clofibrate has been researched along with Condition, Preneoplastic in 24 studies
angiokapsul: contains clofibrate & insoitolnicotinate
| Excerpt | Relevance | Reference |
|---|---|---|
| " It is suggested that the liver lesions of this woman may be related to long-term administration of hypolipidemic drug clofibrate for hypercholesteremia and the lesions could be one of the precursor changes of human hepatocellular carcinoma." | 3.66 | Adenoma with multiple hyperplastic nodules in noncirrhotic liver possibly related to long-term administration of a hypolipidemic drug. ( Mori, H; Sugie, S; Takahashi, M; Tanaka, T, 1982) |
| "Incidences of hepatocellular carcinomas were 75% (9/12, P < 0." | 1.30 | Dose-dependent induction of carcinomas and glutathione S-transferase placental form negative eosinophilic foci in the rat liver by di(2-ethylhexyl)phthalate after diethylnitrosamine initiation. ( Hagiwara, A; Hasegawa, R; Imaida, K; Ito, N; Sano, M; Shirai, T; Tamano, S, 1999) |
| "Clofibrate (CF) was therefore administered for 2 or 4 weeks following performance of the Solt-Farber protocol using diethylnitrosamine and 2-acetylaminofluorene." | 1.29 | Lack of peroxisomal enzyme inducibility in rat hepatic preneoplastic lesions induced by mutagenic carcinogens: contrasted expression of glutathione S-transferase P form and enoyl CoA hydratase. ( Hatayama, I; Sato, K; Tsuchida, S; Yokoyama, Y, 1993) |
| "Rats treated with clofibrate revealed foci of cellular alteration that were more often basophilic and occurred slightly sooner (wk 42) than those in untreated controls (wk 60)." | 1.27 | Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their reversibility. ( Greaves, P; Irisarri, E; Monro, AM, 1986) |
| "Altered areas (AA), neoplastic nodules (NN) and hepatocellular carcinomas (HCC) induced by chronic administration of ciprofibrate and Wy-14,643 were examined for iron accumulation after systemic iron overload." | 1.27 | Increased resistance of peroxisome proliferator-induced hepatic lesions to iron overload in rats. ( Rao, MS; Reddy, JK; Subbarao, V, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (45.83) | 18.7374 |
| 1990's | 12 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (4.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shimizu, T | 1 |
| Fan, Y | 1 |
| Yamana, D | 1 |
| Miura, T | 1 |
| Nanashima, N | 1 |
| Yamada, T | 1 |
| Tsuchida, S | 3 |
| Mori, H | 1 |
| Tanaka, T | 1 |
| Sugie, S | 1 |
| Takahashi, M | 1 |
| Gotoh, M | 4 |
| Mochizuki, Y | 5 |
| Sawada, N | 3 |
| Tsukada, H | 5 |
| Furukawa, K | 3 |
| Sakai, M | 1 |
| Matsushima-Hibiya, Y | 1 |
| Nishizawa, M | 1 |
| Nishi, S | 1 |
| Nishimura, S | 1 |
| Yokoyama, Y | 2 |
| Nakano, H | 1 |
| Satoh, K | 1 |
| Kano, H | 1 |
| Sato, K | 3 |
| Hasegawa, R | 2 |
| Yoshida, T | 1 |
| Mizoguchi, Y | 1 |
| Futakuchi, M | 1 |
| Kim, DJ | 4 |
| Cui, L | 1 |
| Ito, N | 6 |
| de Camargo, JL | 1 |
| Tsuda, H | 4 |
| Asamoto, M | 3 |
| Tagawa, Y | 1 |
| Wada, S | 2 |
| Nagase, S | 1 |
| Hatayama, I | 1 |
| Baba-Toriyama, H | 2 |
| Iwahori, Y | 2 |
| Hori, T | 2 |
| Tsuchiya, T | 2 |
| Mutai, M | 3 |
| Yamasaki, H | 2 |
| Ota, T | 1 |
| Uehara, N | 1 |
| Krutovskikh, VA | 1 |
| Takasuka, N | 1 |
| Tatematsu, M | 3 |
| Lee, KK | 1 |
| Hong, JT | 1 |
| Sano, M | 1 |
| Hagiwara, A | 1 |
| Tamano, S | 1 |
| Imaida, K | 1 |
| Shirai, T | 1 |
| Itabashi, M | 1 |
| Ozaki, K | 1 |
| Uwagawa, S | 1 |
| Yamaguchi, S | 1 |
| Hakoi, K | 1 |
| Aoki, T | 3 |
| Kato, T | 1 |
| Gerbracht, U | 1 |
| Bursch, W | 1 |
| Kraus, P | 1 |
| Putz, B | 1 |
| Reinacher, M | 1 |
| Timmermann-Trosiener, I | 1 |
| Schulte-Hermann, R | 1 |
| Yeldandi, AV | 1 |
| Subbarao, V | 3 |
| Rajan, A | 1 |
| Reddy, JK | 3 |
| Rao, MS | 3 |
| Hosokawa, S | 1 |
| Nakanowatari, J | 1 |
| Igarashi, T | 1 |
| Greaves, P | 1 |
| Irisarri, E | 1 |
| Monro, AM | 1 |
24 other studies available for clofibrate and Condition, Preneoplastic
| Article | Year |
|---|---|
Glutathione S-transferase A4 is a positive marker for rat hepatic foci induced by clofibrate and genotoxic carcinogens.
Topics: Animals; Biomarkers, Tumor; Clofibrate; Glutathione S-Transferase pi; Glutathione Transferase; Immun | 2010 |
Adenoma with multiple hyperplastic nodules in noncirrhotic liver possibly related to long-term administration of a hypolipidemic drug.
Topics: Aged; Carcinoma, Hepatocellular; Clofibrate; Female; Humans; Hypercholesterolemia; Hyperplasia; Hype | 1982 |
Matrical inclusions of peroxisomes induced by clofibrate in preneoplastic hepatocytes of rats fed 3'-methyl-4-dimethyl-aminoazobenzene.
Topics: Animals; Clofibrate; Inclusion Bodies; Liver Neoplasms, Experimental; Male; Methyldimethylaminoazobe | 1982 |
Primary culture of preneoplastic hepatocytes from rats treated with 2-acetylaminofluorene and clofibrate: relationship between resistance to dimethylnitrosamine and responsiveness of peroxisomes.
Topics: 2-Acetylaminofluorene; Animals; Cells, Cultured; Clofibrate; Dimethylnitrosamine; Drug Resistance; L | 1982 |
Hepatocytes with extraperoxisomal catalase in rats fed 3'-methyl-4-dimethylaminoazobenzene.
Topics: Animals; Catalase; Clofibrate; Enzyme Activation; Histocytochemistry; Liver Neoplasms, Experimental; | 1982 |
Suppression of rat glutathione transferase P expression by peroxisome proliferators: interaction between Jun and peroxisome proliferator-activated receptor alpha.
Topics: Animals; Base Sequence; Clofibrate; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; G | 1995 |
Decreased expression of glutathione S-transferases and increased fatty change in peroxisomal enzyme-negative foci induced by clofibrate in rat livers.
Topics: Animals; Clofibrate; Enoyl-CoA Hydratase; Fats; Glutathione Transferase; Immunohistochemistry; Liver | 1995 |
Phenotypic alteration of hepatocellular foci in rats treated with clofibrate and phenobarbital.
Topics: Animals; Clofibrate; Glutathione Transferase; Liver Neoplasms; Liver Neoplasms, Experimental; Male; | 1994 |
Modifying effects of chemicals on the development of liver preneoplastic placental glutathione S-transferase positive foci in analbuminemic and Sprague-Dawley rats.
Topics: Acetylglucosaminidase; Animals; Butylated Hydroxyanisole; Carcinogens; Clofibrate; Diethylnitrosamin | 1993 |
Lack of peroxisomal enzyme inducibility in rat hepatic preneoplastic lesions induced by mutagenic carcinogens: contrasted expression of glutathione S-transferase P form and enoyl CoA hydratase.
Topics: Animals; Cells, Cultured; Clofibrate; Clofibric Acid; Dexamethasone; Enoyl-CoA Hydratase; Enzyme Ind | 1993 |
Clofibrate-induced neoplastic development in the rat liver is associated with decreased connexin 32 expression but not with a co-ordinated shift in expression of marker enzymes.
Topics: Animals; Clofibrate; Connexins; Gap Junction beta-1 Protein; Gap Junctions; Liver; Liver Neoplasms, | 1995 |
Decreased connexin32 and a characteristic enzyme phenotype in clofibrate-induced preneoplastic lesions not shared with spontaneously occurring lesions in the rat liver.
Topics: Animals; Carcinogens; Clofibrate; Connexins; Diethylnitrosamine; gamma-Glutamyltransferase; Gap Junc | 1996 |
Differential effects of nongenotoxic and genotoxic carcinogens on the preneoplastic lesions in the rat liver.
Topics: Administration, Oral; Animals; Body Weight; Carcinogens; Cell Count; Clofibrate; Diethylnitrosamine; | 1998 |
Dose-dependent induction of carcinomas and glutathione S-transferase placental form negative eosinophilic foci in the rat liver by di(2-ethylhexyl)phthalate after diethylnitrosamine initiation.
Topics: Adenoma, Liver Cell; Animals; Body Weight; Carcinoma, Hepatocellular; Clofibrate; Cocarcinogenesis; | 1999 |
Changes in peroxisomes in preneoplastic liver and hepatoma of mice induced by alpha-benzene hexachloride.
Topics: Animals; Clofibrate; Hexachlorocyclohexane; Hyperplasia; Liver Neoplasms, Experimental; Male; Mice; | 1979 |
Changes in peroxisomes in preneoplastic liver of rats induced by 3'-methyl-4-dimethylaminoazobenzene.
Topics: Animals; Carcinoma, Hepatocellular; Catalase; Cell Differentiation; Clofibrate; Enzyme Induction; Hy | 1977 |
Effects of modifying agents on conformity of enzyme phenotype and proliferative potential in focal preneoplastic and neoplastic liver cell lesions in rats.
Topics: Adenosine Triphosphatases; Animals; Bromodeoxyuridine; Cell Division; Clofibrate; Diethylhexyl Phtha | 1992 |
Effects of hypolipidemic drugs nafenopin and clofibrate on phenotypic expression and cell death (apoptosis) in altered foci of rat liver.
Topics: Animals; Body Weight; Carcinogens; Cell Survival; Clofibrate; Cyproterone; Cyproterone Acetate; Fema | 1990 |
Modulatory interaction between initial clofibrate treatment and subsequent administration of 2-acetylaminofluorene or sodium phenobarbital on glutathione S-transferase positive lesion development.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Clofibrate; Drug Interactions; Glutathione Transferase; | 1990 |
gamma-Glutamyltranspeptidase-negative phenotypic property of preneoplastic and neoplastic liver lesions induced by ciprofibrate does not change following 2-acetylaminofluorene administration.
Topics: 2-Acetylaminofluorene; Animals; Clofibrate; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase; | 1989 |
Modulation of diethylnitrosamine-initiated placental glutathione S-transferase positive preneoplastic and neoplastic lesions by clofibrate, a hepatic peroxisome proliferator.
Topics: Animals; Body Weight; Clofibrate; Diethylnitrosamine; Female; Glutathione Transferase; Immunoenzyme | 1989 |
Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their reversibility.
Topics: Animals; Body Weight; Clofibrate; Diethylnitrosamine; gamma-Glutamyltransferase; Glucosephosphate De | 1986 |
Peroxisome proliferator-induced hepatocarcinogenesis: histochemical analysis of ciprofibrate-induced preneoplastic and neoplastic lesions for gamma-glutamyl transpeptidase activity.
Topics: Animals; Clofibrate; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase; Histocytochemistry; Li | 1986 |
Increased resistance of peroxisome proliferator-induced hepatic lesions to iron overload in rats.
Topics: Animals; Cell Division; Clofibrate; Clofibric Acid; Fibric Acids; Iron; Liver; Liver Neoplasms, Expe | 1986 |