clofazimine has been researched along with Pregnancy in 11 studies
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clofazimine enterophathy is a serious complication of clofazimine when used at high doses for treatment of type 2 lepra or or erythema nodosum leprosum." | 7.75 | [Persistent type 2 lepra reaction (erythema nodosum) and clofazimine-induced lethal enteropathy]. ( Gómez, Y; López, F; Pinto, R; Rodríguez, G, 2009) |
| "Little is known of the perinatal consequences of the use of clofazimine (B663, Lamprene) to treat leprosy." | 7.66 | Clofazimine in pregnancy complicated by leprosy. ( Farb, H; Pedvis-Leftick, A; West, DP, 1982) |
| "Clofazimine enterophathy is a serious complication of clofazimine when used at high doses for treatment of type 2 lepra or or erythema nodosum leprosum." | 3.75 | [Persistent type 2 lepra reaction (erythema nodosum) and clofazimine-induced lethal enteropathy]. ( Gómez, Y; López, F; Pinto, R; Rodríguez, G, 2009) |
| "Little is known of the perinatal consequences of the use of clofazimine (B663, Lamprene) to treat leprosy." | 3.66 | Clofazimine in pregnancy complicated by leprosy. ( Farb, H; Pedvis-Leftick, A; West, DP, 1982) |
| " The elimination half-life is variable, with values as long as 70 days being quoted in the literature." | 2.38 | Clinical pharmacokinetics of clofazimine. A review. ( Holdiness, MR, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (72.73) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ozturk, Z | 1 |
| Tatliparmak, A | 1 |
| Rodríguez, G | 1 |
| Pinto, R | 1 |
| López, F | 1 |
| Gómez, Y | 1 |
| Duncan, ME | 1 |
| Oakey, RE | 1 |
| Farb, H | 1 |
| West, DP | 1 |
| Pedvis-Leftick, A | 1 |
| Bhargava, P | 1 |
| Kuldeep, CM | 1 |
| Mathur, NK | 1 |
| Reich, CV | 1 |
| de la Cruz, E | 1 |
| Morrison, NE | 1 |
| Karat, AB | 1 |
| Plock, H | 1 |
| Leiker, DL | 1 |
| Holdiness, MR | 2 |
2 reviews available for clofazimine and Pregnancy
| Article | Year |
|---|---|
Leprosy treatment during pregnancy and breastfeeding: A case report and brief review of literature.
Topics: Adult; Breast Feeding; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Leprostatic | 2017 |
Clinical pharmacokinetics of clofazimine. A review.
Topics: Clofazimine; Female; Humans; Pregnancy | 1989 |
1 trial available for clofazimine and Pregnancy
| Article | Year |
|---|---|
Long-term follow-up of clofazimine (Lamprene) in the management of reactive phases of leprosy.
Topics: Clinical Trials as Topic; Clofazimine; Dapsone; Female; Follow-Up Studies; Humans; Leprosy; Pregnanc | 1975 |
8 other studies available for clofazimine and Pregnancy
| Article | Year |
|---|---|
[Persistent type 2 lepra reaction (erythema nodosum) and clofazimine-induced lethal enteropathy].
Topics: Abdominal Pain; Adult; Arthritis, Rheumatoid; Child; Child, Preschool; Clofazimine; Constipation; Di | 2009 |
Reduced estrogen excretion due to clofazimine?
Topics: Clofazimine; Estrogens; Female; Humans; Leprosy; Pregnancy | 1983 |
Clofazimine in pregnancy complicated by leprosy.
Topics: Adult; Clofazimine; Female; Humans; Infant, Newborn; Leprosy; Pregnancy; Pregnancy Complications, In | 1982 |
Antileprosy drugs, pregnancy and fetal outcome.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Animals; Clofazimine; Dapsone; Drug Therapy, Combina | 1996 |
The effect on pregnant mice of 0.05% B1912 fed in the diet.
Topics: Animals; Clofazimine; Female; Leprostatic Agents; Mice; Pregnancy; Pregnancy, Animal | 1979 |
Abortifacient activity of B1912.
Topics: Abortion, Spontaneous; Animals; Clofazimine; Female; Leprostatic Agents; Mice; Pregnancy | 1979 |
A long term trial with clofazimine in reactive lepromatous leprosy.
Topics: Clofazimine; Drug Evaluation; Female; Gastrointestinal Diseases; Humans; Leprosy; Pregnancy; Time Fa | 1976 |
Clofazimine in pregnancy.
Topics: Clofazimine; Female; Fetal Death; Fetal Diseases; Humans; Leprosy; Pregnancy; Pregnancy Complication | 1989 |