Page last updated: 2024-10-25

clofazimine and Vitiligo

clofazimine has been researched along with Vitiligo in 8 studies

Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.

Vitiligo: A disorder consisting of areas of macular depigmentation, commonly on extensor aspects of extremities, on the face or neck, and in skin folds. Age of onset is often in young adulthood and the condition tends to progress gradually with lesions enlarging and extending until a quiescent state is reached.

Research Excerpts

ExcerptRelevanceReference
"20 patients with vitiligo were treated with 100 mg of clofazimine daily."9.05Evaluation of clofazimine in vitiligo. ( Shukla, SR, 1981)
"Leprosy and vitiligo are common affections in the West Indies."1.31High prevalence of vitiligo in lepromatous leprosy. ( Boisseau-Garsaud, AM; Garsaud, P; Helenon, R; Quist, D; Saint-Cyr, I; Vezon, G, 2000)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19905 (62.50)18.7374
1990's1 (12.50)18.2507
2000's1 (12.50)29.6817
2010's1 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nordlund, JJ1
Beurey, J1
Weber, M1
Chaulieu, Y1
Talhari, S1
Cunha, MG1
Barros, ML1
Gadelha, AD1
Kumar, B1
Bahadur, B1
Broor, SL1
Kaur, S1
Gangwar, DN1
Malik, AK1
Shukla, SR1
Brown-Harrell, V1
Nitta, AT1
Goble, M1
Boisseau-Garsaud, AM1
Vezon, G1
Helenon, R1
Garsaud, P1
Saint-Cyr, I1
Quist, D1
Pavithran, K1

Reviews

2 reviews available for clofazimine and Vitiligo

ArticleYear
The Medical Treatment of Vitiligo: An Historical Review.
    Dermatologic clinics, 2017, Volume: 35, Issue:2

    Topics: Administration, Cutaneous; Adrenal Cortex Hormones; Anthelmintics; Antimalarials; Antimetabolites, A

2017
[Lamprène. New therapeutic indications (excluding leprosy)].
    LARC medical, 1982, Volume: 2, Issue:1

    Topics: Acne Vulgaris; Adult; Clofazimine; Female; Humans; Lupus Erythematosus, Discoid; Lupus Vulgaris; Mal

1982

Trials

1 trial available for clofazimine and Vitiligo

ArticleYear
Evaluation of clofazimine in vitiligo.
    Dermatologica, 1981, Volume: 163, Issue:2

    Topics: Adolescent; Adult; Clofazimine; Female; Humans; Male; Sunlight; Vitiligo

1981

Other Studies

5 other studies available for clofazimine and Vitiligo

ArticleYear
[Jorge Lobo disease. Study of 22 new cases].
    Medicina cutanea ibero-latino-americana, 1981, Volume: 9, Issue:2

    Topics: Adult; Aged; Brazil; Clofazimine; Dermatomycoses; Electrocoagulation; Female; Humans; Leishmaniasis;

1981
Study of toxicity of clofazimine with special reference to structural and functional status of small intestine.
    Leprosy in India, 1982, Volume: 54, Issue:2

    Topics: Clofazimine; Digestive System; Eye; Humans; Intestinal Absorption; Jejunum; Leprosy; Skin Pigmentati

1982
Apparent exacerbation of vitiligo syndrome in a patient with pulmonary Mycobacterium avium complex disease who received clofazimine therapy.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1996, Volume: 22, Issue:3

    Topics: Aged; Clofazimine; Female; Humans; Mycobacterium avium Complex; Mycobacterium avium-intracellulare I

1996
High prevalence of vitiligo in lepromatous leprosy.
    International journal of dermatology, 2000, Volume: 39, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Clofazimine; Dapsone; Female; Humans; Leprostatic Agents; Leprosy, L

2000
Vitiligo following type II lepra reaction.
    Indian journal of leprosy, 1989, Volume: 61, Issue:1

    Topics: Autoimmune Diseases; Clofazimine; Dapsone; Drug Therapy, Combination; Follow-Up Studies; Humans; Lep

1989