clofibrate has been researched along with Acute Liver Injury, Drug-Induced in 35 studies
angiokapsul: contains clofibrate & insoitolnicotinate
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clofibrate is a known rodent hepatotoxicant classically associated with hepatocellular hypertrophy and increased serum activities of cellular alanine aminotransferase/aspartate aminotransferase (ALT/AST) in the absence of microscopic hepatocellular degeneration." | 1.46 | Assessment of Preclinical Liver and Skeletal Muscle Biomarkers Following Clofibrate Administration in Wistar Rats. ( Bánfai, B; Bennecke, M; Christen, F; Festag, M; Lenz, B; Maliver, P; Winter, M, 2017) |
| "Pretreatment with clofibrate, a peroxisome proliferator-activated receptor alpha (PPARa) agonist, protects mice from acetaminophen (APAP) injury." | 1.43 | Enhanced hepatotoxicity by acetaminophen in Vanin-1 knockout mice is associated with deficient proliferative and immune responses. ( Chasson, L; Ferreira, DW; Galland, F; Goedken, MJ; Manautou, JE; Naquet, P; Rommelaere, S, 2016) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| " Primary hepatocytes isolated from mice dosed with CFB are resistant to APAP toxicity." | 1.34 | Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen. ( Aleksunes, LM; Kardas, MJ; Klaassen, CD; Manautou, JE; Moffit, JS; Slitt, AL, 2007) |
| "Clofibrate treatment elevated the levels of N-methylnicotinamide and 3,4-dihydroxymandelate and decreased the levels of 2-oxoglutarate and N-acetylaspartate." | 1.33 | A metabonomics study of the hepatotoxicants galactosamine, methylene dianiline and clofibrate in rats. ( Aoki, T; Ishihara, K; Katsutani, N, 2006) |
| " So, the toxicogenomics through this technology may be very powerful for understanding the effect of unknown toxic mechanisms in biological system." | 1.32 | Gene expression analysis of peroxisome proliferators- and phenytoin-induced hepatotoxicity using cDNA microarray. ( Hwang, JW; Hwang, SY; Jeon, KS; Jung, JW; Kang, JS; Kang, KS; Kim, YS; Lee, GJ; Lee, WS; Lee, YS; Li, P; Oh, MJ; Park, JE; Park, JS; Song, BS; Um, CH; Yeo, CD; Youn, JP, 2004) |
| "Malondialdehyde levels were elevated by 227%, 191%, and 118% by treatment with TCE, clofibrate, and TCA, respectively." | 1.29 | Increased oxidative stress in the liver of mice treated with trichloroethylene. ( Atkinson, A; Meeks, RG; Roy, D, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (25.71) | 18.7374 |
| 1990's | 4 (11.43) | 18.2507 |
| 2000's | 9 (25.71) | 29.6817 |
| 2010's | 12 (34.29) | 24.3611 |
| 2020's | 1 (2.86) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Morgan, RE | 2 |
| Trauner, M | 1 |
| van Staden, CJ | 2 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 2 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 2 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 3 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Liu, H | 1 |
| Zhang, P | 1 |
| Ge, X | 1 |
| Wu, Q | 1 |
| Han, C | 1 |
| Zhang, L | 1 |
| Hua, Y | 1 |
| Zhang, Y | 1 |
| Liu, J | 1 |
| Shi, Y | 1 |
| Wang, B | 1 |
| Wang, X | 1 |
| Wang, W | 1 |
| Jiang, Y | 1 |
| Zhang, H | 1 |
| Deng, C | 1 |
| Xie, Y | 1 |
| Liu, Y | 1 |
| He, S | 1 |
| Maliver, P | 1 |
| Festag, M | 1 |
| Bennecke, M | 1 |
| Christen, F | 1 |
| Bánfai, B | 1 |
| Lenz, B | 1 |
| Winter, M | 1 |
| Nafisi, S | 1 |
| Heidari, R | 1 |
| Ghaffarzadeh, M | 1 |
| Ziaee, M | 1 |
| Hamzeiy, H | 1 |
| Garjani, A | 1 |
| Eghbal, MA | 1 |
| Ferreira, DW | 1 |
| Goedken, MJ | 1 |
| Rommelaere, S | 1 |
| Chasson, L | 1 |
| Galland, F | 1 |
| Naquet, P | 1 |
| Manautou, JE | 7 |
| Chen, C | 3 |
| Hennig, GE | 4 |
| Whiteley, HE | 4 |
| Jung, JW | 1 |
| Park, JS | 1 |
| Hwang, JW | 1 |
| Kang, KS | 1 |
| Lee, YS | 1 |
| Song, BS | 1 |
| Lee, GJ | 1 |
| Yeo, CD | 1 |
| Kang, JS | 1 |
| Lee, WS | 1 |
| Jeon, KS | 1 |
| Um, CH | 1 |
| Kim, YS | 1 |
| Oh, MJ | 1 |
| Youn, JP | 1 |
| Li, P | 1 |
| Park, JE | 1 |
| Hwang, SY | 1 |
| Bertolami, MC | 1 |
| Ishihara, K | 1 |
| Katsutani, N | 1 |
| Aoki, T | 1 |
| Moffit, JS | 2 |
| Aleksunes, LM | 1 |
| Kardas, MJ | 1 |
| Slitt, AL | 1 |
| Klaassen, CD | 1 |
| Koza-Taylor, PH | 1 |
| Holland, RD | 1 |
| Thibodeau, MS | 1 |
| Beger, RD | 1 |
| Lawton, MP | 1 |
| Wójcicki, J | 1 |
| Atkinson, A | 1 |
| Meeks, RG | 1 |
| Roy, D | 1 |
| Carfagna, MA | 1 |
| Young, KM | 1 |
| Susick, RL | 1 |
| Silva, VM | 2 |
| Nguyen, KA | 1 |
| Carbone, JM | 1 |
| Nicholls-Grzemski, FA | 1 |
| Calder, IC | 1 |
| Priestly, BG | 1 |
| Burcham, PC | 1 |
| Mehendale, HM | 1 |
| Corton, JC | 1 |
| Stejskal, R | 1 |
| Itabashi, M | 1 |
| Stanek, J | 1 |
| Hruban, Z | 1 |
| Pierce, EH | 1 |
| Chesler, DL | 1 |
| Tuchweber, B | 1 |
| Salas, M | 1 |
| Marmo, E | 1 |
| Spadaro, R | 1 |
| Vacca, C | 1 |
| De Rosa, G | 1 |
| Thines-Sempoux, D | 1 |
| Bovy-Kesler, C | 1 |
| Debruyne, E | 1 |
| Roba, J | 1 |
| Migneco, G | 1 |
| Mascarella, A | 1 |
| La Ferla, A | 1 |
| Attianese, R | 1 |
| McNicol, GP | 1 |
| Davies, JA | 1 |
| Van Thiel, DH | 1 |
| De Belle, R | 1 |
| Mellow, M | 1 |
| Widerlite, L | 1 |
| Philipps, E | 1 |
3 reviews available for clofibrate and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
PPAR-alpha: a key to the mechanism of hepatoprotection by clofibrate.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Clofibrate; Drug Resistance; Hypolip | 2000 |
Advances in medicine.
Topics: Anemia, Macrocytic; Anti-Arrhythmia Agents; Anticoagulants; Azathioprine; Chemical and Drug Induced | 1972 |
32 other studies available for clofibrate and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Optimization of clofibrate with O-desmethyl anetholtrithione lead to a novel hypolipidemia compound with hepatoprotective effect.
Topics: Anethole Trithione; Animals; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Li | 2022 |
Assessment of Preclinical Liver and Skeletal Muscle Biomarkers Following Clofibrate Administration in Wistar Rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Anticholesteremic Agents; Arginase; Aspartate A | 2017 |
Cytoprotective effects of silafibrate, a newly-synthesised siliconated derivative of clofibrate, against acetaminophen-induced toxicity in isolated rat hepatocytes.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Inj | 2014 |
Enhanced hepatotoxicity by acetaminophen in Vanin-1 knockout mice is associated with deficient proliferative and immune responses.
Topics: Acetaminophen; Amidohydrolases; Animals; Cell Proliferation; Chemical and Drug Induced Liver Injury; | 2016 |
Protection against acetaminophen hepatotoxicity by clofibrate pretreatment: role of catalase induction.
Topics: Acetaminophen; Administration, Oral; Amitrole; Analgesics, Non-Narcotic; Animals; Bile; Catalase; Ch | 2002 |
Gene expression analysis of peroxisome proliferators- and phenytoin-induced hepatotoxicity using cDNA microarray.
Topics: Animals; Anticonvulsants; Chemical and Drug Induced Liver Injury; Clofibrate; Dose-Response Relation | 2004 |
[Mechanisms of hepatotoxicity].
Topics: Chemical and Drug Induced Liver Injury; Clofibrate; Drug Interactions; Humans; Hydroxymethylglutaryl | 2005 |
A metabonomics study of the hepatotoxicants galactosamine, methylene dianiline and clofibrate in rats.
Topics: Aniline Compounds; Animals; Chemical and Drug Induced Liver Injury; Clofibrate; Galactosamine; Liver | 2006 |
Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Blotting, Western; Chemical and Dru | 2007 |
Differential gene expression in mouse liver associated with the hepatoprotective effect of clofibrate.
Topics: Acetaminophen; Acyl-CoA Oxidase; Amidohydrolases; Animals; Anticholesteremic Agents; Cell Adhesion M | 2007 |
[Current data on adverse effects of clofibrate].
Topics: Biliary Tract Diseases; Cardiovascular Diseases; Chemical and Drug Induced Liver Injury; Clofibrate; | 1980 |
Increased oxidative stress in the liver of mice treated with trichloroethylene.
Topics: Animals; Chemical and Drug Induced Liver Injury; Clofibrate; Liver; Male; Malondialdehyde; Mice; Mic | 1993 |
Sex differences in rat hepatic cytolethality of the protein kinase C inhibitor safingol: role of biotransformation.
Topics: Administration, Oral; Animals; Biotransformation; Cell Count; Cell Death; Cell Survival; Cells, Cult | 1996 |
Repeated dosing with the peroxisome proliferator clofibrate decreases the toxicity of model hepatotoxic agents in male mice.
Topics: Administration, Oral; Animals; Anticholesteremic Agents; Blood Urea Nitrogen; Bromobenzenes; Carbon | 1998 |
The PPAR activator docosahexaenoic acid prevents acetaminophen hepatotoxicity in male CD-1 mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anticholesteremic Agents; Biotransformation; Blott | 1999 |
Clofibrate-induced in vitro hepatoprotection against acetaminophen is not due to altered glutathione homeostasis.
Topics: Acetaminophen; Animals; Antidotes; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver I | 2000 |
Peroxisome proliferator-activated receptor alpha-null mice lack resistance to acetaminophen hepatotoxicity following clofibrate exposure.
Topics: Acetaminophen; Administration, Oral; Analgesics; Animals; Chemical and Drug Induced Liver Injury; Cl | 2000 |
Experimental porphyria induced by 3-(2,4,6-trimethylphenyl)-thioethyl)-4 methylsydnone.
Topics: Alcohol Oxidoreductases; Animals; Bile Ducts, Intrahepatic; Body Weight; Catalase; Chemical and Drug | 1975 |
Possible association of granulomatous hepatitis with clofibrate therapy.
Topics: Aged; Chemical and Drug Induced Liver Injury; Clofibrate; Female; Granuloma; Humans; Kidney Diseases | 1978 |
Prevention of CeCl3-induced hepatotoxicity by hypolipidemic compounds.
Topics: Adenine; Animals; Cesium; Chemical and Drug Induced Liver Injury; Cholesterol; Clofibrate; Female; H | 1978 |
[Analysis of the hypolipemic, hypocholesteremic and platelet anti-aggregating effects of tibric acid].
Topics: Animals; Anticholesteremic Agents; Benzoates; Bile; Carbon Tetrachloride Poisoning; Chemical and Dru | 1975 |
Effect of suloctidil on rat liver.
Topics: Animals; Chemical and Drug Induced Liver Injury; Clofibrate; Liver; Male; Mitochondria, Liver; Propa | 1986 |
[Clofibrate hepatitis. A case report].
Topics: Chemical and Drug Induced Liver Injury; Clofibrate; Female; Fenofibrate; Humans; Middle Aged; Time F | 1986 |
Tolazamide hepatotoxicity. A case report.
Topics: Chemical and Drug Induced Liver Injury; Clofibrate; Humans; Jaundice; Liver; Male; Middle Aged; Tola | 1974 |