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clofazimine and Leprosy

clofazimine has been researched along with Leprosy in 321 studies

Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.

Leprosy: A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid.

Research Excerpts

ExcerptRelevanceReference
"Monthly doses of rifampin, ofloxacin, and minocycline (ROM) are expected to be effective treatment for multi-bacillary leprosy."9.11Parallel assessment of 24 monthly doses of rifampin, ofloxacin, and minocycline versus two years of World Health Organization multi-drug therapy for multi-bacillary leprosy. ( Abalos, RM; Balagon, MV; Cellona, RV; Dela Cruz, EC; Fajardo, TT; Tan, EV; Villahermosa, LG; Walsh, DS; Walsh, GP, 2004)
"Gastrointestinal toxicity and red skin discoloration were the major side effects observed in leprosy patients undergoing long-term treatment with clofazimine (CFZ)."9.10Biochemical and hematological side effects of clofazimine in leprosy patients. ( Costa Queiroz, RH; de Souza, AM; Melchior, E; Sampaio, SV, 2002)
"Methaemoglobinaemia and haemolytic anaemia were the principal side-effects observed in 30 leprosy patients undergoing long-term treatment with dapsone as a single drug or as part of multidrug therapy."9.08Influence of acetylator phenotype on the haematological and biochemical effects associated with dapsone in leprosy patients. ( Carvalho, D; Gouveia, EG; Melchior, E; Queiroz, RH; Souza, AM, 1997)
"During treatment of multibacillary leprosy with the combination rifampin (RMP) 600 mg, ethionamide (ETH) 500 mg, and either dapsone (DDS) or clofazimine (CLO) 100 mg, hepatotoxicity was observed in 4."9.05Hepatotoxicity of the combination of rifampin-ethionamide in the treatment of multibacillary leprosy. ( Bourland, J; Davies, EM; Feracci, C; Grillone, S; Janssens, L; Pattyn, SR; Saylan, T, 1984)
"The effects of clofazimine on neutrophil activities such as random motility, migration to the leukoattractants endotoxin-activated serum and N-formyl-L-methionyl-L-leucyl-L-phenylalanine phagocytosis of Candida albicans, postphagocytic hexose-monophosphate shunt activity, and myeloperoxidase-mediated iodination and the effects of clofazimine on lymphocyte transformation to mitogens were assessed in vitro and after ingestion of the drug by normal individuals and patients with lepromatous leprosy."9.05Effects of clofazimine alone or combined with dapsone on neutrophil and lymphocyte functions in normal individuals and patients with lepromatous leprosy. ( Anderson, R; Gatner, EM; Imkamp, FM; van Rensburg, CE, 1982)
"Patients with previously untreated borderline-lepromatous or fully lepromatous leprosy were treated with one of five clofazimine (B663) regimens: 1) 200 mg daily 6 days per week; 2) 100 mg three times weekly; 3) 300 mg weekly; 4) 600 mg every other week; and 5) 600 mg on 2 consecutive days every 4 weeks."9.04Spaced clofazimine therapy of lepromatous leprosy. ( , 1976)
"The usefulness of clofazimine (CLO, CAS 2030-63-9) in the treatment of mycobacterial infections with special emphasis on treatment of leprosy is critically discussed."8.78Critical comments on the treatment of leprosy and other mycobacterial infections with clofazimine. ( Freerksen, E; Seydel, JK, 1992)
"This article reviews the chemistry, pharmacology, spectrum of activity, pharmacokinetics, clinical efficacy in leprosy and Mycobacterium avium complex (MAC) infection, adverse effects, drug interactions, and special considerations of clofazimine."8.78Clofazimine: a review of its use in leprosy and Mycobacterium avium complex infection. ( Garrelts, JC, 1991)
"Dapsone hypersensitivity syndrome (DHS) is the most serious adverse reaction associated with dapsone administration and one of the major causes of death in patients with leprosy, whose standard treatment includes multidrug therapy (MDT) with dapsone, rifampicin, and clofazimine."7.91Evaluation of Prospective HLA-B*13:01 Screening to Prevent Dapsone Hypersensitivity Syndrome in Patients With Leprosy. ( Bao, F; Cao, J; Cao, Q; Chai, Z; Chen, S; Cheng, X; Chu, T; Duan, Q; Fu, F; Fu, X; Irwanto, A; Ke, W; Krismawati, H; Kuang, Y; Lang, X; Li, J; Li, L; Li, M; Li, W; Lin, Z; Liu, D; Liu, H; Liu, J; Liu, Q; Mi, Z; Ning, Y; Pan, Q; Shang, X; Shen, J; Shen, Y; Sun, L; Sun, Y; Wang, C; Wang, H; Wang, L; Wang, X; Wang, Y; Wang, Z; Wu, W; Xiao, B; Xiao, P; Xiong, F; Xiong, J; Xiong, L; Xiong, M; Xu, Y; Yan, L; Yang, B; Yang, J; You, J; Yu, G; Yu, W; Yue, Z; Zhan, X; Zhang, F; Zhang, G; Zhang, H; Zhang, L; Zhang, Y; Zhao, Q; Zhao, W; Zheng, H, 2019)
"Six male patients of lepromatous leprosy with erythema nodosum leprosum reaction (ENL) reactions diagnosed clinically and by slit skin smear were treated with aspirin and clofazimine."7.83A Traditional NSAID Aspirin along with Clofazimine in Erythema Nodosum Leprosum Reaction: Study of Six Cases. ( Sharma, PK; Singh, DK, 2016)
"This study aims to assess the oxidative stress in leprosy patients under multidrug therapy (MDT; dapsone, clofazimine and rifampicin), evaluating the nitric oxide (NO) concentration, catalase (CAT) and superoxide dismutase (SOD) activities, glutathione (GSH) levels, total antioxidant capacity, lipid peroxidation, and methemoglobin formation."7.80Clinical oxidative stress during leprosy multidrug therapy: impact of dapsone oxidation. ( Batista Júnior, J; Borges, RS; Coleman, MD; Monteiro, MC; Oliveira, FR; Romão, PR; Salgado, CG; Schalcher, TR; Vieira, JL, 2014)
"Multidrug therapy for leprosy is currently done with dapsone, clofazimine and rifampicin."7.78Hemolytic anemia in patients receiving daily dapsone for the treatment of leprosy. ( Deps, P; Guerra, P; Nasser, S; Simon, M, 2012)
"To evaluate the occurrence of relapse of multibacillary leprosy after multi-drug treatment including daily rifampin."7.77Evaluation of multi-drug therapy for leprosy in the United States using daily rifampin. ( Dacso, MM; Jacobson, RR; Prestigiacomo, JF; Scollard, DM; Stryjewska, BM, 2011)
"Dapsone Hypersensitivity Syndrome (DHS) occurs in approximately 2% of leprosy patients in Nepal."7.74A retrospective study of the effect of modified multi-drug therapy in Nepali leprosy patients following the development of adverse effects due to dapsone. ( Pandey, B; Sapkota, BR; Shrestha, K; Walker, SL, 2008)
"This reports a long-term follow-up study on clinical effects of ofloxacin (OFLX)-combined therapy to 14 leprosy patients with various types and stages."7.74[Long-term follow-up of ofloxacin-combined therapy for leprosy patients]. ( Ishikawa, M; Ozaki, M, 2007)
"Dapsone syndrome is a rare hypersensitivity reaction to dapsone and is characterized by high fever, papular or exfoliative dermatitis, progressing to liver toxicity and generalized lymphadenopathy, resembling a mononucleosis infection."7.73Dapsone syndrome with acute renal failure during leprosy treatment: case report. ( Alves-Rodrigues, EN; Fontes, CJ; Ribeiro, LC; Silva, MD; Takiuchi, A, 2005)
"Clofazimine-induced crystal-storing histiocytosis is a rare but well-recognized condition in the literature."7.70Clofazimine-induced crystal-storing histiocytosis producing chronic abdominal pain in a leprosy patient. ( Akaraviputh, T; Chanchairujira, T; Hargrove, NS; Kachintorn, U; Manatsathit, S; Siritanaratkul, N; Sukpanichnant, S; Thakerngpol, K, 2000)
"We describe a 41 yr old leprosy patient treated for 10 yrs with clofazimine who underwent laparotomy for severe abdominal pain."7.68Severe abdominal pain in low dosage clofazimine. ( Chong, PY; Ti, TK, 1993)
"Side-effects of leprosy treatment with dapsone are said to be uncommon, with drug allergy occurring in only one of every several hundred patients treated with dapsone."7.68Dapsone syndrome in Vanuatu: a high incidence during multidrug treatment (MDT) of leprosy. ( Ala, J; Hall, JJ; Reeve, PA, 1992)
"In leprosy patients in Nigeria the influence of daily clofazimine and of once-monthly rifampicin on the pharmacokinetics of dapsone has been investigated."7.67Influence of once-monthly rifampicin and daily clofazimine on the pharmacokinetics of dapsone in leprosy patients in Nigeria. ( Pieters, FA; Woonink, F; Zuidema, J, 1988)
"A preliminary report is presented on the finding in a patient with lepromatous leprosy relapsing after maintaining clinical inactivity and bacterial negativity with dapsone monotherapy for a period of 23 years."7.67Combined clofazimine- and dapsone-resistant leprosy. A case report. ( Bhatia, VN; Harikrishnan, S; Kar, HK, 1986)
"Fifteen untreated leprosy patients were given rifampicin and dapsone for seven days, and then rifampicin, dapsone and clofazimine for seven days."7.67The effect of clofazimine on the pharmacokinetics of rifampicin and dapsone in leprosy. ( Bharadwaj, VP; Girdhar, BK; Mathur, A; Venkatesan, K, 1986)
"Little is known of the perinatal consequences of the use of clofazimine (B663, Lamprene) to treat leprosy."7.66Clofazimine in pregnancy complicated by leprosy. ( Farb, H; Pedvis-Leftick, A; West, DP, 1982)
"Clofazimine is a valuable drug which is used worldwide in the treatment of leprosy."7.66Clofazimine-induced ichthyosis and its treatment. ( Caver, CV, 1982)
"This paper records the results of treatment with clofazimine of a group of 31 patients of mixed racial origin in the United Kingdom suffering from lepromatous or borderline-lepromatous leprosy."7.66Clofazimine (Lamprene, B663) in the treatment of lepromatous leprosy in the United Kingdom. A 12 year review of 31 cases, 1966-1978. ( Browne, SG; Harman, DJ; McDougall, AC; Waudby, H, 1981)
"Patients of lepromatous leprosy who have evolved from the borderline type of disease are known to revert to the borderline state through a reactionary phenomenon under anti-leprosy chemotherapy with Dapsone."7.65Transformation from lepromatous to borderline leprosy under clofazimine therapy. ( Mahapatra, SB; Ramu, G, 1976)
"This paper summarises our clinical experience with clofazimine in the treatment of 25 cases of reactive states of lepromatous and borderline leprosy and 7 lepromatous patients not responding to dapsone."7.65Clinical trial with clofazimine in leprosy. ( Dongre, VV; Ganapati, R, 1976)
"Leprosy is a stigmatizing, chronic infection which degenerates the nervous system and often leads to incapacitation."5.56Validation study of HLA-B*13:01 as a biomarker of dapsone hypersensitivity syndrome in leprosy patients in Indonesia. ( Irwan, ID; Irwanto, A; Krismawati, H; Liu, H; Liu, J; Maladan, Y; Oktavian, A; Pongtiku, A; Sitanggang, YA; Sun, Y; Tanjung, R; Wahyuni, T; Zhang, F, 2020)
"Dapsone resistance was found in 4 of 6 biopsies from American Samoa patients."5.48Dapsone Resistance in Leprosy Patients Originally from American Samoa, United States, 2010-2012. ( Araujo, S; Scollard, D; Stryjewska, BM; Williams, DL, 2018)
"The World Health Organization (WHO) recommends multidrug therapy (MDT) with rifampicin, dapsone, and clofazimine for treating leprosy, which is based on very low-quality evidence."5.41Seventy years of evidence on the efficacy and safety of drugs for treating leprosy: a network meta-analysis. ( Bao, F; Chen, J; Dong, Y; Fan, Y; Gao, L; Ji, Z; Kong, J; Li, B; Liu, A; Liu, M; Luo, S; Ma, W; Peng, L; Song, J; Wu, X; Yang, J, 2023)
"It is the drug of choice for the treatment of leprosy and prophylaxis of malaria."5.30Haematological and biochemical alterations in leprosy patients already treated with dapsone and MDT. ( Barbosa, JC; de Carvalho, D; de Souza, AM; Gouveia, E; Melchior Júnior, E; Queiroz, RH, 1997)
"Clofazimine was administered initially 100 mg three times daily for one month and then gradually reduced to a dose of 100 mg biweekly for the last three months."5.27Effect of one year clofazimine therapy on autonomic functions in lepromatous leprosy with lepra (ENL) reaction. ( Balsara, JJ; Bulakh, PM; Burte, NP; Chandorkar, AG; Muley, MP, 1983)
"Monthly doses of rifampin, ofloxacin, and minocycline (ROM) are expected to be effective treatment for multi-bacillary leprosy."5.11Parallel assessment of 24 monthly doses of rifampin, ofloxacin, and minocycline versus two years of World Health Organization multi-drug therapy for multi-bacillary leprosy. ( Abalos, RM; Balagon, MV; Cellona, RV; Dela Cruz, EC; Fajardo, TT; Tan, EV; Villahermosa, LG; Walsh, DS; Walsh, GP, 2004)
"Gastrointestinal toxicity and red skin discoloration were the major side effects observed in leprosy patients undergoing long-term treatment with clofazimine (CFZ)."5.10Biochemical and hematological side effects of clofazimine in leprosy patients. ( Costa Queiroz, RH; de Souza, AM; Melchior, E; Sampaio, SV, 2002)
"Methaemoglobinaemia and haemolytic anaemia were the principal side-effects observed in 30 leprosy patients undergoing long-term treatment with dapsone as a single drug or as part of multidrug therapy."5.08Influence of acetylator phenotype on the haematological and biochemical effects associated with dapsone in leprosy patients. ( Carvalho, D; Gouveia, EG; Melchior, E; Queiroz, RH; Souza, AM, 1997)
"Pyrazinamide in a dose of 1500 mg was given to 63 borderline lepromatous (BL) and lepromatous (LL) leprosy patients on different drug regimens for the initial 2 months of therapy."5.06Pyrazinamide as a part of combination therapy for BL and LL patients--a preliminary report. ( Katoch, K; Ramanathan, U; Ramu, G, 1988)
"Clofazimine (CFZ), an old hydrophobic riminophenazine, has a wide range of antimycobacterial activity ranging from leprosy to nontuberculous mycobacterial diseases."5.05Clofazimine: an old drug for never-ending diseases. ( Besozzi, G; Biagio, AD; Canetti, D; Codecasa, L; Comelli, A; Diaw, MM; Gaiera, G; Giacomelli, A; Intini, E; Riccardi, N; Udwadia, Z, 2020)
"Twenty patients of lepromatous leprosy with lepra reaction and suspected dapsone resistance were treated with tapering doses of clofazimine."5.05Clofazimine in lepra (ENL) reaction, one year clinical trial. ( Balsara, JJ; Bulakh, PM; Burte, NP; Chandorkar, AG; Muley, MP, 1983)
"During treatment of multibacillary leprosy with the combination rifampin (RMP) 600 mg, ethionamide (ETH) 500 mg, and either dapsone (DDS) or clofazimine (CLO) 100 mg, hepatotoxicity was observed in 4."5.05Hepatotoxicity of the combination of rifampin-ethionamide in the treatment of multibacillary leprosy. ( Bourland, J; Davies, EM; Feracci, C; Grillone, S; Janssens, L; Pattyn, SR; Saylan, T, 1984)
"The effects of clofazimine on neutrophil activities such as random motility, migration to the leukoattractants endotoxin-activated serum and N-formyl-L-methionyl-L-leucyl-L-phenylalanine phagocytosis of Candida albicans, postphagocytic hexose-monophosphate shunt activity, and myeloperoxidase-mediated iodination and the effects of clofazimine on lymphocyte transformation to mitogens were assessed in vitro and after ingestion of the drug by normal individuals and patients with lepromatous leprosy."5.05Effects of clofazimine alone or combined with dapsone on neutrophil and lymphocyte functions in normal individuals and patients with lepromatous leprosy. ( Anderson, R; Gatner, EM; Imkamp, FM; van Rensburg, CE, 1982)
"Patients with previously untreated borderline-lepromatous or fully lepromatous leprosy were treated with one of five clofazimine (B663) regimens: 1) 200 mg daily 6 days per week; 2) 100 mg three times weekly; 3) 300 mg weekly; 4) 600 mg every other week; and 5) 600 mg on 2 consecutive days every 4 weeks."5.04Spaced clofazimine therapy of lepromatous leprosy. ( , 1976)
"The usefulness of clofazimine (CLO, CAS 2030-63-9) in the treatment of mycobacterial infections with special emphasis on treatment of leprosy is critically discussed."4.78Critical comments on the treatment of leprosy and other mycobacterial infections with clofazimine. ( Freerksen, E; Seydel, JK, 1992)
"This article reviews the chemistry, pharmacology, spectrum of activity, pharmacokinetics, clinical efficacy in leprosy and Mycobacterium avium complex (MAC) infection, adverse effects, drug interactions, and special considerations of clofazimine."4.78Clofazimine: a review of its use in leprosy and Mycobacterium avium complex infection. ( Garrelts, JC, 1991)
"BACKGROUND: Clofazimine (CFZ) is routinely used worldwide for the treatment of leprosy and TB."4.31Extemporaneously compounded liquid formulations of clofazimine. ( Fourie, CL; Garcia-Prats, AJ; Hesseling, AC; Hoddinott, G; Jew, RK; Nahata, MC; Pande, PG; Scarim, A; Scarim, J; Schaaf, HS; Taneja, R, 2023)
"Dapsone hypersensitivity syndrome (DHS) is the most serious adverse reaction associated with dapsone administration and one of the major causes of death in patients with leprosy, whose standard treatment includes multidrug therapy (MDT) with dapsone, rifampicin, and clofazimine."3.91Evaluation of Prospective HLA-B*13:01 Screening to Prevent Dapsone Hypersensitivity Syndrome in Patients With Leprosy. ( Bao, F; Cao, J; Cao, Q; Chai, Z; Chen, S; Cheng, X; Chu, T; Duan, Q; Fu, F; Fu, X; Irwanto, A; Ke, W; Krismawati, H; Kuang, Y; Lang, X; Li, J; Li, L; Li, M; Li, W; Lin, Z; Liu, D; Liu, H; Liu, J; Liu, Q; Mi, Z; Ning, Y; Pan, Q; Shang, X; Shen, J; Shen, Y; Sun, L; Sun, Y; Wang, C; Wang, H; Wang, L; Wang, X; Wang, Y; Wang, Z; Wu, W; Xiao, B; Xiao, P; Xiong, F; Xiong, J; Xiong, L; Xiong, M; Xu, Y; Yan, L; Yang, B; Yang, J; You, J; Yu, G; Yu, W; Yue, Z; Zhan, X; Zhang, F; Zhang, G; Zhang, H; Zhang, L; Zhang, Y; Zhao, Q; Zhao, W; Zheng, H, 2019)
"Six male patients of lepromatous leprosy with erythema nodosum leprosum reaction (ENL) reactions diagnosed clinically and by slit skin smear were treated with aspirin and clofazimine."3.83A Traditional NSAID Aspirin along with Clofazimine in Erythema Nodosum Leprosum Reaction: Study of Six Cases. ( Sharma, PK; Singh, DK, 2016)
"This study aims to assess the oxidative stress in leprosy patients under multidrug therapy (MDT; dapsone, clofazimine and rifampicin), evaluating the nitric oxide (NO) concentration, catalase (CAT) and superoxide dismutase (SOD) activities, glutathione (GSH) levels, total antioxidant capacity, lipid peroxidation, and methemoglobin formation."3.80Clinical oxidative stress during leprosy multidrug therapy: impact of dapsone oxidation. ( Batista Júnior, J; Borges, RS; Coleman, MD; Monteiro, MC; Oliveira, FR; Romão, PR; Salgado, CG; Schalcher, TR; Vieira, JL, 2014)
"Multidrug therapy for leprosy is currently done with dapsone, clofazimine and rifampicin."3.78Hemolytic anemia in patients receiving daily dapsone for the treatment of leprosy. ( Deps, P; Guerra, P; Nasser, S; Simon, M, 2012)
"To evaluate the occurrence of relapse of multibacillary leprosy after multi-drug treatment including daily rifampin."3.77Evaluation of multi-drug therapy for leprosy in the United States using daily rifampin. ( Dacso, MM; Jacobson, RR; Prestigiacomo, JF; Scollard, DM; Stryjewska, BM, 2011)
"Multidrug therapy (WHO/MDT) in multibacillary leprosy consists of treatment with rifampicin, dapsone and clofazimine."3.75Agranulocytosis induced by multidrug therapy in leprosy treatment: a case report. ( Guedes Filho, G; Guedes, WR; Oliveira, BB; Oliveira, CA; Oliveira, DA; Silva, IM, 2009)
"Dapsone Hypersensitivity Syndrome (DHS) occurs in approximately 2% of leprosy patients in Nepal."3.74A retrospective study of the effect of modified multi-drug therapy in Nepali leprosy patients following the development of adverse effects due to dapsone. ( Pandey, B; Sapkota, BR; Shrestha, K; Walker, SL, 2008)
"A pale ginger cat was treated with clofazimine for feline leprosy."3.74Photosensitisation induced by clofazimine in a cat. ( Bennett, Sl, 2007)
"This reports a long-term follow-up study on clinical effects of ofloxacin (OFLX)-combined therapy to 14 leprosy patients with various types and stages."3.74[Long-term follow-up of ofloxacin-combined therapy for leprosy patients]. ( Ishikawa, M; Ozaki, M, 2007)
"The WHO MDT for leprosy treatment was officially introduced in Brazil in 1991 and comprises three drugs: dapsone, rifampicin and clofazimine."3.74Adverse effects from multi-drug therapy in leprosy: a Brazilian study. ( Birshner, Rde C; Deps, PD; Guerra, P; Nasser, S; Rodrigues, LC; Simon, M, 2007)
"Dapsone syndrome is a rare hypersensitivity reaction to dapsone and is characterized by high fever, papular or exfoliative dermatitis, progressing to liver toxicity and generalized lymphadenopathy, resembling a mononucleosis infection."3.73Dapsone syndrome with acute renal failure during leprosy treatment: case report. ( Alves-Rodrigues, EN; Fontes, CJ; Ribeiro, LC; Silva, MD; Takiuchi, A, 2005)
" The patient began treatment with clofazimine, rifampicin, and dapsone, but 15 days afterwards he complained of acral edema with godet sign."3.73Remitting seronegative symmetrical synovitis with pitting edema in leprosy. ( Helling, CA; Locursio, A; Manzur, ME; Sormani de Fonseca, ML, 2006)
"Between 1989 and 1993, 136 multibacillary leprosy patients received a 6-week treatment regimen consisting of daily rifampicin 600 mg, ofloxacin 400 mg, clofazimine 100 mg and a weekly dose of 100 mg minocycline."3.71Relapse rates and a 10-year follow-up of a 6-week quadruple drug regimen for multibacillary leprosy. ( Grillone, S; Pattyn, S, 2002)
"Clofazimine-induced crystal-storing histiocytosis is a rare but well-recognized condition in the literature."3.70Clofazimine-induced crystal-storing histiocytosis producing chronic abdominal pain in a leprosy patient. ( Akaraviputh, T; Chanchairujira, T; Hargrove, NS; Kachintorn, U; Manatsathit, S; Siritanaratkul, N; Sukpanichnant, S; Thakerngpol, K, 2000)
"Twenty-five compounds structurally related to clofazimine were tested for their ability to inhibit the growth of Mycobacterium leprae using the kinetic method of drug evaluation in the mouse foot pad model of leprosy."3.68Activity of phenazine analogs against Mycobacterium leprae infections in mice. ( O'Sullivan, JF; Shinnick, TM; Van Landingham, RM; Walker, LL, 1993)
"To describe the role of the clinical pharmacist in a Hansen's disease (HD, leprosy) clinic and to describe the development, validation, and operation of a dapsone compliance monitoring program."3.68Therapeutic monitoring and pharmacist intervention in a Hansen's disease clinic. ( Danziger, LH; Fischer, JH; Hill, C; Occhipinti, DJ; Piscitelli, SC; West, DP, 1993)
"We describe a 41 yr old leprosy patient treated for 10 yrs with clofazimine who underwent laparotomy for severe abdominal pain."3.68Severe abdominal pain in low dosage clofazimine. ( Chong, PY; Ti, TK, 1993)
"The proportion of relapses among all patients detected each year increased steadily since the initiation of the national leprosy control program in China with dapsone monotherapy in 1955, reaching 18%-24% in the more leprosy-endemic provinces along the coast."3.68Problems of leprosy relapse in China. ( Li, HY, 1993)
"Side-effects of leprosy treatment with dapsone are said to be uncommon, with drug allergy occurring in only one of every several hundred patients treated with dapsone."3.68Dapsone syndrome in Vanuatu: a high incidence during multidrug treatment (MDT) of leprosy. ( Ala, J; Hall, JJ; Reeve, PA, 1992)
"In 1982, following the recommendations of a WHO study group, multidrug therapy (MDT) was introduced into French Polynesia to treat all patients suffering from active leprosy, and--only on request--those still on dapsone monotherapy."3.68Leprosy in French Polynesia. The possible impact of multidrug therapy on epidemiological trends. ( Cartel, JL; Grosset, JH; Martin, PM; Moulia-Pelat, JP; Nguyen Ngoc, L; Spiegel, A, 1992)
"An ambulatory treatment regimen for multibacillary leprosy, of 34 weeks duration composed of 8 weeks daily supervised rifampicin, ethionamide (ETH), dapsone (DDS) and clofazimine (CLO) followed by 26 weeks of unsupervised ETH, DDS and CLO, introduced in 1983 has been evaluated; 268 patients were followed for a mean of 4."3.68Ambulatory treatment of multibacillary leprosy with a regimen of 8 months duration. ( Bourland, J; Pattyn, SR, 1992)
"The feasibility and effects of a 3-year treatment using rifampicin (RFP), clofazimine (B663) and dapsone (DDS) in multibacillary leprosy patients in Yangzhou Prefecture and Dongtai County (1983-1986) are reported."3.68Effect of three-year multidrug therapy in multibacillary leprosy patients. ( Ji, F; Li, W; Luo, J; Tao, M; Wang, C; Yang, Z; Ye, G, 1990)
"A 24 year old man admitted to hospital with borderline lepromatous leprosy was treated with rifampicin, dapsone, and clofazimine."3.67Successful plasma exchange in type 1 leprosy reversal reaction. ( Bonhomme, J; Chalopin, JM; Lucht, F; Portier, H; Rifle, G, 1984)
"Fifty three multibacillary leprosy cases were treated with two regimens of MDT L1 consisting of Rifampicin, Dapsone and Ethionamide and L2 consisting of Rifampicin, Dapsone and clofazimine."3.67Evaluation of two multidrug regimen in hospitalised multibacillary cases. ( Bhate, RD; Bhate, RP; Chattopadhyay, SP; Gupta, CM, 1989)
"In leprosy patients in Nigeria the influence of daily clofazimine and of once-monthly rifampicin on the pharmacokinetics of dapsone has been investigated."3.67Influence of once-monthly rifampicin and daily clofazimine on the pharmacokinetics of dapsone in leprosy patients in Nigeria. ( Pieters, FA; Woonink, F; Zuidema, J, 1988)
"A preliminary report is presented on the finding in a patient with lepromatous leprosy relapsing after maintaining clinical inactivity and bacterial negativity with dapsone monotherapy for a period of 23 years."3.67Combined clofazimine- and dapsone-resistant leprosy. A case report. ( Bhatia, VN; Harikrishnan, S; Kar, HK, 1986)
"The rise in the incidence of dapsone-resistant leprosy requires new therapeutic approaches."3.67[Therapy of leprosy today]. ( Bahmer, FA; Menzel, S, 1987)
"Fifteen untreated leprosy patients were given rifampicin and dapsone for seven days, and then rifampicin, dapsone and clofazimine for seven days."3.67The effect of clofazimine on the pharmacokinetics of rifampicin and dapsone in leprosy. ( Bharadwaj, VP; Girdhar, BK; Mathur, A; Venkatesan, K, 1986)
"A comparative study with 2 tier and 3 tier combination of Rifampicin, Clofazimine, DDS, INAH and Thiacetazone was conducted on fifty lepromatous leprosy cases for varying periods."3.66Multiple drug therapy--a comparative study with 2 tier and 3 tier combination of rifampicin, clofazimine, DDS, INAH and thiacetazone in lepromatous cases. ( Chaudhury, S; Ghosh, S; Hazra, S; Kundu, SK, 1981)
"The practical problems related to dapsone monotherapy for a prolonged period to infectious leprosy patients are well known to the scientific community and combined treatment of dapsone with clofazimine, rifampicin or prothionamide has been successfully carried out by several workers in hospitalised leprosy patients."3.66Field application of combined therapy for infectious leprosy cases. A feasibility study in Bombay. ( Ganapati, R; Naik, SS; Revankar, CR, 1983)
"Oral zinc sulfate was tried in Eight cases of recurrent Erythema Nodosum Leprosum."3.66Oral zinc in recurrent Erythema Nodosum Leprosum reaction. ( Bumb, RA; Mangal, HN; Mathur, NK, 1983)
"Little is known of the perinatal consequences of the use of clofazimine (B663, Lamprene) to treat leprosy."3.66Clofazimine in pregnancy complicated by leprosy. ( Farb, H; Pedvis-Leftick, A; West, DP, 1982)
"Clofazimine is a valuable drug which is used worldwide in the treatment of leprosy."3.66Clofazimine-induced ichthyosis and its treatment. ( Caver, CV, 1982)
"This paper records the results of treatment with clofazimine of a group of 31 patients of mixed racial origin in the United Kingdom suffering from lepromatous or borderline-lepromatous leprosy."3.66Clofazimine (Lamprene, B663) in the treatment of lepromatous leprosy in the United Kingdom. A 12 year review of 31 cases, 1966-1978. ( Browne, SG; Harman, DJ; McDougall, AC; Waudby, H, 1981)
"Thirty three leprosy patients in reaction were treated with a combination of Metronidazole--Diethyl carbamazine citrate--Chloroquin which was reinforced either with prednisolone and/or Clofazimine in some, depending on the clinical state."3.66Multi-drug treatment for reactions in leprosy. ( Razack, EM; Zahra, A, 1981)
"Three out of 30 patients of leprosy getting clofazimine therapy developed severe gastrointestinal side effects following the therapy in the dose of 100 mg after one month, eight months and five weeks respectively."3.66Gastro-intestinal side effects of clofazimine. ( Garg, BR; Hameedulla, A; Lal, S, 1981)
" Reactive episodes continue to be a serious complication, but the availability of thalidomide to control erythema nodosum leprosum has markedly improved the prognosis."3.65The diagnosis and treatment of leprosy. ( Jacobson, RR; Trautman, JR, 1976)
"Patients of lepromatous leprosy who have evolved from the borderline type of disease are known to revert to the borderline state through a reactionary phenomenon under anti-leprosy chemotherapy with Dapsone."3.65Transformation from lepromatous to borderline leprosy under clofazimine therapy. ( Mahapatra, SB; Ramu, G, 1976)
"This paper summarises our clinical experience with clofazimine in the treatment of 25 cases of reactive states of lepromatous and borderline leprosy and 7 lepromatous patients not responding to dapsone."3.65Clinical trial with clofazimine in leprosy. ( Dongre, VV; Ganapati, R, 1976)
"The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil (U-MDT/CT-BR), designed to evaluate the effectiveness of a six-months regimen, assessed the adverse effects caused by the drugs."2.87Clinical trial for uniform multidrug therapy for leprosy patients in Brazil (U-MDT/CT-BR): adverse effects approach. ( Bührer-Sékula, S; Cruz, RCDS; Gonçalves, HS; Moraes, MEA; Penna, GO; Penna, MLF; Pontes, MAA; Stefani, MMA; Talhari, S, 2018)
"Type 2 lepra reaction (T2R) is a difficult-to-manage condition in leprosy, and an effective and safe steroid-sparing agent is needed for its management."2.80Effectiveness and safety of clofazimine and pentoxifylline in type 2 lepra reaction: a double-blind, randomized, controlled study. ( Bandyopadhyay, D; Das, NK; Roy, K; Sil, A, 2015)
"Incidence of neuritis associated with RR as well as isolated neuritis was similar in both groups."2.67Reversal reaction in multibacillary leprosy patients following MDT with and without immunotherapy with a candidate for an antileprosy vaccine, Mycobacterium w. ( Beena, KR; Kar, HK; Misra, RS; Mukherjee, A; Mukherjee, R; Nair, NS; Parida, SK; Sharma, AK; Walia, R; Zaheer, SA, 1993)
" In patients who received the same drug regimens but with a reduced dosage of ethionamide to 5 mg/k bodyweight, the incidence of hepatitis was significantly lower but the relapse rate was 7."2.67Treatment of multibacillary leprosy with a regimen of 13 weeks duration. ( Groenen, G; Janssens, L; Kuykens, L; Mputu, LB; Pattyn, SR, 1992)
"Leprosy is a chronic infectious disease caused my Mycobacterium leprae that primarily affects peripheral nervous system and extremities and is prevalent in tropical countries."2.66Metabolism and interactions of antileprosy drugs. ( George, J, 2020)
"Histoid leprosy is a rare variant of leprosy with a unique clinical presentation and bacilli rich histology."2.66Treatment of histoid leprosy: a lack of consensus. ( Bartos, G; Combs, A; Rivlin, D; Sheuring, R, 2020)
"Leprosy is present in more than 100 countries, where it remains a major cause of peripheral neuropathy and disability."2.55Multidrug therapy for leprosy: a game changer on the path to elimination. ( Aerts, A; Kawuma, J; Kita, E; Saunderson, P; Smith, CS; Virmond, M, 2017)
"Leprosy is a chronic disease with many clinical manifestations, which affect mainly the skin, the peripheral nerves, mucosa of the upper respiratory tract and the eyes."2.53Leprosy – an old infectious disease with unsolved matters. ( Stock, I, 2016)
"Leprosy is an infectious disease that has now been reported for more than 2000 years."2.52Update on the epidemiology, diagnosis, and treatment of leprosy. ( Aubry, A; Cambau, E; Reibel, F, 2015)
"Leprosy is a granulomatous disease affecting the skin and peripheral nerves caused by Mycobacterium leprae."2.44[Hansen's disease: case report and review of literature]. ( Concha R, M; Cossio T, ML; Fich S, F; González B, S; Pérez C, C; Salazar S, I, 2008)
"The diagnosis of leprosy is frequently not considered, with resultant pathological and psychological problems for patients."2.41Update on leprosy. ( Lockwood, DN; Marlowe, SN, 2001)
"Current treatment of leprosy involves use of 3 drugs: rifampicin (rifampin); clofazimine; and dapsone."2.41Leprosy. Recognition and treatment. ( Ramos-e-Silva, M; Rebello, PF, 2001)
" In many cases dose and intervals were based on WHO protocol, however smaller dosage was used in some cases."2.40[Chemotherapy of Hansen's disease in Japan--present status]. ( Goto, M; Kitajima, S; Miyagi, S; Takizawa, H, 1998)
"Leprosy is a stigmatizing, chronic infection which degenerates the nervous system and often leads to incapacitation."1.56Validation study of HLA-B*13:01 as a biomarker of dapsone hypersensitivity syndrome in leprosy patients in Indonesia. ( Irwan, ID; Irwanto, A; Krismawati, H; Liu, H; Liu, J; Maladan, Y; Oktavian, A; Pongtiku, A; Sitanggang, YA; Sun, Y; Tanjung, R; Wahyuni, T; Zhang, F, 2020)
"Dapsone resistance was found in 4 of 6 biopsies from American Samoa patients."1.48Dapsone Resistance in Leprosy Patients Originally from American Samoa, United States, 2010-2012. ( Araujo, S; Scollard, D; Stryjewska, BM; Williams, DL, 2018)
"To assess the adverse effects of multi drug therapy (MDT) in leprosy patients."1.37Adverse effects of multi-drug therapy in leprosy, a two years' experience (2006-2008) in tertiary health care centre in the tribal region of Chhattisgarh State (Bastar, Jagdalpur). ( Dey, V; Dulhani, N; Nel, B; Singh, H; Tiwari, P, 2011)
"Leprosy is a rare cause of neuropathy in Europeans."1.35[Sensory-motor neuropathy: a slow and misleading case of leprosy]. ( Andre, P; Camu, W; Flageul, B; Gabelle, A; Vallat, JM, 2008)
"Leprosy is well controlled in Hong Kong but continued surveillance is required to detect relapses and to ensure good patient compliance with treatment."1.33Epidemiology of leprosy and response to treatment in Hong Kong. ( Ho, CK; Lo, KK, 2006)
"Leprosy is an ancient disease, which was treated by local application of chaulmoogra/hydnocarpus oil during prechemotherapeutic era."1.33Multidrug therapy in leprosy. ( Arif, MA; Manglani, PR, 2006)
"Areas of low endemicity of Hansen's disease, such as Texas, California, and Hawaii, exist due to immigration and rare autochthonous infections."1.32Short report: Treatment failure in Hansen's disease. ( Joyce, MP; Longfield, RN; Murray, CK, 2003)
" The results of the study therefore reveal that patients undergoing therapy had significantly greater DNA damage than untreated patients, indicating bacterial infection and drug therapy as the causal factors, since lepromatous-type disease is the more severe form with the patients having lower resistance to Mycobacterium leprae and requiring heavier and prolonged dosage of antibiotics."1.32DNA damage studies in untreated and treated leprosy patients. ( Gandhi, G; Singh, B, 2004)
" Prednisolone in standard dosage schedule as recommended by WHO is now being widely used in control programmes."1.32Reactions and their management. ( Ganapati, R; Pai, VV, 2004)
"It is the drug of choice for the treatment of leprosy and prophylaxis of malaria."1.30Haematological and biochemical alterations in leprosy patients already treated with dapsone and MDT. ( Barbosa, JC; de Carvalho, D; de Souza, AM; Gouveia, E; Melchior Júnior, E; Queiroz, RH, 1997)
"In the present study, we evaluated the in vivo anti-Mycobacterium leprae activities of KRM-1648 (KRM) given at long intervals in combination with ofloxacin (OFLX), clofazimine (CFZ), and dapsone (DDS)."1.30Studies on therapeutic activity of benzoxazinorifamycin KRM-1648 in combination with other antimicrobial agents and biological response modifiers interferon-gamma and granulocyte-macrophage colony-stimulating factor against M. leprae infection in athymic ( Maw, WW; Saito, H; Sato, K; Tomioka, H, 1997)
"In this study, the in vitro and in vivo anti-Mycobacterium leprae activity of the newly developed benzoxazinorifamycin, KRM-1648, in combination with clofazimine (CFZ) or dapsone (DDS) was evaluated."1.29Therapeutic efficacy of benzoxazinorifamycin, KRM-1648, in combination with other antimicrobials against Mycobacterium leprae infection induced in nude mice. ( Dekio, S; Saito, H; Sato, K; Tomioka, H, 1994)
"The difficulty in treating leprosy may be partly ascribable to decreased phagocytic OH X generation, which in leprosy patients is apparently due to the uptake of Hansen bacillus-derived SOD."1.27Oxygen metabolism in phagocytes of leprotic patients: enhanced endogenous superoxide dismutase activity and hydroxyl radical generation by clofazimine. ( Miyachi, Y; Niwa, Y; Ozaki, M; Sakane, T, 1984)
"Clofazimine was administered in different doses over a period of 12 months."1.27The effect of clofazimine on liver function tests in lepra reaction (ENL). ( Bulakh, PM; Burte, NP; Chandorkar, AG; Kowale, CN; Ranade, SM, 1983)
"Clofazimine was administered initially 100 mg three times daily for one month and then gradually reduced to a dose of 100 mg biweekly for the last three months."1.27Effect of one year clofazimine therapy on autonomic functions in lepromatous leprosy with lepra (ENL) reaction. ( Balsara, JJ; Bulakh, PM; Burte, NP; Chandorkar, AG; Muley, MP, 1983)
" ENL was also more frequent in regimens C and D and was not prevented by CLO in the dosage used."1.27Prospective study on the relationship between intensive bactericidal therapy and leprosy reactions. ( Coussens, L; Groenen, G; Janssens, L; Kayembe, T; Nollet, E; Pattyn, SR, 1986)
"Only in lepromatous cases was complete ageusia seen (9."1.27Electrogustometry in Hansen's disease (study of 225 cases). ( Chaturvedi, VN; Jain, SK; Raizada, RM; Rathi, SS, 1986)
" The initial dosage of either of the drugs was 300 mg daily administered in divided doses of 100 mg three times a day."1.26Treatment of steroid dependant cases of recurrent lepra reaction with a combination of thalidomide and clofazimine. ( Girdhar, A; Ramu, G, 1979)
"In rifampin-treated immunosuppressed animals the survival half-life of solid bacilli, in the absence of host immunity, was 12-13 days."1.26Effect of rifampin, clofazimine, and B1912 on the viability of Mycobacterium leprae in established mouse footpad infection. ( Banerjee, DK; Hilson, GR; Holmes, IB, 1976)
" The common side effect in all cases consisted of red and dark skin pigmentation of varying intensity occuring within 10 weeks of the commencement of therapy."1.26Side effects of clofazimine therapy. ( Iyer, GG; Ramu, G, 1976)

Research

Studies (321)

TimeframeStudies, this research(%)All Research%
pre-1990179 (55.76)18.7374
1990's55 (17.13)18.2507
2000's47 (14.64)29.6817
2010's28 (8.72)24.3611
2020's12 (3.74)2.80

Authors

AuthorsStudies
Bera, S1
Mondal, D1
Chakraborty, A1
Ghosh, R1
Biswas, A1
Chavhan, SD1
Jawade, S1
Yang, J2
Kong, J1
Li, B1
Ji, Z1
Liu, A1
Chen, J1
Liu, M1
Fan, Y1
Peng, L1
Song, J1
Wu, X1
Gao, L1
Ma, W1
Dong, Y1
Luo, S1
Bao, F2
Taneja, R1
Nahata, MC1
Scarim, J1
Pande, PG1
Scarim, A1
Hoddinott, G1
Fourie, CL1
Jew, RK1
Schaaf, HS1
Hesseling, AC1
Garcia-Prats, AJ1
George, J2
Riccardi, N1
Giacomelli, A1
Canetti, D1
Comelli, A1
Intini, E1
Gaiera, G1
Diaw, MM1
Udwadia, Z1
Besozzi, G1
Codecasa, L1
Biagio, AD1
Bartos, G1
Sheuring, R1
Combs, A1
Rivlin, D1
Lee, JH1
An, HK1
Sohn, MG1
Kivela, P1
Oh, S1
Krismawati, H2
Irwanto, A2
Pongtiku, A1
Irwan, ID1
Maladan, Y1
Sitanggang, YA1
Wahyuni, T1
Tanjung, R1
Sun, Y2
Liu, H2
Zhang, F2
Oktavian, A1
Liu, J3
Lavania, M1
Darlong, J1
Singh, I1
Ahuja, M1
Turankar, RP1
Pathak, VK1
Kumar, A1
Nathan, R1
Sengupta, U2
Sharma, A1
Pai, VV4
Mhatre, M1
Cerqueira, SRPS1
Deps, PD2
Cunha, DV1
Bezerra, NVF1
Barroso, DH1
Pinheiro, ABS1
Pillegi, GS1
Repsold, TAR1
Kurizky, PS1
Collin, SM1
Gomes, CM1
Smith, CS1
Aerts, A1
Saunderson, P1
Kawuma, J1
Kita, E1
Virmond, M1
Bass, M1
Foster, K1
Studdiford, J1
Labuda, SM1
Schieffelin, JS1
Shaffer, JG1
Stryjewska, BM3
Kar, HK5
Gupta, L1
Sharma, PK1
Singh, DK1
Cruz, RCDS1
Bührer-Sékula, S1
Penna, GO1
Moraes, MEA1
Gonçalves, HS1
Stefani, MMA1
Penna, MLF1
Pontes, MAA1
Talhari, S2
Stock, I1
Williams, DL2
Araujo, S1
Scollard, D1
Wang, Z1
Wang, C2
Sun, L1
Zhang, H1
Yu, G1
Mi, Z1
Li, J3
Li, L1
Zhao, Q1
Yue, Z1
Zhao, W1
Yu, W1
Cao, J1
Xiong, F1
Wang, Y2
Chai, Z1
Cheng, X1
Zhang, Y1
Fu, F1
Lang, X1
Wang, X1
Fu, X1
You, J1
Pan, Q1
Chu, T1
Liu, D1
Chen, S1
Shen, J1
Yan, L2
Zhang, G1
Xiong, L1
Ke, W1
Li, M2
Ning, Y1
Xiong, J1
Xiong, M1
Yang, B1
Duan, Q1
Wang, H1
Li, W3
Kuang, Y1
Wang, L1
Cao, Q1
Xiao, P1
Xiao, B1
Zhang, L1
Lin, Z1
Shen, Y1
Wu, W1
Zheng, H1
Zhan, X1
Shang, X1
Xu, Y1
Liu, Q1
Bishnoi, A1
Chatterjee, D1
Narang, T1
Dogra, S1
Bhaumik, S1
Ker, KJ1
Pan, JY1
Lui, NL1
Tey, HL1
Schalcher, TR1
Borges, RS1
Coleman, MD1
Batista Júnior, J1
Salgado, CG1
Vieira, JL1
Romão, PR1
Oliveira, FR1
Monteiro, MC1
Marcos, LA1
Conerly, S1
Walker, S1
Roy, K1
Sil, A1
Das, NK1
Bandyopadhyay, D1
Reibel, F1
Cambau, E1
Aubry, A1
Bharucha, T1
Lockwood, D2
Medeiros, S1
Catorze, MG1
Vieira, MR1
Gabelle, A1
Vallat, JM1
Flageul, B3
Andre, P1
Camu, W1
Sapkota, BR1
Shrestha, K1
Pandey, B1
Walker, SL1
Mendonça, VA1
Costa, RD1
Lyon, S1
Penido, RA1
Borges, VO1
Bretas, TL1
Antunes, CM1
Teixeira, MM1
Teixeira, AL1
Silva, IM1
Oliveira, CA1
Guedes, WR1
Oliveira, BB1
Oliveira, DA1
Guedes Filho, G1
Sheetal, S1
Arvind, C1
Levis, WR2
Spencer, TI1
Ladizinski, B1
Chauhan, S1
Wakhlu, A1
Agarwal, V1
Velayati, AA1
Farnia, P1
Khalizadeh, S1
Farahbod, AM1
Hasanzadh, M1
Sheikolslam, MF1
Singh, H1
Nel, B1
Dey, V1
Tiwari, P1
Dulhani, N1
Sekar, B2
Arunagiri, K2
Kumar, BN1
Narayanan, S1
Menaka, K1
Oommen, PK1
Dacso, MM1
Jacobson, RR3
Scollard, DM1
Prestigiacomo, JF1
Cholo, MC1
Steel, HC1
Fourie, PB1
Germishuizen, WA1
Anderson, R4
Lockwood, DN2
Cunha, Mda G1
Deps, P1
Guerra, P2
Nasser, S2
Simon, M2
Costa Queiroz, RH1
de Souza, AM2
Sampaio, SV1
Melchior, E3
Elangeswaran, N1
Jayarama, E1
Rajendran, M1
Kumar, SS1
Vijayaraghavan, R1
Anandan, D1
Pattyn, S2
Grillone, S4
Murray, CK1
Joyce, MP1
Longfield, RN1
Shaw, IN2
Christian, M2
Jesudasan, K2
Kurian, N1
Rao, GS2
BROWNE, SG10
HOGENZEIL, LM2
HOGERZEIL, LM3
BARRY, VC1
CONALTY, ML1
Queiroz, RH3
Pereira, RC1
Gotardo, MA1
Cordeiro, DS1
Villahermosa, LG1
Fajardo, TT1
Abalos, RM1
Cellona, RV1
Balagon, MV1
Dela Cruz, EC1
Tan, EV1
Walsh, GP2
Walsh, DS1
Aranda, J1
Hoang, MP1
Cohen, JB1
Gandhi, G1
Singh, B1
Sunderkötter, CH1
Lan Ma, H1
Ganapati, R6
Biswas, SK1
Alves-Rodrigues, EN2
Ribeiro, LC2
Silva, MD2
Takiuchi, A2
Fontes, CJ2
Helling, CA1
Locursio, A1
Manzur, ME1
Sormani de Fonseca, ML1
Rabel-Filho, OC1
Martini-Filho, D1
Roca, B1
Ho, CK1
Lo, KK1
Goto, M2
Nogami, R1
Hatano, K1
Okano, Y1
Ishii, N1
Gidoh, M2
Ishida, Y1
Ozaki, M4
Yamazaki, T1
Matsuoka, M2
Firooz, A1
Burns, J1
Manglani, PR1
Arif, MA1
Lewallen, S1
Courtright, P1
Bennett, Sl1
Ishikawa, M1
Birshner, Rde C1
Rodrigues, LC1
Concha R, M1
Cossio T, ML1
Salazar S, I1
Fich S, F1
Pérez C, C1
González B, S1
Kroger, A1
Pannikar, V1
Htoon, MT1
Jamesh, A1
Katoch, K3
Krishnamurthy, P1
Ramalingam, K1
Jianping, S1
Jadhav, V1
Gupte, MD1
Manickam, P1
Abide, JM1
Webb, RM1
Jones, HL1
Young, L1
Niwa, Y2
Sakane, T1
Miyachi, Y1
Ramu, G13
Desikan, KV5
Kundu, SK2
Ghosh, S2
Hazra, S1
Chaudhury, S1
Seshadri, PS2
Ravi, NT1
Hooper, M1
Purohit, MG1
Jopling, WH4
McDougall, AC4
Jones, RL1
Levy, L3
Sansarricq, H1
Burte, NP3
Chandorkar, AG3
Muley, MP2
Balsara, JJ2
Bulakh, PM3
Waters, MF4
Prabhakar, MC1
Appa Rao, AV1
Krishna, DR1
Ramanakar, TV1
Moschella, SL1
Pattyn, SR11
Janssens, L5
Bourland, J3
Saylan, T2
Davies, EM1
Feracci, C1
Keeler, RF1
Lucht, F1
Rifle, G1
Portier, H1
Chalopin, JM1
Bonhomme, J1
Nêgrel, AD1
Chovet, M1
Baquillon, G1
Lagadec, R1
Riley, DN1
Le, KZ1
Nguen, TD1
Smirnov, VS1
Nguen, N1
Nguen, KA1
Revankar, CR2
Naik, SS1
Mathur, NK2
Bumb, RA1
Mangal, HN1
Kowale, CN1
Ranade, SM1
Valdes-Portela, A1
Vazquez, AM1
Finlay, CM1
Moore, VJ1
Duncan, ME1
Oakey, RE1
Winsley, BE1
Brown, KE1
Warndorff-van Diepen, T1
Beeching, NJ1
Ellis, CJ1
Brazin, SA1
Rees, RJ1
Lang, WR1
Cunha, MG1
Barros, ML1
Gadelha, AD1
Binford, CH1
Meyers, WM1
van Rensburg, CE1
Gatner, EM2
Imkamp, FM4
Farb, H1
West, DP2
Pedvis-Leftick, A1
Caver, CV1
Peters, JH1
Hamme, KJ1
Gordon, GR1
Guha, PK1
Ghosh, M1
Bharadwaj, VP3
Sritharan, V1
Venkatesan, K3
Girdhar, A2
Kumar, B1
Bahadur, B1
Broor, SL1
Kaur, S3
Gangwar, DN1
Malik, AK1
Harman, DJ1
Waudby, H1
Paul, S1
Rose, ET1
Pannikar, VK1
Arunthathi, S2
Dubey, GK1
Joglekar, VK1
Hardas, UD1
Chaubey, BS1
Razack, EM1
Zahra, A1
Lal, S1
Garg, BR1
Hameedulla, A1
Leiker, DL6
Dutta, RK2
Ross, WF1
Vasireddi, SS1
Chowdappa, J1
Choudhury, HS1
Vu, TT1
Hoang, TL1
Nguyen, DQ1
Ho, ML1
Nguyen, DH1
Le, TH1
Dang, DT1
Nguyen, QA1
Le, TP1
Tran, HK1
Jackson, T1
Mendis, S1
Somasiri, KG1
Chularatna, W1
Saito, H2
Tomioka, H2
Sato, K2
Dekio, S1
Ghys, P3
Tshilumba, K1
Kuykens, L2
Karibushi, N1
Denis, P1
Van Landingham, RM1
Walker, LL1
O'Sullivan, JF2
Shinnick, TM1
Sharma, AK1
Misra, RS3
Beena, KR1
Zaheer, SA1
Mukherjee, R3
Mukherjee, A3
Parida, SK1
Walia, R1
Nair, NS1
Piscitelli, SC1
Occhipinti, DJ1
Danziger, LH1
Hill, C2
Fischer, JH1
Chong, PY1
Ti, TK1
Li, HY2
Lim, JT1
Tan, T1
Sticht-Groh, V1
Bretzel, G1
Kohli, MM1
Ganguly, NK2
Sharma, VK3
O'Connor, R1
O'Kennedy, R2
Bhargava, P1
Kuldeep, CM1
Naafs, B2
Souza, AM1
Gouveia, EG1
Carvalho, D1
Melchior Júnior, E1
Gouveia, E1
Barbosa, JC1
de Carvalho, D1
Maw, WW1
Ji, B1
Miyagi, S1
Takizawa, H1
Kitajima, S1
Moubasher, AD1
Kamel, NA1
Zedan, H1
Raheem, DD1
Barral-Netto, M1
Santos, S1
Santos, I1
von Sohsten, R1
Bittencourt, AL1
Carvalho, EM1
Barral, A1
Waters, M1
MacLean, S1
Stietenroth, K1
Prange, H1
Vides, EA1
Cabrera, A1
Ahern, KP1
Mysore, V1
al-Suwaid, AR1
Sharma, P2
Kaur, H2
Rani, R2
Ebenezer, GJ1
Job, A1
Abraham, S1
Rao, PS1
Job, CK2
Bulchand, HO1
Sukpanichnant, S1
Hargrove, NS1
Kachintorn, U1
Manatsathit, S1
Chanchairujira, T1
Siritanaratkul, N1
Akaraviputh, T1
Thakerngpol, K1
Winter, CA1
Hsu, S1
Singh, HB1
Natrajan, M1
Sharma, RK1
Gupta, UD1
Sharma, VD1
Singh, D1
Chauhan, DS1
Srivastava, K1
Katoch, VM1
Roche, PW2
Neupane, KD2
Failbus, SS2
Butlin, CR1
Sen, P1
Ranjan, R1
Middleton, JR1
Natrajan, MM1
Kavitha, M1
Kashiwabara, Y1
Namisato, M1
Marlowe, SN1
Ramos-e-Silva, M1
Rebello, PF1
Alto, WA1
Ohman, L1
Wahlberg, I1
Hentschel, B1
Jolliffe, DS1
Faber, WR1
Yawalkar, SJ1
Vischer, W1
Bryceson, A1
Ellis, BP1
Holmes, IB1
Banerjee, DK3
Hilson, GR1
Taylor, PM1
Alexander, R1
Mason, GH1
Ellis-Pegler, RB1
Arthur, JF1
Balakrishnan, S4
Barrett, DF1
Trautman, JR2
Mahapatra, SB1
Irani, SJ1
Iyer, CG2
Hazra, SK1
Choudhury, S1
Dongre, VV1
Theophilus, S1
Iyer, GG1
Karat, AB2
Prabhudas, N1
Ramanujam, K2
Rollier, MT1
Rollier, R1
Saerens, EJ1
Dockx, P1
Gatti, JC1
Languillon, J1
Azulay, RD1
da Silva, NC1
Zeo, A1
de Jesus, M1
Franca, CB1
Beiguelman, B1
Ahrens, TF1
Pettit, JH1
Ridley, DS1
Glaus, L1
Steenbergen, GJ1
Pfaltzgraff, RE3
Plock, H1
Reeve, PA1
Ala, J1
Hall, JJ1
Cartel, JL1
Spiegel, A1
Nguyen Ngoc, L1
Moulia-Pelat, JP1
Martin, PM1
Grosset, JH2
Freerksen, E2
Seydel, JK1
Becx-Bleumink, M2
Gillis, TP1
Fiallo, P1
Gelber, RH2
Izumi, S1
Groenen, G4
Mputu, LB1
Oommen, T2
Natu, MV1
Wilfred, D1
Britton, WJ1
Cho, SN1
Theuvenet, WJ1
Blok, LM1
Bloos, LJ1
van den Berg, G1
Patki, AH2
Gilbody, JS1
Garrelts, JC1
Stone, OJ1
Vignon-Pennamen, MD1
Wallach, D2
Pennec, J1
Cottenot, F2
Ellard, GA4
Aoyagi, T1
Toyoda, T1
Ye, G1
Yang, Z1
Tao, M1
Luo, J1
Ji, F1
O'Sullivan, S1
Corcoran, M1
Byrne, M1
McGrath, S1
Ramanathan, U1
Jadhav, VH1
Mehta, JM1
Deverchin, J1
Chatterjee, G1
Vaishnavi, C1
Holdiness, MR1
Chopra, NK1
Agarwal, JS1
Pandya, PG1
Chattopadhyay, SP1
Gupta, CM1
Bhate, RD1
Bhate, RP1
Baohang, J1
Noordeen, SK1
Chatterjee, BR2
Yu, XL1
Zhang, MS1
Duan, CX1
Huang, WB1
Zhang, SB1
Zhu, K1
Ma, JF1
Pavithran, K1
Garraud, O1
Ribierre, O1
Bach, MA2
Li, WZ1
Sehgal, VN1
Sharma, V1
Rao, CK1
Mittal, BN1
Dharmshaktu, NS1
Tiwari, VD1
Tutakne, MA1
Singh, G1
Bourée, P1
Carré, N1
Drahmane, S1
Ramakrishnan, KR1
Arora, PN1
Aggarwal, SK1
Ramachandra, S1
Baohong, J1
Matsuo, Y1
Colston, MJ1
Pieters, FA1
Woonink, F1
Zuidema, J1
Ye, GY1
Bhatia, VN2
Floch, HA1
Hoffenbach, A1
Harikrishnan, S1
Davy, C1
Riveau, E1
Bousquet, JC1
Curet, P1
Vayre, P1
Cortez, A1
Grellet, J1
Bahmer, FA1
Menzel, S1
Onsun, N1
Martinez Cruz, D1
Mehta, J1
Gandhi, IS1
Sane, SB1
Wamburkar, MN1
Andrade, VL1
Marques, AB1
da Cunha, LH1
Avelleira, JR1
Kayembe, T1
Nollet, E1
Coussens, L1
Rathi, SS1
Chaturvedi, VN1
Raizada, RM1
Jain, SK1
van Asbeck-Raat, AM1
Hassan, M1
Chaumet, S1
Brauner, M1
Labadie, H1
Mathur, A1
Girdhar, BK1
Ffytche, TJ1
Ji, BH1
Parikh, DA1
Maniar, JK1
Parikh, AC1
Rook, GA1
Samuel, NM1
Samual, S1
Fairbairn, T1
Adiga, RB1
Gammon, PT1
Mansfield, RE1
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Kiszkiss, DF1
Choi, YS1
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Rosenfeld, M1
Shepard, CC1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy and Safety Study of Immunomodulator (Mycobacterium w) as an Adjunct Therapy in Category-II Pulmonary Tuberculosis Along With Assessment of Immunological Parameters[NCT00265226]Phase 31,020 participants (Actual)Interventional2005-03-31Completed
Efficacy and Safety of Immunomodulator (Mycobacterium w.) as an Adjunct Therapy in Category I Pulmonary Tuberculosis and Along With Assessment of Immunological Parameters[NCT00341328]Phase 3300 participants (Actual)Interventional2007-03-31Completed
Independent Study to Establish the Efficacy of the Six Doses Uniform MDT Regimen (U-MDT) for Leprosy Patients[NCT00669643]Phase 4859 participants (Actual)Interventional2007-02-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

38 reviews available for clofazimine and Leprosy

ArticleYear
Insights of synthetic analogues of anti-leprosy agents.
    Bioorganic & medicinal chemistry, 2019, 07-01, Volume: 27, Issue:13

    Topics: Humans; Leprostatic Agents; Leprosy; Structure-Activity Relationship

2019
Seventy years of evidence on the efficacy and safety of drugs for treating leprosy: a network meta-analysis.
    The Journal of infection, 2023, Volume: 86, Issue:4

    Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Humans; Leprostatic Agents; Leprosy; Leprosy, Multi

2023
Metabolism and interactions of antileprosy drugs.
    Biochemical pharmacology, 2020, Volume: 177

    Topics: Acedapsone; Biological Availability; Biotransformation; Clofazimine; Cytochrome P-450 CYP3A; Dapsone

2020
Clofazimine: an old drug for never-ending diseases.
    Future microbiology, 2020, Volume: 15

    Topics: Animals; Anti-Bacterial Agents; Clofazimine; Drug Resistance, Bacterial; Humans; Leprosy; Mycobacter

2020
Treatment of histoid leprosy: a lack of consensus.
    International journal of dermatology, 2020, Volume: 59, Issue:10

    Topics: Clofazimine; Consensus; Dapsone; Drug Therapy, Combination; Humans; Leprostatic Agents; Leprosy

2020
Multidrug therapy for leprosy: a game changer on the path to elimination.
    The Lancet. Infectious diseases, 2017, Volume: 17, Issue:9

    Topics: Clofazimine; Dapsone; Disease Eradication; Drug Therapy, Combination; Humans; Leprostatic Agents; Le

2017
Leprosy – an old infectious disease with unsolved matters.
    Medizinische Monatsschrift fur Pharmazeuten, 2016, Volume: 39, Issue:12

    Topics: Animals; Armadillos; Clofazimine; Cross-Sectional Studies; Dapsone; Disease Reservoirs; Drug Therapy

2016
Update on the epidemiology, diagnosis, and treatment of leprosy.
    Medecine et maladies infectieuses, 2015, Volume: 45, Issue:9

    Topics: Antibodies, Bacterial; Bacteriological Techniques; Biopsy; Clofazimine; Dapsone; Drug Resistance, Ba

2015
Arthritis in leprosy.
    Rheumatology (Oxford, England), 2010, Volume: 49, Issue:12

    Topics: Arthritis; Clofazimine; Dapsone; Diagnosis, Differential; Humans; Leprostatic Agents; Leprosy; Mycob

2010
Clofazimine: current status and future prospects.
    The Journal of antimicrobial chemotherapy, 2012, Volume: 67, Issue:2

    Topics: Anti-Inflammatory Agents; Antitubercular Agents; Clofazimine; Drug Resistance, Multiple, Bacterial;

2012
Leprosy.
    Clinical evidence, 2002, Issue:8

    Topics: Bacterial Vaccines; BCG Vaccine; Clofazimine; Dapsone; Drug Therapy, Combination; Humans; Leprosy; M

2002
THE ANTIMYCOBACTERIAL ACTIVITY OF B 663.
    Leprosy review, 1965, Volume: 36

    Topics: Animals; Anti-Bacterial Agents; Antitubercular Agents; Clofazimine; Cricetinae; Drug Resistance; Dru

1965
A overview of ocular leprosy after 2 decades of multidrug therapy.
    International ophthalmology clinics, 2007,Summer, Volume: 47, Issue:3

    Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Eye Infections, Bacterial; Global Health; Humans; L

2007
[Hansen's disease: case report and review of literature].
    Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia, 2008, Volume: 25, Issue:1

    Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Humans; Leprostatic Agents; Leprosy; Male; Middle A

2008
The chemotherapy of leprosy.
    Progress in medicinal chemistry, 1983, Volume: 20

    Topics: Animals; Clofazimine; Drug Evaluation, Preclinical; Drug Therapy, Combination; Humans; Kinetics; Lep

1983
Evolution of the modern chemotherapy of leprosy.
    Leprosy review, 1983, Volume: Spec No

    Topics: Animals; Clofazimine; Dapsone; Drug Evaluation; Drug Evaluation, Preclinical; Drug Resistance, Micro

1983
Recent changes in leprosy control.
    Leprosy review, 1983, Volume: Spec No

    Topics: Bacterial Vaccines; Clofazimine; Dapsone; Drug Resistance, Microbial; Humans; Leprosy; Mycobacterium

1983
The immunopharmacology of antileprosy agents.
    Leprosy review, 1983, Volume: 54, Issue:2

    Topics: Antigens, Bacterial; Clofazimine; Dapsone; Erythema Nodosum; Humans; Immune Tolerance; Immunity, Cel

1983
Leprosy (Hansen's disease).
    Otolaryngologic clinics of North America, 1982, Volume: 15, Issue:3

    Topics: Clofazimine; Dapsone; Ear Deformities, Acquired; Humans; Leprosy; Mouth Diseases; Nose Deformities,

1982
[Leprosy--current aspects of a disease from biblical times].
    Immunitat und Infektion, 1995, Volume: 23, Issue:6

    Topics: Bible; Clofazimine; Glucocorticoids; History, Ancient; Humans; Immunotherapy; Leprostatic Agents; Le

1995
The pharmacology, metabolism, and chemistry of clofazimine.
    Drug metabolism reviews, 1995, Volume: 27, Issue:4

    Topics: Absorption; Animals; Biological Availability; Chromatography, High Pressure Liquid; Clofazimine; Hal

1995
Bangkok Workshop on Leprosy Research. Treatment of reactions and nerve damage.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1996, Volume: 64, Issue:4 Suppl

    Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Clofazimine; Cyclosporine; Drug A

1996
[Chemotherapy of Hansen's disease in Japan--present status].
    Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association, 1998, Volume: 67, Issue:2

    Topics: Anti-Infective Agents; Clofazimine; Drug Administration Schedule; Drug Therapy, Combination; Humans;

1998
Update on leprosy.
    Hospital medicine (London, England : 1998), 2001, Volume: 62, Issue:8

    Topics: Clofazimine; Dapsone; Diagnosis, Differential; Drug Therapy, Combination; Humans; Leprostatic Agents

2001
Leprosy.
    Indian journal of medical sciences, 2001, Volume: 55, Issue:5

    Topics: Clofazimine; Cost-Benefit Analysis; Dapsone; Drug Therapy, Combination; Global Health; Humans; Inter

2001
Leprosy. Recognition and treatment.
    American journal of clinical dermatology, 2001, Volume: 2, Issue:4

    Topics: Adolescent; Adult; Age Factors; Biopsy; Child; Clinical Trials as Topic; Clofazimine; Dapsone; Diagn

2001
Leprosy reactional states and their treatment.
    The British journal of dermatology, 1977, Volume: 97, Issue:3

    Topics: Antigen-Antibody Complex; Clofazimine; Dapsone; Humans; Immunity, Cellular; Leprosy; Prednisolone; T

1977
Lamprene (clofazimine) in leprosy. Basic information.
    Leprosy review, 1979, Volume: 50, Issue:2

    Topics: Chemical Phenomena; Chemistry; Clofazimine; Humans; Leprosy

1979
Chemotherapy in Leprosy.
    International journal of dermatology, 1975, Volume: 14, Issue:4

    Topics: Acetamides; Anemia, Hemolytic; Aniline Compounds; Animals; Clofazimine; Dapsone; Disease Models, Ani

1975
[Leprosy therapy and pharmacogenetics (author's transl)].
    Revista medica de Chile, 1975, Volume: 103, Issue:5

    Topics: Acetyltransferases; Clofazimine; Cytochrome-B(5) Reductase; Dapsone; Glucosephosphate Dehydrogenase;

1975
Critical comments on the treatment of leprosy and other mycobacterial infections with clofazimine.
    Arzneimittel-Forschung, 1992, Volume: 42, Issue:10

    Topics: Clofazimine; Humans; Leprosy; Mycobacterium Infections

1992
Relapses among leprosy patients treated with multidrug therapy: experience in the leprosy control program of the All Africa Leprosy and Rehabilitation Training Center (ALERT) in Ethiopia; practical difficulties with diagnosing relapses; operational proced
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1992, Volume: 60, Issue:3

    Topics: Clofazimine; Dapsone; Epidemiologic Methods; Ethiopia; Humans; Incidence; Leprostatic Agents; Lepros

1992
Clofazimine: a review of its use in leprosy and Mycobacterium avium complex infection.
    DICP : the annals of pharmacotherapy, 1991, Volume: 25, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Clofazimine; Drug Interactions; Gastrointestinal Diseases; Human

1991
Chemotherapy of leprosy.
    British medical bulletin, 1988, Volume: 44, Issue:3

    Topics: Clofazimine; Dapsone; Drug Administration Schedule; Drug Therapy, Combination; Humans; Leprosy; Rifa

1988
Screening of drugs for activity against Mycobacterium leprae.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1987, Volume: 55, Issue:4 Suppl

    Topics: Animals; Clofazimine; Dapsone; Drug Evaluation, Preclinical; Leprostatic Agents; Leprosy; Mice; Myco

1987
Drug resistance in leprosy--a review.
    Leprosy review, 1985, Volume: 56, Issue:4

    Topics: Animals; Clofazimine; Dapsone; Drug Resistance, Microbial; Ethionamide; Humans; Leprosy; Mice; Micro

1985
Growing points in leprosy research. 4. Recent advances in the chemotherapy of leprosy.
    Leprosy review, 1974, Volume: 45, Issue:1

    Topics: Clofazimine; Dapsone; Ethionamide; Humans; Leprosy; Rifampin; Sulfonamides; Thioacetazone; Thiourea

1974
The first decade in experimental leprosy.
    Bulletin of the World Health Organization, 1971, Volume: 44, Issue:6

    Topics: Animals; BCG Vaccine; Clofazimine; Dapsone; Disease Models, Animal; Drug Evaluation; Drug Evaluation

1971

Trials

41 trials available for clofazimine and Leprosy

ArticleYear
Comparative efficacy of four treatment regimens in Type 2 Leprosy Reactions (Prednisolone alone, Thalidomide alone, Prednisolone plus Thalidomide and Prednisolone plus Clofazimine).
    Indian journal of leprosy, 2016, Volume: 88, Issue:1

    Topics: Adult; Clofazimine; Drug Therapy, Combination; Female; Humans; Leprostatic Agents; Leprosy; Longitud

2016
Clinical trial for uniform multidrug therapy for leprosy patients in Brazil (U-MDT/CT-BR): adverse effects approach.
    Anais brasileiros de dermatologia, 2018, Volume: 93, Issue:3

    Topics: Adolescent; Adult; Anemia; Brazil; Child; Clofazimine; Dapsone; Drug Therapy, Combination; Female; H

2018
Effectiveness and safety of clofazimine and pentoxifylline in type 2 lepra reaction: a double-blind, randomized, controlled study.
    International journal of dermatology, 2015, Volume: 54, Issue:11

    Topics: Adult; Arthritis, Reactive; Clofazimine; Double-Blind Method; Female; Humans; Inflammation; Leprosta

2015
Plasma levels of chemokines during leprosy specific treatment.
    Acta tropica, 2010, Volume: 113, Issue:2

    Topics: Adult; Aged; Chemokine CCL11; Chemokine CCL24; Chemokines; Clofazimine; Dapsone; Drug Therapy, Combi

2010
Biochemical and hematological side effects of clofazimine in leprosy patients.
    Pharmacological research, 2002, Volume: 46, Issue:2

    Topics: Blood Cell Count; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Leprostatic Agent

2002
Parallel assessment of 24 monthly doses of rifampin, ofloxacin, and minocycline versus two years of World Health Organization multi-drug therapy for multi-bacillary leprosy.
    The American journal of tropical medicine and hygiene, 2004, Volume: 70, Issue:2

    Topics: Adolescent; Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Leprostatic Agen

2004
International open trial of uniform multi-drug therapy regimen for 6 months for all types of leprosy patients: rationale, design and preliminary results.
    Tropical medicine & international health : TM & IH, 2008, Volume: 13, Issue:5

    Topics: Adolescent; Adult; Aged; Child; China; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Huma

2008
Treatment of sulphone resistant leprosy--a review of sixty one cases.
    Leprosy in India, 1982, Volume: 54, Issue:4

    Topics: Adult; Clinical Trials as Topic; Clofazimine; Drug Resistance, Microbial; Female; Humans; Leprostati

1982
Clofazimine in lepra (ENL) reaction, one year clinical trial.
    Leprosy in India, 1983, Volume: 55, Issue:2

    Topics: Adult; Clinical Trials as Topic; Clofazimine; Erythema Nodosum; Female; Humans; Leprosy; Male; Middl

1983
THELEP controlled clinical trials in lepromatous leprosy.
    Leprosy review, 1983, Volume: 54, Issue:3

    Topics: Animals; Clinical Trials as Topic; Clofazimine; Dapsone; Female; Humans; Leprostatic Agents; Leprosy

1983
[Field experiences with therapy protocols in leprosy].
    Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie, 1983, Volume: 45, Issue:3

    Topics: Clinical Trials as Topic; Clofazimine; Dapsone; Drug Administration Schedule; Humans; Leprostatic Ag

1983
Hepatotoxicity of the combination of rifampin-ethionamide in the treatment of multibacillary leprosy.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1984, Volume: 52, Issue:1

    Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; Clinical Trials as Topic; Clofazim

1984
Multidrug therapy for leprosy in Trinidad and Tobago: a preliminary report.
    Leprosy review, 1984, Volume: 55, Issue:4

    Topics: Acedapsone; Adolescent; Adult; Aged; Child; Child, Preschool; Clinical Trials as Topic; Clofazimine;

1984
Effects of clofazimine alone or combined with dapsone on neutrophil and lymphocyte functions in normal individuals and patients with lepromatous leprosy.
    Antimicrobial agents and chemotherapy, 1982, Volume: 21, Issue:5

    Topics: Candida albicans; Cell Movement; Clofazimine; Dapsone; Drug Therapy, Combination; Humans; Leprosy; L

1982
Vitamin A levels of ichthyotic and non-ichthyotic skin and plasma of leprosy patients with and without clofazimine therapy.
    The Indian journal of medical research, 1982, Volume: 75

    Topics: Clofazimine; Humans; Ichthyosis; Leprosy; Skin; Vitamin A

1982
Long-term evaluation of immune status in leprosy patients undergoing multiple drug therapy.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1994, Volume: 62, Issue:3

    Topics: Agglutination Tests; Antibodies, Bacterial; Antigens, Bacterial; Clofazimine; Dapsone; Drug Therapy,

1994
A randomized clinical trial of two single-dose treatments for paucibacillary leprosy.
    Leprosy review, 1994, Volume: 65, Issue:1

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Clofazimine; Dapsone; Drug Administration Schedule

1994
Reversal reaction in multibacillary leprosy patients following MDT with and without immunotherapy with a candidate for an antileprosy vaccine, Mycobacterium w.
    Leprosy review, 1993, Volume: 64, Issue:3

    Topics: Bacterial Vaccines; Clofazimine; Combined Modality Therapy; Dapsone; Drug Therapy, Combination; Huma

1993
Influence of acetylator phenotype on the haematological and biochemical effects associated with dapsone in leprosy patients.
    Leprosy review, 1997, Volume: 68, Issue:3

    Topics: Blood Cell Count; Blood Chemical Analysis; Clofazimine; Dapsone; Drug Therapy, Combination; Female;

1997
Cytokines in leprosy, II. Effect of treatment on serum cytokines in leprosy.
    International journal of dermatology, 1998, Volume: 37, Issue:10

    Topics: Adrenal Cortex Hormones; Clofazimine; Cytokines; Drug Therapy, Combination; Female; Follow-Up Studie

1998
Immunochemotherapy with interferon-gamma and multidrug therapy for multibacillary leprosy.
    Acta tropica, 1999, Mar-15, Volume: 72, Issue:2

    Topics: Adolescent; Adult; Antibodies, Bacterial; Child; Clofazimine; Dapsone; Drug Therapy, Combination; Fe

1999
Effect of zafirlukast on leprosy reactions.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1999, Volume: 67, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Clofazimine; Cohort Studies; D

1999
Efficacy of WHO regimens in the management of leprosy patients with G6PD deficiency.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1999, Volume: 67, Issue:2

    Topics: Adolescent; Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Glucosephosphate Dehydro

1999
Induction of lepromin positivity following immuno-chemotherapy with Mycobacterium w vaccine and multidrug therapy and its impact on bacteriological clearance in multibacillary leprosy: report on a hospital-based clinical trial with the candidate antilepro
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1999, Volume: 67, Issue:3

    Topics: Bacterial Vaccines; Clofazimine; Dapsone; Double-Blind Method; Drug Therapy, Combination; Humans; Im

1999
Induction of lepromin positivity following immuno-chemotherapy with Mycobacterium w vaccine and multidrug therapy and its impact on bacteriological clearance in multibacillary leprosy: report on a hospital-based clinical trial with the candidate antilepro
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1999, Volume: 67, Issue:3

    Topics: Bacterial Vaccines; Clofazimine; Dapsone; Double-Blind Method; Drug Therapy, Combination; Humans; Im

1999
Induction of lepromin positivity following immuno-chemotherapy with Mycobacterium w vaccine and multidrug therapy and its impact on bacteriological clearance in multibacillary leprosy: report on a hospital-based clinical trial with the candidate antilepro
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1999, Volume: 67, Issue:3

    Topics: Bacterial Vaccines; Clofazimine; Dapsone; Double-Blind Method; Drug Therapy, Combination; Humans; Im

1999
Induction of lepromin positivity following immuno-chemotherapy with Mycobacterium w vaccine and multidrug therapy and its impact on bacteriological clearance in multibacillary leprosy: report on a hospital-based clinical trial with the candidate antilepro
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1999, Volume: 67, Issue:3

    Topics: Bacterial Vaccines; Clofazimine; Dapsone; Double-Blind Method; Drug Therapy, Combination; Humans; Im

1999
A 6 week quadruple drug regimen for the treatment of multibacillary leprosy.
    Leprosy review, 2000, Volume: 71, Issue:1

    Topics: Clofazimine; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Hum

2000
Long-term follow up of multibacillary leprosy patients with high BI treated with WHO/MDT regimen for a fixed duration of two years.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 2000, Volume: 68, Issue:4

    Topics: Adult; Clofazimine; Cohort Studies; Dapsone; Drug Therapy, Combination; Female; Follow-Up Studies; H

2000
A statistical analysis of two chemotherapy trials in lepromatous leprosy. I. The response to therapy as measured by inoculation of mice.
    The American journal of tropical medicine and hygiene, 1978, Volume: 27, Issue:5

    Topics: Adolescent; Adult; Aged; Animals; Clinical Trials as Topic; Clofazimine; Dapsone; Female; Humans; Le

1978
A statistical analysis of two chemotherapy trials in lepromatous leprosy. II. Interactions among patient variables.
    The American journal of tropical medicine and hygiene, 1978, Volume: 27, Issue:5

    Topics: Adolescent; Adult; Age Factors; Aged; Cell Count; Clinical Trials as Topic; Clofazimine; Dapsone; Fe

1978
Evaluation of treatment of lepromatous leprosy patients in the Netherlands.
    Dermatologica, 1979, Volume: 158, Issue:1

    Topics: Clinical Trials as Topic; Clofazimine; Dapsone; Drug Evaluation; Humans; Leprostatic Agents; Leprosy

1979
Spaced clofazimine therapy of lepromatous leprosy.
    The American journal of tropical medicine and hygiene, 1976, Volume: 25, Issue:3

    Topics: Adolescent; Adult; Aged; Biopsy; Clofazimine; Dapsone; Drug Evaluation; Female; Humans; Leprosy; Mal

1976
Long-term follow-up of clofazimine (Lamprene) in the management of reactive phases of leprosy.
    Leprosy review, 1975, Volume: 46, Issue:2 Suppl

    Topics: Clinical Trials as Topic; Clofazimine; Dapsone; Female; Follow-Up Studies; Humans; Leprosy; Pregnanc

1975
The effect of long-term steroid therapy on patients treated with clofazimine (Lamprene).
    Leprosy review, 1975, Volume: 46, Issue:2 Suppl

    Topics: Clinical Trials as Topic; Clofazimine; Drug Administration Schedule; Drug Therapy, Combination; Huma

1975
Open trial with clofazimine in the management of recurrent lepra reaction and of sulphone sensitive cases: a preliminary report.
    Leprosy review, 1975, Volume: 46, Issue:2 Suppl

    Topics: Adult; Clinical Trials as Topic; Clofazimine; Drug Hypersensitivity; Humans; Leprosy; Male; Sulfones

1975
A controlled clinical trial of continuous and intermittent rifampicin therapy during an initial three months period in lepromatous leprosy: final analysis.
    Leprosy review, 1975, Volume: 46, Issue:2 Suppl

    Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Clofazimine; Dapsone; Female; Humans; Leprosy; Ma

1975
Combined therapy in leprosy.
    Leprosy review, 1975, Volume: 46, Issue:2 Suppl

    Topics: Adult; Clinical Trials as Topic; Clofazimine; Dapsone; Drug Therapy, Combination; Humans; Leprostati

1975
Personal experience with clofazimine in the treatment of leprosy.
    Leprosy review, 1975, Volume: 46, Issue:2 Suppl

    Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Clofazimine; Female; Humans; Leprosy; Male; Middl

1975
Treatment of multibacillary leprosy with a regimen of 13 weeks duration.
    Leprosy review, 1992, Volume: 63, Issue:1

    Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Ethionamide; Humans; Leprostatic Agents; Leprosy; P

1992
Pyrazinamide as a part of combination therapy for BL and LL patients--a preliminary report.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1988, Volume: 56, Issue:1

    Topics: Adolescent; Adult; Animals; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Isoniaz

1988
Combined regimens of one year duration in the treatment of multibacillary leprosy--I. Combined regimens with rifampicin administered during one year.
    Leprosy review, 1989, Volume: 60, Issue:2

    Topics: Clinical Trials as Topic; Clofazimine; Cohort Studies; Dapsone; Drug Administration Schedule; Ethion

1989
Combined regimens of one year duration in the treatment of multibacillary leprosy--II. Combined regimens with rifampicin administered during 6 months.
    Leprosy review, 1989, Volume: 60, Issue:2

    Topics: Clinical Trials as Topic; Clofazimine; Cohort Studies; Dapsone; Drug Administration Schedule; Ethion

1989
Efficacy of different regimens in multibacillary leprosy.
    Leprosy review, 1986, Volume: 57 Suppl 3

    Topics: Clinical Trials as Topic; Clofazimine; Dapsone; Drug Administration Schedule; Drug Therapy, Combinat

1986

Other Studies

242 other studies available for clofazimine and Leprosy

ArticleYear
Interaction of constituents of MDT regimen for leprosy with Mycobacterium leprae HSP18: impact on its structure and function.
    The FEBS journal, 2022, Volume: 289, Issue:3

    Topics: Antigens, Bacterial; Bacterial Proteins; Clofazimine; Dapsone; Heat-Shock Proteins; Host-Pathogen In

2022
Clofazimine induced pigmentation in leprosy patches.
    The Pan African medical journal, 2022, Volume: 42

    Topics: Clofazimine; Humans; Leprosy; Pigmentation; Pigmentation Disorders

2022
Extemporaneously compounded liquid formulations of clofazimine.
    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2023, 02-01, Volume: 27, Issue:2

    Topics: Child; Clofazimine; Drug Compounding; Humans; Leprosy; Pharmaceutical Services; Tuberculosis

2023
4,4'-Diaminodiphenyl Sulfone (DDS) as an Inflammasome Competitor.
    International journal of molecular sciences, 2020, Aug-19, Volume: 21, Issue:17

    Topics: Alzheimer Disease; Clofazimine; Cognitive Dysfunction; Coronavirus Infections; COVID-19; Dapsone; Hu

2020
Validation study of HLA-B*13:01 as a biomarker of dapsone hypersensitivity syndrome in leprosy patients in Indonesia.
    PLoS neglected tropical diseases, 2020, Volume: 14, Issue:10

    Topics: Adolescent; Adult; Alleles; Biomarkers; Case-Control Studies; Clofazimine; Dapsone; Drug Hypersensit

2020
Analysis of bacteriological Index between fixed multidrug therapy and new WHO recommended alternative regimen with ofloxacin, minocycline and clofazimine of rifampicin resistant cases from the hospitals of The Leprosy Mission, India.
    Journal of global antimicrobial resistance, 2020, Volume: 23

    Topics: Clofazimine; Drug Therapy, Combination; Hospitals; Humans; India; Leprostatic Agents; Leprosy; Minoc

2020
Endemic leprosy, scarcity of clofazimine in pharmacies, and the ensuing therapeutic void.
    Dermatologic therapy, 2021, Volume: 34, Issue:1

    Topics: Clofazimine; Humans; Leprosy; Pharmacies

2021
The influence of leprosy-related clinical and epidemiological variables in the occurrence and severity of COVID-19: A prospective real-world cohort study.
    PLoS neglected tropical diseases, 2021, Volume: 15, Issue:7

    Topics: Adrenal Cortex Hormones; BCG Vaccine; Brazil; Clofazimine; Cohort Studies; COVID-19; COVID-19 Drug T

2021
Painless Nodular Rash in a Young Man.
    American family physician, 2017, Aug-01, Volume: 96, Issue:3

    Topics: Adult; Clofazimine; Dapsone; Diagnosis, Differential; Exanthema; Humans; Leprostatic Agents; Leprosy

2017
Hansen's Disease and Rheumatoid Arthritis Crossover of Clinical Symptoms: A Case Series of 18 Patients in the United States.
    The American journal of tropical medicine and hygiene, 2017, Volume: 97, Issue:6

    Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Clofazimine; Cross-Over Studies; Drug Therapy, Co

2017
A Traditional NSAID Aspirin along with Clofazimine in Erythema Nodosum Leprosum Reaction: Study of Six Cases.
    Indian journal of leprosy, 2016, Volume: 87, Issue:4

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clofazimine; Dapsone; Drug Therapy, Combina

2016
Dapsone Resistance in Leprosy Patients Originally from American Samoa, United States, 2010-2012.
    Emerging infectious diseases, 2018, Volume: 24, Issue:8

    Topics: American Samoa; Biopsy; Clofazimine; Dapsone; Drug Administration Schedule; Drug Resistance, Bacteri

2018
Evaluation of Prospective HLA-B*13:01 Screening to Prevent Dapsone Hypersensitivity Syndrome in Patients With Leprosy.
    JAMA dermatology, 2019, 06-01, Volume: 155, Issue:6

    Topics: Adult; Alleles; China; Clofazimine; Cohort Studies; Dapsone; Drug Hypersensitivity Syndrome; Drug Th

2019
Image Gallery: Clofazimine-induced hyperpigmentation of leprosy plaques.
    The British journal of dermatology, 2019, Volume: 181, Issue:4

    Topics: Clofazimine; Drug Therapy, Combination; Face; Humans; Hyperpigmentation; Leprosy; Male; Skin

2019
Clofazimine should be used in all cases of leprosy, says Indian research council.
    BMJ (Clinical research ed.), 2013, Mar-26, Volume: 346

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Clofazimine; Humans; India; Leprostatic Agents; Leprosy

2013
An under-recognized cause of polyarthritis: leprosy.
    Annals of the Academy of Medicine, Singapore, 2013, Volume: 42, Issue:7

    Topics: Anti-Inflammatory Agents; Arthritis; Arthritis, Rheumatoid; Clofazimine; Dapsone; Delayed Diagnosis;

2013
Clinical oxidative stress during leprosy multidrug therapy: impact of dapsone oxidation.
    PloS one, 2014, Volume: 9, Issue:1

    Topics: Adult; Analysis of Variance; Catalase; Clofazimine; Cytochrome P-450 CYP2C19; Dapsone; Drug Therapy,

2014
Leprosy.
    The American journal of tropical medicine and hygiene, 2014, Volume: 91, Issue:2

    Topics: Aged, 80 and over; Clofazimine; Dapsone; Humans; Leprostatic Agents; Leprosy; Male; Mycobacterium le

2014
Leprosy in the UK.
    British journal of hospital medicine (London, England : 2005), 2016, Volume: 77, Issue:10

    Topics: Clofazimine; Dapsone; Humans; Leprostatic Agents; Leprosy; Peripheral Nervous System Diseases; Rifam

2016
Hansen's disease in Portugal: multibacillary patients treated between 1988 and 2003.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2009, Volume: 23, Issue:1

    Topics: Aged; Anti-Bacterial Agents; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Lepros

2009
[Sensory-motor neuropathy: a slow and misleading case of leprosy].
    Revue neurologique, 2008, Volume: 164, Issue:11

    Topics: Adrenal Cortex Hormones; Aged; Aspirin; Clofazimine; Dapsone; Diagnosis, Differential; Female; Human

2008
A retrospective study of the effect of modified multi-drug therapy in Nepali leprosy patients following the development of adverse effects due to dapsone.
    Leprosy review, 2008, Volume: 79, Issue:4

    Topics: Adolescent; Adult; Aged; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Leprostati

2008
Agranulocytosis induced by multidrug therapy in leprosy treatment: a case report.
    The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases, 2009, Volume: 13, Issue:2

    Topics: Adult; Agranulocytosis; Anemia, Hemolytic; Clofazimine; Dapsone; Drug Therapy, Combination; Female;

2009
Lest we forget Hansen's disease (leprosy): an unusual presentation with an acute onset of inflammatory polyarthritis and the rheumatology experience.
    International journal of rheumatic diseases, 2009, Volume: 12, Issue:1

    Topics: Acute Disease; Aged; Arthritis; Clofazimine; Dapsone; Diagnosis, Differential; Drug Therapy, Combina

2009
Minocycline is effective and cosmetically preferred to clofazimine by leprosy patients in New York.
    Journal of drugs in dermatology : JDD, 2010, Volume: 9, Issue:8

    Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Humans; Hyperpigmentation; Leprostatic Agents; Lepr

2010
Interferon-gamma receptor-1 gene promoter polymorphisms and susceptibility to leprosy in children of a single family.
    The American journal of tropical medicine and hygiene, 2011, Volume: 84, Issue:4

    Topics: Child; Clofazimine; Family; Genetic Predisposition to Disease; Humans; Interferon gamma Receptor; Le

2011
Adverse effects of multi-drug therapy in leprosy, a two years' experience (2006-2008) in tertiary health care centre in the tribal region of Chhattisgarh State (Bastar, Jagdalpur).
    Leprosy review, 2011, Volume: 82, Issue:1

    Topics: Adolescent; Adult; Body Mass Index; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans;

2011
Detection of mutations in folp1, rpoB and gyrA genes of M. leprae by PCR- direct sequencing--a rapid tool for screening drug resistance in leprosy.
    Leprosy review, 2011, Volume: 82, Issue:1

    Topics: Animals; Bacterial Proteins; Biopsy; Clofazimine; Cross-Sectional Studies; Dapsone; Dihydropteroate

2011
Evaluation of multi-drug therapy for leprosy in the United States using daily rifampin.
    Southern medical journal, 2011, Volume: 104, Issue:10

    Topics: Administration, Cutaneous; Administration, Oral; Adult; Aged; Biopsy; Clofazimine; Dapsone; Drug Adm

2011
Developing new MDT regimens for MB patients; time to test ROM 12 month regimens globally.
    Leprosy review, 2012, Volume: 83, Issue:3

    Topics: Clofazimine; Dapsone; Drug Administration Schedule; Drug Therapy, Combination; Humans; Leprostatic A

2012
Hemolytic anemia in patients receiving daily dapsone for the treatment of leprosy.
    Leprosy review, 2012, Volume: 83, Issue:3

    Topics: Adolescent; Adult; Aged; Anemia, Hemolytic; Brazil; Clofazimine; Dapsone; Drug Therapy, Combination;

2012
Drug susceptibility of Mycobacterium leprae: a retrospective analysis of mouse footpad inoculation results from 1983 to 1997.
    Leprosy review, 2002, Volume: 73, Issue:3

    Topics: Adult; Animals; Clofazimine; Dapsone; Drug Resistance, Multiple, Bacterial; Female; Humans; India; L

2002
Relapse rates and a 10-year follow-up of a 6-week quadruple drug regimen for multibacillary leprosy.
    Leprosy review, 2002, Volume: 73, Issue:3

    Topics: Belgium; Clofazimine; Drug Administration Schedule; Drug Therapy, Combination; Follow-Up Studies; Hu

2002
Short report: Treatment failure in Hansen's disease.
    The American journal of tropical medicine and hygiene, 2003, Volume: 68, Issue:2

    Topics: Adolescent; Adult; Aged; Child; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Lep

2003
Effectiveness of multidrug therapy in multibacillary leprosy: a long-term follow-up of 34 multibacillary leprosy patients treated with multidrug regimens till skin smear negativity.
    Leprosy review, 2003, Volume: 74, Issue:2

    Topics: Acedapsone; Adult; Clofazimine; Dapsone; Drug Administration Schedule; Drug Therapy, Combination; Fe

2003
"B 663" in the treatment of leprosy. Supplementary report of the pilot trial.
    Leprosy review, 1962, Volume: 33

    Topics: Clofazimine; Heterocyclic Compounds; Leprosy

1962
Apparent resistance of M. leprae to "B 663".
    Leprosy review, 1962, Volume: 33

    Topics: Clofazimine; Heterocyclic Compounds; Leprosy; Mycobacterium leprae

1962
"B 663" in the treatment of leprosy. Preliminary report of a pilot trial.
    Leprosy review, 1962, Volume: 33

    Topics: Clofazimine; Heterocyclic Compounds; Leprosy

1962
TREATMENT OF LEPROSY WITH B 663 APPRAISAL OF THE PILOT TRIAL AFTER THREE YEARS.
    Leprosy review, 1965, Volume: 36

    Topics: Antitubercular Agents; Biomedical Research; Black People; Clofazimine; Drug Therapy; Humans; Leprosy

1965
RED AND BLACK PIGMENTATION DEVELOPING DURING TREATMENT OF LEPROSY WITH 'B 663'.
    Leprosy review, 1965, Volume: 36

    Topics: Antitubercular Agents; Black People; Clofazimine; Drug Therapy; Humans; Leprosy; Pathology; Phenazin

1965
'B 663' POSSIBLE ANTI-INFLAMMATORY ACTION IN LEPROMATOUS LEPROSY.
    Leprosy review, 1965, Volume: 36

    Topics: Anti-Inflammatory Agents; Antitubercular Agents; Clofazimine; Drug Resistance; Drug Resistance, Micr

1965
Determination of clofazimine in leprosy patients by high-performance liquid chromatography.
    Journal of analytical toxicology, 2003, Volume: 27, Issue:6

    Topics: Chromatography, High Pressure Liquid; Clofazimine; Drug Monitoring; Female; Humans; Leprostatic Agen

2003
Shiny red-brown papules in a 21-year-old man. Histoid leprosy.
    Archives of dermatology, 2004, Volume: 140, Issue:6

    Topics: Adult; Clofazimine; Dapsone; Diagnosis, Differential; Drug Therapy, Combination; Face; Humans; Lepro

2004
DNA damage studies in untreated and treated leprosy patients.
    Mutagenesis, 2004, Volume: 19, Issue:6

    Topics: Adolescent; Adult; Aged; Clofazimine; Dapsone; DNA Damage; Female; Humans; Leprostatic Agents; Lepro

2004
[Clofazimine. Current status of therapy with clofazimine (Lampren) for leprosy, erythema leprosum , and other dermatoses after donation of the medicine to the WHO by Novartis].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2005, Volume: 56, Issue:5

    Topics: Charities; Clinical Trials as Topic; Clofazimine; Erythema Nodosum; Germany; Humans; Leprosy; Skin D

2005
Reactions and their management.
    Journal of the Indian Medical Association, 2004, Volume: 102, Issue:12

    Topics: Arthritis; Cicatrix; Clofazimine; Dose-Response Relationship, Drug; Drug-Related Side Effects and Ad

2004
Chemotherapy of leprosy.
    Journal of the Indian Medical Association, 2004, Volume: 102, Issue:12

    Topics: Anti-Bacterial Agents; Clofazimine; Dapsone; Dose-Response Relationship, Drug; Drug Combinations; Dr

2004
Dapsone syndrome with acute renal failure during leprosy treatment: case report.
    The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases, 2005, Volume: 9, Issue:1

    Topics: Acute Kidney Injury; Adult; Clofazimine; Dapsone; Drug Hypersensitivity; Drug Therapy, Combination;

2005
Remitting seronegative symmetrical synovitis with pitting edema in leprosy.
    Clinical rheumatology, 2006, Volume: 25, Issue:1

    Topics: Aged; Clofazimine; Dapsone; Drug Therapy, Combination; Edema; Foot; Humans; Leprostatic Agents; Lepr

2006
Renal hypersensitivity vasculitis associated with dapsone.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2005, Volume: 46, Issue:4

    Topics: Adult; Anti-Bacterial Agents; Antitubercular Agents; Clofazimine; Cyclophosphamide; Dapsone; Drug Hy

2005
[Dermopathy and peripheral neuropathy].
    Enfermedades infecciosas y microbiologia clinica, 2005, Volume: 23, Issue:10

    Topics: Aged; Clofazimine; Dapsone; Exanthema; Humans; Hypesthesia; Leprostatic Agents; Leprosy; Male; Rifam

2005
Epidemiology of leprosy and response to treatment in Hong Kong.
    Hong Kong medical journal = Xianggang yi xue za zhi, 2006, Volume: 12, Issue:3

    Topics: Clofazimine; Dapsone; Drug Resistance, Bacterial; Drug Therapy, Combination; Hong Kong; Humans; Inci

2006
[Guideline for the treatment of Hansen's disease in Japan (Second edition)].
    Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association, 2006, Volume: 75, Issue:3

    Topics: Clofazimine; Congenital Abnormalities; Dapsone; Drug Resistance, Microbial; Drug Therapy, Combinatio

2006
[Basic evaluation for new antimicrobial susceptibility testing of Mycobacterium leprae by bioluminescence assay (ATP method)].
    Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association, 2006, Volume: 75, Issue:3

    Topics: Animals; Clarithromycin; Clofazimine; Drug Resistance, Bacterial; Leprostatic Agents; Leprosy; Lucif

2006
Multidrug therapy regimen for leprosy.
    Journal of the American Academy of Dermatology, 2006, Volume: 55, Issue:6

    Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Humans; Leprostatic Agents; Leprosy; Practice Guide

2006
An unusual rash in an elderly man.
    JAAPA : official journal of the American Academy of Physician Assistants, 2007, Volume: 20, Issue:3

    Topics: Age Factors; Aged, 80 and over; Clofazimine; Dapsone; Diagnosis, Differential; Exanthema; Humans; Le

2007
Multidrug therapy in leprosy.
    Journal of the Indian Medical Association, 2006, Volume: 104, Issue:12

    Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Humans; Leprostatic Agents; Leprosy; Rifampin; Worl

2006
Photosensitisation induced by clofazimine in a cat.
    Australian veterinary journal, 2007, Volume: 85, Issue:9

    Topics: Animals; Cat Diseases; Cats; Clofazimine; Female; Leprostatic Agents; Leprosy; Photosensitivity Diso

2007
[Long-term follow-up of ofloxacin-combined therapy for leprosy patients].
    Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association, 2007, Volume: 76, Issue:3

    Topics: Aged; Anti-Bacterial Agents; Clofazimine; Cystamine; Drug Therapy, Combination; Follow-Up Studies; H

2007
Adverse effects from multi-drug therapy in leprosy: a Brazilian study.
    Leprosy review, 2007, Volume: 78, Issue:3

    Topics: Adult; Brazil; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Leprostatic Agents;

2007
Three indigenous cases of leprosy in the Mississippi delta.
    Southern medical journal, 2008, Volume: 101, Issue:6

    Topics: Aged; Aged, 80 and over; Animals; Armadillos; Biopsy; Clofazimine; Dapsone; Diagnosis, Differential;

2008
Oxygen metabolism in phagocytes of leprotic patients: enhanced endogenous superoxide dismutase activity and hydroxyl radical generation by clofazimine.
    Journal of clinical microbiology, 1984, Volume: 20, Issue:5

    Topics: Adult; Clofazimine; Edetic Acid; Female; Ferrous Compounds; Free Radicals; Humans; Hydroxides; Hydro

1984
Evaluation of multiple regimens in leprosy.
    Leprosy in India, 1981, Volume: 53, Issue:2

    Topics: Clofazimine; Dapsone; Drug Evaluation; Drug Therapy, Combination; Humans; Leprosy; Male; Rifampin; S

1981
Multiple drug therapy--a comparative study with 2 tier and 3 tier combination of rifampicin, clofazimine, DDS, INAH and thiacetazone in lepromatous cases.
    Leprosy in India, 1981, Volume: 53, Issue:2

    Topics: Adolescent; Adult; Child; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Isoniazid

1981
Evaluation of drug regimen in lepromatous leprosy--II.
    Leprosy in India, 1983, Volume: 55, Issue:2

    Topics: Adult; Animals; Clofazimine; Dapsone; Drug Administration Schedule; Drug Resistance, Microbial; Huma

1983
Side-effects of antileprosy drugs in common use.
    Leprosy review, 1983, Volume: 54, Issue:4

    Topics: Clofazimine; Dapsone; Drug Hypersensitivity; Ethionamide; Humans; Leprostatic Agents; Leprosy; Rifam

1983
Intra-neural ceroid-like pigment following the treatment of lepromatous leprosy with clofazimine (B663; Lamprene).
    Journal of neurology, neurosurgery, and psychiatry, 1981, Volume: 44, Issue:2

    Topics: Adult; Ceroid; Clofazimine; Dapsone; Drug Therapy, Combination; Histocytochemistry; Humans; Leprosy;

1981
The treatment of leprosy.
    Tubercle, 1983, Volume: 64, Issue:3

    Topics: Adult; Animals; Clofazimine; Dapsone; Drug Resistance, Microbial; Erythema Nodosum; Ethionamide; Hum

1983
How much non-infectious are the "non-infectious" lepromatous leprosy patients?
    Leprosy in India, 1983, Volume: 55, Issue:3

    Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Humans; Leprosy; Mycobacterium leprae; Nose; Rifamp

1983
Leprosy today.
    The Australasian journal of dermatology, 1983, Volume: 24, Issue:2

    Topics: Clofazimine; Dapsone; Disease Models, Animal; Drug Resistance, Microbial; Humans; Leprosy; Mycobacte

1983
Successful plasma exchange in type 1 leprosy reversal reaction.
    British medical journal (Clinical research ed.), 1984, Dec-15, Volume: 289, Issue:6459

    Topics: Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Humans; Leprosy; Leukocyte Count; Male; Plas

1984
Clofazimine and the eye: preliminary communication.
    Leprosy review, 1984, Volume: 55, Issue:4

    Topics: Adolescent; Adult; Clofazimine; Eye; Female; Humans; Leprosy; Male; Middle Aged; Pigmentation

1984
Treatment of leprosy in rural India as seen on a medical student elective.
    Leprosy review, 1984, Volume: 55, Issue:4

    Topics: Clofazimine; Dapsone; Developing Countries; Drug Therapy, Combination; Humans; India; Leprosy; Patie

1984
[Features of the clinical picture and treatment of leprosy in Vietnam].
    Vestnik dermatologii i venerologii, 1983, Issue:8

    Topics: Clofazimine; Female; Humans; Leprostatic Agents; Leprosy; Male; Rifampin; Vietnam

1983
[Effects of antileprotic agents (clofazimine) on the phagocytosis of leprotic patients and possible etiological explanation of Hansen's disease].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1983, Volume: 24, Issue:8

    Topics: Adult; Clofazimine; Female; Humans; Leprosy; Male; Middle Aged; Phagocytosis

1983
New approaches to chemotherapy for leprosy.
    Drugs, 1983, Volume: 26, Issue:6

    Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Humans; Leprostatic Agents; Leprosy; Rifampin

1983
Field application of combined therapy for infectious leprosy cases. A feasibility study in Bombay.
    Leprosy in India, 1983, Volume: 55, Issue:3

    Topics: Adolescent; Adult; Clofazimine; Dapsone; Drug Evaluation; Drug Therapy, Combination; Humans; India;

1983
Oral zinc in recurrent Erythema Nodosum Leprosum reaction.
    Leprosy in India, 1983, Volume: 55, Issue:3

    Topics: Administration, Oral; Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Erythema Nodosum; Fema

1983
The effect of clofazimine on liver function tests in lepra reaction (ENL).
    Leprosy in India, 1983, Volume: 55, Issue:4

    Topics: Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Blood Proteins;

1983
The effect of clofazimine on the plaque-forming cell response.
    Leprosy review, 1983, Volume: 54, Issue:4

    Topics: Animals; Antibody Formation; Clofazimine; Erythrocytes; Female; Immunity, Cellular; Leprosy; Mice; M

1983
A review of side-effects experienced by patients taking clofazimine.
    Leprosy review, 1983, Volume: 54, Issue:4

    Topics: Clofazimine; Digestive System; Eye Diseases; Humans; Leprosy; Pigmentation Disorders; Time Factors

1983
Reduced estrogen excretion due to clofazimine?
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1983, Volume: 51, Issue:1

    Topics: Clofazimine; Estrogens; Female; Humans; Leprosy; Pregnancy

1983
Chemotherapy of leprosy; "bubble" or "calendar" packs for the administration of rifampin, dapsone, clofazimine, or prothionamide/ethionamide.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1983, Volume: 51, Issue:4

    Topics: Clofazimine; Dapsone; Drug Packaging; Ethionamide; Humans; Leprostatic Agents; Leprosy; Prothionamid

1983
Effect of one year clofazimine therapy on autonomic functions in lepromatous leprosy with lepra (ENL) reaction.
    Leprosy in India, 1983, Volume: 55, Issue:2

    Topics: Autonomic Nervous System; Blood Pressure; Clofazimine; Erythema Nodosum; Histamine; Humans; Leprosy;

1983
Clofazimine-resistant leprosy, a case report.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1982, Volume: 50, Issue:2

    Topics: Animals; Clofazimine; Drug Resistance, Microbial; Humans; Leprosy; Male; Mice; Microbial Sensitivity

1982
Leprosy and its chemotherapy.
    The Journal of antimicrobial chemotherapy, 1982, Volume: 10, Issue:2

    Topics: Clofazimine; Dapsone; Drug Resistance, Microbial; Humans; Leprosy; Mycobacterium leprae; Rifampin

1982
Chemotherapy of leprosy for control programmes: scientific basis and practical application.
    Leprosy review, 1983, Volume: 54, Issue:2

    Topics: Clofazimine; Costs and Cost Analysis; Dapsone; Drug Resistance, Microbial; Humans; Leprostatic Agent

1983
Leprosy in Auckland.
    The New Zealand medical journal, 1980, Oct-08, Volume: 92, Issue:669

    Topics: Adult; Clofazimine; Dapsone; Female; Fiji; Humans; Independent State of Samoa; Leprosy; Male; New Ze

1980
[Jorge Lobo disease. Study of 22 new cases].
    Medicina cutanea ibero-latino-americana, 1981, Volume: 9, Issue:2

    Topics: Adult; Aged; Brazil; Clofazimine; Dermatomycoses; Electrocoagulation; Female; Humans; Leishmaniasis;

1981
Leprosy.
    JAMA, 1982, Apr-23, Volume: 247, Issue:16

    Topics: Animals; Armadillos; Cercopithecidae; Clofazimine; Cricetinae; Disease Models, Animal; Female; Human

1982
Clofazimine in pregnancy complicated by leprosy.
    Obstetrics and gynecology, 1982, Volume: 59, Issue:1

    Topics: Adult; Clofazimine; Female; Humans; Infant, Newborn; Leprosy; Pregnancy; Pregnancy Complications, In

1982
Clofazimine-induced ichthyosis and its treatment.
    Cutis, 1982, Volume: 29, Issue:4

    Topics: Clofazimine; Humans; Ichthyosis; Leprosy

1982
Determination of clofazimine in plasma by high-performance liquid chromatography.
    Journal of chromatography, 1982, May-14, Volume: 229, Issue:2

    Topics: Chromatography, High Pressure Liquid; Clofazimine; Humans; Leprosy; Reference Values

1982
Progressive lepra reaction. A case report.
    Leprosy in India, 1982, Volume: 54, Issue:1

    Topics: Adrenal Cortex Hormones; Adult; Clofazimine; Humans; Leprosy; Male

1982
Possible incompatibility of dapsone with clofazimine in the treatment of patients with erythema nodosum leprosum.
    Leprosy review, 1982, Volume: 53, Issue:2

    Topics: Clofazimine; Dapsone; Erythema Nodosum; Female; Humans; Leprosy; Male

1982
Study of toxicity of clofazimine with special reference to structural and functional status of small intestine.
    Leprosy in India, 1982, Volume: 54, Issue:2

    Topics: Clofazimine; Digestive System; Eye; Humans; Intestinal Absorption; Jejunum; Leprosy; Skin Pigmentati

1982
Clofazimine (Lamprene, B663) in the treatment of lepromatous leprosy in the United Kingdom. A 12 year review of 31 cases, 1966-1978.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1981, Volume: 49, Issue:2

    Topics: Adolescent; Adult; Aged; Biopsy; Child; Clofazimine; Female; Humans; Leprosy; Male; Middle Aged; Ski

1981
Rifampin 1200 mg once monthly together with daily Lamprene and dapsone in treatment of refactory patients with lepromatous leprosy.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1981, Volume: 49, Issue:3

    Topics: Adolescent; Adult; Clofazimine; Dapsone; Drug Administration Schedule; Drug Therapy, Combination; Fe

1981
Drug interactions -- the influence of rifampicin and clofazimine on the urinary excretion of DDS.
    Leprosy in India, 1981, Volume: 53, Issue:1

    Topics: Clofazimine; Creatinine; Dapsone; Drug Interactions; Humans; Leprosy; Rifampin

1981
Leprosy in an albino.
    Leprosy in India, 1981, Volume: 53, Issue:1

    Topics: Adult; Albinism; Clofazimine; Humans; Leprosy; Male

1981
Clofazimine (lamprene or B663) in lepra reactions.
    Leprosy review, 1981, Volume: 52, Issue:2

    Topics: Adult; Clofazimine; Dapsone; Female; Humans; Leprosy; Prednisolone

1981
A study of cell mediated immunity in leprosy.
    Leprosy in India, 1981, Volume: 53, Issue:2

    Topics: Adolescent; Adult; Child; Clofazimine; Dapsone; Female; Humans; Immunity, Cellular; Leprostatic Agen

1981
Multi-drug treatment for reactions in leprosy.
    Leprosy in India, 1981, Volume: 53, Issue:2

    Topics: Adolescent; Adult; Child; Chloroquine; Clofazimine; Diethylcarbamazine; Drug Therapy, Combination; F

1981
Gastro-intestinal side effects of clofazimine.
    Leprosy in India, 1981, Volume: 53, Issue:2

    Topics: Adult; Clofazimine; Female; Gastrointestinal Diseases; Humans; Leprosy; Male

1981
[Chemotherapy of leprosy. II. Sulfones and sulfonamides].
    Nederlands tijdschrift voor geneeskunde, 1980, Jan-12, Volume: 124, Issue:2

    Topics: Clofazimine; Drug Resistance, Microbial; Ethionamide; Humans; Leprostatic Agents; Leprosy; Prothiona

1980
Study on drug interactions.
    Leprosy in India, 1980, Volume: 52, Issue:2

    Topics: Adult; Clofazimine; Dapsone; Drug Interactions; Drug Therapy, Combination; Humans; Isoniazid; Lepros

1980
Clofazimine and dapsone--a combination therapy in erythema nodosum leprosum syndrome.
    Leprosy in India, 1980, Volume: 52, Issue:2

    Topics: Adolescent; Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Erythema Nodosum; Female; Humans

1980
Does clofazimine have any value in the management of reversal reaction?
    Leprosy review, 1980, Volume: 51, Issue:1

    Topics: Clofazimine; Humans; Leprosy

1980
Leprosy.
    Lancet (London, England), 1995, May-06, Volume: 345, Issue:8958

    Topics: Clofazimine; Dapsone; Drug Administration Schedule; Drug Resistance, Microbial; Humans; Leprostatic

1995
Treating Hansen's disease in developing countries.
    The Western journal of medicine, 1994, Volume: 160, Issue:3

    Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Humans; Leprosy; Rifampin

1994
Effect of drug treatment on electroneurological measures of peripheral nerve function in leprosy patients.
    The Ceylon medical journal, 1993, Volume: 38, Issue:4

    Topics: Adolescent; Adult; Aged; Child; Clofazimine; Dapsone; Drug Therapy, Combination; Electrophysiology;

1993
Therapeutic efficacy of benzoxazinorifamycin, KRM-1648, in combination with other antimicrobials against Mycobacterium leprae infection induced in nude mice.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1994, Volume: 62, Issue:1

    Topics: Animals; Clofazimine; Dapsone; Drug Therapy, Combination; Leprostatic Agents; Leprosy; Mice; Mice, I

1994
Activity of phenazine analogs against Mycobacterium leprae infections in mice.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1993, Volume: 61, Issue:3

    Topics: Abdomen; Adipose Tissue; Animals; Clofazimine; Disease Models, Animal; Drug Evaluation, Preclinical;

1993
Therapeutic monitoring and pharmacist intervention in a Hansen's disease clinic.
    The Annals of pharmacotherapy, 1993, Volume: 27, Issue:12

    Topics: Academic Medical Centers; Chicago; Clofazimine; Dapsone; Drug Monitoring; Humans; Leprosy; Patient C

1993
Severe abdominal pain in low dosage clofazimine.
    Pathology, 1993, Volume: 25, Issue:1

    Topics: Abdominal Pain; Adult; Clofazimine; Humans; Leprosy; Lymph Nodes; Male

1993
Problems of leprosy relapse in China.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1993, Volume: 61, Issue:1

    Topics: China; Clofazimine; Dapsone; Drug Therapy, Combination; Follow-Up Studies; Humans; Leprosy; Recurren

1993
Efficacy and safety of multidrug therapy in paucibacillary leprosy in Singapore.
    Leprosy review, 1993, Volume: 64, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Lep

1993
Urinary excretion of renal brush border membrane enzymes in leprosy patients--effect of multidrug therapy.
    Experientia, 1996, Feb-15, Volume: 52, Issue:2

    Topics: Alkaline Phosphatase; Biomarkers; Clofazimine; Dapsone; Drug Monitoring; Drug Therapy, Combination;

1996
Antileprosy drugs, pregnancy and fetal outcome.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1996, Volume: 64, Issue:4

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Animals; Clofazimine; Dapsone; Drug Therapy, Combina

1996
Haematological and biochemical alterations in leprosy patients already treated with dapsone and MDT.
    Pharmaceutica acta Helvetiae, 1997, Volume: 72, Issue:4

    Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Leprostatic Agents; Leprosy; Male;

1997
Studies on therapeutic activity of benzoxazinorifamycin KRM-1648 in combination with other antimicrobial agents and biological response modifiers interferon-gamma and granulocyte-macrophage colony-stimulating factor against M. leprae infection in athymic
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1997, Volume: 65, Issue:3

    Topics: Adoptive Transfer; Animals; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Granulocyte-Mac

1997
[New WHO recommendations for the treatment of leprosy].
    Acta leprologica, 1997, Volume: 10, Issue:4

    Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Humans; Leprostatic Agents; Leprosy; Minocycline; M

1997
Leprosy.
    Indian journal of medical sciences, 1997, Volume: 51, Issue:12

    Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Humans; Leprostatic Agents; Leprosy; Rifampin

1997
Why multidrug therapy for multibacillary leprosy can be shortened to 12 months.
    Leprosy review, 1998, Volume: 69, Issue:2

    Topics: Clofazimine; Dapsone; Drug Administration Schedule; Drug Resistance, Microbial; Drug Therapy, Combin

1998
Serum markers of treatment success in leprosy.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1999, Volume: 67, Issue:1

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Biomarkers; Child; Clofazimine; Dapsone; Dr

1999
Disabilities in multibacillary leprosy following multidrug therapy with and without immunotherapy with Mycobacterium w antileprosy vaccine.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1999, Volume: 67, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Bacterial Vaccines; Clofazimine; Disabled Persons; Double-B

1999
Disabilities in multibacillary leprosy following multidrug therapy with and without immunotherapy with Mycobacterium w antileprosy vaccine.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1999, Volume: 67, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Bacterial Vaccines; Clofazimine; Disabled Persons; Double-B

1999
Disabilities in multibacillary leprosy following multidrug therapy with and without immunotherapy with Mycobacterium w antileprosy vaccine.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1999, Volume: 67, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Bacterial Vaccines; Clofazimine; Disabled Persons; Double-B

1999
Disabilities in multibacillary leprosy following multidrug therapy with and without immunotherapy with Mycobacterium w antileprosy vaccine.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1999, Volume: 67, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Bacterial Vaccines; Clofazimine; Disabled Persons; Double-B

1999
Nasal mucosa and skin of smear-positive leprosy patients after 24 months of fixed duration MDT: histopathological and microbiological study.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1999, Volume: 67, Issue:3

    Topics: Adult; Animals; Biological Assay; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Histocyto

1999
Single-dose treatment for paucibacillary leprosy; clinical problems and management.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1999, Volume: 67, Issue:3

    Topics: Adolescent; Anti-Bacterial Agents; Anti-Infective Agents; Child; Clofazimine; Drug Therapy, Combinat

1999
Clofazimine-induced crystal-storing histiocytosis producing chronic abdominal pain in a leprosy patient.
    The American journal of surgical pathology, 2000, Volume: 24, Issue:1

    Topics: Abdominal Pain; Adult; Biopsy; Chronic Disease; Clofazimine; Crystallization; Cytoplasm; Diagnosis,

2000
Ominous sign of a disfiguring disease. Leprosy (Hansen's disease).
    Postgraduate medicine, 2000, May-01, Volume: 107, Issue:5

    Topics: Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Humans; Leprostatic Agents; Leprosy; Leprosy

2000
Clofazimine: new products. Major antileprous drug.
    Prescrire international, 1999, Volume: 8, Issue:40

    Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Humans; Leprostatic Agents; Leprosy; Rifampin; Trea

1999
Viewpoint: leprosy after the year 2000.
    Tropical medicine & international health : TM & IH, 2000, Volume: 5, Issue:6

    Topics: Clofazimine; Drug Therapy, Combination; Global Health; Humans; Hypersensitivity, Delayed; Leprostati

2000
Effect of treatment on PCR positivity in multibacillary leprosy patients treated with conventional and newer drugs ofloxacin and minocycline.
    Acta leprologica, 1999, Volume: 11, Issue:4

    Topics: Adenosine Triphosphate; Biopsy; Clofazimine; Dapsone; DNA, Bacterial; Drug Evaluation; Drug Therapy,

1999
Dapsone drug resistance in the MDT era.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 2000, Volume: 68, Issue:3

    Topics: Clofazimine; Dapsone; Drug Resistance, Microbial; Drug Therapy, Combination; Humans; Leprostatic Age

2000
Hansen's disease in a native-born, United States resident, after a brief stay in an endemic area abroad.
    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2001, Volume: 5, Issue:1

    Topics: Aged; Cell Count; China; Clofazimine; Dapsone; Diabetes Mellitus, Type 1; Emigration and Immigration

2001
A Mycobacterium leprae isolate resistant to dapsone, rifampin, ofloxacin and sparfloxacin.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 2000, Volume: 68, Issue:4

    Topics: Animals; Anti-Infective Agents; Antitubercular Agents; Clarithromycin; Clofazimine; Colony Count, Mi

2000
Treatment of Hansen's disease.
    American family physician, 2002, Apr-01, Volume: 65, Issue:7

    Topics: Clofazimine; Dapsone; Dermatomycoses; Diagnosis, Differential; Drug Therapy, Combination; Humans; Le

2002
Letter: Ocular side-effects of clofazimine.
    Lancet (London, England), 1975, Nov-08, Volume: 2, Issue:7941

    Topics: Clofazimine; Cornea; Eye; Humans; Leprosy; Retina

1975
[Leprosy and the nervous system (author's transl)].
    Der Nervenarzt, 1979, Volume: 50, Issue:6

    Topics: Adult; Antibody Formation; Central Nervous System Diseases; Clofazimine; Dapsone; Diagnosis, Differe

1979
Management of sulphone-resistant lepromatous leprosy.
    Leprosy review, 1977, Volume: 48, Issue:2

    Topics: Clofazimine; Dapsone; Drug Resistance, Microbial; Humans; Leprosy; Mycobacterium leprae; Thalidomide

1977
The diagnosis and management of dapsone-resistant leprosy.
    Leprosy review, 1977, Volume: 48, Issue:2

    Topics: Clofazimine; Dapsone; Diagnosis, Differential; Drug Resistance, Microbial; Humans; Leprosy; Mycobact

1977
Committee 4: workshop on experimental chemotherapy of leprosy.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1979, Volume: 47, Issue:2 Suppl

    Topics: Animals; Antitubercular Agents; Clofazimine; Dapsone; Drug Resistance, Microbial; Leprostatic Agents

1979
The treatment of leprosy today and tomorrow: the LEPRA consultation on chemotherapy.
    Leprosy review, 1977, Volume: 48, Issue:4

    Topics: Clofazimine; Dapsone; Drug Resistance, Microbial; Humans; Leprosy; Mycobacterium leprae; Patient Com

1977
Workshop on "chemotherapy of leprosy" at the Central Leprosy Teaching and Research Institute, Chengalpattu (Tamil Nadu) on 21 January 1978.
    Leprosy in India, 1979, Volume: 51, Issue:1

    Topics: Clofazimine; Dapsone; Humans; India; Leprosy; Recurrence; Rifampin; Thalidomide

1979
Treatment of steroid dependant cases of recurrent lepra reaction with a combination of thalidomide and clofazimine.
    Leprosy in India, 1979, Volume: 51, Issue:4

    Topics: Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Humans; Leprosy; Male; Recurrence; Steroids;

1979
Unnecessary laparotomy for abdominal pain and fever due to clofazimine.
    Leprosy review, 1979, Volume: 50, Issue:3

    Topics: Abdomen; Adult; Clofazimine; Fever; Humans; Leprosy; Male; Pain

1979
Leprosy and the rheumatoid factor.
    The Central African journal of medicine, 1978, Volume: 24, Issue:1

    Topics: Clofazimine; Dapsone; Humans; Leprosy; Rheumatoid Factor

1978
Effect of rifampin, clofazimine, and B1912 on the viability of Mycobacterium leprae in established mouse footpad infection.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1976, Volume: 151, Issue:4

    Topics: Animals; Antibodies, Bacterial; Clofazimine; Immunosuppression Therapy; Leprosy; Mice; Mycobacterium

1976
Studies of experimental chemotherapy of leprosy.
    Leprosy in India, 1976, Volume: 48, Issue:4 Suppl

    Topics: Animals; Clofazimine; Leprosy; Mice; Mycobacterium leprae; Phenazines

1976
Clofazimine in the treatment of dapsone resistant leprosy.
    Leprosy in India, 1976, Volume: 48, Issue:4 Suppl

    Topics: Clofazimine; Dapsone; Drug Resistance, Microbial; Humans; Leprosy; Mycobacterium leprae

1976
Clofazimine and eosinophilic enteritis.
    Leprosy review, 1977, Volume: 48, Issue:3

    Topics: Adult; Clofazimine; Enteritis; Eosinophils; Female; Humans; Leprosy

1977
Tissue levels of clofazimine in a case of leprosy.
    Leprosy review, 1976, Volume: 47, Issue:2

    Topics: Adolescent; Clofazimine; Humans; Intestinal Mucosa; Leprosy; Male; Mononuclear Phagocyte System

1976
Lepromatous leprosy: dapsone resistance.
    Proceedings of the Royal Society of Medicine, 1976, Volume: 69, Issue:6

    Topics: Clofazimine; Dapsone; Drug Resistance, Microbial; Female; Foot Deformities, Acquired; Humans; Lepros

1976
The diagnosis and treatment of leprosy.
    Southern medical journal, 1976, Volume: 69, Issue:8

    Topics: Biopsy; Clofazimine; Dapsone; Erythema Nodosum; Humans; Immunotherapy; Leprosy; Recurrence; Rifampin

1976
Treatment of Hansen's disease.
    Cutis, 1976, Volume: 18, Issue:1

    Topics: Chloroquine; Clofazimine; Dapsone; Drug Resistance, Microbial; Erythema Nodosum; Humans; Leprosy; Pr

1976
Transformation from lepromatous to borderline leprosy under clofazimine therapy.
    Leprosy in India, 1976, Volume: 48, Issue:2

    Topics: Adult; Clofazimine; Dapsone; Humans; Leprosy; Male; Skin

1976
The pharmacological aspects and the therapeutic effects of clofazimine.
    Leprosy in India, 1976, Volume: 48, Issue:4 Suppl

    Topics: Absorption; Animals; Clofazimine; Humans; Leprosy

1976
An open trial with clofazimine in the management of recurrent lepra reaction using thalidomide as a control drug.
    Leprosy in India, 1976, Volume: 48, Issue:4 Suppl

    Topics: Adolescent; Adult; Clofazimine; Humans; Leprosy; Male; Middle Aged; Recurrence; Thalidomide

1976
Experiences with clofazimine therapy in leprosy.
    Leprosy in India, 1976, Volume: 48, Issue:4 Suppl

    Topics: Adolescent; Adult; Clofazimine; Female; Humans; Leprosy; Male; Middle Aged

1976
Clinical trial with clofazimine in leprosy.
    Leprosy in India, 1976, Volume: 48, Issue:4 Suppl

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Child; Clofazimine; Dapsone; Drug Therapy, Combination;

1976
Experiences in treatment of histoid cases with clofazimine.
    Leprosy in India, 1976, Volume: 48, Issue:4 Suppl

    Topics: Clofazimine; Dapsone; Humans; Leprosy

1976
Experience with the combination of clofazimine (Lamprene) and long-term steroid therapy in the treatment of leprosy.
    Leprosy in India, 1976, Volume: 48, Issue:4 Suppl

    Topics: Clofazimine; Drug Therapy, Combination; Humans; Leprosy; Prednisolone

1976
Side effects of clofazimine therapy.
    Leprosy in India, 1976, Volume: 48, Issue:4 Suppl

    Topics: Adolescent; Adult; Clofazimine; Dapsone; Female; Humans; Ichthyosis; Isoniazid; Leprosy; Male; Skin

1976
Quantitative estimation of clofazimine in tissue.
    Leprosy in India, 1976, Volume: 48, Issue:4 Suppl

    Topics: Adolescent; Autopsy; Clofazimine; Humans; Leprosy; Skin

1976
Viability of Myco. leprae in the skin and bone marrow of patients with lepromatous leprosy while on dapsone or lamprene.
    Leprosy review, 1975, Volume: 46, Issue:2 Suppl

    Topics: Bone Marrow; Clofazimine; Dapsone; Humans; Leprosy; Mycobacterium leprae; Skin

1975
Treatment of leprosy with clofazimine, rifampicin and Bayrena.
    Leprosy review, 1975, Volume: 46, Issue:2 Suppl

    Topics: Clofazimine; Drug Resistance, Microbial; Humans; Leprosy; Mycobacterium leprae; Rifampin; Sulfameter

1975
Multicentre controlled comparative trial of clofazimine and dapsone in low dosages.
    Leprosy review, 1975, Volume: 46, Issue:4

    Topics: Clofazimine; Dapsone; Dose-Response Relationship, Drug; Drug Evaluation; Humans; Leprosy; Mycobacter

1975
Treatment of neuritis in borderline leprosy with rifampicin and corticosteroids--a pilot trial.
    Leprosy review, 1975, Volume: 46, Issue:2

    Topics: Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Leprosy; Male; Neuritis; Pil

1975
Autopsy findings in a case of lepromatous leprosy treated with clofazimine.
    Leprosy review, 1975, Volume: 46, Issue:3

    Topics: Adult; Autopsy; Clofazimine; Diarrhea; Female; Humans; Leprosy

1975
The drug treatment of leprosy.
    The Practitioner, 1975, Volume: 215, Issue:1288

    Topics: Acute Disease; Adrenal Cortex Hormones; Aniline Compounds; Clofazimine; Dapsone; Drug Therapy, Combi

1975
Complications of treatment with clofazimine (Lamprene: B663).
    Leprosy review, 1976, Volume: 47, Issue:1

    Topics: Clofazimine; Gastrointestinal Diseases; Humans; Leprosy; Skin Diseases

1976
A long term trial with clofazimine in reactive lepromatous leprosy.
    Leprosy review, 1976, Volume: 47, Issue:1

    Topics: Clofazimine; Drug Evaluation; Female; Gastrointestinal Diseases; Humans; Leprosy; Pregnancy; Time Fa

1976
Dapsone syndrome in Vanuatu: a high incidence during multidrug treatment (MDT) of leprosy.
    The Journal of tropical medicine and hygiene, 1992, Volume: 95, Issue:4

    Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Clofazimine; Dapsone; Drug Eruptions; Dru

1992
Leprosy in French Polynesia. The possible impact of multidrug therapy on epidemiological trends.
    Leprosy review, 1992, Volume: 63, Issue:3

    Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Ethionamide; Humans; Leprosy; Polynesia; Rifampin

1992
Detection of Mycobacterium leprae and the potential for monitoring antileprosy drug therapy directly from skin biopsies by PCR.
    Molecular and cellular probes, 1992, Volume: 6, Issue:5

    Topics: Anti-Bacterial Agents; Biopsy; Clofazimine; Dapsone; DNA Probes; DNA, Bacterial; Drug Therapy, Combi

1992
Ambulatory treatment of multibacillary leprosy with a regimen of 8 months duration.
    Leprosy review, 1992, Volume: 63, Issue:1

    Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Ethionamide; Humans; Leprostatic Agents; Leprosy

1992
Comment: clofazimine-induced lymphoedema.
    Leprosy review, 1991, Volume: 62, Issue:3

    Topics: Adolescent; Adult; Child; Clofazimine; Female; Humans; Leprosy; Lymphedema; Male; Middle Aged

1991
The response to chemotherapy of serum Mycobacterium leprae-specific antigen in multibacillary leprosy patients.
    The American journal of tropical medicine and hygiene, 1991, Volume: 44, Issue:6

    Topics: Antibodies, Bacterial; Antigens, Bacterial; Carbohydrate Sequence; Clofazimine; Dapsone; Drug Therap

1991
A retrospective study on seven years of multiple drug treatment for paucibacillary and multibacillary leprosy, in Bayara General Hospital, Nigeria.
    Leprosy review, 1991, Volume: 62, Issue:2

    Topics: Adolescent; Adult; Clofazimine; Dapsone; Drug Administration Schedule; Drug Resistance, Microbial; D

1991
Comment: Clofazimine-induced lymphoedema.
    Leprosy review, 1991, Volume: 62, Issue:2

    Topics: Clofazimine; Humans; Leprosy; Lymphedema

1991
Impact of multidrug therapy on the treatment and control of leprosy.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1991, Volume: 59, Issue:3

    Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Global Health; Humans; Leprosy; Patient Compliance;

1991
Sulfapyridine and sulfones decrease glycosaminoglycans viscosity in dermatitis herpetiformis, ulcerative colitis, and pyoderma gangrenosum.
    Medical hypotheses, 1990, Volume: 31, Issue:2

    Topics: Clofazimine; Colitis, Ulcerative; Dermatitis Herpetiformis; Glycosaminoglycans; Humans; Leprosy; Pyo

1990
Clofazimine-induced lymphoedema.
    Leprosy review, 1990, Volume: 61, Issue:3

    Topics: Adult; Clofazimine; Female; Humans; Leprosy; Lymphedema; Male; Middle Aged

1990
[Late reversal reactions in leprosy].
    Acta leprologica, 1990, Volume: 7, Issue:2

    Topics: Clofazimine; Dapsone; Drug Combinations; Ethionamide; Female; Humans; Leprosy; Male; Recurrence; Rif

1990
The chemotherapy of leprosy. Part 1.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1990, Volume: 58, Issue:4

    Topics: Animals; Clofazimine; Dapsone; Drug Resistance, Microbial; Drug Therapy, Combination; Ethionamide; H

1990
[Drugs used in tuberculosis and leprosy].
    Nihon rinsho. Japanese journal of clinical medicine, 1990, Volume: 48, Issue:10

    Topics: Administration, Oral; Antibiotics, Antitubercular; Clofazimine; Dapsone; Humans; Injections, Intramu

1990
Effect of three-year multidrug therapy in multibacillary leprosy patients.
    Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao, 1990, Volume: 5, Issue:1

    Topics: Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Leprosy; Leprosy, Borderline

1990
Absorption and analysis of clofazimine and its derivatives.
    Biochemical Society transactions, 1990, Volume: 18, Issue:2

    Topics: Absorption; Animals; Clofazimine; Leprosy; Mice; Structure-Activity Relationship; Tissue Distributio

1990
A study of dermatological conditions in leprosy in-patients.
    Indian journal of leprosy, 1989, Volume: 61, Issue:1

    Topics: Clofazimine; Drug Eruptions; Female; Humans; Inpatients; Keratosis; Leprosy; Male; Pigmentation Diso

1989
The management of reaction in leprosy.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1989, Volume: 57, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibody Formation; Aspirin; Benzenesulfonates; Chloroquine

1989
Bacillaemia in leprosy and effect of multidrug therapy.
    Leprosy review, 1989, Volume: 60, Issue:3

    Topics: Adolescent; Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Leprosy; Leprosy

1989
Clofazimine in pregnancy.
    Early human development, 1989, Volume: 18, Issue:4

    Topics: Clofazimine; Female; Fetal Death; Fetal Diseases; Humans; Leprosy; Pregnancy; Pregnancy Complication

1989
Impact of multidrug therapy on leprosy in Baroda district (Gujarat).
    Indian journal of leprosy, 1989, Volume: 61, Issue:2

    Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Humans; India; Leprosy; National Health Programs; P

1989
Evaluation of two multidrug regimen in hospitalised multibacillary cases.
    Indian journal of leprosy, 1989, Volume: 61, Issue:2

    Topics: Clofazimine; Dapsone; Drug Evaluation; Drug Resistance, Microbial; Drug Therapy, Combination; Hospit

1989
Comments on an editorial by B. R. Chatterjee "On Multi-Drug Combinations in the Treatment of Leprosy".
    Indian journal of leprosy, 1989, Volume: 61, Issue:3

    Topics: Animals; Clofazimine; Dapsone; Drug Administration Schedule; Drug Therapy, Combination; Humans; Ison

1989
Drug resistance and multi-drug therapy in leprosy.
    Indian journal of leprosy, 1989, Volume: 61, Issue:3

    Topics: Animals; Clofazimine; Dapsone; Drug Administration Schedule; Drug Therapy, Combination; Humans; Lepr

1989
Short-term multidrug therapy in multibacillary leprosy--review of 80 cases in two provinces of China (1983-1988).
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1989, Volume: 57, Issue:3

    Topics: Adult; China; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Leprostatic Agents; L

1989
Bilateral ulnar nerve abscesses in lepromatous leprosy.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1987, Volume: 55, Issue:3

    Topics: Abscess; Clofazimine; Humans; Leprosy; Peripheral Nervous System Diseases; Ulnar Nerve

1987
Exfoliative dermatitis after clofazimine.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1985, Volume: 53, Issue:4

    Topics: Clofazimine; Dermatitis, Exfoliative; Drug Eruptions; Humans; Leprosy; Male; Middle Aged

1985
A follow up of T-cell subsets and of anti-M. leprae antibody titer as measured by the FLA-ABS test in Melanesian leprosy patients under polychemotherapy.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1986, Volume: 54, Issue:1

    Topics: Adolescent; Adult; Antibodies, Bacterial; Child; Clofazimine; Dapsone; Drug Therapy, Combination; Er

1986
[Effect of rifampicin, clofazimine and dapsone in treating 296 cases of multibacillary leprosy].
    Zhonghua yi xue za zhi, 1987, Volume: 67, Issue:1

    Topics: Adolescent; Adult; Aged; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Leprosy; M

1987
The effect of anti-reactional drugs on complement components in the type II, erythema nodosum leprosum, reaction.
    The British journal of dermatology, 1988, Volume: 119, Issue:2

    Topics: Chloroquine; Clofazimine; Complement C3; Complement Factor B; Complement System Proteins; Erythema N

1988
Leprosy control based on multi drug treatment in India.
    Indian journal of leprosy, 1988, Volume: 60, Issue:2

    Topics: Allied Health Personnel; Clofazimine; Dapsone; Data Collection; Drug Administration Schedule; Drug T

1988
Multidrug therapy in hospitalised leprosy cases.
    Indian journal of leprosy, 1988, Volume: 60, Issue:1

    Topics: Adult; Clofazimine; Dapsone; Drug Resistance, Microbial; Drug Therapy, Combination; Female; Humans;

1988
[Guinea: detection of leprosy and treatment by polychemotherapy].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1988, Volume: 81, Issue:4

    Topics: Africa, Western; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Leprosy; Male; Rif

1988
On multi-drug combinations in the treatment of leprosy.
    Indian journal of leprosy, 1988, Volume: 60, Issue:4

    Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Ethionamide; Humans; Leprosy; Rifampin

1988
Paucibacillary leprosy: a comparative study of different schedules of multidrug therapy.
    Indian journal of leprosy, 1988, Volume: 60, Issue:4

    Topics: Adult; Clofazimine; Dapsone; Drug Administration Schedule; Drug Therapy, Combination; Humans; Lepros

1988
The killing of Mycobacterium leprae in mice by various dietary concentrations of clofazimine and ethionamide.
    Leprosy review, 1987, Volume: 58, Issue:4

    Topics: Administration, Oral; Animals; Clofazimine; Dose-Response Relationship, Drug; Ethionamide; Female; L

1987
Influence of once-monthly rifampicin and daily clofazimine on the pharmacokinetics of dapsone in leprosy patients in Nigeria.
    European journal of clinical pharmacology, 1988, Volume: 34, Issue:1

    Topics: Adolescent; Adult; Aged; Clofazimine; Dapsone; Drug Administration Schedule; Drug Interactions; Drug

1988
Diagnosis of leprosy.
    International journal of dermatology, 1988, Volume: 27, Issue:4

    Topics: Clofazimine; Dapsone; Diagnosis, Differential; Drug Combinations; Humans; Leprosy; Rifampin

1988
Drug interaction during multidrug regimens for treatment of leprosy.
    The Indian journal of medical research, 1988, Volume: 87

    Topics: Clofazimine; Dapsone; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Hu

1988
[Sulfone-resistance of Mycobacterium leprae--monotherapy with diaminodiphenylsulfone--the value of triple-drug combinations].
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1986, Volume: 54, Issue:1

    Topics: Clofazimine; Dapsone; Drug Resistance, Microbial; Drug Therapy, Combination; Humans; Leprosy; Mycoba

1986
Clofazimine-resistant M. leprae.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1986, Volume: 54, Issue:1

    Topics: Animals; Clofazimine; Dapsone; Drug Resistance, Microbial; Humans; Leprosy; Mice; Mycobacterium lepr

1986
Antibodies to phenolic glycolipid-1 and to whole Mycobacterium leprae in leprosy patients: evolution during therapy.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1986, Volume: 54, Issue:2

    Topics: Antibodies, Bacterial; Antigens, Bacterial; Clofazimine; Dapsone; Drug Therapy, Combination; Ethiona

1986
Combined clofazimine- and dapsone-resistant leprosy. A case report.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1986, Volume: 54, Issue:3

    Topics: Adult; Animals; Clofazimine; Dapsone; Drug Resistance, Microbial; Humans; Leprosy; Male; Mice; Mycob

1986
[Small intestine transit anomalies in a patient with chronic abdominal pain and treated for Hansen's disease].
    Journal de radiologie, 1986, Volume: 67, Issue:3

    Topics: Abdomen; Chronic Disease; Clofazimine; Female; Gastrointestinal Motility; Humans; Intestinal Disease

1986
[Therapy of leprosy today].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1987, Volume: 38, Issue:1

    Topics: Clofazimine; Dapsone; Drug Resistance; Drug Therapy, Combination; Humans; Leprostatic Agents; Lepros

1987
Combined chemotherapy of multibacillary leprosy of 6 months' duration.
    Leprosy review, 1986, Volume: 57 Suppl 3

    Topics: Adolescent; Adult; Child; Child, Preschool; Clofazimine; Dapsone; Drug Therapy, Combination; Female;

1986
The future of leprosy in the Dominican Republic: experience with multidrug therapy.
    Leprosy review, 1986, Volume: 57 Suppl 3

    Topics: Adolescent; Child; Child, Preschool; Clofazimine; Dapsone; Dominican Republic; Drug Therapy, Combina

1986
Preliminary results of treatment of leprosy patients in The Netherlands with daily rifampicin, dapsone and clofazimine.
    Leprosy review, 1986, Volume: 57 Suppl 3

    Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Humans; Leprosy; Netherlands; Recurrence; Rifampin

1986
Effect of clofazimine and dapsone on rifampicin (Lositril) pharmacokinetics in multibacillary and paucibacillary leprosy cases.
    Leprosy review, 1986, Volume: 57 Suppl 3

    Topics: Adolescent; Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Humans; Kinetics; Leprosy; Male;

1986
Clofazimine for leprosy and Mycobacterium avium complex infections.
    The Medical letter on drugs and therapeutics, 1987, Aug-14, Volume: 29, Issue:746

    Topics: Clofazimine; Humans; Leprosy; Mycobacterium avium; Mycobacterium Infections

1987
Feasibility of multidrug therapy (MDT) in Hansen's disease in an urban population--Curupaiti State Hospital, Rio de Janeiro, Brazil.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1987, Volume: 55, Issue:3

    Topics: Adolescent; Adult; Brazil; Clofazimine; Dapsone; Drug Therapy, Combination; Ethionamide; Female; Hum

1987
Prospective study on the relationship between intensive bactericidal therapy and leprosy reactions.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1986, Volume: 54, Issue:2

    Topics: Adult; Child; Clofazimine; Dapsone; Drug Therapy, Combination; Edema; Erythema Nodosum; Ethionamide;

1986
Electrogustometry in Hansen's disease (study of 225 cases).
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1986, Volume: 54, Issue:2

    Topics: Adolescent; Adult; Ageusia; Clofazimine; Dapsone; Erythema Nodosum; Facial Paralysis; Female; Humans

1986
Monitoring dapsone self-administration in a multidrug therapy programme.
    Leprosy review, 1986, Volume: 57, Issue:2

    Topics: Adolescent; Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Ethiopia; Female; Humans; Lepros

1986
[Combination chemotherapy in leprosy].
    Nederlands tijdschrift voor geneeskunde, 1986, Oct-25, Volume: 130, Issue:43

    Topics: Clofazimine; Dapsone; Drug Administration Schedule; Drug Therapy, Combination; Humans; Leprostatic A

1986
[An unusual cause of parietal intestinal involvement: enteropathy due to clofazimine. Apropos of a case].
    Annales de radiologie, 1986, Volume: 29, Issue:6

    Topics: Adult; Clofazimine; Humans; Ileal Diseases; Intestinal Obstruction; Leprosy; Male; Radiography

1986
The effect of clofazimine on the pharmacokinetics of rifampicin and dapsone in leprosy.
    The Journal of antimicrobial chemotherapy, 1986, Volume: 18, Issue:6

    Topics: Clofazimine; Dapsone; Half-Life; Humans; Kinetics; Leprosy; Rifampin

1986
Leprosy and the eye: a review.
    Journal of the Royal Society of Medicine, 1985, Volume: 78, Issue:5

    Topics: Bacterial Vaccines; Clofazimine; Dapsone; Drug Therapy, Combination; Eye Diseases; Humans; Leprosy;

1985
Recent trends in chemotherapy of leprosy.
    The Journal of the Association of Physicians of India, 1985, Volume: 33, Issue:9

    Topics: Clofazimine; Dapsone; Drug Combinations; Drug Therapy, Combination; Humans; Isoniazid; Leprostatic A

1985
Absence from sera from normal individuals or from rifampin-treated leprosy patients (THELEP trials) of antibody to rifamycin-protein or rifamycin-membrane conjugates.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1985, Volume: 53, Issue:1

    Topics: Animals; Antibodies, Bacterial; Clofazimine; Coombs Test; Dapsone; Drug Therapy, Combination; Enzyme

1985
Polytherapy in multibacillary leprosy patients in Nepal.
    Singapore medical journal, 1985, Volume: 26, Issue:2

    Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Leprostatic Agents; Leprosy; Male;

1985
Some observations on the pharmacology of clofazimine (B663).
    The American journal of tropical medicine and hygiene, 1974, Volume: 23, Issue:6

    Topics: Aniline Compounds; Animals; Clofazimine; Dose-Response Relationship, Drug; Feces; Humans; Isoniazid;

1974
Tissue concentrations of clofazimine (B663) in man.
    The American journal of tropical medicine and hygiene, 1974, Volume: 23, Issue:6

    Topics: Adipose Tissue; Adrenal Glands; Autopsy; Clofazimine; Female; Gallbladder; Humans; Kidney; Leprosy;

1974
Editorial: Problems and opportunities in the therapy of leprosy.
    Leprosy review, 1974, Volume: 45, Issue:4

    Topics: Clofazimine; Dapsone; Drug Resistance, Microbial; Humans; Leprostatic Agents; Leprosy; Rifampin

1974
Thymus-dependent lymphocytes of peripheral blood in leprosy patients.
    Infection and immunity, 1974, Volume: 9, Issue:2

    Topics: Adult; Aged; Animals; Blood Cell Count; Clofazimine; Dapsone; Erythema Nodosum; Erythrocytes; Humans

1974
Fundamental data, methods and goals of present research on the treatment of leprosy.
    Zeitschrift fur Tropenmedizin und Parasitologie, 1973, Volume: 24

    Topics: Animals; Animals, Laboratory; Antitubercular Agents; Clofazimine; Dapsone; Ethionamide; Humans; In V

1973
Dapsone resistance in leprosy.
    Transactions of the St. John's Hospital Dermatological Society, 1973, Volume: 59, Issue:2

    Topics: Animals; Clofazimine; Dapsone; Drug Resistance, Microbial; Leprosy; Mice; Mycobacterium leprae; Rifa

1973
Pharmacologic studies of clofazimine.
    The American journal of tropical medicine and hygiene, 1974, Volume: 23, Issue:6

    Topics: Administration, Oral; Animals; Clofazimine; Diet; Dose-Response Relationship, Drug; Half-Life; Human

1974
The treatment of corticosteroid-dependent lepromatous patients in persistent Erythema nodosum leprosum with clofazimine.
    Leprosy review, 1973, Volume: 44, Issue:3

    Topics: Adrenal Cortex Hormones; Clofazimine; Erythema Nodosum; Female; Follow-Up Studies; Humans; Leprosy;

1973
Management of reactions in leprosy.
    Journal of the Indian Medical Association, 1973, Nov-01, Volume: 61, Issue:9

    Topics: Adrenal Cortex Hormones; Clofazimine; Hand Deformities, Acquired; Humans; Leprosy; Neuritis; Skin Ul

1973