Page last updated: 2024-10-25

clofazimine and Sensitivity and Specificity

clofazimine has been researched along with Sensitivity and Specificity in 9 studies

Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.

Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)

Research Excerpts

ExcerptRelevanceReference
"Prostate cancer was the most common form and had the second highest death rate of male cancer in the United States in 2015."1.51Photoacoustic imaging of clofazimine hydrochloride nanoparticle accumulation in cancerous vs normal prostates. ( Murashov, MD; Rosania, GR; Tan, JWY; Wang, X, 2019)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (55.56)18.2507
2000's1 (11.11)29.6817
2010's3 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Li, W1
Doherty, J1
Fu, Y1
Flarakos, J1
Tan, JWY1
Murashov, MD1
Rosania, GR1
Wang, X1
Srikanth, CH1
Joshi, P1
Bikkasani, AK1
Porwal, K1
Gayen, JR1
Queiroz, RH1
Pereira, RC1
Gotardo, MA1
Cordeiro, DS1
Melchior, E1
Gomez-Flores, R1
Gupta, S1
Tamez-Guerra, R1
Mehta, RT1
O'Connor, R1
O'Sullivan, JF1
O'Kennedy, R1
Singh, HB1
Katoch, K1
Natrajan, M1
Sharma, RK1
Gupta, UD1
Sharma, VD1
Singh, D1
Chauhan, DS1
Srivastava, K1
Katoch, VM1
Krishnan, TR1
Abraham, I1
Williams, DL1
Gillis, TP1
Fiallo, P1
Job, CK1
Gelber, RH1
Hill, C1
Izumi, S1

Other Studies

9 other studies available for clofazimine and Sensitivity and Specificity

ArticleYear
Quantitative analysis of clofazimine (Lamprene®), an antileprosy agent, in human dried blood spots using liquid chromatography-tandem mass spectrometry.
    Biomedical chromatography : BMC, 2018, Volume: 32, Issue:2

    Topics: Chromatography, Liquid; Clofazimine; Dried Blood Spot Testing; Drug Stability; Humans; Linear Models

2018
Photoacoustic imaging of clofazimine hydrochloride nanoparticle accumulation in cancerous vs normal prostates.
    PloS one, 2019, Volume: 14, Issue:7

    Topics: Adenocarcinoma; Animals; Chlorides; Clofazimine; Contrast Media; Disease Models, Animal; Male; Mice;

2019
Bone distribution study of anti leprotic drug clofazimine in rat bone marrow cells by a sensitive reverse phase liquid chromatography method.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2014, Jun-01, Volume: 960

    Topics: Animals; Bone Marrow Cells; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Clo

2014
Determination of clofazimine in leprosy patients by high-performance liquid chromatography.
    Journal of analytical toxicology, 2003, Volume: 27, Issue:6

    Topics: Chromatography, High Pressure Liquid; Clofazimine; Drug Monitoring; Female; Humans; Leprostatic Agen

2003
Determination of MICs for Mycobacterium avium-M. intracellulare complex in liquid medium by a colorimetric method.
    Journal of clinical microbiology, 1995, Volume: 33, Issue:7

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; Biological Transport, Active; Clofazimine; Colorimetry

1995
Determination of serum and tissue levels of phenazines including clofazimine.
    Journal of chromatography. B, Biomedical applications, 1996, Jun-07, Volume: 681, Issue:2

    Topics: Adipose Tissue; Animals; Chromatography, High Pressure Liquid; Clofazimine; Leprostatic Agents; Orga

1996
Effect of treatment on PCR positivity in multibacillary leprosy patients treated with conventional and newer drugs ofloxacin and minocycline.
    Acta leprologica, 1999, Volume: 11, Issue:4

    Topics: Adenosine Triphosphate; Biopsy; Clofazimine; Dapsone; DNA, Bacterial; Drug Evaluation; Drug Therapy,

1999
A rapid and sensitive high performance liquid chromatographic analysis of clofazimine in plasma.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1992, Volume: 60, Issue:4

    Topics: Animals; Chromatography, High Pressure Liquid; Clofazimine; Humans; Male; Rabbits; Reproducibility o

1992
Detection of Mycobacterium leprae and the potential for monitoring antileprosy drug therapy directly from skin biopsies by PCR.
    Molecular and cellular probes, 1992, Volume: 6, Issue:5

    Topics: Anti-Bacterial Agents; Biopsy; Clofazimine; Dapsone; DNA Probes; DNA, Bacterial; Drug Therapy, Combi

1992