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clofibrate and Hypothyroidism

clofibrate has been researched along with Hypothyroidism in 20 studies

angiokapsul: contains clofibrate & insoitolnicotinate

Hypothyroidism: A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction.

Research Excerpts

ExcerptRelevanceReference
"A single oral dose of the hypolipidaemic agent ethyl-p-chlorophenoxyisobutyrate (clofibrate, 750 mg) produced a significant reduction on the high basal serum TSH level in patients with primary hypothyroidism."7.66Clofibrate and a related compound suppress TSH secretion in primary hypothyroidism. ( Fukuda, H; Kamio, N; Kobayashi, I; Maruta, S; Mori, M; Ohshima, K; Shimomura, Y, 1980)
"A single oral dose of the hypolipidaemic agent ethyl-p-chlorophenoxyisobutyrate (clofibrate, 750 mg) produced a significant reduction on the high basal serum TSH level in patients with primary hypothyroidism."3.66Clofibrate and a related compound suppress TSH secretion in primary hypothyroidism. ( Fukuda, H; Kamio, N; Kobayashi, I; Maruta, S; Mori, M; Ohshima, K; Shimomura, Y, 1980)
"Hypothyroidism is common in the elderly, especially among women."1.33[Hypolipidemic therapy in special situations: hypothyroidism and liver disease]. ( Cesena, FH; Luz, PL; Xavier, HT, 2005)
" It is demonstrated that propylthiouracil-induced hypothyroid-hyperlipidemic chick develops severe toxic manifestations following clofibrate administration."1.27Propylthiouracil-induced hypothyroid hyperlipidemic chick: a model for clofibrate-induced toxicity. ( Cho, C; Linscheer, WG; Raheja, KL, 1986)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-199018 (90.00)18.7374
1990's1 (5.00)18.2507
2000's1 (5.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cesena, FH1
Xavier, HT1
Luz, PL1
Raheja, KL3
Lincheer, WG1
Cho, C2
Kawashima, Y2
Kozuka, H2
Katoh, H1
Kobayashi, I1
Shimomura, Y1
Maruta, S1
Ohshima, K1
Mori, M1
Kamio, N1
Fukuda, H1
Linscheer, WG2
Patel, DG1
Rao, AV1
Ramakrishnan, S1
Mehrotra, K1
Morgenstern, R1
Lundqvist, G1
Becedas, L1
Bengtsson Ahlberg, M1
Georgellis, A1
Rumpf, KW2
Albers, R1
Scheler, F2
Bruns, W1
Scott, HW1
Pagliano, FM1
Bombara, R1
Giraldi, B1
Visca, U1
Quellhrost, E1
Pioda, GB1
Del Favero, A1
Rambotti, P1
Parker, F1
Mitchell, WD1
Fredrickson, DS1
Krüskemper, HL1
Duncan, GG1
Elliott, FA1
Duncan, TG1
Schatanoff, J1

Reviews

1 review available for clofibrate and Hypothyroidism

ArticleYear
A physician's guide to hyperlipidemia.
    Modern concepts of cardiovascular disease, 1972, Volume: 41, Issue:7

    Topics: Adult; Cholesterol; Chylomicrons; Clofibrate; Diabetes Complications; Diet Therapy; Female; Humans;

1972

Other Studies

19 other studies available for clofibrate and Hypothyroidism

ArticleYear
[Hypolipidemic therapy in special situations: hypothyroidism and liver disease].
    Arquivos brasileiros de cardiologia, 2005, Volume: 85 Suppl 5

    Topics: Age Factors; Azetidines; Clofibrate; Drug Interactions; Dyslipidemias; Ezetimibe; Female; Humans; Hy

2005
Glycogenolytic and hypolipidemic effect of clofibrate (CPIB) in the hypothyroid chick.
    Comparative biochemistry and physiology. C: Comparative pharmacology, 1980, Volume: 66, Issue:2

    Topics: Animals; Bile; Blood Glucose; Body Weight; Chickens; Clofibrate; Hypothyroidism; Kidney; Lipid Metab

1980
Increased activity of stearoyl-CoA desaturation in liver from rat fed clofibric acid.
    Biochimica et biophysica acta, 1982, Dec-13, Volume: 713, Issue:3

    Topics: Acyl Coenzyme A; Animals; Clofibrate; Clofibric Acid; Diabetes Mellitus, Experimental; Fatty Acid De

1982
Differential effects of altered hormonal state on the induction of acyl-CoA hydrolases and peroxisomal beta-oxidation by clofibric acid.
    Biochimica et biophysica acta, 1983, Feb-07, Volume: 750, Issue:2

    Topics: Adrenalectomy; Animals; Clofibrate; Clofibric Acid; Dexamethasone; Diabetes Mellitus, Experimental;

1983
Clofibrate and a related compound suppress TSH secretion in primary hypothyroidism.
    Acta endocrinologica, 1980, Volume: 94, Issue:1

    Topics: Adult; Clofibrate; Female; Glycolates; Humans; Hypothyroidism; Male; Meclofenoxate; Thyrotropin; Thy

1980
Hypolipidemic and glycogenolytic effect of clofibrate (CPIB) in hypothyroid mice: role of insulin and glucagon.
    General pharmacology, 1982, Volume: 13, Issue:1

    Topics: Animals; Clofibrate; Glucagon; Glycogen; Hypolipidemic Agents; Hypothyroidism; Insulin; Lipid Metabo

1982
14C-cholesterol distribution & cholesterol content of various tissues in different applied conditions in rats.
    Indian journal of experimental biology, 1982, Volume: 20, Issue:8

    Topics: Aging; Animals; Cholesterol; Clofibrate; Diabetes Mellitus; Ethanol; Hypothyroidism; Rats; Sucrose

1982
Effects of peroxisome proliferators and/or hypothyroidism on xenobiotic-metabolizing enzymes in rat testis.
    Chemico-biological interactions, 1997, May-02, Volume: 104, Issue:2-3

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arylsulfotransferase; Aspiri

1997
Letter: Clofibrate-induced myopathy syndrome.
    Lancet (London, England), 1976, Jan-31, Volume: 1, Issue:7953

    Topics: Adult; Clofibrate; Diabetes Complications; Diabetes Mellitus; Female; Humans; Hypothyroidism; Kidney

1976
[Secondary hyperlipoproteinemias].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1977, May-01, Volume: 32, Issue:9

    Topics: Acute Disease; Clofibrate; Female; Hepatitis; Humans; Hyperlipidemias; Hypothyroidism; Lipoproteins,

1977
Ileal bypass in the control of hyperlipidemia and atherosclerosis.
    Archives of surgery (Chicago, Ill. : 1960), 1978, Volume: 113, Issue:1

    Topics: Adult; Animals; Aorta; Cholesterol; Cholesterol, Dietary; Cholestyramine Resin; Clofibrate; Coronary

1978
[Changes in lipid metabolism in a case of associated primary hypothyroidism, obesity and diabetes mellitus].
    Minerva medica, 1976, Jul-21, Volume: 67, Issue:35

    Topics: Aged; Cholesterol; Clofibrate; Diabetes Complications; Diabetes Mellitus; Female; Glyburide; Humans;

1976
[Diabetic nephropathy, hypothyroidism and colfibrate-induced myopathy (author's transl)].
    Medizinische Klinik, 1976, Nov-12, Volume: 71, Issue:46

    Topics: Adult; Clofibrate; Diabetes Complications; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Diabet

1976
[Bone marrow aplasia associated with ticlopidine treatment in a patient with idiopathic hypothyroidism].
    La Clinica terapeutica, 1989, Sep-30, Volume: 130, Issue:6

    Topics: Anemia, Aplastic; Clofibrate; Female; Humans; Hypolipidemic Agents; Hypothyroidism; Lymphocyte Activ

1989
Propylthiouracil-induced hypothyroid hyperlipidemic chick: a model for clofibrate-induced toxicity.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1986, Volume: 85, Issue:2

    Topics: Animals; Chickens; Clofibrate; Hyperlipidemias; Hypothyroidism; Male; Muscles; Propylthiouracil

1986
Xanthomas and hyperlipidemias.
    Journal of the American Academy of Dermatology, 1985, Volume: 13, Issue:1

    Topics: Apoproteins; Arteriosclerosis; Cholestasis; Cholestyramine Resin; Clofibrate; Colestipol; Dextrothyr

1985
A comparison of the effect of clofibrate and thyroxine on serum lipids in three hypothyroid subjects.
    Clinica chimica acta; international journal of clinical chemistry, 1971, Volume: 35, Issue:2

    Topics: Cholesterol; Clofibrate; Female; Humans; Hypothyroidism; Lipids; Middle Aged; Thyroid Function Tests

1971
[Androgens, anabolic steroids and lipid metabolism].
    Zeitschrift fur Ernahrungswissenschaft. Journal of nutritional sciences. Supplementa, 1972, Volume: 12

    Topics: Adult; Anabolic Agents; Androgens; Androsterone; Cholesterol; Clofibrate; Ethylestrenol; Female; Hum

1972
Some clinical potentials of chlorophenoxyisobutyrate (Clofibrate) therapy. (Hyperlipidemia--angina pectoris--blood sludging--diabetic neuropathy).
    Transactions of the American Clinical and Climatological Association, 1968, Volume: 79

    Topics: Adult; Aged; Angina Pectoris; Anticoagulants; Blood Coagulation Disorders; Clofibrate; Diabetic Neur

1968