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clofazimine and Leprosy, Macular

clofazimine has been researched along with Leprosy, Macular in 19 studies

Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.

Research Excerpts

ExcerptRelevanceReference
"This study sought to verify the correlation between leprosy types and the adverse effects of treatment drugs."2.77Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects. ( Almeida, PC; Bührer-Sékula, S; Cruz, R; Gonçalves, Hde S; Moraes, ME; Penna, GO; Pontes, MA, 2012)
"No confirmed relapse has been observed within a follow-up period of 6 months to 7 years and 3 months [59 person-years at risk (PYR)] for TT/BT patients and of 4 months to 5 years and 10 months (100 PYR) for BB/BL/LL patients."2.68Daily multidrug therapy for leprosy; results of a fourteen-year experience. ( Cottenot, F; de Carsalade, GY; Flageul, B; Pennec, J; Spindler, E; Wallach, D, 1997)
"Current treatment of leprosy involves use of 3 drugs: rifampicin (rifampin); clofazimine; and dapsone."2.41Leprosy. Recognition and treatment. ( Ramos-e-Silva, M; Rebello, PF, 2001)
"A patient is described with tuberculoid leprosy and Type 1 (lepra) reaction from Sicily a non-endemic region, who lived previously in Manila from 2000 to 2005."1.35Tuberculoid leprosy and Type 1 lepra reaction. ( Aricò, M; Bongiorno, MR; Noto, S; Pistone, G, 2008)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19902 (10.53)18.7374
1990's6 (31.58)18.2507
2000's8 (42.11)29.6817
2010's3 (15.79)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fischer, M1
Bongiorno, MR1
Pistone, G1
Noto, S1
Aricò, M1
Kalisiak, M1
Yeung, R1
Dytoc, M1
Marzano, AV1
Tosi, D1
Cusini, M1
Nunzi, E1
Massone, C1
Crosti, C1
Gonçalves, Hde S1
Pontes, MA1
Bührer-Sékula, S1
Cruz, R1
Almeida, PC1
Moraes, ME1
Penna, GO1
Arora, SK1
Jardim, MR1
Illarramendi, X1
Nascimento, OJ1
Nery, JA1
Sales, AM1
Sampaio, EP1
Sarno, EN1
Mendis, S1
Somasiri, KG1
Chularatna, W1
Bhattacharya, SN1
Chattopadhaya, D1
Saha, K1
de Carsalade, GY1
Wallach, D1
Spindler, E1
Pennec, J1
Cottenot, F1
Flageul, B1
Moubasher, AD1
Kamel, NA1
Zedan, H1
Raheem, DD1
Young, RJ1
Gilson, RT1
Elston, DM1
Winter, CA1
Hsu, S1
Burdick, AE1
Hendi, A1
Elgart, GW1
Barquin, L1
Scollard, DM1
Ramos-e-Silva, M1
Rebello, PF1
Becx-Bleumink, M1
Venkateswarlu, B1
Venkataramana, D1
Rao, AV1
Prabhakar, MC1
Reddy, BM1
Rabinowitz, LG1
Yuengel, C1
Honig, PJ1
Solomon, AR1
Ekambaram, V1
Rao, MK1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Independent Study to Establish the Efficacy of the Six Doses Uniform MDT Regimen (U-MDT) for Leprosy Patients[NCT00669643]Phase 4859 participants (Actual)Interventional2007-02-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for clofazimine and Leprosy, Macular

ArticleYear
Leprosy - an overview of clinical features, diagnosis, and treatment.
    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2017, Volume: 15, Issue:8

    Topics: Adult; Aged; Child; Clofazimine; Cross-Sectional Studies; Dapsone; Disease Progression; Drug Adminis

2017
Leprosy. Recognition and treatment.
    American journal of clinical dermatology, 2001, Volume: 2, Issue:4

    Topics: Adolescent; Adult; Age Factors; Biopsy; Child; Clinical Trials as Topic; Clofazimine; Dapsone; Diagn

2001
Relapses among leprosy patients treated with multidrug therapy: experience in the leprosy control program of the All Africa Leprosy and Rehabilitation Training Center (ALERT) in Ethiopia; practical difficulties with diagnosing relapses; operational proced
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1992, Volume: 60, Issue:3

    Topics: Clofazimine; Dapsone; Epidemiologic Methods; Ethiopia; Humans; Incidence; Leprostatic Agents; Lepros

1992

Trials

3 trials available for clofazimine and Leprosy, Macular

ArticleYear
Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects.
    Memorias do Instituto Oswaldo Cruz, 2012, Volume: 107 Suppl 1

    Topics: Adolescent; Adult; Aged; Child; Clofazimine; Dapsone; Drug Therapy, Combination; Humans; Leprostatic

2012
Daily multidrug therapy for leprosy; results of a fourteen-year experience.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1997, Volume: 65, Issue:1

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Clofazimine; Dapsone; Drug Resistance, Microbial;

1997
Cytokines in leprosy, II. Effect of treatment on serum cytokines in leprosy.
    International journal of dermatology, 1998, Volume: 37, Issue:10

    Topics: Adrenal Cortex Hormones; Clofazimine; Cytokines; Drug Therapy, Combination; Female; Follow-Up Studie

1998

Other Studies

13 other studies available for clofazimine and Leprosy, Macular

ArticleYear
Tuberculoid leprosy and Type 1 lepra reaction.
    Travel medicine and infectious disease, 2008, Volume: 6, Issue:5

    Topics: Adult; Biopsy; Clofazimine; Dapsone; Diagnosis, Differential; Humans; Leprostatic Agents; Leprosy, T

2008
Question: Can you identify this condition? Tuberculoid leprosy.
    Canadian family physician Medecin de famille canadien, 2009, Volume: 55, Issue:1

    Topics: Adult; Asian People; Clofazimine; Dapsone; Diagnosis, Differential; Drug Therapy, Combination; Femal

2009
Facial reversal reaction: a dermatological emergency.
    The Journal of dermatology, 2012, Volume: 39, Issue:2

    Topics: Adult; Antigens, CD; Antigens, Differentiation, Myelomonocytic; B-Lymphocytes; CD3 Complex; Clofazim

2012
Leprosy in a preschool child--a case report.
    Journal of the Indian Medical Association, 2007, Volume: 105, Issue:3

    Topics: Child, Preschool; Clofazimine; Dapsone; Drug Administration Schedule; Drug Therapy, Combination; Fem

2007
Pure neural leprosy: steroids prevent neuropathy progression.
    Arquivos de neuro-psiquiatria, 2007, Volume: 65, Issue:4A

    Topics: Adult; Aged; Clofazimine; Dapsone; Drug Therapy, Combination; Electrophysiology; Female; Follow-Up S

2007
Effect of drug treatment on electroneurological measures of peripheral nerve function in leprosy patients.
    The Ceylon medical journal, 1993, Volume: 38, Issue:4

    Topics: Adolescent; Adult; Aged; Child; Clofazimine; Dapsone; Drug Therapy, Combination; Electrophysiology;

1993
Tumor necrosis factor: status in reactions in leprosy before and after treatment.
    International journal of dermatology, 1993, Volume: 32, Issue:6

    Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Chloroquine; Clofazimine; Eryt

1993
Generalized annular borderline tuberculoid leprosy and update in management of Hansen's disease.
    Cutis, 2000, Volume: 65, Issue:4

    Topics: Aged; Clofazimine; Dapsone; DNA, Bacterial; Drug Therapy, Combination; Humans; Leprostatic Agents; L

2000
Ominous sign of a disfiguring disease. Leprosy (Hansen's disease).
    Postgraduate medicine, 2000, May-01, Volume: 107, Issue:5

    Topics: Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Humans; Leprostatic Agents; Leprosy; Leprosy

2000
Hansen's disease in a patient with a history of sarcoidosis.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 2000, Volume: 68, Issue:3

    Topics: Anti-Inflammatory Agents; Biopsy; Clofazimine; Dapsone; Dermatologic Agents; Electromyography; Femal

2000
Role of rifampin and clofazimine ointments in the treatment of leprosy.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1992, Volume: 60, Issue:2

    Topics: Clofazimine; Dermatitis; Drug Combinations; Edema; Erythema; Humans; Leprosy, Tuberculoid; Ointments

1992
A papulosquamous eruption in a 12-year-old cambodian boy.
    Pediatric dermatology, 1989, Volume: 6, Issue:2

    Topics: Biopsy; Cambodia; Child; Clofazimine; Diagnosis, Differential; Drug Therapy, Combination; Humans; Le

1989
Changing picture of leprosy in North Arcot District, Tamil Nadu after M.D.T.
    Indian journal of leprosy, 1989, Volume: 61, Issue:1

    Topics: Clofazimine; Cohort Studies; Dapsone; Drug Therapy, Combination; Follow-Up Studies; Humans; India; L

1989