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clofazimine and Pregnancy

clofazimine has been researched along with Pregnancy in 11 studies

Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
"Clofazimine enterophathy is a serious complication of clofazimine when used at high doses for treatment of type 2 lepra or or erythema nodosum leprosum."7.75[Persistent type 2 lepra reaction (erythema nodosum) and clofazimine-induced lethal enteropathy]. ( Gómez, Y; López, F; Pinto, R; Rodríguez, G, 2009)
"Little is known of the perinatal consequences of the use of clofazimine (B663, Lamprene) to treat leprosy."7.66Clofazimine in pregnancy complicated by leprosy. ( Farb, H; Pedvis-Leftick, A; West, DP, 1982)
"Clofazimine enterophathy is a serious complication of clofazimine when used at high doses for treatment of type 2 lepra or or erythema nodosum leprosum."3.75[Persistent type 2 lepra reaction (erythema nodosum) and clofazimine-induced lethal enteropathy]. ( Gómez, Y; López, F; Pinto, R; Rodríguez, G, 2009)
"Little is known of the perinatal consequences of the use of clofazimine (B663, Lamprene) to treat leprosy."3.66Clofazimine in pregnancy complicated by leprosy. ( Farb, H; Pedvis-Leftick, A; West, DP, 1982)
" The elimination half-life is variable, with values as long as 70 days being quoted in the literature."2.38Clinical pharmacokinetics of clofazimine. A review. ( Holdiness, MR, 1989)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19908 (72.73)18.7374
1990's1 (9.09)18.2507
2000's1 (9.09)29.6817
2010's1 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ozturk, Z1
Tatliparmak, A1
Rodríguez, G1
Pinto, R1
López, F1
Gómez, Y1
Duncan, ME1
Oakey, RE1
Farb, H1
West, DP1
Pedvis-Leftick, A1
Bhargava, P1
Kuldeep, CM1
Mathur, NK1
Reich, CV1
de la Cruz, E1
Morrison, NE1
Karat, AB1
Plock, H1
Leiker, DL1
Holdiness, MR2

Reviews

2 reviews available for clofazimine and Pregnancy

ArticleYear
Leprosy treatment during pregnancy and breastfeeding: A case report and brief review of literature.
    Dermatologic therapy, 2017, Volume: 30, Issue:1

    Topics: Adult; Breast Feeding; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Leprostatic

2017
Clinical pharmacokinetics of clofazimine. A review.
    Clinical pharmacokinetics, 1989, Volume: 16, Issue:2

    Topics: Clofazimine; Female; Humans; Pregnancy

1989

Trials

1 trial available for clofazimine and Pregnancy

ArticleYear
Long-term follow-up of clofazimine (Lamprene) in the management of reactive phases of leprosy.
    Leprosy review, 1975, Volume: 46, Issue:2 Suppl

    Topics: Clinical Trials as Topic; Clofazimine; Dapsone; Female; Follow-Up Studies; Humans; Leprosy; Pregnanc

1975

Other Studies

8 other studies available for clofazimine and Pregnancy

ArticleYear
[Persistent type 2 lepra reaction (erythema nodosum) and clofazimine-induced lethal enteropathy].
    Biomedica : revista del Instituto Nacional de Salud, 2009, Volume: 29, Issue:1

    Topics: Abdominal Pain; Adult; Arthritis, Rheumatoid; Child; Child, Preschool; Clofazimine; Constipation; Di

2009
Reduced estrogen excretion due to clofazimine?
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1983, Volume: 51, Issue:1

    Topics: Clofazimine; Estrogens; Female; Humans; Leprosy; Pregnancy

1983
Clofazimine in pregnancy complicated by leprosy.
    Obstetrics and gynecology, 1982, Volume: 59, Issue:1

    Topics: Adult; Clofazimine; Female; Humans; Infant, Newborn; Leprosy; Pregnancy; Pregnancy Complications, In

1982
Antileprosy drugs, pregnancy and fetal outcome.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1996, Volume: 64, Issue:4

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Animals; Clofazimine; Dapsone; Drug Therapy, Combina

1996
The effect on pregnant mice of 0.05% B1912 fed in the diet.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1979, Volume: 47, Issue:4

    Topics: Animals; Clofazimine; Female; Leprostatic Agents; Mice; Pregnancy; Pregnancy, Animal

1979
Abortifacient activity of B1912.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1979, Volume: 47, Issue:4

    Topics: Abortion, Spontaneous; Animals; Clofazimine; Female; Leprostatic Agents; Mice; Pregnancy

1979
A long term trial with clofazimine in reactive lepromatous leprosy.
    Leprosy review, 1976, Volume: 47, Issue:1

    Topics: Clofazimine; Drug Evaluation; Female; Gastrointestinal Diseases; Humans; Leprosy; Pregnancy; Time Fa

1976
Clofazimine in pregnancy.
    Early human development, 1989, Volume: 18, Issue:4

    Topics: Clofazimine; Female; Fetal Death; Fetal Diseases; Humans; Leprosy; Pregnancy; Pregnancy Complication

1989