clofazimine has been researched along with Lung Neoplasms in 6 studies
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
Lung Neoplasms: Tumors or cancer of the LUNG.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clofazimine was shown to have a direct cytotoxic effect in vitro with an ID50 of 10." | 1.29 | Clofazimine alters the energy metabolism and inhibits the growth rate of a human lung-cancer cell line in vitro and in vivo. ( Fearon, KC; Plumb, JA; Sri-Pathmanathan, RM, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Parvathaneni, V | 1 |
| Chilamakuri, R | 1 |
| Kulkarni, NS | 1 |
| Wang, X | 1 |
| Agarwal, S | 1 |
| Gupta, V | 1 |
| Van Rensburg, CE | 3 |
| Anderson, R | 2 |
| Myer, MS | 1 |
| Jooné, GK | 1 |
| O'Sullivan, JF | 1 |
| Sri-Pathmanathan, RM | 1 |
| Plumb, JA | 1 |
| Fearon, KC | 1 |
| Jooné, G | 1 |
| Durandt, C | 1 |
| Wilkie, D | 1 |
6 other studies available for clofazimine and Lung Neoplasms
| Article | Year |
|---|---|
Repurposing clofazimine for malignant pleural mesothelioma treatment - In-vitro assessment of efficacy and mechanism of action.
Topics: Antineoplastic Agents; Apoptosis; beta Catenin; Cell Line, Tumor; Cell Proliferation; Clofazimine; D | 2022 |
The riminophenazine agents clofazimine and B669 reverse acquired multidrug resistance in a human lung cancer cell line.
Topics: Anti-Infective Agents; Antineoplastic Agents; Carbon Radioisotopes; Carcinoma, Small Cell; Cell Divi | 1994 |
Clofazimine alters the energy metabolism and inhibits the growth rate of a human lung-cancer cell line in vitro and in vivo.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Carcinoma, Non-Small-Cell Lung; Cell Divisio | 1994 |
Alpha-tocopherol antagonizes the multidrug-resistance-reversal activity of cyclosporin A, verapamil, GF120918, clofazimine and B669.
Topics: Acridines; Cell Death; Clofazimine; Cyclosporine; Drug Resistance, Multiple; Humans; Isoquinolines; | 1998 |
Effects of tetramethylpiperidine (TMP)-substituted phenazines on membrane stability and P-glycoprotein function.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzothiazoles; Carcinoma, Small Cell; Cell | 2001 |
Antimitochondrial drugs in cancer chemotherapy: preliminary communication.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Clofazimine; Clomipramine; Cricetinae; Lung Neoplas | 1979 |