Page last updated: 2024-10-25

clofibrate and Aging

clofibrate has been researched along with Aging in 21 studies

angiokapsul: contains clofibrate & insoitolnicotinate

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Clofibrate treatment in vivo (of which clofibric acid is the ester hydrolysis product) had no effect on clofibric acid glucuronidation in vitro."1.27Hepatic microsomal glucuronidation of clofibric acid in the adult and neonate albino rat. ( Odum, J; Orton, TC, 1983)
"Clofibrate treatment resulted in significant increases in the volumes of the hepatocytes and their constituent mitochondria and microbodies and caused a proliferation of the smooth-surfaced endoplasmic reticulum."1.26A quantitative analysis of fine structure and drug metabolism in livers of clofibrate-treated young adult and retired breeder rats. ( Anthony, LE; Jones, AL; Mooney, JS; Schmucker, DL, 1978)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-199012 (57.14)18.7374
1990's7 (33.33)18.2507
2000's2 (9.52)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Youssef, JA1
Bouziane, M1
Badr, MZ1
Sankaralingam, S1
Desai, KM1
Glaeser, H1
Kim, RB1
Wilson, TW1
Odum, J1
Orton, TC1
Van Arsdalen, KN1
Wein, AJ1
Calatayud, JM1
Gustafsson, K1
Kiessling, H1
Rao, AV1
Ramakrishnan, S1
Lin, F1
Abraham, NG1
Schwartzman, ML1
Kvannes, J1
Eikhom, TS1
Flatmark, T1
Périchon, R2
Bourre, JM2
Yamoto, T1
Ohashi, Y1
Furukawa, T1
Teranishi, M1
Manabe, S1
Makita, T1
Chatelain, F1
Pégorier, JP1
Minassian, C1
Bruni, N1
Tarpin, S1
Girard, J1
Mithieux, G1
Turunen, M1
Sindelar, P1
Dallner, G1
Dilman, VM1
Yü, TF1
Dorph, DJ1
Smith, H1
Anthony, LE1
Schmucker, DL1
Mooney, JS1
Jones, AL1
Chhabra, S1
Kurup, CK1
Guntheroth, WG1
Inamdar, AR1
Person, R2
Mackler, B2
Inamder, AR1
Baird, MB1
Zimmerman, JA1
Massie, HR1
Samis, HV1

Reviews

1 review available for clofibrate and Aging

ArticleYear
Hyperlipidemia in primary gout.
    Seminars in arthritis and rheumatism, 1978, Volume: 7, Issue:4

    Topics: Adolescent; Adult; Aged; Aging; Alcohol Drinking; Cholesterol; Clofibrate; Dextrothyroxine; Diabetes

1978

Other Studies

20 other studies available for clofibrate and Aging

ArticleYear
Age-dependent effects of nongenotoxic hepatocarcinogens on liver apoptosis in vivo.
    Mechanisms of ageing and development, 2003, Volume: 124, Issue:3

    Topics: Aging; Animals; Apoptosis; Carcinogens; Cell Count; Cholesterol; Clofibrate; Hepatocytes; Hepatomega

2003
Inability to upregulate cytochrome P450 4A and 2C causes salt sensitivity in young Sprague-Dawley rats.
    American journal of hypertension, 2006, Volume: 19, Issue:11

    Topics: Aging; Animals; Anticholesteremic Agents; Blood Pressure; Clofibrate; Cytochrome P-450 CYP4A; Cytoch

2006
Hepatic microsomal glucuronidation of clofibric acid in the adult and neonate albino rat.
    Biochemical pharmacology, 1983, Dec-01, Volume: 32, Issue:23

    Topics: Aging; Animals; Animals, Newborn; Clofibrate; Clofibric Acid; Digitonin; Enzyme Activation; Enzyme I

1983
Drug-induced sexual dysfunction in older men.
    Geriatrics, 1984, Volume: 39, Issue:10

    Topics: Aged; Aging; Antihypertensive Agents; Cimetidine; Clofibrate; Estrogens; Female; Humans; Male; Metoc

1984
Favorable effects of the lipid-lowering and platelet antiaggregant Plafibride on the aging process of mice of the C57bl/6J strain.
    Methods and findings in experimental and clinical pharmacology, 1983, Volume: 5, Issue:10

    Topics: Aging; Animal Feed; Animals; Body Weight; Clofibrate; Clofibric Acid; Hypolipidemic Agents; Lipofusc

1983
The spontaneously hyperlipidemic old rat as a model for evaluation of hypolipoproteinemic drugs. Effects of nicotinic acid, clofibrate and ethyl 2-(4-dibenzofuranyloxy)-2-methylpropionate on plasma lipoproteins.
    Zeitschrift fur Versuchstierkunde, 1982, Volume: 24, Issue:5-6

    Topics: Aging; Animals; Cholesterol; Clofibrate; Drug Evaluation, Preclinical; Hyperlipidemias; Lipoproteins

1982
14C-cholesterol distribution & cholesterol content of various tissues in different applied conditions in rats.
    Indian journal of experimental biology, 1982, Volume: 20, Issue:8

    Topics: Aging; Animals; Cholesterol; Clofibrate; Diabetes Mellitus; Ethanol; Hypothyroidism; Rats; Sucrose

1982
Arachidonic acid omega-hydroxylation and cytochrome P450 4A expression in the rat kidney.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1995, Volume: 23

    Topics: Aging; Animals; Arachidonic Acid; Clofibrate; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System

1995
The peroxisomal beta-oxidation enzyme system of rat heart. Basal level and effect of the peroxisome proliferator clofibrate.
    Biochimica et biophysica acta, 1994, Nov-11, Volume: 1201, Issue:2

    Topics: 3-Hydroxyacyl CoA Dehydrogenases; Acyl-CoA Oxidase; Aging; Amino Acid Sequence; Animals; Clofibrate;

1994
Liver peroxisomal fatty acid oxidizing system during aging in control and clofibrate-treated mice.
    Biochemistry and molecular biology international, 1995, Volume: 37, Issue:3

    Topics: Acyl-CoA Oxidase; Aging; Animals; Catalase; Clofibrate; Fatty Acids; Female; Liver; Mice; Microbodie

1995
Change of the sex-dependent response to clofibrate in F344 rat liver during postnatal development.
    Toxicology letters, 1996, Volume: 85, Issue:2

    Topics: Administration, Oral; Aging; Animals; Body Weight; Cholesterol; Clofibrate; Cytochrome P-450 Enzyme

1996
Aging-related decrease in liver peroxisomal fatty acid oxidation in control and clofibrate-treated mice. A biochemical study and mechanistic approach.
    Mechanisms of ageing and development, 1996, Jun-07, Volume: 87, Issue:2

    Topics: Age Factors; Aging; Animals; Clofibrate; Fatty Acids; Female; Liver; Mice; Mice, Inbred Strains; Mic

1996
Development and regulation of glucose-6-phosphatase gene expression in rat liver, intestine, and kidney: in vivo and in vitro studies in cultured fetal hepatocytes.
    Diabetes, 1998, Volume: 47, Issue:6

    Topics: Aging; Animals; Animals, Newborn; Bucladesine; Cells, Cultured; Clofibrate; Diet, Fat-Restricted; Di

1998
Induction of endogenous coenzyme Q biosynthesis by administration of peroxisomal inducers.
    BioFactors (Oxford, England), 1999, Volume: 9, Issue:2-4

    Topics: Aging; Animals; Aspirin; Clofibrate; Dehydroepiandrosterone; Diethylhexyl Phthalate; Intracellular M

1999
Ageing, metabolic immunodepression and carcinogenesis.
    Mechanisms of ageing and development, 1978, Volume: 8, Issue:3

    Topics: Adult; Aged; Aging; Cell Transformation, Neoplastic; Cholesterol; Clofibrate; Coronary Disease; Diab

1978
A quantitative analysis of fine structure and drug metabolism in livers of clofibrate-treated young adult and retired breeder rats.
    Journal of lipid research, 1978, Volume: 19, Issue:2

    Topics: Aging; Animals; Clofibrate; Cytochromes; Hypercholesterolemia; Lipid Metabolism; Liver; Male; Micros

1978
Maternal transport of chlorophenoxyisobutyrate at the foetal and neonatal stages of development.
    Biochemical pharmacology, 1978, Volume: 27, Issue:16

    Topics: Aging; Animals; Animals, Newborn; Body Weight; Clofibrate; Female; Fetus; In Vitro Techniques; Liver

1978
Clofibrate effects: mitochondria vs exercise tolerance in aging hamsters.
    American heart journal, 1977, Volume: 94, Issue:4

    Topics: Aging; Animals; Clofibrate; Cricetinae; Mitochondria, Heart; Mitochondria, Muscle; Motor Activity; P

1977
Protective effects of atromid-S in vivo on mitochondrial stability in tissues of aged hamsters.
    Journal of gerontology, 1975, Volume: 30, Issue:5

    Topics: Aging; Animals; Clofibrate; Cricetinae; Liver; Male; Mitochondria, Liver; Mitochondria, Muscle; Musc

1975
Response of liver and kidney catalase to alpha-p-chlorophenoxyisobutyrate (clofibrate) in C57B1/6J male mice of different ages.
    Gerontologia, 1974, Volume: 20, Issue:3

    Topics: Aging; Animals; Catalase; Clofibrate; Hepatomegaly; Kidney; Liver; Male; Mice; Mice, Inbred C57BL; O

1974