Page last updated: 2024-10-25

clofazimine and Leukemia, Myeloid, Acute

clofazimine has been researched along with Leukemia, Myeloid, Acute in 2 studies

Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.

Leukemia, Myeloid, Acute: Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.

Research Excerpts

ExcerptRelevanceReference
"Mycobacterial osteomyelitis is rare, difficult to diagnose and treat, and may necessitate prolonged interruption of anti-leukemic therapy."5.62A child with acute myeloid leukemia complicated by calcaneal osteomyelitis due to Mycobacterium abscessus infection after induction chemotherapy successfully salvaged with bedaquiline and clofazimine. ( Chan, WY; Ha, SY; Ho, KW; Ho, PL; Lam, AY; Lau, TW; So, NL; To, KK, 2021)
"Mycobacterial osteomyelitis is rare, difficult to diagnose and treat, and may necessitate prolonged interruption of anti-leukemic therapy."1.62A child with acute myeloid leukemia complicated by calcaneal osteomyelitis due to Mycobacterium abscessus infection after induction chemotherapy successfully salvaged with bedaquiline and clofazimine. ( Chan, WY; Ha, SY; Ho, KW; Ho, PL; Lam, AY; Lau, TW; So, NL; To, KK, 2021)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19901 (50.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's1 (50.00)2.80

Authors

AuthorsStudies
Chan, WY1
Ho, PL1
To, KK1
Lam, AY1
Ho, KW1
Lau, TW1
So, NL1
Ha, SY1
Berg, B1
Brandt, L1

Other Studies

2 other studies available for clofazimine and Leukemia, Myeloid, Acute

ArticleYear
A child with acute myeloid leukemia complicated by calcaneal osteomyelitis due to Mycobacterium abscessus infection after induction chemotherapy successfully salvaged with bedaquiline and clofazimine.
    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2021, Volume: 103

    Topics: Anti-Bacterial Agents; Child, Preschool; Clofazimine; Combined Modality Therapy; Diarylquinolines; D

2021
Syndrome of anaemia, thrombocytopenia and subnormal granulocyte function in elderly patients.
    Scandinavian journal of haematology, 1973, Volume: 10, Issue:3

    Topics: Aged; Alkaline Phosphatase; Anemia; Biopsy, Needle; Bone Marrow; Clofazimine; Humans; Leukemia, Myel

1973