clofibrate and Aging
clofibrate has been researched along with Aging in 21 studies
angiokapsul: contains clofibrate & insoitolnicotinate
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clofibrate treatment in vivo (of which clofibric acid is the ester hydrolysis product) had no effect on clofibric acid glucuronidation in vitro." | 1.27 | Hepatic microsomal glucuronidation of clofibric acid in the adult and neonate albino rat. ( Odum, J; Orton, TC, 1983) |
| "Clofibrate treatment resulted in significant increases in the volumes of the hepatocytes and their constituent mitochondria and microbodies and caused a proliferation of the smooth-surfaced endoplasmic reticulum." | 1.26 | A quantitative analysis of fine structure and drug metabolism in livers of clofibrate-treated young adult and retired breeder rats. ( Anthony, LE; Jones, AL; Mooney, JS; Schmucker, DL, 1978) |
Research
Studies (21)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (57.14) | 18.7374 |
| 1990's | 7 (33.33) | 18.2507 |
| 2000's | 2 (9.52) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Youssef, JA | 1 |
| Bouziane, M | 1 |
| Badr, MZ | 1 |
| Sankaralingam, S | 1 |
| Desai, KM | 1 |
| Glaeser, H | 1 |
| Kim, RB | 1 |
| Wilson, TW | 1 |
| Odum, J | 1 |
| Orton, TC | 1 |
| Van Arsdalen, KN | 1 |
| Wein, AJ | 1 |
| Calatayud, JM | 1 |
| Gustafsson, K | 1 |
| Kiessling, H | 1 |
| Rao, AV | 1 |
| Ramakrishnan, S | 1 |
| Lin, F | 1 |
| Abraham, NG | 1 |
| Schwartzman, ML | 1 |
| Kvannes, J | 1 |
| Eikhom, TS | 1 |
| Flatmark, T | 1 |
| Périchon, R | 2 |
| Bourre, JM | 2 |
| Yamoto, T | 1 |
| Ohashi, Y | 1 |
| Furukawa, T | 1 |
| Teranishi, M | 1 |
| Manabe, S | 1 |
| Makita, T | 1 |
| Chatelain, F | 1 |
| Pégorier, JP | 1 |
| Minassian, C | 1 |
| Bruni, N | 1 |
| Tarpin, S | 1 |
| Girard, J | 1 |
| Mithieux, G | 1 |
| Turunen, M | 1 |
| Sindelar, P | 1 |
| Dallner, G | 1 |
| Dilman, VM | 1 |
| Yü, TF | 1 |
| Dorph, DJ | 1 |
| Smith, H | 1 |
| Anthony, LE | 1 |
| Schmucker, DL | 1 |
| Mooney, JS | 1 |
| Jones, AL | 1 |
| Chhabra, S | 1 |
| Kurup, CK | 1 |
| Guntheroth, WG | 1 |
| Inamdar, AR | 1 |
| Person, R | 2 |
| Mackler, B | 2 |
| Inamder, AR | 1 |
| Baird, MB | 1 |
| Zimmerman, JA | 1 |
| Massie, HR | 1 |
| Samis, HV | 1 |
Reviews
1 review available for clofibrate and Aging
| Article | Year |
|---|---|
Hyperlipidemia in primary gout.
Topics: Adolescent; Adult; Aged; Aging; Alcohol Drinking; Cholesterol; Clofibrate; Dextrothyroxine; Diabetes | 1978 |
Other Studies
20 other studies available for clofibrate and Aging
| Article | Year |
|---|---|
Age-dependent effects of nongenotoxic hepatocarcinogens on liver apoptosis in vivo.
Topics: Aging; Animals; Apoptosis; Carcinogens; Cell Count; Cholesterol; Clofibrate; Hepatocytes; Hepatomega | 2003 |
Inability to upregulate cytochrome P450 4A and 2C causes salt sensitivity in young Sprague-Dawley rats.
Topics: Aging; Animals; Anticholesteremic Agents; Blood Pressure; Clofibrate; Cytochrome P-450 CYP4A; Cytoch | 2006 |
Hepatic microsomal glucuronidation of clofibric acid in the adult and neonate albino rat.
Topics: Aging; Animals; Animals, Newborn; Clofibrate; Clofibric Acid; Digitonin; Enzyme Activation; Enzyme I | 1983 |
Drug-induced sexual dysfunction in older men.
Topics: Aged; Aging; Antihypertensive Agents; Cimetidine; Clofibrate; Estrogens; Female; Humans; Male; Metoc | 1984 |
Favorable effects of the lipid-lowering and platelet antiaggregant Plafibride on the aging process of mice of the C57bl/6J strain.
Topics: Aging; Animal Feed; Animals; Body Weight; Clofibrate; Clofibric Acid; Hypolipidemic Agents; Lipofusc | 1983 |
The spontaneously hyperlipidemic old rat as a model for evaluation of hypolipoproteinemic drugs. Effects of nicotinic acid, clofibrate and ethyl 2-(4-dibenzofuranyloxy)-2-methylpropionate on plasma lipoproteins.
Topics: Aging; Animals; Cholesterol; Clofibrate; Drug Evaluation, Preclinical; Hyperlipidemias; Lipoproteins | 1982 |
14C-cholesterol distribution & cholesterol content of various tissues in different applied conditions in rats.
Topics: Aging; Animals; Cholesterol; Clofibrate; Diabetes Mellitus; Ethanol; Hypothyroidism; Rats; Sucrose | 1982 |
Arachidonic acid omega-hydroxylation and cytochrome P450 4A expression in the rat kidney.
Topics: Aging; Animals; Arachidonic Acid; Clofibrate; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System | 1995 |
The peroxisomal beta-oxidation enzyme system of rat heart. Basal level and effect of the peroxisome proliferator clofibrate.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Acyl-CoA Oxidase; Aging; Amino Acid Sequence; Animals; Clofibrate; | 1994 |
Liver peroxisomal fatty acid oxidizing system during aging in control and clofibrate-treated mice.
Topics: Acyl-CoA Oxidase; Aging; Animals; Catalase; Clofibrate; Fatty Acids; Female; Liver; Mice; Microbodie | 1995 |
Change of the sex-dependent response to clofibrate in F344 rat liver during postnatal development.
Topics: Administration, Oral; Aging; Animals; Body Weight; Cholesterol; Clofibrate; Cytochrome P-450 Enzyme | 1996 |
Aging-related decrease in liver peroxisomal fatty acid oxidation in control and clofibrate-treated mice. A biochemical study and mechanistic approach.
Topics: Age Factors; Aging; Animals; Clofibrate; Fatty Acids; Female; Liver; Mice; Mice, Inbred Strains; Mic | 1996 |
Development and regulation of glucose-6-phosphatase gene expression in rat liver, intestine, and kidney: in vivo and in vitro studies in cultured fetal hepatocytes.
Topics: Aging; Animals; Animals, Newborn; Bucladesine; Cells, Cultured; Clofibrate; Diet, Fat-Restricted; Di | 1998 |
Induction of endogenous coenzyme Q biosynthesis by administration of peroxisomal inducers.
Topics: Aging; Animals; Aspirin; Clofibrate; Dehydroepiandrosterone; Diethylhexyl Phthalate; Intracellular M | 1999 |
Ageing, metabolic immunodepression and carcinogenesis.
Topics: Adult; Aged; Aging; Cell Transformation, Neoplastic; Cholesterol; Clofibrate; Coronary Disease; Diab | 1978 |
A quantitative analysis of fine structure and drug metabolism in livers of clofibrate-treated young adult and retired breeder rats.
Topics: Aging; Animals; Clofibrate; Cytochromes; Hypercholesterolemia; Lipid Metabolism; Liver; Male; Micros | 1978 |
Maternal transport of chlorophenoxyisobutyrate at the foetal and neonatal stages of development.
Topics: Aging; Animals; Animals, Newborn; Body Weight; Clofibrate; Female; Fetus; In Vitro Techniques; Liver | 1978 |
Clofibrate effects: mitochondria vs exercise tolerance in aging hamsters.
Topics: Aging; Animals; Clofibrate; Cricetinae; Mitochondria, Heart; Mitochondria, Muscle; Motor Activity; P | 1977 |
Protective effects of atromid-S in vivo on mitochondrial stability in tissues of aged hamsters.
Topics: Aging; Animals; Clofibrate; Cricetinae; Liver; Male; Mitochondria, Liver; Mitochondria, Muscle; Musc | 1975 |
Response of liver and kidney catalase to alpha-p-chlorophenoxyisobutyrate (clofibrate) in C57B1/6J male mice of different ages.
Topics: Aging; Animals; Catalase; Clofibrate; Hepatomegaly; Kidney; Liver; Male; Mice; Mice, Inbred C57BL; O | 1974 |