clofazimine has been researched along with Vitiligo in 8 studies
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
Vitiligo: A disorder consisting of areas of macular depigmentation, commonly on extensor aspects of extremities, on the face or neck, and in skin folds. Age of onset is often in young adulthood and the condition tends to progress gradually with lesions enlarging and extending until a quiescent state is reached.
Excerpt | Relevance | Reference |
---|---|---|
"20 patients with vitiligo were treated with 100 mg of clofazimine daily." | 9.05 | Evaluation of clofazimine in vitiligo. ( Shukla, SR, 1981) |
"Leprosy and vitiligo are common affections in the West Indies." | 1.31 | High prevalence of vitiligo in lepromatous leprosy. ( Boisseau-Garsaud, AM; Garsaud, P; Helenon, R; Quist, D; Saint-Cyr, I; Vezon, G, 2000) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 5 (62.50) | 18.7374 |
1990's | 1 (12.50) | 18.2507 |
2000's | 1 (12.50) | 29.6817 |
2010's | 1 (12.50) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Nordlund, JJ | 1 |
Beurey, J | 1 |
Weber, M | 1 |
Chaulieu, Y | 1 |
Talhari, S | 1 |
Cunha, MG | 1 |
Barros, ML | 1 |
Gadelha, AD | 1 |
Kumar, B | 1 |
Bahadur, B | 1 |
Broor, SL | 1 |
Kaur, S | 1 |
Gangwar, DN | 1 |
Malik, AK | 1 |
Shukla, SR | 1 |
Brown-Harrell, V | 1 |
Nitta, AT | 1 |
Goble, M | 1 |
Boisseau-Garsaud, AM | 1 |
Vezon, G | 1 |
Helenon, R | 1 |
Garsaud, P | 1 |
Saint-Cyr, I | 1 |
Quist, D | 1 |
Pavithran, K | 1 |
2 reviews available for clofazimine and Vitiligo
Article | Year |
---|---|
The Medical Treatment of Vitiligo: An Historical Review.
Topics: Administration, Cutaneous; Adrenal Cortex Hormones; Anthelmintics; Antimalarials; Antimetabolites, A | 2017 |
[Lamprène. New therapeutic indications (excluding leprosy)].
Topics: Acne Vulgaris; Adult; Clofazimine; Female; Humans; Lupus Erythematosus, Discoid; Lupus Vulgaris; Mal | 1982 |
1 trial available for clofazimine and Vitiligo
Article | Year |
---|---|
Evaluation of clofazimine in vitiligo.
Topics: Adolescent; Adult; Clofazimine; Female; Humans; Male; Sunlight; Vitiligo | 1981 |
5 other studies available for clofazimine and Vitiligo
Article | Year |
---|---|
[Jorge Lobo disease. Study of 22 new cases].
Topics: Adult; Aged; Brazil; Clofazimine; Dermatomycoses; Electrocoagulation; Female; Humans; Leishmaniasis; | 1981 |
Study of toxicity of clofazimine with special reference to structural and functional status of small intestine.
Topics: Clofazimine; Digestive System; Eye; Humans; Intestinal Absorption; Jejunum; Leprosy; Skin Pigmentati | 1982 |
Apparent exacerbation of vitiligo syndrome in a patient with pulmonary Mycobacterium avium complex disease who received clofazimine therapy.
Topics: Aged; Clofazimine; Female; Humans; Mycobacterium avium Complex; Mycobacterium avium-intracellulare I | 1996 |
High prevalence of vitiligo in lepromatous leprosy.
Topics: Adult; Aged; Aged, 80 and over; Clofazimine; Dapsone; Female; Humans; Leprostatic Agents; Leprosy, L | 2000 |
Vitiligo following type II lepra reaction.
Topics: Autoimmune Diseases; Clofazimine; Dapsone; Drug Therapy, Combination; Follow-Up Studies; Humans; Lep | 1989 |