clofibrate has been researched along with Carcinoma, Hepatocellular in 26 studies
angiokapsul: contains clofibrate & insoitolnicotinate
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| " It is suggested that the liver lesions of this woman may be related to long-term administration of hypolipidemic drug clofibrate for hypercholesteremia and the lesions could be one of the precursor changes of human hepatocellular carcinoma." | 3.66 | Adenoma with multiple hyperplastic nodules in noncirrhotic liver possibly related to long-term administration of a hypolipidemic drug. ( Mori, H; Sugie, S; Takahashi, M; Tanaka, T, 1982) |
| "Clofibrate treatment, however, resulted in a significant decrease in both parameters (p<0." | 1.34 | Role of cytosolic liver fatty acid binding protein in hepatocellular oxidative stress: effect of dexamethasone and clofibrate treatment. ( Burczynski, FJ; Gong, Y; Jiang, P; Rajaraman, G; Wang, GQ; Yan, J, 2007) |
| "When overexpressed in rat hepatoma cells (H4IIE) using a recombinant adenovirus, the mutated PPARalpha receptor antagonized the clofibrate-induced L-CPT I gene expression, whereas it did not affect LCFA-induced L-CPT I." | 1.33 | Fatty acids induce L-CPT I gene expression through a PPARalpha-independent mechanism in rat hepatoma cells. ( Burnol, AF; Caüzac, M; Diradourian, C; Girard, J; Le May, C; Pégorier, JP; Perdereau, D, 2005) |
| "In rat hepatoma (Fao) cells, treatment with WY-14,643 also increased the mRNA concentration of OCTN-2." | 1.33 | PPARalpha agonists up-regulate organic cation transporters in rat liver cells. ( Eder, K; Geissler, S; Hirche, F; Koch, A; König, B; Luci, S; Stangl, GI, 2006) |
| "Clofibrate treatment did not statistically affect growth rate." | 1.32 | Effect of dexamethasone, 2-bromopalmitate and clofibrate on L-FABP mediated hepatoma proliferation. ( Burczynski, FJ; Rajaraman, G, 2004) |
| "Lipid extracts of hepatoma cells or of liver or kidney stimulated expression of the reporter; extracts of CV-1 cells were far less effective." | 1.30 | High-level expression of RXRalpha and the presence of endogenous ligands contribute to expression of a peroxisome proliferator-activated receptor-responsive gene in hepatoma cells. ( Crabb, D; Dorris, R; Galli, A; Stewart, M, 1998) |
| " Transfected cells were dosed with several known inducers of CYP3A4 and the levels of SPAP were measured." | 1.30 | A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro. ( Gibson, GG; Goldfarb, PS; Gray, TJ; Ogg, MS; Tarbit, M; Williams, JM, 1999) |
| "Incidences of hepatocellular carcinomas were 75% (9/12, P < 0." | 1.30 | Dose-dependent induction of carcinomas and glutathione S-transferase placental form negative eosinophilic foci in the rat liver by di(2-ethylhexyl)phthalate after diethylnitrosamine initiation. ( Hagiwara, A; Hasegawa, R; Imaida, K; Ito, N; Sano, M; Shirai, T; Tamano, S, 1999) |
| "A transformed human hepatoma cell line was examined to determine if it was an appropriate model system for studying the mechanism of action of two peroxisome proliferators that lower blood lipids." | 1.29 | Inverse relationship between peroxisomal and mitochondrial beta-oxidation in HepG2 cells treated with dehydroepiandrosterone and clofibric acid. ( Chance, DS; McIntosh, MK; Wu, SM, 1995) |
| "Fenofibrate was compared to clofibrate to investigate whether their relative effects on lipoprotein production in Hep G2 cells were comparable to their relative effects on plasma lipoproteins." | 1.28 | Modulation of lipoprotein production in Hep G2 cells by fenofibrate and clofibrate. ( Goldberg, DM; Hahn, SE, 1992) |
| "In clofibrate-treated rats, the tumor cells showed a slight increase in the size of microbodies and in catalase activity; however, the tumor microbodies did not increase in number." | 1.25 | Response of microbodies in Morris hepatoma 9618A to clofibrate. ( Gotoh, M; Itabashi, M; Mochizuki, Y; Morris, HP; Tsukada, H, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (19.23) | 18.7374 |
| 1990's | 10 (38.46) | 18.2507 |
| 2000's | 9 (34.62) | 29.6817 |
| 2010's | 2 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jendralla, H | 1 |
| Granzer, E | 1 |
| von Kerekjarto, B | 1 |
| Krause, R | 1 |
| Schacht, U | 1 |
| Baader, E | 1 |
| Bartmann, W | 1 |
| Beck, G | 1 |
| Bergmann, A | 1 |
| Kesseler, K | 1 |
| Penna, F | 1 |
| Reffo, P | 1 |
| Muzio, G | 2 |
| Canuto, RA | 2 |
| Baccino, FM | 1 |
| Bonelli, G | 1 |
| Costelli, P | 1 |
| Maggiora, M | 1 |
| Oraldi, M | 1 |
| Yan, J | 2 |
| Gong, Y | 3 |
| Wang, G | 1 |
| Burczynski, FJ | 3 |
| Akbiyik, F | 1 |
| Ray, DM | 1 |
| Bozkaya, H | 1 |
| Demirpence, E | 1 |
| Rajaraman, G | 2 |
| Le May, C | 1 |
| Caüzac, M | 1 |
| Diradourian, C | 1 |
| Perdereau, D | 1 |
| Girard, J | 1 |
| Burnol, AF | 1 |
| Pégorier, JP | 1 |
| Drímal, J | 2 |
| Fáberová, V | 1 |
| Schmidtová, L | 1 |
| Bednáriková, M | 1 |
| Drímal, D | 1 |
| Wang, GQ | 1 |
| Jiang, P | 1 |
| Luci, S | 1 |
| Geissler, S | 1 |
| König, B | 1 |
| Koch, A | 1 |
| Stangl, GI | 1 |
| Hirche, F | 1 |
| Eder, K | 1 |
| Tanaka, N | 1 |
| Moriya, K | 1 |
| Kiyosawa, K | 1 |
| Koike, K | 1 |
| Gonzalez, FJ | 1 |
| Aoyama, T | 1 |
| Mori, H | 1 |
| Tanaka, T | 1 |
| Sugie, S | 1 |
| Takahashi, M | 1 |
| Scotto, C | 1 |
| Keller, JM | 1 |
| Schohn, H | 1 |
| Dauça, M | 1 |
| Chance, DS | 1 |
| Wu, SM | 1 |
| McIntosh, MK | 1 |
| Crowe, TC | 1 |
| Loidl, NM | 1 |
| Payne, KL | 1 |
| Topliss, DJ | 1 |
| Stockigt, JR | 1 |
| Barlow, JW | 1 |
| Authier, F | 1 |
| Cameron, PH | 1 |
| Taupin, V | 1 |
| Kauffmann, HM | 1 |
| Schrenk, D | 1 |
| Galli, A | 1 |
| Stewart, M | 1 |
| Dorris, R | 1 |
| Crabb, D | 1 |
| Ogg, MS | 1 |
| Williams, JM | 1 |
| Tarbit, M | 1 |
| Goldfarb, PS | 1 |
| Gray, TJ | 1 |
| Gibson, GG | 1 |
| Sano, M | 1 |
| Hagiwara, A | 1 |
| Tamano, S | 1 |
| Hasegawa, R | 1 |
| Imaida, K | 1 |
| Ito, N | 1 |
| Shirai, T | 1 |
| Kovacs, W | 1 |
| Stangl, H | 1 |
| Völkl, A | 1 |
| Schad, A | 1 |
| Dariush Fahimi, H | 1 |
| Baumgart, E | 1 |
| Tsukada, H | 2 |
| Mochizuki, Y | 2 |
| Itabashi, M | 2 |
| Gotoh, M | 1 |
| Morris, HP | 1 |
| Hahn, SE | 1 |
| Goldberg, DM | 1 |
| Hertz, R | 1 |
| Arnon, J | 1 |
| Hoter, A | 1 |
| Shouval, D | 1 |
| Bar-Tana, J | 1 |
| Reddy, J | 1 |
| Svoboda, D | 1 |
26 other studies available for clofibrate and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Synthesis and biological activity of new HMG-CoA reductase inhibitors. 3. Lactones of 6-phenoxy-3,5-dihydroxyhexanoic acids.
Topics: Animals; Anticholesteremic Agents; Caproates; Carcinoma, Hepatocellular; Cholesterol; Dogs; Humans; | 1991 |
Mechanisms of clofibrate-induced apoptosis in Yoshida AH-130 hepatoma cells.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Caspase 8; Caspase | 2009 |
Involvement of PPARα and PPARγ in apoptosis and proliferation of human hepatocarcinoma HepG2 cells.
Topics: Apoptosis; bcl-Associated Death Protein; Carcinoma, Hepatocellular; Cell Cycle; Cell Proliferation; | 2010 |
Regulation of liver fatty acid binding protein expression by clofibrate in hepatoma cells.
Topics: Anilides; Animals; Carcinoma, Hepatocellular; Catalase; Cell Line, Tumor; Clofibrate; Fatty Acid-Bin | 2010 |
Ligand- and species-dependent activation of PPARalpha.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Clofibrate; DNA; Electrophoreti | 2004 |
Effect of dexamethasone, 2-bromopalmitate and clofibrate on L-FABP mediated hepatoma proliferation.
Topics: Animals; Carcinoma, Hepatocellular; Carrier Proteins; Cell Proliferation; Clofibrate; Dexamethasone; | 2004 |
Fatty acids induce L-CPT I gene expression through a PPARalpha-independent mechanism in rat hepatoma cells.
Topics: Adenoviridae; Animals; Carcinoma, Hepatocellular; Carnitine O-Palmitoyltransferase; Cell Line, Tumor | 2005 |
The ACAT inhibitor VULM1457 significantly reduced production and secretion of adrenomedullin (AM) and down-regulated AM receptors on human hepatoblastic cells.
Topics: Adrenomedullin; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Tumor; Clofibrate; Dose-Response | 2005 |
Role of cytosolic liver fatty acid binding protein in hepatocellular oxidative stress: effect of dexamethasone and clofibrate treatment.
Topics: Carcinoma, Hepatocellular; Catalase; Cell Hypoxia; Clofibrate; Cytosol; Dexamethasone; Fatty Acid-Bi | 2007 |
PPARalpha agonists up-regulate organic cation transporters in rat liver cells.
Topics: Animals; Carcinoma, Hepatocellular; Catecholamine Plasma Membrane Transport Proteins; Cells, Culture | 2006 |
PPARalpha activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Clofibrate; DNA Damage; Fatty Acids; Fatty L | 2008 |
Adenoma with multiple hyperplastic nodules in noncirrhotic liver possibly related to long-term administration of a hypolipidemic drug.
Topics: Aged; Carcinoma, Hepatocellular; Clofibrate; Female; Humans; Hypercholesterolemia; Hyperplasia; Hype | 1982 |
Comparative effects of clofibrate on peroxisomal enzymes of human (Hep EBNA2) and rat (FaO) hepatoma cell lines.
Topics: Acyl-CoA Oxidase; Animals; Base Sequence; Carcinoma, Hepatocellular; Catalase; Clofibrate; Humans; I | 1995 |
Inverse relationship between peroxisomal and mitochondrial beta-oxidation in HepG2 cells treated with dehydroepiandrosterone and clofibric acid.
Topics: Analysis of Variance; Biomarkers; Carcinoma, Hepatocellular; Carnitine O-Palmitoyltransferase; Catal | 1995 |
Differential modulation of thyroid hormone responsiveness by retinoids in a human cell line.
Topics: Carcinoma, Hepatocellular; Clofibrate; Dose-Response Relationship, Drug; Humans; Sex Hormone-Binding | 1996 |
Association of insulin-degrading enzyme with a 70 kDa cytosolic protein in hepatoma cells.
Topics: Animals; Blotting, Northern; Carcinoma, Hepatocellular; Cells, Cultured; CHO Cells; Clofibrate; Cric | 1996 |
Sequence analysis and functional characterization of the 5'-flanking region of the rat multidrug resistance protein 2 (mrp2) gene.
Topics: 2-Acetylaminofluorene; Animals; Binding Sites; Carcinoma, Hepatocellular; Cisplatin; Clofibrate; Clo | 1998 |
High-level expression of RXRalpha and the presence of endogenous ligands contribute to expression of a peroxisome proliferator-activated receptor-responsive gene in hepatoma cells.
Topics: Carcinoma, Hepatocellular; Clofibrate; Gene Expression Regulation; Gene Expression Regulation, Neopl | 1998 |
A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro.
Topics: Alkaline Phosphatase; beta-Naphthoflavone; Caffeine; Carbamazepine; Carcinoma, Hepatocellular; Clofi | 1999 |
Dose-dependent induction of carcinomas and glutathione S-transferase placental form negative eosinophilic foci in the rat liver by di(2-ethylhexyl)phthalate after diethylnitrosamine initiation.
Topics: Adenoma, Liver Cell; Animals; Body Weight; Carcinoma, Hepatocellular; Clofibrate; Cocarcinogenesis; | 1999 |
Localization of mRNAs encoding peroxisomal proteins in cell culture by non-radioactive in situ hybridization. Comparison of rat and human hepatoma cells and their responses to two divergent hypolipidemic drugs.
Topics: 4-Aminobenzoic Acid; Acyl-CoA Oxidase; Animals; ATP-Binding Cassette Transporters; Carcinoma, Hepato | 2001 |
Response of microbodies in Morris hepatoma 9618A to clofibrate.
Topics: Animals; Animals, Newborn; Carcinoma, Hepatocellular; Catalase; Clofibrate; Female; Liver Neoplasms; | 1975 |
Changes in peroxisomes in preneoplastic liver of rats induced by 3'-methyl-4-dimethylaminoazobenzene.
Topics: Animals; Carcinoma, Hepatocellular; Catalase; Cell Differentiation; Clofibrate; Enzyme Induction; Hy | 1977 |
Modulation of lipoprotein production in Hep G2 cells by fenofibrate and clofibrate.
Topics: Apolipoproteins A; Apolipoproteins B; Carcinoma, Hepatocellular; Cell Line; Cholesterol; Cholesterol | 1992 |
Clofibrate does not induce peroxisomal proliferation in human hepatoma cell lines PLC/PRF/5 and SK-HEP-1.
Topics: Carcinoma, Hepatocellular; Cell Division; Cell Line; Clofibrate; Humans; Liver Neoplasms; Microbodie | 1987 |
Proliferation of microbodies and synthesis of catalase in rat liver. Induction in tumor-bearing host by CPIB.
Topics: Aflatoxins; Animals; Anticholesteremic Agents; Carcinoma, Hepatocellular; Catalase; Clofibrate; Cyto | 1971 |