clofibrate has been researched along with Experimental Hepatoma in 69 studies
angiokapsul: contains clofibrate & insoitolnicotinate
| Excerpt | Relevance | Reference |
|---|---|---|
| "We showed previously that the peroxisome proliferators di(2-ethylhexyl)phthalate (DEHP), clofibrate, and 4-chloro-6-(2,3 xylidino)-2-pyrimidinylthio (N-beta-hydroxyl)acetamide (BR931) alter hepatic sex steroid metabolism and receptor expression during induction of hepatic hyperplasia and hepatocellular carcinoma (HCC) in rats." | 3.69 | Hepatic hyperplasia and cancer in rats: metabolic alterations associated with cell growth. ( Brady, EP; Chandar, N; Eagon, PK; Elm, MS; Kelly, RH; Rao, B; Rao, KN; Shinozuka, H, 1997) |
| "Clofibrate treated pigs also had higher hepatic mRNA concentrations of bax and the proto-oncogenes c-myc and c-jun and a lower mRNA concentration of bcl-XL than control pigs (P < 0." | 1.34 | Clofibrate treatment in pigs: effects on parameters critical with respect to peroxisome proliferator-induced hepatocarcinogenesis in rodents. ( Eder, K; Giemsa, B; Hause, G; Kluge, H; Luci, S, 2007) |
| "Clofibrate is a hypolipidemic drug belonging to the peroxisome proliferator (PP) family." | 1.32 | Apoptosis induced by clofibrate in Yoshida AH-130 hepatoma cells: role of HMG-CoA reductase. ( Autelli, R; Baccino, FM; Bonelli, G; Canuto, RA; Costelli, P; Maggiora, M; Martinasso, G; Muzio, G; Trombetta, A, 2003) |
| "Incidences of hepatocellular carcinomas were 75% (9/12, P < 0." | 1.30 | Dose-dependent induction of carcinomas and glutathione S-transferase placental form negative eosinophilic foci in the rat liver by di(2-ethylhexyl)phthalate after diethylnitrosamine initiation. ( Hagiwara, A; Hasegawa, R; Imaida, K; Ito, N; Sano, M; Shirai, T; Tamano, S, 1999) |
| "Clofibrate is a peroxisome proliferator that can cause hepatic cancer in rodents." | 1.30 | Mitochondrial damage by the "pro-oxidant" peroxisomal proliferator clofibrate. ( Halliwell, B; Li, QT; Ong, CN; Qu, B; Wong, KP, 1999) |
| "Clofibrate (CF) was therefore administered for 2 or 4 weeks following performance of the Solt-Farber protocol using diethylnitrosamine and 2-acetylaminofluorene." | 1.29 | Lack of peroxisomal enzyme inducibility in rat hepatic preneoplastic lesions induced by mutagenic carcinogens: contrasted expression of glutathione S-transferase P form and enoyl CoA hydratase. ( Hatayama, I; Sato, K; Tsuchida, S; Yokoyama, Y, 1993) |
| "Ciprofibrate treatment did not increase the number or volume of altered hepatic foci (putative preneoplastic lesions)." | 1.28 | Lack of initiating activity of the peroxisome proliferator ciprofibrate in two-stage hepatocarcinogenesis. ( Clark, TD; Glauert, HP, 1989) |
| "Rats treated with clofibrate revealed foci of cellular alteration that were more often basophilic and occurred slightly sooner (wk 42) than those in untreated controls (wk 60)." | 1.27 | Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their reversibility. ( Greaves, P; Irisarri, E; Monro, AM, 1986) |
| " Chronic administration of these non-DNA damaging and nonmutagenic peroxisome proliferators to rats and mice results in the development of hepatocellular carcinomas." | 1.27 | Comparison of hepatic peroxisome proliferative effect and its implication for hepatocarcinogenicity of phthalate esters, di(2-ethylhexyl) phthalate, and di(2-ethylhexyl) adipate with a hypolipidemic drug. ( Lalwani, ND; Rao, MS; Reddy, JK; Reddy, MK; Usman, MI, 1986) |
| "Altered areas (AA), neoplastic nodules (NN) and hepatocellular carcinomas (HCC) induced by chronic administration of ciprofibrate and Wy-14,643 were examined for iron accumulation after systemic iron overload." | 1.27 | Increased resistance of peroxisome proliferator-induced hepatic lesions to iron overload in rats. ( Rao, MS; Reddy, JK; Subbarao, V, 1986) |
| "Treatment with clofibrate in doses which normalized the plasma free fatty acid/albumin ratio also prevented the tumor-associated rise in plasma fibrinogen." | 1.26 | Suppression of tumor-associated hyperfibrinogenemia and free fatty acidemia with p-phenoxybenzalbutyrate (clofibrate). ( Pickart, L; Thaler, MM, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (40.58) | 18.7374 |
| 1990's | 29 (42.03) | 18.2507 |
| 2000's | 6 (8.70) | 29.6817 |
| 2010's | 6 (8.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hirane, M | 1 |
| Ishii, S | 1 |
| Tomimatsu, A | 1 |
| Fukushima, K | 1 |
| Takahashi, K | 1 |
| Fukushima, N | 1 |
| Honoki, K | 1 |
| Tsujiuchi, T | 1 |
| Asano, J | 2 |
| Kudo, T | 2 |
| Shimizu, T | 4 |
| Fan, Y | 4 |
| Nanashima, N | 4 |
| Yamana, D | 3 |
| Miura, T | 3 |
| Yamada, T | 3 |
| Tsuchida, S | 6 |
| Cho, WS | 1 |
| Jeong, J | 1 |
| Choi, M | 1 |
| Park, SN | 1 |
| Han, BS | 1 |
| Son, WC | 1 |
| Hakamada, K | 1 |
| Ozawa, S | 1 |
| Gamou, T | 1 |
| Habano, W | 1 |
| Inoue, K | 1 |
| Yoshida, M | 1 |
| Nishikawa, A | 1 |
| Nemoto, K | 1 |
| Degawa, M | 1 |
| Canuto, RA | 5 |
| Muzio, G | 5 |
| Maggiora, M | 5 |
| Trombetta, A | 3 |
| Martinasso, G | 3 |
| Autelli, R | 2 |
| Costelli, P | 2 |
| Bonelli, G | 2 |
| Baccino, FM | 2 |
| Youssef, JA | 1 |
| Bouziane, M | 1 |
| Badr, MZ | 1 |
| Reffo, P | 1 |
| Colombatto, S | 1 |
| Akita, M | 1 |
| Ookawa, K | 1 |
| Hayakari, M | 1 |
| Yokoyama, Y | 3 |
| Suto, K | 1 |
| Luci, S | 1 |
| Giemsa, B | 1 |
| Hause, G | 1 |
| Kluge, H | 1 |
| Eder, K | 1 |
| Numoto, S | 1 |
| Furukawa, K | 6 |
| Furuya, K | 1 |
| Williams, GM | 2 |
| Gotoh, M | 4 |
| Mochizuki, Y | 6 |
| Sawada, N | 5 |
| Tsukada, H | 4 |
| Radaeva, S | 1 |
| Steinberg, P | 1 |
| Nishimura, S | 2 |
| Nakano, H | 1 |
| Satoh, K | 1 |
| Kano, H | 1 |
| Sato, K | 3 |
| Green, S | 2 |
| Issemann, I | 1 |
| Tugwood, JD | 1 |
| Prince, RA | 1 |
| Aldridge, TC | 1 |
| Cattley, RC | 1 |
| Kato, M | 1 |
| Popp, JA | 2 |
| Teets, VJ | 1 |
| Voss, KS | 1 |
| Wahli, W | 1 |
| Hasegawa, R | 2 |
| Yoshida, T | 1 |
| Mizoguchi, Y | 1 |
| Futakuchi, M | 1 |
| Kim, DJ | 3 |
| Cui, L | 1 |
| Ito, N | 6 |
| de Camargo, JL | 1 |
| Tsuda, H | 4 |
| Asamoto, M | 3 |
| Tagawa, Y | 1 |
| Wada, S | 2 |
| Nagase, S | 1 |
| Schoonjans, K | 1 |
| Staels, B | 1 |
| Grimaldi, P | 1 |
| Auwerx, J | 1 |
| Hatayama, I | 1 |
| Ferro, M | 1 |
| Bassi, AM | 1 |
| Leonarduzzi, G | 1 |
| Adamo, D | 1 |
| Poli, G | 1 |
| Lindahl, R | 1 |
| Baba-Toriyama, H | 2 |
| Iwahori, Y | 2 |
| Hori, T | 2 |
| Tsuchiya, T | 2 |
| Mutai, M | 3 |
| Yamasaki, H | 2 |
| Ota, T | 1 |
| Uehara, N | 1 |
| Krutovskikh, VA | 1 |
| Takasuka, N | 1 |
| Tatematsu, M | 3 |
| Perrone, C | 1 |
| Rao, MS | 10 |
| Reddy, JK | 12 |
| Rao, KN | 1 |
| Elm, MS | 1 |
| Kelly, RH | 1 |
| Chandar, N | 1 |
| Brady, EP | 1 |
| Rao, B | 1 |
| Shinozuka, H | 1 |
| Eagon, PK | 1 |
| Motojima, K | 1 |
| Passilly, P | 1 |
| Peters, JM | 1 |
| Gonzalez, FJ | 1 |
| Latruffe, N | 1 |
| Barbiero, G | 1 |
| Brossa, O | 1 |
| Buchmann, A | 1 |
| Willy, C | 1 |
| Buenemann, CL | 1 |
| Stroh, C | 1 |
| Schmiechen, A | 1 |
| Schwarz, M | 1 |
| Sano, M | 1 |
| Hagiwara, A | 1 |
| Tamano, S | 1 |
| Imaida, K | 1 |
| Shirai, T | 1 |
| Shoda, T | 1 |
| Mitsumori, K | 1 |
| Onodera, H | 1 |
| Toyoda, K | 1 |
| Uneyama, C | 1 |
| Imazawa, T | 1 |
| Hirose, M | 1 |
| Qu, B | 1 |
| Li, QT | 1 |
| Wong, KP | 1 |
| Ong, CN | 1 |
| Halliwell, B | 1 |
| Nagai, MK | 1 |
| Farber, E | 1 |
| Pickart, L | 1 |
| Thaler, MM | 1 |
| Qureshi, SA | 1 |
| Svoboda, DJ | 1 |
| Azarnoff, DL | 1 |
| Ozaki, K | 1 |
| Uwagawa, S | 1 |
| Yamaguchi, S | 1 |
| Hakoi, K | 1 |
| Aoki, T | 3 |
| Kato, T | 1 |
| Tanaka, K | 1 |
| Smith, PF | 1 |
| Stromberg, PC | 1 |
| Eydelloth, RS | 1 |
| Herold, EG | 1 |
| Grossman, SJ | 1 |
| Frank, JD | 1 |
| Hertzog, PR | 1 |
| Soper, KA | 1 |
| Keenan, KP | 1 |
| Gerbracht, U | 1 |
| Bursch, W | 1 |
| Kraus, P | 1 |
| Putz, B | 1 |
| Reinacher, M | 1 |
| Timmermann-Trosiener, I | 1 |
| Schulte-Hermann, R | 1 |
| Giometti, CS | 1 |
| Taylor, J | 1 |
| Gemmell, MA | 1 |
| Tollaksen, SL | 1 |
| Lalwani, ND | 2 |
| Glauert, HP | 2 |
| Beaty, MM | 1 |
| Clark, TD | 2 |
| Greenwell, WS | 1 |
| Tatum, V | 1 |
| Chen, LC | 1 |
| Borges, T | 1 |
| Clark, TL | 1 |
| Srinivasan, SR | 1 |
| Chow, CK | 1 |
| Tamura, H | 1 |
| Iida, T | 1 |
| Watanabe, T | 2 |
| Suga, T | 2 |
| Lee, GH | 1 |
| Nomura, K | 1 |
| Kitagawa, T | 1 |
| Yeldandi, AV | 1 |
| Milano, M | 2 |
| Subbarao, V | 5 |
| Hosokawa, S | 1 |
| Nakanowatari, J | 1 |
| Igarashi, T | 1 |
| Kasai, H | 1 |
| Okada, Y | 1 |
| Plenat, F | 1 |
| Braun, L | 1 |
| Fausto, N | 1 |
| Garvey, LK | 1 |
| Hamm, TE | 1 |
| Swenberg, JA | 1 |
| Greaves, P | 1 |
| Irisarri, E | 1 |
| Monro, AM | 1 |
| Prasad, JD | 1 |
| Dwivedi, RS | 1 |
| Kokkinakis, DM | 1 |
| Nagini, S | 1 |
| Nagarajan, B | 1 |
| Mizumoto, K | 1 |
| Kitazawa, S | 1 |
| Eguchi, T | 1 |
| Nakajima, A | 1 |
| Tsutsumi, M | 1 |
| Ito, S | 1 |
| Danda, A | 1 |
| Konishi, Y | 1 |
| Mitsukawa, M | 1 |
| Horie, S | 1 |
| Seki, K | 1 |
| Reddy, MK | 1 |
| Usman, MI | 1 |
4 reviews available for clofibrate and Experimental Hepatoma
| Article | Year |
|---|---|
Delineating peroxisome proliferator action to improve human risk assessment.
Topics: Acyl-CoA Oxidase; Animals; Base Sequence; Clofibrate; Cloning, Molecular; Diethylhexyl Phthalate; DN | 1994 |
Peroxisome proliferator-activated receptors: finding the orphan a home.
Topics: Acyl-CoA Oxidase; Animals; Base Sequence; Carcinogens; Clofibrate; Cytochrome P-450 Enzyme System; F | 1994 |
Mechanism-based risk assessment of peroxisome proliferating rodent hepatocarcinogens.
Topics: Animals; Carcinogens; Cell Division; Clofibrate; DNA Damage; Dose-Response Relationship, Drug; Human | 1996 |
Hepatocarcinogenesis of peroxisome proliferators.
Topics: Animals; Carcinogens; Cell Division; Clofibrate; DNA Damage; Humans; Hypolipidemic Agents; Liver Neo | 1996 |
65 other studies available for clofibrate and Experimental Hepatoma
| Article | Year |
|---|---|
Different induction of LPA receptors by chemical liver carcinogens regulates cellular functions of liver epithelial WB-F344 cells.
Topics: Animals; Carcinogens; Cell Line; Cell Movement; Clofibrate; Diethylnitrosamine; Epithelial Cells; Ge | 2016 |
Histone acetylation and steroid receptor coactivator expression during clofibrate-induced rat hepatocarcinogenesis.
Topics: Acetyl Coenzyme A; Acetyl-CoA C-Acetyltransferase; Acetylation; Animals; Cell Transformation, Neopla | 2010 |
Glutathione S-transferase A4 is a positive marker for rat hepatic foci induced by clofibrate and genotoxic carcinogens.
Topics: Animals; Biomarkers, Tumor; Clofibrate; Glutathione S-Transferase pi; Glutathione Transferase; Immun | 2010 |
26-Week carcinogenicity study of di-isodecyl phthalate by dietary administration to CB6F1-rasH2 transgenic mice.
Topics: Adenoma, Liver Cell; Administration, Oral; Animals; Carcinogenicity Tests; Carcinogens; Clofibrate; | 2011 |
Decrease of hepatic stellate cells in rats with enhanced sensitivity to clofibrate-induced hepatocarcinogenesis.
Topics: Actins; Animals; Anticholesteremic Agents; Biomarkers, Tumor; Cell Transformation, Neoplastic; Cells | 2011 |
Altered expression of GADD45 genes during the development of chemical-mediated liver hypertrophy and liver tumor promotion in rats.
Topics: Animals; Cell Cycle Proteins; Clofibrate; Cytochrome P-450 Enzyme System; DNA Damage; Down-Regulatio | 2011 |
Apoptosis induced by clofibrate in Yoshida AH-130 hepatoma cells: role of HMG-CoA reductase.
Topics: Animals; Apoptosis; Cholesterol; Clofibrate; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglut | 2003 |
Aldehyde dehydrogenase 3 expression is decreased by clofibrate via PPAR gamma induction in JM2 rat hepatoma cell line.
Topics: Aldehyde Dehydrogenase; Animals; Blotting, Northern; Blotting, Western; Clofibrate; Gene Expression | 2003 |
Age-dependent effects of nongenotoxic hepatocarcinogens on liver apoptosis in vivo.
Topics: Aging; Animals; Apoptosis; Carcinogens; Cell Count; Cholesterol; Clofibrate; Hepatocytes; Hepatomega | 2003 |
Mechanisms involved in growth inhibition induced by clofibrate in hepatoma cells.
Topics: Animals; Cell Division; Clofibrate; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Gene | 2003 |
Different susceptibility to peroxisome proliferator-induced hepatocarcinogenesis in rats with polymorphic glutathione transferase genes.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Amino Acid Substitution; Animals; Cell Differentiation; Clofibrate | 2006 |
Clofibrate treatment in pigs: effects on parameters critical with respect to peroxisome proliferator-induced hepatocarcinogenesis in rodents.
Topics: Acyl-CoA Oxidase; Animals; Clofibrate; Hypolipidemic Agents; Liver; Liver Neoplasms, Experimental; M | 2007 |
Effects of the hepatocarcinogenic peroxisome-proliferating hypolipidemic agents clofibrate and nafenopin on the rat liver cell membrane enzymes gamma-glutamyltranspeptidase and alkaline phosphatase and on the early stages of liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Alkaline Phosphatase; Animals; Body Weight; Cell Division; Cell Membrane; Clo | 1984 |
Matrical inclusions of peroxisomes induced by clofibrate in preneoplastic hepatocytes of rats fed 3'-methyl-4-dimethyl-aminoazobenzene.
Topics: Animals; Clofibrate; Inclusion Bodies; Liver Neoplasms, Experimental; Male; Methyldimethylaminoazobe | 1982 |
Effect of simultaneous administration of clofibrate with diethylnitrosamine on hepatic tumorigenesis in the rat.
Topics: Animals; Clofibrate; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; Liver N | 1983 |
Primary culture of preneoplastic hepatocytes from rats treated with 2-acetylaminofluorene and clofibrate: relationship between resistance to dimethylnitrosamine and responsiveness of peroxisomes.
Topics: 2-Acetylaminofluorene; Animals; Cells, Cultured; Clofibrate; Dimethylnitrosamine; Drug Resistance; L | 1982 |
Hepatocytes with extraperoxisomal catalase in rats fed 3'-methyl-4-dimethylaminoazobenzene.
Topics: Animals; Catalase; Clofibrate; Enzyme Activation; Histocytochemistry; Liver Neoplasms, Experimental; | 1982 |
Effects of various concentrations of ethyl-alpha-p-chlorophenoxyisobutyrate (clofibrate) on diethylnitrosamine-induced hepatic tumorigenesis in the rat.
Topics: Animals; Body Weight; Clofibrate; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, | 1982 |
Phenotype and differentiation patterns of the oval cell lines OC/CDE 6 and OC/CDE 22 derived from the livers of carcinogen-treated rats.
Topics: 3,3'-Diaminobenzidine; Albumins; alpha-Fetoproteins; Animals; Antigens, Neoplasm; Cell Differentiati | 1995 |
Decreased expression of glutathione S-transferases and increased fatty change in peroxisomal enzyme-negative foci induced by clofibrate in rat livers.
Topics: Animals; Clofibrate; Enoyl-CoA Hydratase; Fats; Glutathione Transferase; Immunohistochemistry; Liver | 1995 |
Initiator-specific promotion of hepatocarcinogenesis by WY-14,643 and clofibrate.
Topics: 2-Acetylaminofluorene; Animals; Clofibrate; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; | 1994 |
Phenotypic alteration of hepatocellular foci in rats treated with clofibrate and phenobarbital.
Topics: Animals; Clofibrate; Glutathione Transferase; Liver Neoplasms; Liver Neoplasms, Experimental; Male; | 1994 |
Modifying effects of chemicals on the development of liver preneoplastic placental glutathione S-transferase positive foci in analbuminemic and Sprague-Dawley rats.
Topics: Acetylglucosaminidase; Animals; Butylated Hydroxyanisole; Carcinogens; Clofibrate; Diethylnitrosamin | 1993 |
Acyl-CoA synthetase mRNA expression is controlled by fibric-acid derivatives, feeding and liver proliferation.
Topics: Adipose Tissue; Animals; Clofibrate; Coenzyme A Ligases; Diet; Fenofibrate; Gemfibrozil; Gene Expres | 1993 |
Lack of peroxisomal enzyme inducibility in rat hepatic preneoplastic lesions induced by mutagenic carcinogens: contrasted expression of glutathione S-transferase P form and enoyl CoA hydratase.
Topics: Animals; Cells, Cultured; Clofibrate; Clofibric Acid; Dexamethasone; Enoyl-CoA Hydratase; Enzyme Ind | 1993 |
Effects of aldehyde products of lipid peroxidation on the activity of aldehyde metabolizing enzymes in hepatomas.
Topics: Aldehyde Dehydrogenase; Aldehydes; Animals; Clofibrate; L-Lactate Dehydrogenase; Lipid Peroxidation; | 1993 |
Clofibrate-induced neoplastic development in the rat liver is associated with decreased connexin 32 expression but not with a co-ordinated shift in expression of marker enzymes.
Topics: Animals; Clofibrate; Connexins; Gap Junction beta-1 Protein; Gap Junctions; Liver; Liver Neoplasms, | 1995 |
Decreased connexin32 and a characteristic enzyme phenotype in clofibrate-induced preneoplastic lesions not shared with spontaneously occurring lesions in the rat liver.
Topics: Animals; Carcinogens; Clofibrate; Connexins; Diethylnitrosamine; gamma-Glutamyltransferase; Gap Junc | 1996 |
Hepatic hyperplasia and cancer in rats: metabolic alterations associated with cell growth.
Topics: Animals; Blotting, Western; Carcinogens; Cell Division; Cholesterol; Clofibrate; Diethylhexyl Phthal | 1997 |
Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner.
Topics: Adipates; Adipose Tissue; Animals; Base Sequence; CD36 Antigens; Clofibrate; Diethylhexyl Phthalate; | 1998 |
Peroxisome proliferators induce apoptosis in hepatoma cells.
Topics: Animals; Apoptosis; Cell Membrane; Clofibrate; Deoxyuracil Nucleotides; DNA Fragmentation; DNA Nucle | 1998 |
Inhibition of transforming growth factor beta1-induced hepatoma cell apoptosis by liver tumor promoters: characterization of primary signaling events and effects on CPP32-like caspase activity.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Calcium-Calmodulin-Dependent Protein | 1999 |
Dose-dependent induction of carcinomas and glutathione S-transferase placental form negative eosinophilic foci in the rat liver by di(2-ethylhexyl)phthalate after diethylnitrosamine initiation.
Topics: Adenoma, Liver Cell; Animals; Body Weight; Carcinoma, Hepatocellular; Clofibrate; Cocarcinogenesis; | 1999 |
The relationship between decrease in Cx32 and induction of P450 isozymes in the early phase of clofibrate hepatocarcinogenesis in the rat.
Topics: Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Clofibrate; Connexins; Cytochrome P-450 En | 1999 |
Mitochondrial damage by the "pro-oxidant" peroxisomal proliferator clofibrate.
Topics: Animals; Carcinogens; Clofibrate; DNA Damage; Hypolipidemic Agents; Lipid Peroxidation; Liver Neopla | 1999 |
The slow induction of resistant hepatocytes during initiation of hepatocarcinogenesis by the nongenotoxic carcinogen clofibrate.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Carcinogens; Cell Division; Clofibrate; D | 1999 |
Changes in peroxisomes in preneoplastic liver and hepatoma of mice induced by alpha-benzene hexachloride.
Topics: Animals; Clofibrate; Hexachlorocyclohexane; Hyperplasia; Liver Neoplasms, Experimental; Male; Mice; | 1979 |
Suppression of tumor-associated hyperfibrinogenemia and free fatty acidemia with p-phenoxybenzalbutyrate (clofibrate).
Topics: Animals; Clofibrate; Fatty Acids, Nonesterified; Fibrinogen; Liver Neoplasms, Experimental; Male; Ra | 1979 |
Tumorigenicity of the hypolipidaemic peroxisome proliferator ethyl-alpha-p-chlorophenoxyisobutyrate (clofibrate) in rats.
Topics: Animals; Clofibrate; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Microscopy, Electron; Neop | 1979 |
Tumors in male rats fed ethyl chlorophenoxyisobutyrate, a hypolipidemic drug.
Topics: Animals; Clofibrate; Kidney Neoplasms; Liver Neoplasms, Experimental; Lung Neoplasms; Lymphoma, Non- | 1979 |
Enhancement by Wy-14,643, a hepatic peroxisome proliferator, of diethylnitrosamine-initiated hepatic tumorigenesis in the rat.
Topics: Acetates; Animals; Cell Division; Clofibrate; Diethylnitrosamine; Drug Synergism; Liver; Liver Neopl | 1978 |
Effects of modifying agents on conformity of enzyme phenotype and proliferative potential in focal preneoplastic and neoplastic liver cell lesions in rats.
Topics: Adenosine Triphosphatases; Animals; Bromodeoxyuridine; Cell Division; Clofibrate; Diethylhexyl Phtha | 1992 |
Studies of early hepatocellular proliferation and peroxisomal proliferation in Sprague-Dawley rats treated with tumorigenic doses of clofibrate.
Topics: Administration, Oral; Animals; Bromodeoxyuridine; Cell Nucleus; Clofibrate; Dose-Response Relationsh | 1992 |
Effects of hypolipidemic drugs nafenopin and clofibrate on phenotypic expression and cell death (apoptosis) in altered foci of rat liver.
Topics: Animals; Body Weight; Carcinogens; Cell Survival; Clofibrate; Cyproterone; Cyproterone Acetate; Fema | 1990 |
Quantitative changes in sets of proteins as markers of biological response.
Topics: Animals; Biomarkers; Carcinogens; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; Electrophoresi | 1991 |
Effect of dietary vitamin E on the development of altered hepatic foci and hepatic tumors induced by the peroxisome proliferator ciprofibrate.
Topics: Adenosine Triphosphatases; Animals; Clofibrate; Clofibric Acid; Drug Synergism; Female; Fibric Acids | 1990 |
Modulatory interaction between initial clofibrate treatment and subsequent administration of 2-acetylaminofluorene or sodium phenobarbital on glutathione S-transferase positive lesion development.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Clofibrate; Drug Interactions; Glutathione Transferase; | 1990 |
Long-term effects of peroxisome proliferators on the balance between hydrogen peroxide-generating and scavenging capacities in the liver of Fischer-344 rats.
Topics: Acyl-CoA Oxidase; Animals; Bezafibrate; Cells, Cultured; Clofibrate; Cytosol; Diethylhexyl Phthalate | 1990 |
Comparative study of diethylnitrosamine-initiated two-stage hepatocarcinogenesis in C3H, C57BL and BALB mice promoted by various hepatopromoters.
Topics: Animals; Clofibrate; Diethylnitrosamine; Ethinyl Estradiol; Liver; Liver Neoplasms, Experimental; Li | 1989 |
Evaluation of liver cell proliferation during ciprofibrate-induced hepatocarcinogenesis.
Topics: Animals; Cell Division; Clofibrate; Clofibric Acid; DNA; Ethoxyquin; Fibric Acids; Liver; Liver Neop | 1989 |
Modulation of diethylnitrosamine-initiated placental glutathione S-transferase positive preneoplastic and neoplastic lesions by clofibrate, a hepatic peroxisome proliferator.
Topics: Animals; Body Weight; Clofibrate; Diethylnitrosamine; Female; Glutathione Transferase; Immunoenzyme | 1989 |
Formation of 8-hydroxydeoxyguanosine in liver DNA of rats following long-term exposure to a peroxisome proliferator.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cell Division; Clofibrate; Clofibric Acid; Deoxyguanosine; DNA | 1989 |
Demonstration of glucose-6-phosphatase and peroxisomal catalase activity by ultrastructural cytochemistry in oval cells from livers of carcinogen-treated rats.
Topics: Animals; Carcinogens; Catalase; Cells, Cultured; Clofibrate; Epithelial Cells; Epithelium; Freeze Fr | 1988 |
Lack of hepatic promotional activity by the peroxisomal proliferating hepatocarcinogen di(2-ethylhexyl)phthalate.
Topics: Animals; Cell Division; Clofibrate; Diethylhexyl Phthalate; Diethylnitrosamine; Female; gamma-Glutam | 1985 |
Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their reversibility.
Topics: Animals; Body Weight; Clofibrate; Diethylnitrosamine; gamma-Glutamyltransferase; Glucosephosphate De | 1986 |
Peroxisome proliferator-induced hepatocarcinogenesis: histochemical analysis of ciprofibrate-induced preneoplastic and neoplastic lesions for gamma-glutamyl transpeptidase activity.
Topics: Animals; Clofibrate; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase; Histocytochemistry; Li | 1986 |
Absence of gamma-glutamyltranspeptidase activity in lung metastasis in rats with hepatocellular carcinomas induced by ciprofibrate, a peroxisome proliferator.
Topics: Animals; Cell Division; Clofibrate; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase; Liver; | 1987 |
Induction of peroxisome proliferation and hepatic tumours in C57BL/6N mice by ciprofibrate, a hypolipidaemic compound.
Topics: Adenoma; Animals; Clofibrate; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase; Hypolipidemic | 1988 |
Lack of initiating activity of the peroxisome proliferator ciprofibrate in two-stage hepatocarcinogenesis.
Topics: Animals; Clofibrate; Clofibric Acid; Cocarcinogenesis; Diet; Dose-Response Relationship, Drug; Femal | 1989 |
Peroxisome proliferator-induced hepatocarcinogenesis: levels of activating and detoxifying enzymes in hepatocellular carcinomas induced by ciprofibrate.
Topics: Animals; Clofibrate; Clofibric Acid; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes | 1987 |
Hypolipidemic drug clofibrate promotes hepatic tumor.
Topics: Animals; Carcinogenicity Tests; Clofibrate; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; | 1988 |
Modulation of N-nitrosobis(2-hydroxypropyl)amine-induced carcinogenesis by clofibrate in hamsters.
Topics: Animals; Bile; Carcinogens; Clofibrate; Cricetinae; Gallbladder Neoplasms; Hydrogen Peroxide; Kidney | 1988 |
Effects of some hypolipidemic agents on biochemical values and hepatic peroxisomal enzymes in rats: comparison of probucol, CGA, KCD-232, MLM-160, AL-369 and clinofibrate with clofibrate.
Topics: Animals; Cell Division; Clofibrate; Glycolates; Hypolipidemic Agents; Lipids; Liver; Liver Neoplasms | 1987 |
Comparison of hepatic peroxisome proliferative effect and its implication for hepatocarcinogenicity of phthalate esters, di(2-ethylhexyl) phthalate, and di(2-ethylhexyl) adipate with a hypolipidemic drug.
Topics: Adipates; Animals; Catalase; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; Dose-Response Relat | 1986 |
Increased resistance of peroxisome proliferator-induced hepatic lesions to iron overload in rats.
Topics: Animals; Cell Division; Clofibrate; Clofibric Acid; Fibric Acids; Iron; Liver; Liver Neoplasms, Expe | 1986 |