clofibrate has been researched along with Leigh Disease in 1 studies
angiokapsul: contains clofibrate & insoitolnicotinate
Leigh Disease: A group of metabolic disorders primarily of infancy characterized by the subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, dysphagia, and lactic acidosis. Pathological features include spongy degeneration of the neuropile of the basal ganglia, thalamus, brain stem, and spinal cord. Patterns of inheritance include X-linked recessive, autosomal recessive, and mitochondrial. Leigh disease has been associated with mutations in genes for the PYRUVATE DEHYDROGENASE COMPLEX; CYTOCHROME-C OXIDASE; ATP synthase subunit 6; and subunits of mitochondrial complex I. (From Menkes, Textbook of Child Neurology, 5th ed, p850).
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Frambach, SJCM | 1 |
| van de Wal, MAE | 1 |
| van den Broek, PHH | 1 |
| Smeitink, JAM | 1 |
| Russel, FGM | 1 |
| de Haas, R | 1 |
| Schirris, TJJ | 1 |
1 other study available for clofibrate and Leigh Disease
| Article | Year |
|---|---|
Effects of clofibrate and KH176 on life span and motor function in mitochondrial complex I-deficient mice.
Topics: Adenosine Triphosphate; Animals; Bezafibrate; Chromans; Clofibrate; Electron Transport Complex I; Fa | 2020 |