Animals, Newborn; Carcinoma, Hepatocellular; Catalase; Clofibrate; Female; Liver Neoplasms; | 1975 |
Changes in peroxisomes in preneoplastic liver of rats induced by 3'-methyl-4-dimethylaminoazobenzene.
Topics: Animals; Carcinoma, Hepatocellular; Catalase; Cell Differentiation; Clofibrate; Enzyme Induction; Hy | 1977 |
Enhancement by Wy-14,643, a hepatic peroxisome proliferator, of diethylnitrosamine-initiated hepatic tumorigenesis in the rat.
Topics: Acetates; Animals; Cell Division; Clofibrate; Diethylnitrosamine; Drug Synergism; Liver; Liver Neopl | 1978 |
Matrical inclusions induced by clofibrate in hepatic microbodies of rats fed 2-acetylaminofluorene.
Topics: Clofibrate; Fluorenes; Liver; Liver Neoplasms; Microbodies; Neoplasms, Experimental; Organoids | 1975 |
[Proceedings: Peroxisome in 2-fluorenylacetamide-induced hyperplastic liver nodule cells].
Topics: 2-Acetylaminofluorene; Animals; Clofibrate; Fluorenes; Hyperplasia; Liver Neoplasms; Microbodies; Or | 1975 |
Modulation of lipoprotein production in Hep G2 cells by fenofibrate and clofibrate.
Topics: Apolipoproteins A; Apolipoproteins B; Carcinoma, Hepatocellular; Cell Line; Cholesterol; Cholesterol | 1992 |
On the mechanism of the hepatocarcinogenicity of peroxisome proliferators.
Topics: Animals; Caprylates; Carcinogens; Clofibrate; Clofibric Acid; DNA; DNA Damage; DNA Repair; Fibric Ac | 1991 |
gamma-Glutamyltranspeptidase-negative phenotypic property of preneoplastic and neoplastic liver lesions induced by ciprofibrate does not change following 2-acetylaminofluorene administration.
Topics: 2-Acetylaminofluorene; Animals; Clofibrate; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase; | 1989 |
Altered enzyme profile is possibly related to hepatocarcinogenesis by clofibrate.
Topics: Animals; Arginase; Biomarkers, Tumor; Chromatography, Ion Exchange; Clofibrate; Enzymes; gamma-Gluta | 1987 |
Clofibrate does not induce peroxisomal proliferation in human hepatoma cell lines PLC/PRF/5 and SK-HEP-1.
Topics: Carcinoma, Hepatocellular; Cell Division; Cell Line; Clofibrate; Humans; Liver Neoplasms; Microbodie | 1987 |
32P-postlabeling analysis of peroxisome proliferator-DNA adduct formation in rat liver in vivo and hepatocytes in vitro.
Topics: Animals; Anticholesteremic Agents; Carcinogens; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; | 1985 |
Microbody (peroxisome) matrix: transformation into tubular structures.
Topics: Animals; Clofibrate; Endoplasmic Reticulum; Hypophysectomy; Liver; Liver Neoplasms; Male; Microbodie | 1973 |
Proliferation of microbodies and synthesis of catalase in rat liver. Induction in tumor-bearing host by CPIB.
Topics: Aflatoxins; Animals; Anticholesteremic Agents; Carcinoma, Hepatocellular; Catalase; Clofibrate; Cyto | 1971 |