clofazimine has been researched along with Skin Diseases in 25 studies
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
Skin Diseases: Diseases involving the DERMIS or EPIDERMIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This article reviews the chemistry, pharmacology, spectrum of activity, pharmacokinetics, clinical efficacy in leprosy and Mycobacterium avium complex (MAC) infection, adverse effects, drug interactions, and special considerations of clofazimine." | 8.78 | Clofazimine: a review of its use in leprosy and Mycobacterium avium complex infection. ( Garrelts, JC, 1991) |
| "Twenty patients, ten suffering from disseminated granuloma anulare and ten from necrobiosis lipoidica, were treated with clofazimine 200 mg p." | 7.67 | [Clofazimine--therapeutic alternative in necrobiosis lipoidica and granuloma anulare]. ( Mensing, H, 1989) |
| "This article reviews the chemistry, pharmacology, spectrum of activity, pharmacokinetics, clinical efficacy in leprosy and Mycobacterium avium complex (MAC) infection, adverse effects, drug interactions, and special considerations of clofazimine." | 4.78 | Clofazimine: a review of its use in leprosy and Mycobacterium avium complex infection. ( Garrelts, JC, 1991) |
| "Twenty patients, ten suffering from disseminated granuloma anulare and ten from necrobiosis lipoidica, were treated with clofazimine 200 mg p." | 3.67 | [Clofazimine--therapeutic alternative in necrobiosis lipoidica and granuloma anulare]. ( Mensing, H, 1989) |
| "Clofazimine has been in clinical use for almost 40 years, but little is known of its mechanism of action." | 2.39 | Clofazimine: a review of its medical uses and mechanisms of action. ( Arbiser, JL; Moschella, SL, 1995) |
| " Under clofazimine (Lampren), at an initial dosage of 3 x 100 mg daily by mouth, gradually reduced over 4 months, the cutaneous lesions healed completely and lastingly." | 1.31 | [Disseminated small-node cutaneous sarcoidosis]. ( Djawari, D; Schwarzenbach, R, 2000) |
| "Clofazimine treatment resulted in total remission." | 1.27 | Cutaneous malakoplakia. Report of a case. ( Baradad, M; Bombí, JA; Martín, E; Mascaró, JM; Palou, J; Torras, H, 1988) |
| " When high dosage of clofazimine treatment is carried on during a long period, and drug accumulates in the tissues and precipitates as a solid." | 1.26 | [Enteropathy due to clofazimine treatment. A case report with an ultrastructural study]. ( Boutboul, R; Charpin, C; De Micco, C; Devaux, J; Toga, M, 1982) |
| "Its use in other autoimmune diseases has to be considered." | 1.26 | Clofazimine in dermatology. ( Mackey, JP, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (48.00) | 18.7374 |
| 1990's | 6 (24.00) | 18.2507 |
| 2000's | 6 (24.00) | 29.6817 |
| 2010's | 1 (4.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zheng, S | 1 |
| Gurfinkel, P | 1 |
| Pina, JC | 1 |
| Ramos-e-Silva, M | 1 |
| Aranda, J | 1 |
| Hoang, MP | 1 |
| Cohen, JB | 1 |
| Sunderkötter, CH | 1 |
| Lan Ma, H | 1 |
| Bezerra, EL | 1 |
| Vilar, MJ | 1 |
| da Trindade Neto, PB | 1 |
| Sato, EI | 1 |
| Beurey, J | 1 |
| Weber, M | 1 |
| Chaulieu, Y | 1 |
| Aram, H | 1 |
| Greer, KE | 1 |
| Cooper, PH | 1 |
| De Micco, C | 1 |
| Boutboul, R | 1 |
| Devaux, J | 1 |
| Charpin, C | 1 |
| Toga, M | 1 |
| Arbiser, JL | 1 |
| Moschella, SL | 1 |
| Krop, LC | 1 |
| Johnson, DP | 1 |
| Schwarzenbach, R | 1 |
| Djawari, D | 1 |
| McCauliffe, DP | 1 |
| Mackey, JP | 1 |
| Jopling, WH | 1 |
| Bahmer, FA | 1 |
| Garrelts, JC | 1 |
| Mundell, AC | 1 |
| Herrero, C | 1 |
| Torras, H | 2 |
| Palou, J | 2 |
| Mascaro, JM | 2 |
| Patki, AH | 1 |
| Jadhav, VH | 1 |
| Mehta, JM | 1 |
| Bodemer, C | 1 |
| Durand, C | 1 |
| Blanche, S | 1 |
| Teillac, D | 1 |
| De Prost, Y | 1 |
| Dixit, VB | 1 |
| Chaudhary, SD | 1 |
| Jain, VK | 1 |
| Mensing, H | 1 |
| Baradad, M | 1 |
| Bombí, JA | 1 |
| Martín, E | 1 |
| Landow, RK | 1 |
9 reviews available for clofazimine and Skin Diseases
| Article | Year |
|---|---|
Use of clofazimine in dermatology.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Clofazimine; Humans; Leprostatic | 2009 |
[Lamprène. New therapeutic indications (excluding leprosy)].
Topics: Acne Vulgaris; Adult; Clofazimine; Female; Humans; Lupus Erythematosus, Discoid; Lupus Vulgaris; Mal | 1982 |
Acquired ichthyosis and related conditions.
Topics: Aged; Cimetidine; Clofazimine; Female; Hodgkin Disease; Humans; Ichthyosis; Lymphoma; Male; Neoplasm | 1984 |
Sweet's syndrome (acute febrile neutrophilic dermatosis).
Topics: Adult; Arthritis; Clofazimine; Diagnosis, Differential; Eye Diseases; Female; Fever; Humans; Indomet | 1982 |
Clofazimine: a review of its medical uses and mechanisms of action.
Topics: Clofazimine; DNA, Bacterial; Humans; Intercalating Agents; Mycobacterium Infections; Mycobacterium I | 1995 |
Cutaneous lupus erythematosus.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Biopsy; Clofazimine; Dermatologic Agents; Di | 2001 |
Clofazimine: a review of its use in leprosy and Mycobacterium avium complex infection.
Topics: Acquired Immunodeficiency Syndrome; Clofazimine; Drug Interactions; Gastrointestinal Diseases; Human | 1991 |
New therapeutic agents in veterinary dermatology.
Topics: 4-Quinolones; Animals; Anti-Infective Agents; Cat Diseases; Cats; Chlorambucil; Clofazimine; Dog Dis | 1990 |
New drugs for dermatologic diseases.
Topics: Clofazimine; Cyclosporins; Humans; Psoriasis; Sezary Syndrome; Skin Diseases | 1988 |
1 trial available for clofazimine and Skin Diseases
| Article | Year |
|---|---|
Double-blind, randomized, controlled clinical trial of clofazimine compared with chloroquine in patients with systemic lupus erythematosus.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Chloroquine; Clofazimine; Doub | 2005 |
15 other studies available for clofazimine and Skin Diseases
| Article | Year |
|---|---|
Nodular skin lesion secondary to Mycobacterium abscessus tenosynovitis.
Topics: Aged; Clarithromycin; Clofazimine; Debridement; Female; Fingers; Humans; Mycobacterium abscessus; My | 2018 |
Shiny red-brown papules in a 21-year-old man. Histoid leprosy.
Topics: Adult; Clofazimine; Dapsone; Diagnosis, Differential; Drug Therapy, Combination; Face; Humans; Lepro | 2004 |
[Clofazimine. Current status of therapy with clofazimine (Lampren) for leprosy, erythema leprosum , and other dermatoses after donation of the medicine to the WHO by Novartis].
Topics: Charities; Clinical Trials as Topic; Clofazimine; Erythema Nodosum; Germany; Humans; Leprosy; Skin D | 2005 |
[Enteropathy due to clofazimine treatment. A case report with an ultrastructural study].
Topics: Clofazimine; Female; Humans; Jejunal Diseases; Lymph Nodes; Lymphatic Diseases; Mesentery; Microscop | 1982 |
Cutaneous disease and drug reactions in HIV infection.
Topics: Clofazimine; Drug Eruptions; HIV Infections; Humans; Pigmentation Disorders; Skin Diseases | 1993 |
[Disseminated small-node cutaneous sarcoidosis].
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Clofazimine; Female; Humans; Progn | 2000 |
Clofazimine in dermatology.
Topics: Autoimmune Diseases; Clofazimine; Humans; Ireland; Lupus Erythematosus, Discoid; Skin Diseases | 1976 |
Complications of treatment with clofazimine (Lamprene: B663).
Topics: Clofazimine; Gastrointestinal Diseases; Humans; Leprosy; Skin Diseases | 1976 |
[Therapy of lymphocytic infiltration].
Topics: Azathioprine; Clofazimine; Cyclosporine; Dapsone; Humans; Levamisole; Lymphocytosis; Skin; Skin Dise | 1992 |
Successful treatment of a patient with cutaneous malacoplakia with clofazimine and trimethoprim-sulfamethoxazole.
Topics: Adult; Clofazimine; Female; Humans; Malacoplakia; Skin Diseases; Trimethoprim, Sulfamethoxazole Drug | 1990 |
A study of dermatological conditions in leprosy in-patients.
Topics: Clofazimine; Drug Eruptions; Female; Humans; Inpatients; Keratosis; Leprosy; Male; Pigmentation Diso | 1989 |
[Disseminated Mycobacterium marinum infection].
Topics: Child, Preschool; Clofazimine; Consanguinity; Drug Therapy, Combination; Ethambutol; Female; Hepatom | 1989 |
Clofazimine induced nail changes.
Topics: Clofazimine; Humans; Leprosy, Lepromatous; Nail Diseases; Skin Diseases | 1989 |
[Clofazimine--therapeutic alternative in necrobiosis lipoidica and granuloma anulare].
Topics: Administration, Oral; Adult; Clofazimine; Drug Administration Schedule; Female; Granuloma; Humans; M | 1989 |
Cutaneous malakoplakia. Report of a case.
Topics: Adult; Clofazimine; Escherichia coli Infections; Female; Histiocytes; Humans; Immunosuppression Ther | 1988 |