Page last updated: 2024-10-25

clofazimine and Phagocyte Bactericidal Dysfunction

clofazimine has been researched along with Phagocyte Bactericidal Dysfunction in 2 studies

Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.

Phagocyte Bactericidal Dysfunction: Disorders in which phagocytic cells cannot kill ingested bacteria; characterized by frequent recurring infection with formulation of granulomas.

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19902 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Brandt, L1
Gärtner, I1
Nilsson, PG1
Olofsson, T1
Rister, M1
Fröhlich, G1
Seiferth, J1

Other Studies

2 other studies available for clofazimine and Phagocyte Bactericidal Dysfunction

ArticleYear
Pyoderma gangrenosum associated with regional enteritis. Improvement in defective granulocyte function and healing of skin lesions during administration of clofazimine.
    Acta medica Scandinavica, 1977, Volume: 201, Issue:1-2

    Topics: Adult; Clofazimine; Crohn Disease; Female; Granulocytes; Humans; Oxygen Consumption; Phagocyte Bacte

1977
[Chronic septic granulomatous disease in two brothers (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1974, Oct-25, Volume: 99, Issue:43

    Topics: Adrenal Cortex Hormones; Bronchopneumonia; Child; Child, Preschool; Clofazimine; Dermatitis; Granulo

1974