clofazimine has been researched along with Skin Ulcer in 18 studies
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
Skin Ulcer: An ULCER of the skin and underlying tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Five patients suffering from dermatitis ulcerosa (a variant of pyoderma gangrenosum) were treated with clofazimine in a daily dosage of 200 mg orally." | 9.06 | Clofazimine in dermatitis ulcerosa (pyoderma gangrenosum). Open clinical trial. ( Mensing, H, 1988) |
| "Seven patients with pyoderma gangrenosum have been treated with clofazimine." | 9.05 | Pyoderma gangrenosum treated with clofazimine: clinical evaluation of 7 cases. ( Rasmussen, I, 1983) |
| "Three cases of pyoderma gangrenosum (PG) responsive to clofazimine are reported." | 7.66 | Pyoderma gangrenosum treated with clofazimine. Report of three cases. ( Davis, BR; Kark, EC; Pomeranz, JR, 1981) |
| "A male patient 68 years, suffering from pyoderma gangrenosum which was resistant to conventional treatment, received clofazimine 400 mg daily for 5 months, then reducing to 300 mg daily for the next 6 months." | 7.66 | Splenic infarction and tissue accumulation of crystals associated with the use of clofazimine (Lamprene; B663) in the treatment of pyoderma gangrenosum. ( Chaplin, AJ; Hede, JE; Horsfall, WR; McDougall, AC, 1980) |
| "Five patients suffering from dermatitis ulcerosa (a variant of pyoderma gangrenosum) were treated with clofazimine in a daily dosage of 200 mg orally." | 5.06 | Clofazimine in dermatitis ulcerosa (pyoderma gangrenosum). Open clinical trial. ( Mensing, H, 1988) |
| "Seven patients with pyoderma gangrenosum have been treated with clofazimine." | 5.05 | Pyoderma gangrenosum treated with clofazimine: clinical evaluation of 7 cases. ( Rasmussen, I, 1983) |
| "Three cases of pyoderma gangrenosum (PG) responsive to clofazimine are reported." | 3.66 | Pyoderma gangrenosum treated with clofazimine. Report of three cases. ( Davis, BR; Kark, EC; Pomeranz, JR, 1981) |
| "A male patient 68 years, suffering from pyoderma gangrenosum which was resistant to conventional treatment, received clofazimine 400 mg daily for 5 months, then reducing to 300 mg daily for the next 6 months." | 3.66 | Splenic infarction and tissue accumulation of crystals associated with the use of clofazimine (Lamprene; B663) in the treatment of pyoderma gangrenosum. ( Chaplin, AJ; Hede, JE; Horsfall, WR; McDougall, AC, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (83.33) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Khardenavis, S | 1 |
| Deshpande, A | 1 |
| di Meo, N | 1 |
| Fluehler, C | 1 |
| Perkan, V | 1 |
| Trevisan, G | 1 |
| LUNN, HF | 1 |
| REE, RJ | 1 |
| Rasmussen, I | 1 |
| Beurey, J | 1 |
| Weber, M | 1 |
| Chaulieu, Y | 1 |
| Bentley-Phillips, CB | 1 |
| Cooper, RC | 1 |
| Hallett, AF | 1 |
| Chavaz, P | 1 |
| Laugier, P | 1 |
| Kark, EC | 2 |
| Davis, BR | 2 |
| Pomeranz, JR | 1 |
| Cola, B | 1 |
| Porzio, F | 1 |
| Farella, S | 1 |
| McDougall, AC | 1 |
| Horsfall, WR | 1 |
| Hede, JE | 1 |
| Chaplin, AJ | 1 |
| de Bergeyck, E | 1 |
| Janssens, PG | 1 |
| de Muynck, A | 1 |
| Hameed, A | 1 |
| Beach, FX | 1 |
| Kennedy, RH | 1 |
| Barry, RE | 1 |
| Ellis, BP | 1 |
| Cruickshank, JG | 1 |
| Mensing, H | 1 |
| Berbis, P | 1 |
| Mege, JL | 1 |
| Capo, C | 1 |
| Kaplanski, S | 1 |
| Bongrand, P | 1 |
| Privat, Y | 1 |
| Revill, WD | 1 |
| Morrow, RH | 1 |
| Pike, MC | 1 |
| Ateng, J | 1 |
| Ramu, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Beta-Lactam Containing Regimen for the Shortening of Buruli Ulcer Disease Therapy: Comparison of 8 Weeks Standard Therapy (Rifampicin Plus Clarithromycin) vs. 4 Weeks Standard Plus Amoxicillin/Clavulanate Therapy [RC8 vs. RCA4][NCT05169554] | Phase 2 | 140 participants (Anticipated) | Interventional | 2021-12-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for clofazimine and Skin Ulcer
| Article | Year |
|---|---|
[Lamprène. New therapeutic indications (excluding leprosy)].
Topics: Acne Vulgaris; Adult; Clofazimine; Female; Humans; Lupus Erythematosus, Discoid; Lupus Vulgaris; Mal | 1982 |
3 trials available for clofazimine and Skin Ulcer
| Article | Year |
|---|---|
Pyoderma gangrenosum treated with clofazimine: clinical evaluation of 7 cases.
Topics: Adult; Aged; Chronic Disease; Clinical Trials as Topic; Clofazimine; Female; Humans; Male; Middle Ag | 1983 |
Clofazimine in dermatitis ulcerosa (pyoderma gangrenosum). Open clinical trial.
Topics: Adult; Aged; Clinical Trials as Topic; Clofazimine; Female; Gangrene; Humans; Male; Middle Aged; Pyo | 1988 |
A controlled trial of the treatment of Mycobacterium ulcerans infection with clofazimine.
Topics: Clinical Trials as Topic; Clofazimine; Culture Media; Drug Evaluation; Humans; Mycobacterium; Mycoba | 1973 |
14 other studies available for clofazimine and Skin Ulcer
| Article | Year |
|---|---|
Borderline tuberculoid leprosy with type 1/reversal reaction.
Topics: Clofazimine; Facial Nerve Diseases; Facial Paralysis; Humans; Hyperpigmentation; Leprostatic Agents; | 2014 |
Disseminated superficial porokeratosis and pyoderma gangrenosum.
Topics: Aged, 80 and over; Anti-Bacterial Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-St | 2010 |
TREATMENT OF MYCOBACTERIAL SKIN ULCERS IN UGANDA WITH A RIMINOPHENAZINE DERIVATIVE (B.663).
Topics: Antitubercular Agents; Clofazimine; Mice; Mycobacterium Infections; Phenazines; Skin Ulcer; Uganda | 1964 |
Pharmacological modulation of neutrophil phagocytic function in a patient with recurrent sepsis, pyoderma gangrenosum and impaired phagocytosis.
Topics: Adrenal Cortex Hormones; Bacterial Infections; Clofazimine; Humans; In Vitro Techniques; Levamisole; | 1982 |
[Use of lamprène in dermatology].
Topics: Aged; Clofazimine; Humans; Pyoderma; Skin Ulcer | 1982 |
Pyoderma gangrenosum treated with clofazimine. Report of three cases.
Topics: Chronic Disease; Clofazimine; Female; Humans; Male; Middle Aged; Pyoderma; Skin Ulcer; Wound Healing | 1981 |
[Pyoderma gangrenosum: 2 cases with perineal localization].
Topics: Aged; Clofazimine; Female; Gangrene; Humans; Middle Aged; Perineum; Pyoderma; Skin Ulcer | 1980 |
Clofazimine treatment of pyoderma gangrenosum.
Topics: Clofazimine; Humans; Infarction; Intestines; Male; Middle Aged; Skin Ulcer | 1981 |
Splenic infarction and tissue accumulation of crystals associated with the use of clofazimine (Lamprene; B663) in the treatment of pyoderma gangrenosum.
Topics: Aged; Clofazimine; Humans; Lymph Nodes; Male; Mesentery; Pyoderma; Skin Ulcer; Splenic Infarction | 1980 |
Radiological abnormalities of the ileum associated with the use of clofazimine (Lamprene; B663) in the treatment of skin ulceration due to Mycobacterium ulcerans.
Topics: Adult; Clofazimine; Female; Humans; Ileal Diseases; Mycobacterium Infections; Radiography; Skin Ulce | 1980 |
A case of clofazimine enteropathy.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Clofazimine; Fatal Outcome; Humans; Intestinal | 1998 |
Letter: Topical clofazimine and atypical mycobacteria.
Topics: Administration, Topical; Clofazimine; Humans; Mycobacterium Infections; Skin Ulcer | 1976 |
Hyperimmunoglobulin E and impaired neutrophil functions in a case of pyoderma gangrenosum: effect of clofazimine.
Topics: Adult; Clofazimine; Humans; Hypergammaglobulinemia; Immunoglobulin E; Male; Neutrophils; Pyoderma; S | 1988 |
Management of reactions in leprosy.
Topics: Adrenal Cortex Hormones; Clofazimine; Hand Deformities, Acquired; Humans; Leprosy; Neuritis; Skin Ul | 1973 |