clofazimine has been researched along with Leprosy, Macular in 19 studies
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study sought to verify the correlation between leprosy types and the adverse effects of treatment drugs." | 2.77 | Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects. ( Almeida, PC; Bührer-Sékula, S; Cruz, R; Gonçalves, Hde S; Moraes, ME; Penna, GO; Pontes, MA, 2012) |
| "No confirmed relapse has been observed within a follow-up period of 6 months to 7 years and 3 months [59 person-years at risk (PYR)] for TT/BT patients and of 4 months to 5 years and 10 months (100 PYR) for BB/BL/LL patients." | 2.68 | Daily multidrug therapy for leprosy; results of a fourteen-year experience. ( Cottenot, F; de Carsalade, GY; Flageul, B; Pennec, J; Spindler, E; Wallach, D, 1997) |
| "Current treatment of leprosy involves use of 3 drugs: rifampicin (rifampin); clofazimine; and dapsone." | 2.41 | Leprosy. Recognition and treatment. ( Ramos-e-Silva, M; Rebello, PF, 2001) |
| "A patient is described with tuberculoid leprosy and Type 1 (lepra) reaction from Sicily a non-endemic region, who lived previously in Manila from 2000 to 2005." | 1.35 | Tuberculoid leprosy and Type 1 lepra reaction. ( Aricò, M; Bongiorno, MR; Noto, S; Pistone, G, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.53) | 18.7374 |
| 1990's | 6 (31.58) | 18.2507 |
| 2000's | 8 (42.11) | 29.6817 |
| 2010's | 3 (15.79) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fischer, M | 1 |
| Bongiorno, MR | 1 |
| Pistone, G | 1 |
| Noto, S | 1 |
| Aricò, M | 1 |
| Kalisiak, M | 1 |
| Yeung, R | 1 |
| Dytoc, M | 1 |
| Marzano, AV | 1 |
| Tosi, D | 1 |
| Cusini, M | 1 |
| Nunzi, E | 1 |
| Massone, C | 1 |
| Crosti, C | 1 |
| Gonçalves, Hde S | 1 |
| Pontes, MA | 1 |
| Bührer-Sékula, S | 1 |
| Cruz, R | 1 |
| Almeida, PC | 1 |
| Moraes, ME | 1 |
| Penna, GO | 1 |
| Arora, SK | 1 |
| Jardim, MR | 1 |
| Illarramendi, X | 1 |
| Nascimento, OJ | 1 |
| Nery, JA | 1 |
| Sales, AM | 1 |
| Sampaio, EP | 1 |
| Sarno, EN | 1 |
| Mendis, S | 1 |
| Somasiri, KG | 1 |
| Chularatna, W | 1 |
| Bhattacharya, SN | 1 |
| Chattopadhaya, D | 1 |
| Saha, K | 1 |
| de Carsalade, GY | 1 |
| Wallach, D | 1 |
| Spindler, E | 1 |
| Pennec, J | 1 |
| Cottenot, F | 1 |
| Flageul, B | 1 |
| Moubasher, AD | 1 |
| Kamel, NA | 1 |
| Zedan, H | 1 |
| Raheem, DD | 1 |
| Young, RJ | 1 |
| Gilson, RT | 1 |
| Elston, DM | 1 |
| Winter, CA | 1 |
| Hsu, S | 1 |
| Burdick, AE | 1 |
| Hendi, A | 1 |
| Elgart, GW | 1 |
| Barquin, L | 1 |
| Scollard, DM | 1 |
| Ramos-e-Silva, M | 1 |
| Rebello, PF | 1 |
| Becx-Bleumink, M | 1 |
| Venkateswarlu, B | 1 |
| Venkataramana, D | 1 |
| Rao, AV | 1 |
| Prabhakar, MC | 1 |
| Reddy, BM | 1 |
| Rabinowitz, LG | 1 |
| Yuengel, C | 1 |
| Honig, PJ | 1 |
| Solomon, AR | 1 |
| Ekambaram, V | 1 |
| Rao, MK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Independent Study to Establish the Efficacy of the Six Doses Uniform MDT Regimen (U-MDT) for Leprosy Patients[NCT00669643] | Phase 4 | 859 participants (Actual) | Interventional | 2007-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for clofazimine and Leprosy, Macular
| Article | Year |
|---|---|
Leprosy - an overview of clinical features, diagnosis, and treatment.
Topics: Adult; Aged; Child; Clofazimine; Cross-Sectional Studies; Dapsone; Disease Progression; Drug Adminis | 2017 |
Leprosy. Recognition and treatment.
Topics: Adolescent; Adult; Age Factors; Biopsy; Child; Clinical Trials as Topic; Clofazimine; Dapsone; Diagn | 2001 |
Relapses among leprosy patients treated with multidrug therapy: experience in the leprosy control program of the All Africa Leprosy and Rehabilitation Training Center (ALERT) in Ethiopia; practical difficulties with diagnosing relapses; operational proced
Topics: Clofazimine; Dapsone; Epidemiologic Methods; Ethiopia; Humans; Incidence; Leprostatic Agents; Lepros | 1992 |
3 trials available for clofazimine and Leprosy, Macular
| Article | Year |
|---|---|
Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects.
Topics: Adolescent; Adult; Aged; Child; Clofazimine; Dapsone; Drug Therapy, Combination; Humans; Leprostatic | 2012 |
Daily multidrug therapy for leprosy; results of a fourteen-year experience.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Clofazimine; Dapsone; Drug Resistance, Microbial; | 1997 |
Cytokines in leprosy, II. Effect of treatment on serum cytokines in leprosy.
Topics: Adrenal Cortex Hormones; Clofazimine; Cytokines; Drug Therapy, Combination; Female; Follow-Up Studie | 1998 |
13 other studies available for clofazimine and Leprosy, Macular
| Article | Year |
|---|---|
Tuberculoid leprosy and Type 1 lepra reaction.
Topics: Adult; Biopsy; Clofazimine; Dapsone; Diagnosis, Differential; Humans; Leprostatic Agents; Leprosy, T | 2008 |
Question: Can you identify this condition? Tuberculoid leprosy.
Topics: Adult; Asian People; Clofazimine; Dapsone; Diagnosis, Differential; Drug Therapy, Combination; Femal | 2009 |
Facial reversal reaction: a dermatological emergency.
Topics: Adult; Antigens, CD; Antigens, Differentiation, Myelomonocytic; B-Lymphocytes; CD3 Complex; Clofazim | 2012 |
Leprosy in a preschool child--a case report.
Topics: Child, Preschool; Clofazimine; Dapsone; Drug Administration Schedule; Drug Therapy, Combination; Fem | 2007 |
Pure neural leprosy: steroids prevent neuropathy progression.
Topics: Adult; Aged; Clofazimine; Dapsone; Drug Therapy, Combination; Electrophysiology; Female; Follow-Up S | 2007 |
Effect of drug treatment on electroneurological measures of peripheral nerve function in leprosy patients.
Topics: Adolescent; Adult; Aged; Child; Clofazimine; Dapsone; Drug Therapy, Combination; Electrophysiology; | 1993 |
Tumor necrosis factor: status in reactions in leprosy before and after treatment.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Chloroquine; Clofazimine; Eryt | 1993 |
Generalized annular borderline tuberculoid leprosy and update in management of Hansen's disease.
Topics: Aged; Clofazimine; Dapsone; DNA, Bacterial; Drug Therapy, Combination; Humans; Leprostatic Agents; L | 2000 |
Ominous sign of a disfiguring disease. Leprosy (Hansen's disease).
Topics: Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Humans; Leprostatic Agents; Leprosy; Leprosy | 2000 |
Hansen's disease in a patient with a history of sarcoidosis.
Topics: Anti-Inflammatory Agents; Biopsy; Clofazimine; Dapsone; Dermatologic Agents; Electromyography; Femal | 2000 |
Role of rifampin and clofazimine ointments in the treatment of leprosy.
Topics: Clofazimine; Dermatitis; Drug Combinations; Edema; Erythema; Humans; Leprosy, Tuberculoid; Ointments | 1992 |
A papulosquamous eruption in a 12-year-old cambodian boy.
Topics: Biopsy; Cambodia; Child; Clofazimine; Diagnosis, Differential; Drug Therapy, Combination; Humans; Le | 1989 |
Changing picture of leprosy in North Arcot District, Tamil Nadu after M.D.T.
Topics: Clofazimine; Cohort Studies; Dapsone; Drug Therapy, Combination; Follow-Up Studies; Humans; India; L | 1989 |