clofazimine has been researched along with Neuritis in 11 studies
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
Neuritis: A general term indicating inflammation of a peripheral or cranial nerve. Clinical manifestation may include PAIN; PARESTHESIAS; PARESIS; or HYPESTHESIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A study was undertaken with the aim of testing the usefulness of clofazimine as a prophylactic agent against neuritis and nerve damage." | 9.08 | Does clofazimine have a prophylactic role against neuritis? ( Arunthathi, S; Satheesh, KK, 1997) |
| "A study was undertaken with the aim of testing the usefulness of clofazimine as a prophylactic agent against neuritis and nerve damage." | 5.08 | Does clofazimine have a prophylactic role against neuritis? ( Arunthathi, S; Satheesh, KK, 1997) |
| "Twenty patients of lepromatous leprosy with lepra reaction and suspected dapsone resistance were treated with tapering doses of clofazimine." | 5.05 | Clofazimine in lepra (ENL) reaction, one year clinical trial. ( Balsara, JJ; Bulakh, PM; Burte, NP; Chandorkar, AG; Muley, MP, 1983) |
| " A diagnosis of mycobacterial neuritis was made and the cat was treated with clofazimine and enrofloxacin for extended periods." | 3.70 | Mycobacterial neuritis in a cat. ( Kern, MR; Paulsen, DB; Weigand, CM, 2000) |
| "Incidence of neuritis associated with RR as well as isolated neuritis was similar in both groups." | 2.67 | Reversal reaction in multibacillary leprosy patients following MDT with and without immunotherapy with a candidate for an antileprosy vaccine, Mycobacterium w. ( Beena, KR; Kar, HK; Misra, RS; Mukherjee, A; Mukherjee, R; Nair, NS; Parida, SK; Sharma, AK; Walia, R; Zaheer, SA, 1993) |
| " Prednisolone in standard dosage schedule as recommended by WHO is now being widely used in control programmes." | 1.32 | Reactions and their management. ( Ganapati, R; Pai, VV, 2004) |
| " ENL was also more frequent in regimens C and D and was not prevented by CLO in the dosage used." | 1.27 | Prospective study on the relationship between intensive bactericidal therapy and leprosy reactions. ( Coussens, L; Groenen, G; Janssens, L; Kayembe, T; Nollet, E; Pattyn, SR, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (36.36) | 18.7374 |
| 1990's | 4 (36.36) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ganapati, R | 1 |
| Pai, VV | 1 |
| Burte, NP | 1 |
| Chandorkar, AG | 1 |
| Muley, MP | 1 |
| Balsara, JJ | 1 |
| Bulakh, PM | 1 |
| Kar, HK | 2 |
| Sharma, AK | 1 |
| Misra, RS | 2 |
| Beena, KR | 1 |
| Zaheer, SA | 1 |
| Mukherjee, R | 2 |
| Mukherjee, A | 2 |
| Parida, SK | 1 |
| Walia, R | 1 |
| Nair, NS | 1 |
| Arunthathi, S | 1 |
| Satheesh, KK | 1 |
| Gálvez, J | 1 |
| López-Domínguez, JM | 1 |
| Navarro, A | 1 |
| Creagh, R | 1 |
| Casado, JL | 1 |
| Chinchón Lara, I | 1 |
| Sharma, P | 1 |
| Kaur, H | 1 |
| Rani, R | 1 |
| Paulsen, DB | 1 |
| Kern, MR | 1 |
| Weigand, CM | 1 |
| Shaw, IN | 1 |
| Natrajan, MM | 1 |
| Rao, GS | 1 |
| Jesudasan, K | 1 |
| Christian, M | 1 |
| Kavitha, M | 1 |
| Steenbergen, GJ | 1 |
| Pfaltzgraff, RE | 1 |
| Groenen, G | 1 |
| Janssens, L | 1 |
| Kayembe, T | 1 |
| Nollet, E | 1 |
| Coussens, L | 1 |
| Pattyn, SR | 1 |
| Ramu, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy and Safety Study of Immunomodulator (Mycobacterium w) as an Adjunct Therapy in Category-II Pulmonary Tuberculosis Along With Assessment of Immunological Parameters[NCT00265226] | Phase 3 | 1,020 participants (Actual) | Interventional | 2005-03-31 | Completed | ||
| Efficacy and Safety of Immunomodulator (Mycobacterium w.) as an Adjunct Therapy in Category I Pulmonary Tuberculosis and Along With Assessment of Immunological Parameters[NCT00341328] | Phase 3 | 300 participants (Actual) | Interventional | 2007-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for clofazimine and Neuritis
| Article | Year |
|---|---|
Clofazimine in lepra (ENL) reaction, one year clinical trial.
Topics: Adult; Clinical Trials as Topic; Clofazimine; Erythema Nodosum; Female; Humans; Leprosy; Male; Middl | 1983 |
Reversal reaction in multibacillary leprosy patients following MDT with and without immunotherapy with a candidate for an antileprosy vaccine, Mycobacterium w.
Topics: Bacterial Vaccines; Clofazimine; Combined Modality Therapy; Dapsone; Drug Therapy, Combination; Huma | 1993 |
Does clofazimine have a prophylactic role against neuritis?
Topics: Adolescent; Adult; Case-Control Studies; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Hu | 1997 |
Long-term follow up of multibacillary leprosy patients with high BI treated with WHO/MDT regimen for a fixed duration of two years.
Topics: Adult; Clofazimine; Cohort Studies; Dapsone; Drug Therapy, Combination; Female; Follow-Up Studies; H | 2000 |
7 other studies available for clofazimine and Neuritis
| Article | Year |
|---|---|
Reactions and their management.
Topics: Arthritis; Cicatrix; Clofazimine; Dose-Response Relationship, Drug; Drug-Related Side Effects and Ad | 2004 |
[Patient with Hansen disease and lepromatous reaction with predominant neural involvement].
Topics: Biopsy; Clofazimine; Dapsone; Erythema Nodosum; Humans; Leprostatic Agents; Leprosy, Lepromatous; Ma | 1998 |
Disabilities in multibacillary leprosy following multidrug therapy with and without immunotherapy with Mycobacterium w antileprosy vaccine.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Bacterial Vaccines; Clofazimine; Disabled Persons; Double-B | 1999 |
Disabilities in multibacillary leprosy following multidrug therapy with and without immunotherapy with Mycobacterium w antileprosy vaccine.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Bacterial Vaccines; Clofazimine; Disabled Persons; Double-B | 1999 |
Disabilities in multibacillary leprosy following multidrug therapy with and without immunotherapy with Mycobacterium w antileprosy vaccine.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Bacterial Vaccines; Clofazimine; Disabled Persons; Double-B | 1999 |
Disabilities in multibacillary leprosy following multidrug therapy with and without immunotherapy with Mycobacterium w antileprosy vaccine.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Bacterial Vaccines; Clofazimine; Disabled Persons; Double-B | 1999 |
Mycobacterial neuritis in a cat.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Anti-Infective Agents; Anti-Inflammatory Agents | 2000 |
Treatment of neuritis in borderline leprosy with rifampicin and corticosteroids--a pilot trial.
Topics: Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Leprosy; Male; Neuritis; Pil | 1975 |
Prospective study on the relationship between intensive bactericidal therapy and leprosy reactions.
Topics: Adult; Child; Clofazimine; Dapsone; Drug Therapy, Combination; Edema; Erythema Nodosum; Ethionamide; | 1986 |
Management of reactions in leprosy.
Topics: Adrenal Cortex Hormones; Clofazimine; Hand Deformities, Acquired; Humans; Leprosy; Neuritis; Skin Ul | 1973 |