Page last updated: 2024-10-25

clofibrate and Liver Diseases

clofibrate has been researched along with Liver Diseases in 16 studies

angiokapsul: contains clofibrate & insoitolnicotinate

Liver Diseases: Pathological processes of the LIVER.

Research Excerpts

ExcerptRelevanceReference
"Hypothyroidism is common in the elderly, especially among women."1.33[Hypolipidemic therapy in special situations: hypothyroidism and liver disease]. ( Cesena, FH; Luz, PL; Xavier, HT, 2005)
"Clofibrate treatment elevated the levels of N-methylnicotinamide and 3,4-dihydroxymandelate and decreased the levels of 2-oxoglutarate and N-acetylaspartate."1.33A metabonomics study of the hepatotoxicants galactosamine, methylene dianiline and clofibrate in rats. ( Aoki, T; Ishihara, K; Katsutani, N, 2006)
"Treatment with clofibrate is known to increase drastically the number of peroxisomes in mammalian liver."1.27Unsuccessful attempts to induce peroxisomes in two cases of Zellweger disease by treatment with clofibrate. ( Björkhem, I; Blomstrand, S; Glaumann, H; Strandvik, B, 1985)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-199010 (62.50)18.7374
1990's1 (6.25)18.2507
2000's4 (25.00)29.6817
2010's0 (0.00)24.3611
2020's1 (6.25)2.80

Authors

AuthorsStudies
Liu, H1
Zhang, P1
Ge, X1
Wu, Q1
Han, C1
Zhang, L1
Hua, Y1
Zhang, Y1
Liu, J1
Shi, Y1
Wang, B1
Wang, X1
Wang, W1
Jiang, Y1
Zhang, H1
Deng, C1
Xie, Y1
Liu, Y1
He, S1
BEST, MM1
DUNCAN, CH1
Bertolami, MC1
Cesena, FH1
Xavier, HT1
Luz, PL1
Ishihara, K1
Katsutani, N1
Aoki, T1
Moffit, JS1
Koza-Taylor, PH1
Holland, RD1
Thibodeau, MS1
Beger, RD1
Lawton, MP1
Manautou, JE1
Carfagna, MA1
Young, KM1
Susick, RL1
Dry, J1
Pradalier, A1
Gugler, R1
Kürten, JW1
Jensen, CJ1
Klehr, U1
Hartlapp, J1
Schade, RW1
Demacker, PN1
van't Laar, A1
Cayen, MN1
Björkhem, I1
Blomstrand, S1
Glaumann, H1
Strandvik, B1
Sachs, BA1
Bardfeld, PA1
Bodian, JE1
Sugarman, LA1
Hellman, L1
O'Reilly, RA2
Aggeler, PM1
Moschella, SL1

Reviews

4 reviews available for clofibrate and Liver Diseases

ArticleYear
[Therapeutics in 1978].
    La Revue du praticien, 1978, Sep-21, Volume: 28, Issue:41

    Topics: Amenorrhea; Anticholesteremic Agents; Artificial Organs; Biliary Tract Diseases; Bromocriptine; Chol

1978
Disposition, metabolism and pharmacokinetics of antihyperlipidemic agents in laboratory animals and man.
    Pharmacology & therapeutics, 1985, Volume: 29, Issue:2

    Topics: Animals; Binding Sites; Biological Availability; Biotransformation; Clofibrate; Drug Interactions; H

1985
Drug interactions involving oral anticoagulants.
    Cardiovascular clinics, 1974, Volume: 6, Issue:2

    Topics: Animals; Anticoagulants; Barbiturates; Blood Coagulation; Blood Coagulation Factors; Cholestyramine

1974
Determinants of the response to oral anticoagulant drugs in man.
    Pharmacological reviews, 1970, Volume: 22, Issue:1

    Topics: Administration, Oral; Adrenal Cortex Hormones; Animals; Anti-Bacterial Agents; Anticoagulants; Blood

1970

Trials

1 trial available for clofibrate and Liver Diseases

ArticleYear
Liver scan in hyperlipoproteinemia.
    JAMA, 1974, Feb-25, Volume: 227, Issue:8

    Topics: Adult; Aged; Aspartate Aminotransferases; Blood Protein Disorders; Blood Protein Electrophoresis; Ch

1974

Other Studies

11 other studies available for clofibrate and Liver Diseases

ArticleYear
Optimization of clofibrate with O-desmethyl anetholtrithione lead to a novel hypolipidemia compound with hepatoprotective effect.
    Bioorganic & medicinal chemistry letters, 2022, 09-15, Volume: 72

    Topics: Anethole Trithione; Animals; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Li

2022
HYPOLIPEMIA AND HEPATOMEGALY FROM ETHYL CHLOROPHENOXYISOBUTYRATE (CPIB) IN THE RAT.
    The Journal of laboratory and clinical medicine, 1964, Volume: 64

    Topics: Adrenalectomy; Androsterone; Anticholesteremic Agents; Butyrates; Castration; Cholesterol; Clofibrat

1964
[Mechanisms of hepatotoxicity].
    Arquivos brasileiros de cardiologia, 2005, Volume: 85 Suppl 5

    Topics: Chemical and Drug Induced Liver Injury; Clofibrate; Drug Interactions; Humans; Hydroxymethylglutaryl

2005
[Hypolipidemic therapy in special situations: hypothyroidism and liver disease].
    Arquivos brasileiros de cardiologia, 2005, Volume: 85 Suppl 5

    Topics: Age Factors; Azetidines; Clofibrate; Drug Interactions; Dyslipidemias; Ezetimibe; Female; Humans; Hy

2005
A metabonomics study of the hepatotoxicants galactosamine, methylene dianiline and clofibrate in rats.
    Basic & clinical pharmacology & toxicology, 2006, Volume: 99, Issue:3

    Topics: Aniline Compounds; Animals; Chemical and Drug Induced Liver Injury; Clofibrate; Galactosamine; Liver

2006
Differential gene expression in mouse liver associated with the hepatoprotective effect of clofibrate.
    Toxicology and applied pharmacology, 2007, Jul-15, Volume: 222, Issue:2

    Topics: Acetaminophen; Acyl-CoA Oxidase; Amidohydrolases; Animals; Anticholesteremic Agents; Cell Adhesion M

2007
Sex differences in rat hepatic cytolethality of the protein kinase C inhibitor safingol: role of biotransformation.
    Toxicology and applied pharmacology, 1996, Volume: 137, Issue:2

    Topics: Administration, Oral; Animals; Biotransformation; Cell Count; Cell Death; Cell Survival; Cells, Cult

1996
Clofibrate disposition in renal failure and acute and chronic liver disease.
    European journal of clinical pharmacology, 1979, Jun-12, Volume: 15, Issue:5

    Topics: Acute Disease; Adolescent; Adult; Aged; Chronic Disease; Clofibrate; Female; Half-Life; Humans; Kidn

1979
Clofibrate effect on alkaline phosphatase: bone or liver fraction.
    The New England journal of medicine, 1977, Sep-22, Volume: 297, Issue:12

    Topics: Alkaline Phosphatase; Bone and Bones; Clofibrate; Humans; Liver; Liver Diseases; Osteitis Deformans

1977
Unsuccessful attempts to induce peroxisomes in two cases of Zellweger disease by treatment with clofibrate.
    Pediatric research, 1985, Volume: 19, Issue:6

    Topics: Abnormalities, Multiple; Brain Diseases; Clofibrate; Female; Humans; Infant; Kidney Diseases; Liver

1985
Xanthomatosis, associated with multiple myeloma.
    Archives of dermatology, 1970, Volume: 102, Issue:1

    Topics: Clofibrate; Humans; Lipid Metabolism; Liver Diseases; Male; Melphalan; Middle Aged; Multiple Myeloma

1970