clofazimine has been researched along with Syndrome in 7 studies
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
Syndrome: A characteristic symptom complex.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dapsone syndrome is a rare hypersensitivity reaction to dapsone and is characterized by high fever, papular or exfoliative dermatitis, progressing to liver toxicity and generalized lymphadenopathy, resembling a mononucleosis infection." | 7.73 | Dapsone syndrome with acute renal failure during leprosy treatment: case report. ( Alves-Rodrigues, EN; Fontes, CJ; Ribeiro, LC; Silva, MD; Takiuchi, A, 2005) |
| "Side-effects of leprosy treatment with dapsone are said to be uncommon, with drug allergy occurring in only one of every several hundred patients treated with dapsone." | 7.68 | Dapsone syndrome in Vanuatu: a high incidence during multidrug treatment (MDT) of leprosy. ( Ala, J; Hall, JJ; Reeve, PA, 1992) |
| "Leprosy is a stigmatizing, chronic infection which degenerates the nervous system and often leads to incapacitation." | 5.56 | Validation study of HLA-B*13:01 as a biomarker of dapsone hypersensitivity syndrome in leprosy patients in Indonesia. ( Irwan, ID; Irwanto, A; Krismawati, H; Liu, H; Liu, J; Maladan, Y; Oktavian, A; Pongtiku, A; Sitanggang, YA; Sun, Y; Tanjung, R; Wahyuni, T; Zhang, F, 2020) |
| "Dapsone syndrome is a rare hypersensitivity reaction to dapsone and is characterized by high fever, papular or exfoliative dermatitis, progressing to liver toxicity and generalized lymphadenopathy, resembling a mononucleosis infection." | 3.73 | Dapsone syndrome with acute renal failure during leprosy treatment: case report. ( Alves-Rodrigues, EN; Fontes, CJ; Ribeiro, LC; Silva, MD; Takiuchi, A, 2005) |
| "Side-effects of leprosy treatment with dapsone are said to be uncommon, with drug allergy occurring in only one of every several hundred patients treated with dapsone." | 3.68 | Dapsone syndrome in Vanuatu: a high incidence during multidrug treatment (MDT) of leprosy. ( Ala, J; Hall, JJ; Reeve, PA, 1992) |
| "Leprosy is a stigmatizing, chronic infection which degenerates the nervous system and often leads to incapacitation." | 1.56 | Validation study of HLA-B*13:01 as a biomarker of dapsone hypersensitivity syndrome in leprosy patients in Indonesia. ( Irwan, ID; Irwanto, A; Krismawati, H; Liu, H; Liu, J; Maladan, Y; Oktavian, A; Pongtiku, A; Sitanggang, YA; Sun, Y; Tanjung, R; Wahyuni, T; Zhang, F, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (57.14) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Krismawati, H | 1 |
| Irwanto, A | 1 |
| Pongtiku, A | 1 |
| Irwan, ID | 1 |
| Maladan, Y | 1 |
| Sitanggang, YA | 1 |
| Wahyuni, T | 1 |
| Tanjung, R | 1 |
| Sun, Y | 1 |
| Liu, H | 1 |
| Zhang, F | 1 |
| Oktavian, A | 1 |
| Liu, J | 1 |
| Alves-Rodrigues, EN | 1 |
| Ribeiro, LC | 1 |
| Silva, MD | 1 |
| Takiuchi, A | 1 |
| Fontes, CJ | 1 |
| Aram, H | 1 |
| Moschella, SL | 1 |
| Greer, KE | 1 |
| Cooper, PH | 1 |
| Reeve, PA | 1 |
| Ala, J | 1 |
| Hall, JJ | 1 |
| Berg, B | 1 |
| Brandt, L | 1 |
2 reviews available for clofazimine and Syndrome
| Article | Year |
|---|---|
Acquired ichthyosis and related conditions.
Topics: Aged; Cimetidine; Clofazimine; Female; Hodgkin Disease; Humans; Ichthyosis; Lymphoma; Male; Neoplasm | 1984 |
Sweet's syndrome (acute febrile neutrophilic dermatosis).
Topics: Adult; Arthritis; Clofazimine; Diagnosis, Differential; Eye Diseases; Female; Fever; Humans; Indomet | 1982 |
5 other studies available for clofazimine and Syndrome
| Article | Year |
|---|---|
Validation study of HLA-B*13:01 as a biomarker of dapsone hypersensitivity syndrome in leprosy patients in Indonesia.
Topics: Adolescent; Adult; Alleles; Biomarkers; Case-Control Studies; Clofazimine; Dapsone; Drug Hypersensit | 2020 |
Dapsone syndrome with acute renal failure during leprosy treatment: case report.
Topics: Acute Kidney Injury; Adult; Clofazimine; Dapsone; Drug Hypersensitivity; Drug Therapy, Combination; | 2005 |
Leprosy today.
Topics: Clofazimine; Dapsone; Disease Models, Animal; Drug Resistance, Microbial; Humans; Leprosy; Mycobacte | 1983 |
Dapsone syndrome in Vanuatu: a high incidence during multidrug treatment (MDT) of leprosy.
Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Clofazimine; Dapsone; Drug Eruptions; Dru | 1992 |
Syndrome of anaemia, thrombocytopenia and subnormal granulocyte function in elderly patients.
Topics: Aged; Alkaline Phosphatase; Anemia; Biopsy, Needle; Bone Marrow; Clofazimine; Humans; Leukemia, Myel | 1973 |