clofazimine has been researched along with Leprosy, Cutaneous in 98 studies
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clofazimine enterophathy is a serious complication of clofazimine when used at high doses for treatment of type 2 lepra or or erythema nodosum leprosum." | 7.75 | [Persistent type 2 lepra reaction (erythema nodosum) and clofazimine-induced lethal enteropathy]. ( Gómez, Y; López, F; Pinto, R; Rodríguez, G, 2009) |
| " The majority of these patients become steroid-dependent and suffer from the adverse effects of long-term corticosteroid use." | 7.01 | Comparison of the efficacy and safety of minocycline and clofazimine in chronic and recurrent erythema nodosum leprosum-A randomized clinical trial. ( Dogra, S; Hanumanthu, V; Narang, T; Thakur, V, 2021) |
| " The patient responded well to fluoroquinolone, rifampicin and clofazimine, with however, the occurrence of erythema nodosum leprosum." | 4.82 | [Histoid leprosy with erythema nodosum leprosum]. ( Alioua, Z; Benomar, S; Boudi, O; Bouzidi, A; Elhaouri, M; Ghfir, M; Sbai, M; Sedrati, OL, 2003) |
| "Clofazimine enterophathy is a serious complication of clofazimine when used at high doses for treatment of type 2 lepra or or erythema nodosum leprosum." | 3.75 | [Persistent type 2 lepra reaction (erythema nodosum) and clofazimine-induced lethal enteropathy]. ( Gómez, Y; López, F; Pinto, R; Rodríguez, G, 2009) |
| "A 66-year-old Indian male who had been treated for recurrent erythema nodosum leprosum with 300 mg of clofazimine per day for 11 months presented to hospital with a 4 week history of severe gastrointestinal upset." | 3.69 | Clofazimine induced cardiotoxicity--a case report. ( Butany, JW; Choudhri, SH; Harris, L; Keystone, JS, 1995) |
| "A patient of lepromatous leprosy, who received a high dose of clofazimine as part of multidrug therapy, for chronic erythema nodosum leprosum (ENL) had frequent 'haemoptysis'." | 3.68 | Red discoloration of the sputum by clofazimine simulating haemoptysis--a case report. ( Chauhan, SL; Girdhar, A; Girdhar, BK; Malaviya, GN; Venkatesan, K, 1992) |
| "The feasibility and effects of a 3-year treatment using rifampicin (RFP), clofazimine (B663) and dapsone (DDS) in multibacillary leprosy patients in Yangzhou Prefecture and Dongtai County (1983-1986) are reported." | 3.68 | Effect of three-year multidrug therapy in multibacillary leprosy patients. ( Ji, F; Li, W; Luo, J; Tao, M; Wang, C; Yang, Z; Ye, G, 1990) |
| " The majority of these patients become steroid-dependent and suffer from the adverse effects of long-term corticosteroid use." | 3.01 | Comparison of the efficacy and safety of minocycline and clofazimine in chronic and recurrent erythema nodosum leprosum-A randomized clinical trial. ( Dogra, S; Hanumanthu, V; Narang, T; Thakur, V, 2021) |
| "This study sought to verify the correlation between leprosy types and the adverse effects of treatment drugs." | 2.77 | Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects. ( Almeida, PC; Bührer-Sékula, S; Cruz, R; Gonçalves, Hde S; Moraes, ME; Penna, GO; Pontes, MA, 2012) |
| "No confirmed relapse has been observed within a follow-up period of 6 months to 7 years and 3 months [59 person-years at risk (PYR)] for TT/BT patients and of 4 months to 5 years and 10 months (100 PYR) for BB/BL/LL patients." | 2.68 | Daily multidrug therapy for leprosy; results of a fourteen-year experience. ( Cottenot, F; de Carsalade, GY; Flageul, B; Pennec, J; Spindler, E; Wallach, D, 1997) |
| " Its optimal dosage appears to be 400 mg daily, and combination with dapsone and clofazimine does not enhance its activity." | 2.67 | Clinical trial of ofloxacin alone and in combination with dapsone plus clofazimine for treatment of lepromatous leprosy. ( Grosset, JH; Ji, B; N'Deli, L; Perani, EG; Petinom, C, 1994) |
| "Forty-five previously untreated lepromatous leprosy patients were allocated randomly to three groups and treated, respectively, with Regimen A, standard dosage of clofazimine (CLO) in multidrug therapy (MDT) regimen; Regimen B, CLO 600 mg once every 4 weeks; and Regimen C, CLO 1200 mg once every 4 weeks." | 2.67 | Short-term trial of clofazimine in previously untreated lepromatous leprosy. ( Husser, JA; Jamet, P; Ji, B; Traore, I, 1992) |
| "Clofazimine treatment was superior to prednisolone (more treatment successes; RR 3." | 2.45 | Interventions for erythema nodosum leprosum. ( Lockwood, DN; Ramirez, J; Richardus, JH; van Brakel, WH; Van Veen, NH, 2009) |
| "Clofazimine treatment was superior to prednisolone (more treatment successes; RR 3." | 2.45 | Interventions for erythema nodosum leprosum. A Cochrane review. ( Lockwood, DN; Ramirez, J; Richardus, JH; Van Brakel, WH; Van Veen, NH, 2009) |
| "Current treatment of leprosy involves use of 3 drugs: rifampicin (rifampin); clofazimine; and dapsone." | 2.41 | Leprosy. Recognition and treatment. ( Ramos-e-Silva, M; Rebello, PF, 2001) |
| "Relapses are an indicator of MDT effectiveness and can reflect Mycobacterium leprae persistence or re-infection." | 1.62 | Low rate of relapse after twelve-dose multidrug therapy for hansen's disease: A 20-year cohort study in a brazilian reference center. ( Hacker, MAVB; Illarramendi, X; Maia, RC; Moraes, MO; Nery, JAC; Sales, AM; Sarno, EN, 2021) |
| "Lepromatous leprosy is associated with a high bacillary load and poor cellular immune response." | 1.56 | Lepromatous leprosy presenting with type II reaction before and type I reaction after treatment. ( Bidari-Zerehpoosh, F; Bizaval, Z; Mozafari, N; Niknejad, N; Robati, RM, 2020) |
| "Clofazimine (CLF) has been included as an essential component of MDT, which is the standard WHO regimen for treatment of leprosy." | 1.35 | Does clofazimine (B663) reach Mycobacterium leprae persisting in Schwann cells and endothelial cells of endoneurial blood vessels in peripheral nerves? ( Kumar, V, 2008) |
| " An autopsy study was done on a 45 year old female of lepromatous leprosy (LL) on MDT and long term high dosage of clofazimine." | 1.32 | Tissue concentration, systemic distribution and toxicity of clofazimine--an autopsy study. ( Deore, SS; Jadhav, MV; Joghi, NG; Joshi, NG; Patil, PG; Sathe, AG, 2004) |
| "Leprosy and vitiligo are common affections in the West Indies." | 1.31 | High prevalence of vitiligo in lepromatous leprosy. ( Boisseau-Garsaud, AM; Garsaud, P; Helenon, R; Quist, D; Saint-Cyr, I; Vezon, G, 2000) |
| "Clofazimine was assayed in the milk and plasma samples by HPTLC." | 1.30 | Excretion of clofazimine in human milk in leprosy patients. ( Girdhar, A; Girdhar, BK; Mathur, A; Venkatesan, K, 1997) |
| "Two cases of acute uveitis have been reported in reversal reactions in lepromatous patients treated with anti-hansenian multidrug therapy with daily rifampicin." | 1.28 | [Acute uveitis in reversal reactions]. ( Deplus, S; Flageul, B; Spindler, E, 1991) |
| " He received clofazimine (Lamprene) at a dosage of 100 mg twice daily." | 1.28 | Polychromatic corneal and conjunctival crystals secondary to clofazimine therapy in a leper. ( Font, RL; Matoba, A; Sobol, W, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (15.31) | 18.7374 |
| 1990's | 31 (31.63) | 18.2507 |
| 2000's | 22 (22.45) | 29.6817 |
| 2010's | 25 (25.51) | 24.3611 |
| 2020's | 5 (5.10) | 2.80 |
| Authors | Studies |
|---|---|
| Hanumanthu, V | 1 |
| Thakur, V | 1 |
| Narang, T | 3 |
| Dogra, S | 3 |
| Duran Merino, CE | 1 |
| Ortiz Úsuga, MC | 1 |
| Jaramillo, MJ | 1 |
| Rodríguez, AM | 1 |
| Robati, RM | 1 |
| Mozafari, N | 1 |
| Bidari-Zerehpoosh, F | 1 |
| Niknejad, N | 1 |
| Bizaval, Z | 1 |
| Ashraf, R | 1 |
| Kumaran, MS | 1 |
| Nery, JAC | 1 |
| Sales, AM | 1 |
| Hacker, MAVB | 1 |
| Moraes, MO | 1 |
| Maia, RC | 1 |
| Sarno, EN | 2 |
| Illarramendi, X | 1 |
| Fischer, M | 1 |
| Pretty, M | 1 |
| Bifi, J | 1 |
| Radhakrishnan, K | 1 |
| Hashba, H | 1 |
| Müller, A | 1 |
| Wolfsperger, F | 1 |
| Kofler, L | 1 |
| Yazdi, AS | 1 |
| Tirhazouine, I | 1 |
| Chiheb, S | 1 |
| Hali, F | 1 |
| Rifki, A | 1 |
| Benchikhi, H | 1 |
| Yang, S | 1 |
| Makredes, M | 1 |
| O'Donnell, P | 1 |
| Levin, NA | 1 |
| El Morabite, K | 1 |
| Tbatou, F | 1 |
| Ait Ourhroui, M | 1 |
| Senouci, K | 1 |
| Hassam, B | 1 |
| Preimesberger, J | 1 |
| Mirfazaelian, H | 1 |
| Eilami, O | 1 |
| Afzalimoghadam, M | 1 |
| Daneshbod, Y | 1 |
| Kline, L | 1 |
| Powers, R | 1 |
| Defazio, J | 1 |
| Fu, X | 1 |
| Liu, H | 1 |
| Zhang, F | 1 |
| Han, XY | 1 |
| Quintanilla, M | 1 |
| Sakia, UN | 1 |
| Kim, JS | 1 |
| Kwon, SH | 1 |
| Shin, JY | 1 |
| Ganesan, V | 1 |
| Mandal, J | 1 |
| Coelho de Sousa, V | 1 |
| Laureano, A | 1 |
| Cardoso, J | 1 |
| Ozturk, Z | 1 |
| Tatliparmak, A | 1 |
| Kumar, V | 1 |
| Ezzedine, K | 1 |
| Malvy, D | 1 |
| Beylot, C | 1 |
| Longy-Boursier, M | 1 |
| Van Veen, NH | 2 |
| Lockwood, DN | 2 |
| van Brakel, WH | 2 |
| Ramirez, J | 2 |
| Richardus, JH | 2 |
| Rodríguez, G | 1 |
| Pinto, R | 1 |
| López, F | 1 |
| Gómez, Y | 1 |
| Raftopoulos, SC | 1 |
| Fermoyle, S | 1 |
| Balagon, M | 1 |
| Saunderson, PR | 1 |
| Gelber, RH | 1 |
| Apte, G | 1 |
| Gedam, JR | 1 |
| Poojary, S | 1 |
| Nagpur, NG | 1 |
| Pai, VV | 2 |
| Ganapathi, R | 1 |
| Yuchua-Guillen, A | 1 |
| Dofitas, BL | 1 |
| Chakma, JK | 1 |
| Malaviya, GN | 2 |
| Girdhar, A | 3 |
| Hussein, S | 1 |
| Mahajan, N | 1 |
| Rao, S | 1 |
| Sobti, P | 1 |
| Khurana, N | 1 |
| Garg, VK | 1 |
| Jain, S | 1 |
| Adar, T | 1 |
| Tayer-Shifman, O | 1 |
| Mizrahi, M | 1 |
| Tavdi, S | 1 |
| Barak, O | 1 |
| Shalit, M | 1 |
| Gonçalves, Hde S | 1 |
| Pontes, MA | 1 |
| Bührer-Sékula, S | 1 |
| Cruz, R | 1 |
| Almeida, PC | 1 |
| Moraes, ME | 1 |
| Penna, GO | 1 |
| Massone, C | 1 |
| Clapasson, A | 1 |
| Nunzi, E | 1 |
| Kaur, I | 1 |
| Kumar, B | 1 |
| Agrawal, US | 1 |
| Saxena, A | 1 |
| Meena, RS | 1 |
| Saini, M | 1 |
| Saxena, V | 1 |
| BROWNE, SG | 1 |
| Schreuder, PA | 1 |
| Naafs, B | 3 |
| Alioua, Z | 1 |
| Sbai, M | 1 |
| Elhaouri, M | 1 |
| Bouzidi, A | 1 |
| Boudi, O | 1 |
| Ghfir, M | 1 |
| Benomar, S | 1 |
| Sedrati, OL | 1 |
| Norman, G | 1 |
| Joseph, G | 1 |
| Richard, J | 1 |
| Pais, AV | 1 |
| Pereira, S | 1 |
| Garg, I | 1 |
| Stephen, J | 1 |
| Antony, M | 1 |
| Inchara, YK | 1 |
| Katoch, K | 3 |
| Katoch, VM | 3 |
| Natrajan, M | 1 |
| Gupta, UD | 1 |
| Sharma, VD | 2 |
| Shivanavar, CT | 1 |
| Armour, KS | 1 |
| Scolyer, RA | 1 |
| Barnetson, RS | 1 |
| Goulart, IM | 1 |
| Reis, AC | 1 |
| De Rezende, TM | 1 |
| Borges, AS | 1 |
| Ferreira, MS | 1 |
| Nishioka, SA | 1 |
| Jadhav, MV | 1 |
| Sathe, AG | 1 |
| Deore, SS | 1 |
| Patil, PG | 1 |
| Joshi, NG | 1 |
| Joghi, NG | 1 |
| Meyer, M | 1 |
| Ingen-Housz-Oro, S | 1 |
| Ighilahriz, O | 1 |
| Wendling, J | 1 |
| Gaulier, A | 1 |
| Levy-Weil, F | 1 |
| Sigal-Grinberg, M | 1 |
| Flageul, B | 3 |
| Choudhri, SH | 1 |
| Harris, L | 1 |
| Butany, JW | 1 |
| Keystone, JS | 1 |
| Becker, D | 1 |
| Bräuninger, W | 1 |
| Chin-a-Lien, RA | 1 |
| Altes-Levy, HR | 1 |
| Ji, B | 2 |
| Perani, EG | 1 |
| Petinom, C | 1 |
| N'Deli, L | 1 |
| Grosset, JH | 1 |
| Mendis, S | 1 |
| Somasiri, KG | 1 |
| Chularatna, W | 1 |
| Oommen, ST | 1 |
| Natu, MV | 1 |
| Mahajan, MK | 1 |
| Kadyan, RS | 1 |
| Bhattacharya, SN | 1 |
| Chattopadhaya, D | 1 |
| Saha, K | 1 |
| Drowart, A | 1 |
| Chanteau, S | 1 |
| Huygen, K | 1 |
| De Cock, M | 1 |
| Cartel, JL | 1 |
| De Bruyn, J | 1 |
| Launois, P | 1 |
| Yernault, JC | 1 |
| Van Vooren, JP | 1 |
| Sampaio, EP | 1 |
| Malta, AM | 1 |
| Kaplan, G | 1 |
| Rao, PS | 1 |
| Ramachandran, A | 1 |
| Sekar, B | 1 |
| Ravi, S | 1 |
| Subramanian, M | 1 |
| Shetty, VP | 1 |
| Uplekar, MW | 1 |
| Antia, NH | 1 |
| de Carsalade, GY | 1 |
| Wallach, D | 1 |
| Spindler, E | 2 |
| Pennec, J | 1 |
| Cottenot, F | 1 |
| Venkatesan, K | 2 |
| Mathur, A | 1 |
| Girdhar, BK | 2 |
| Ganapati, R | 1 |
| Banerji, U | 1 |
| Thomas, J | 1 |
| Saha, B | 1 |
| Gálvez, J | 1 |
| López-Domínguez, JM | 1 |
| Navarro, A | 1 |
| Creagh, R | 1 |
| Casado, JL | 1 |
| Chinchón Lara, I | 1 |
| Moubasher, AD | 1 |
| Kamel, NA | 1 |
| Zedan, H | 1 |
| Raheem, DD | 1 |
| Fajardo, TT | 3 |
| Abalos, RM | 3 |
| dela Cruz, EC | 2 |
| Villahermosa, LG | 2 |
| Walsh, DS | 2 |
| Cellona, RV | 2 |
| Balagon, MV | 1 |
| Tan, EV | 1 |
| Walsh, GP | 2 |
| Veerasubramanian, P | 1 |
| Krishna, KK | 1 |
| Manandhar, R | 1 |
| LeMaster, JW | 1 |
| Roche, PW | 2 |
| Welsh, O | 1 |
| Gómez, M | 1 |
| Mancias, C | 1 |
| Ibarra-Leal, S | 1 |
| Millikan, LE | 1 |
| Boisseau-Garsaud, AM | 1 |
| Vezon, G | 1 |
| Helenon, R | 1 |
| Garsaud, P | 1 |
| Saint-Cyr, I | 1 |
| Quist, D | 1 |
| Shaw, IN | 1 |
| Ebenezer, G | 1 |
| Rao, GS | 1 |
| Natrajan, MM | 1 |
| Balasundaram, B | 1 |
| Baxt, RD | 1 |
| Ramos-e-Silva, M | 1 |
| Rebello, PF | 1 |
| Prince, JM | 1 |
| Janner, D | 1 |
| Malik, R | 1 |
| Hughes, MS | 1 |
| James, G | 1 |
| Martin, P | 1 |
| Wigney, DI | 1 |
| Canfield, PJ | 1 |
| Chen, SC | 1 |
| Mitchell, DH | 1 |
| Love, DN | 1 |
| Jamet, P | 1 |
| Traore, I | 1 |
| Husser, JA | 1 |
| Becx-Bleumink, M | 1 |
| Chauhan, SL | 1 |
| Britton, WJ | 1 |
| Neupane, KD | 1 |
| Failbus, SS | 1 |
| Cho, SN | 1 |
| Theuvenet, WJ | 1 |
| Deplus, S | 1 |
| Natarajan, M | 1 |
| Bagga, A | 1 |
| Job, CK | 1 |
| Yoder, L | 1 |
| Jacobson, RR | 1 |
| Hastings, RC | 1 |
| Thomas, A | 2 |
| Balakrishnan, A | 1 |
| Nagarajan, M | 2 |
| Prabhakar, R | 2 |
| Tripathy, SP | 1 |
| Christian, M | 2 |
| Somasundaram, PR | 2 |
| Li, W | 1 |
| Ye, G | 1 |
| Yang, Z | 1 |
| Tao, M | 1 |
| Luo, J | 1 |
| Wang, C | 1 |
| Ji, F | 1 |
| Kulkarni, V | 1 |
| Gharpuray, MB | 1 |
| Kulkarni, DS | 1 |
| Dixit, VB | 2 |
| Chaudhary, SD | 2 |
| Jain, VK | 2 |
| Douglas, JT | 1 |
| Hirsch, DS | 1 |
| de la Cruz, EC | 1 |
| Madarang, MG | 1 |
| de Wit, MY | 1 |
| Klatser, PR | 1 |
| Ramu, G | 1 |
| Ramanathan, U | 1 |
| Sengupta, U | 1 |
| Shivannavar, CT | 1 |
| Chatterjee, G | 1 |
| Kaur, S | 2 |
| Sharma, VK | 2 |
| Vaishnavi, C | 2 |
| Ganguly, NK | 2 |
| Pavithran, K | 1 |
| Font, RL | 1 |
| Sobol, W | 1 |
| Matoba, A | 1 |
| Li, HY | 1 |
| Yu, XL | 1 |
| Zhang, MS | 1 |
| Duan, CX | 1 |
| Huang, WB | 1 |
| Zhang, SB | 1 |
| Zhu, K | 1 |
| Ma, JF | 1 |
| Ekambaram, V | 1 |
| Rao, MK | 1 |
| Chandrasekaran, V | 1 |
| Hari, L | 1 |
| Kumar, A | 1 |
| Bhatia, VN | 1 |
| Roy, RG | 1 |
| Ellard, GA | 1 |
| Pannikar, VK | 1 |
| Jesudasan, K | 1 |
| Kaur, H | 1 |
| Sen, R | 1 |
| Chaudhury, S | 1 |
| Hazra, S | 1 |
| Podder, GC | 1 |
| Poddar, S | 1 |
| Sarkar, S | 1 |
| Das, PK | 1 |
| Chaudhury, SN | 1 |
| Majumder, V | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study to Evaluate the Efficacy and Safety of Apremilast in Patients of Chronic and Recurrent Erythema Nodosum Leprosum[NCT04822909] | Phase 4 | 10 participants (Actual) | Interventional | 2019-09-15 | Completed | ||
| Independent Study to Establish the Efficacy of the Six Doses Uniform MDT Regimen (U-MDT) for Leprosy Patients[NCT00669643] | Phase 4 | 859 participants (Actual) | Interventional | 2007-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 reviews available for clofazimine and Leprosy, Cutaneous
| Article | Year |
|---|---|
Chronic Unilateral Uveitis as a Manifestation of Leprosy: A Case Report and Literature Review.
Topics: Aged; Atrophy; Biopsy; Chronic Disease; Clofazimine; Dapsone; Drug Therapy, Combination; Eye Infecti | 2021 |
Leprosy - an overview of clinical features, diagnosis, and treatment.
Topics: Adult; Aged; Child; Clofazimine; Cross-Sectional Studies; Dapsone; Disease Progression; Drug Adminis | 2017 |
Leprosy treatment during pregnancy and breastfeeding: A case report and brief review of literature.
Topics: Adult; Breast Feeding; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Leprostatic | 2017 |
Interventions for erythema nodosum leprosum.
Topics: Aspirin; Clofazimine; Erythema Nodosum; Humans; Leprostatic Agents; Leprosy, Lepromatous; Prednisolo | 2009 |
Interventions for erythema nodosum leprosum. A Cochrane review.
Topics: Aspirin; Clofazimine; Erythema Nodosum; Humans; Leprostatic Agents; Leprosy, Lepromatous; Prednisolo | 2009 |
Anaplastic large cell lymphoma and lepromatous leprosy: a rare coexistence.
Topics: Adult; Cell Nucleus Shape; Clofazimine; Histiocytes; Humans; Immunohistochemistry; Ki-1 Antigen; Lep | 2012 |
[Histoid leprosy with erythema nodosum leprosum].
Topics: Adult; Clofazimine; Dapsone; Erythema Nodosum; Fluoroquinolones; Histiocytes; Humans; Leprostatic Ag | 2003 |
Intra-abdominal, crystal-storing histiocytosis due to clofazimine in a patient with lepromatous leprosy and concurrent carcinoma of the colon.
Topics: Abdominal Pain; Adenocarcinoma; Adult; Clofazimine; Colonic Neoplasms; Crystallization; Female; Hist | 2004 |
Bangkok Workshop on Leprosy Research. Treatment of reactions and nerve damage.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Clofazimine; Cyclosporine; Drug A | 1996 |
Leprosy. Recognition and treatment.
Topics: Adolescent; Adult; Age Factors; Biopsy; Child; Clinical Trials as Topic; Clofazimine; Dapsone; Diagn | 2001 |
Relapses among leprosy patients treated with multidrug therapy: experience in the leprosy control program of the All Africa Leprosy and Rehabilitation Training Center (ALERT) in Ethiopia; practical difficulties with diagnosing relapses; operational proced
Topics: Clofazimine; Dapsone; Epidemiologic Methods; Ethiopia; Humans; Incidence; Leprostatic Agents; Lepros | 1992 |
13 trials available for clofazimine and Leprosy, Cutaneous
| Article | Year |
|---|---|
Comparison of the efficacy and safety of minocycline and clofazimine in chronic and recurrent erythema nodosum leprosum-A randomized clinical trial.
Topics: Clofazimine; Erythema Nodosum; Humans; Leprostatic Agents; Leprosy, Lepromatous; Minocycline; Prospe | 2021 |
Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects.
Topics: Adolescent; Adult; Aged; Child; Clofazimine; Dapsone; Drug Therapy, Combination; Humans; Leprostatic | 2012 |
Relapses in multibacillary patients treated with multi-drug therapy until smear negativity: findings after twenty years.
Topics: Acedapsone; Aged; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Follow-Up Studies; Humans | 2004 |
10-12 years follow-up of highly bacillated BL/LL leprosy patients on combined chemotherapy and immunotherapy.
Topics: Adenosine Triphosphate; Adolescent; Adult; Animals; BCG Vaccine; Biological Assay; Clofazimine; Comb | 2004 |
Clinical trial of ofloxacin alone and in combination with dapsone plus clofazimine for treatment of lepromatous leprosy.
Topics: Adolescent; Adult; Animals; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Foot; Humans; L | 1994 |
Effect of rhuIFN-gamma treatment in multibacillary leprosy patients.
Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Erythema Nodosum; Humans; Interferon-gamma; Leprost | 1996 |
Ofloxacin-containing combined drug regimens in the treatment of lepromatous leprosy.
Topics: Adult; Animals; Anti-Infective Agents; Biopsy, Needle; Clofazimine; Dapsone; Drug Therapy, Combinati | 1994 |
Daily multidrug therapy for leprosy; results of a fourteen-year experience.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Clofazimine; Dapsone; Drug Resistance, Microbial; | 1997 |
A multicenter study of recombinant interferon-alpha 2b in the treatment of multibacillary leprosy.
Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Erythema; Humans; Interferon Type I; Lepromin; Lepr | 1997 |
Cytokines in leprosy, II. Effect of treatment on serum cytokines in leprosy.
Topics: Adrenal Cortex Hormones; Clofazimine; Cytokines; Drug Therapy, Combination; Female; Follow-Up Studie | 1998 |
Short-term trial of clofazimine in previously untreated lepromatous leprosy.
Topics: Adolescent; Adult; Animals; Clofazimine; Drug Tolerance; Female; Humans; Leprosy, Lepromatous; Male; | 1992 |
Controlled clinical trial of two multidrug regimens with and without rifampin in highly bacilliferous BL/LL south Indian patients: a five-year report.
Topics: Adolescent; Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Infant, Newborn; | 1990 |
A double-blind controlled clinical trial to assess the role of anti-histamines in the treatment of multi-bacillary leprosy.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Clofazimine; Dapsone; Double-Blind Method; Drug T | 1988 |
74 other studies available for clofazimine and Leprosy, Cutaneous
| Article | Year |
|---|---|
Lepromatous leprosy presenting with type II reaction before and type I reaction after treatment.
Topics: Clofazimine; Dapsone; Disease Progression; Drug Therapy, Combination; Erythema Nodosum; Humans; Lepr | 2020 |
Lepromatous Leprosy with Crusted Scabies.
Topics: Adult; Animals; Clofazimine; Humans; Insecticides; Ivermectin; Leprostatic Agents; Leprosy, Lepromat | 2020 |
Low rate of relapse after twelve-dose multidrug therapy for hansen's disease: A 20-year cohort study in a brazilian reference center.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Brazil; Child; Child, Preschool; Clofazimine; Dapsone; D | 2021 |
Systemic nocardiosis in a lepromatous leprosy patient with type 2 reaction.
Topics: Adrenal Cortex Hormones; Adult; Azathioprine; Biopsy, Needle; Clofazimine; Drug Therapy, Combination | 2018 |
Multiple livid-erythematous macules and plaques with slight scaling in a young man.
Topics: Clofazimine; Dapsone; Drug Administration Schedule; Drug Therapy, Combination; Erythema; Humans; Lep | 2018 |
[Histoid leprosy].
Topics: Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Granuloma; Guinea; Histiocytes; Humans; Lepr | 2013 |
A case of Hansen Disease presenting as tinea versicolor.
Topics: Clofazimine; Contraindications; Dapsone; Delayed Diagnosis; Diagnostic Errors; Humans; Hypesthesia; | 2013 |
[Borderline lepromatous leprosy].
Topics: Adult; Biopsy; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Leprosy, Borderline; | 2014 |
[A 26-year old with multiple plaques on face, torso, and extremities].
Topics: Adult; Clofazimine; Drug Therapy, Combination; Humans; Leg Dermatoses; Leprostatic Agents; Leprosy, | 2014 |
A man with facial changes.
Topics: Clofazimine; Dapsone; Facies; Humans; Leprostatic Agents; Leprosy, Lepromatous; Male; Mycobacterium | 2014 |
What is your diagnosis? Lepromatous leprosy.
Topics: Adult; Clofazimine; Diagnosis, Differential; Drug Therapy, Combination; Glucocorticoids; Humans; Lep | 2015 |
Borderline Lepromatous Leprosy with Type 1 (Reversal) Reactions in a Chinese Man.
Topics: Clofazimine; Dapsone; Humans; Leprostatic Agents; Leprosy, Borderline; Leprosy, Lepromatous; Male; M | 2015 |
Diffuse Lepromatous Leprosy Due to Mycobacterium lepromatosis in Quintana Roo, Mexico.
Topics: Adult; Base Sequence; Clofazimine; Dapsone; DNA, Bacterial; Drug Combinations; Female; Humans; Lepro | 2015 |
Persistent serpentine supravenous hyperpigmented eruption in lepromatous leprosy after minocycline.
Topics: Adult; Anti-Bacterial Agents; Clofazimine; Humans; Hyperpigmentation; Leprostatic Agents; Leprosy, L | 2015 |
Leproma Presenting as a Nasal Cavity Mass.
Topics: Biopsy; Clofazimine; Dapsone; Diagnosis, Differential; Endoscopy; Female; Follow-Up Studies; Humans; | 2015 |
Primary oral tuberculosis in a patient with lepromatous leprosy: Diagnostic dilemma.
Topics: Anti-Inflammatory Agents; Clofazimine; Coinfection; Female; Humans; Leprostatic Agents; Leprosy, Lep | 2016 |
Wade histoid leprosy revisited.
Topics: Adolescent; Clofazimine; Dapsone; Drug Therapy, Combination; Humans; Leprostatic Agents; Leprosy, Le | 2016 |
Does clofazimine (B663) reach Mycobacterium leprae persisting in Schwann cells and endothelial cells of endoneurial blood vessels in peripheral nerves?
Topics: Adult; Antitubercular Agents; Clofazimine; Drug Therapy, Combination; Endothelial Cells; Humans; Lep | 2008 |
Autochthonous leprosy in metropolitan France presenting with a diffuse infiltration of the face and febrile illness.
Topics: Biopsy, Needle; Clofazimine; Dapsone; Diagnosis, Differential; Drug Therapy, Combination; Facial Der | 2009 |
[Persistent type 2 lepra reaction (erythema nodosum) and clofazimine-induced lethal enteropathy].
Topics: Abdominal Pain; Adult; Arthritis, Rheumatoid; Child; Child, Preschool; Clofazimine; Constipation; Di | 2009 |
An unusual cause of small-intestine mucosal pigmentation.
Topics: Adult; Clofazimine; Duodenal Diseases; Endoscopy, Digestive System; Erythema Nodosum; Humans; Lepros | 2011 |
Does clofazimine prevent erythema nodosum leprosum (ENL) in leprosy? A retrospective study, comparing the experience of multibacillary patients receiving either 12 or 24 months WHO-MDT.
Topics: Adolescent; Adult; Age Distribution; Aged; Child; Clofazimine; Drug Therapy, Combination; Erythema N | 2011 |
Chromoblastomycosis in a case of borderline lepromatous leprosy with recurrent type II lepra reaction.
Topics: Antifungal Agents; Biopsy; Chromoblastomycosis; Cladosporium; Clofazimine; Humans; Itraconazole; Lep | 2011 |
Atypical Hansen's disease presenting as florid verrucous plaques on the lower extremities: a case report.
Topics: Biopsy; Clofazimine; Dapsone; Drug Therapy, Combination; Erythema Nodosum; Glucocorticoids; Humans; | 2012 |
Florid reactive periostitis ossificans of long bones and digits associated with reaction in a patient with leprosy.
Topics: Adolescent; Clofazimine; Dapsone; Erythema Nodosum; Humans; Leprostatic Agents; Leprosy, Lepromatous | 2012 |
Dapsone induced eosinophilic pneumonia.
Topics: Aged; Biopsy; Clofazimine; Dapsone; Humans; Leprostatic Agents; Leprosy, Lepromatous; Male; Pulmonar | 2012 |
Borderline lepromatous leprosy in an Italian man.
Topics: Aged; Clofazimine; Humans; Leprosy, Borderline; Leprosy, Lepromatous; Male; Minocycline; Mycobacteri | 2013 |
Bullous reaction in leprosy: a rare phenomenon.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Blister; Clofazimine; Cloxacillin; Humans; India; Le | 2002 |
Hansen's disease mimicking palmoplantar keratoderma.
Topics: Child; Clofazimine; Dapsone; Diagnosis, Differential; Drug Therapy, Combination; Humans; Keratoderma | 2002 |
'B 663' POSSIBLE ANTI-INFLAMMATORY ACTION IN LEPROMATOUS LEPROSY.
Topics: Anti-Inflammatory Agents; Antitubercular Agents; Clofazimine; Drug Resistance; Drug Resistance, Micr | 1965 |
Chronic recurrent ENL, steroid dependent: long-term treatment with high dose clofazimine.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Clofazimine; Dose-Response Relationship, D | 2003 |
Borderline lepromatous leprosy presenting as a single cutaneous plaque.
Topics: Administration, Oral; Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Forearm; Glucocorticoi | 2005 |
Aplastic anaemia associated with multidrug therapy (dapsone, rifampicin and clofazimine) in a patient with lepromatous leprosy.
Topics: Adult; Anemia, Aplastic; Brazil; Clofazimine; Dapsone; Disease Progression; Drug Therapy, Combinatio | 2005 |
Tissue concentration, systemic distribution and toxicity of clofazimine--an autopsy study.
Topics: Autopsy; Clofazimine; Fatal Outcome; Female; Humans; Leprostatic Agents; Leprosy, Lepromatous; Middl | 2004 |
[Polyarthritis and papular eruption revealing leprosy].
Topics: Administration, Oral; Adrenal Cortex Hormones; Adult; Arthritis; Biopsy; Clofazimine; Dapsone; Drug | 2008 |
Clofazimine induced cardiotoxicity--a case report.
Topics: Aged; Arrhythmias, Cardiac; Clofazimine; Erythema Nodosum; Humans; Leprosy, Lepromatous; Male | 1995 |
[Clinical aspects and therapy of early lepromatous leprosy with a case example].
Topics: Adult; Biopsy; Clofazimine; Diagnosis, Differential; Dose-Response Relationship, Drug; Drug Therapy, | 1994 |
Midborderline (BB)-borderline lepromatous (BL) leprosy with reversal reaction (RR).
Topics: Aged; Biopsy; Clofazimine; Cyclosporine; Dapsone; Diabetes Complications; Humans; Leprosy, Lepromato | 1994 |
Effect of drug treatment on electroneurological measures of peripheral nerve function in leprosy patients.
Topics: Adolescent; Adult; Aged; Child; Clofazimine; Dapsone; Drug Therapy, Combination; Electrophysiology; | 1993 |
Lymphangiographic evaluation of patients with clinical lepromatous leprosy on clofazimine.
Topics: Adolescent; Adult; Clofazimine; Humans; Leprosy, Lepromatous; Lymphedema; Lymphography; Middle Aged | 1994 |
Tumor necrosis factor: status in reactions in leprosy before and after treatment.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Chloroquine; Clofazimine; Eryt | 1993 |
Effects of chemotherapy on antibody levels directed against PGL-I and 85A and 85B protein antigens in lepromatous patients.
Topics: Antibodies, Bacterial; Antigens, Bacterial; Clofazimine; Dapsone; Drug Therapy, Combination; Glycoli | 1993 |
Primary resistance to single and multiple drugs in leprosy--a mouse footpad study.
Topics: Adult; Animals; Armadillos; Clofazimine; Dapsone; Drug Resistance, Microbial; Female; Humans; Lepros | 1996 |
Excretion of clofazimine in human milk in leprosy patients.
Topics: Adult; Chromatography, High Pressure Liquid; Clofazimine; Female; Humans; Leprostatic Agents; Lepros | 1997 |
[Patient with Hansen disease and lepromatous reaction with predominant neural involvement].
Topics: Biopsy; Clofazimine; Dapsone; Erythema Nodosum; Humans; Leprostatic Agents; Leprosy, Lepromatous; Ma | 1998 |
Clofazimine therapy for lepromatous leprosy: a historical perspective.
Topics: Adult; Clofazimine; History, 20th Century; Humans; Leprostatic Agents; Leprosy, Lepromatous; Male; M | 1999 |
Resolution of lepromatous leprosy after a short course of amoxicillin/clavulanic acid, followed by ofloxacin and clofazimine.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Clavulanic Acid; Clofazimine; Drug Therapy, Combination; | 1999 |
Histoid leprosy; report of three cases.
Topics: Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Leprostatic Agents; Leprosy, | 1999 |
Risk factors for erythema nodosum leprosum.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Child; Child, Preschool; Clofazimine; Cohor | 1999 |
A new therapeutic approach to type II leprosy reaction.
Topics: Adult; Aged; Clofazimine; Drug Therapy, Combination; Erythema Nodosum; Female; Humans; Leprostatic A | 1999 |
High prevalence of vitiligo in lepromatous leprosy.
Topics: Adult; Aged; Aged, 80 and over; Clofazimine; Dapsone; Female; Humans; Leprostatic Agents; Leprosy, L | 2000 |
Relapse as histoid leprosy after receiving multidrug therapy (MDT); a report of three cases.
Topics: Acedapsone; Adolescent; Adult; Animals; Child; Clofazimine; Dapsone; Drug Resistance, Microbial; Dru | 2000 |
Lepromatous leprosy with drug reaction.
Topics: Clofazimine; Dapsone; Drug Eruptions; Drug Therapy, Combination; Humans; Leprostatic Agents; Leprosy | 2000 |
Nodular rash in an Indonesian girl.
Topics: Adolescent; Clofazimine; Dapsone; Diagnosis, Differential; Drug Therapy, Combination; Female; Humans | 2001 |
Feline leprosy: two different clinical syndromes.
Topics: Animals; Cat Diseases; Cats; Clarithromycin; Clofazimine; Female; Leprostatic Agents; Leprosy, Lepro | 2002 |
Red discoloration of the sputum by clofazimine simulating haemoptysis--a case report.
Topics: Adolescent; Clofazimine; Diagnostic Errors; Erythema Nodosum; Hemoptysis; Humans; Leprosy, Lepromato | 1992 |
The response to chemotherapy of serum Mycobacterium leprae-specific antigen in multibacillary leprosy patients.
Topics: Antibodies, Bacterial; Antigens, Bacterial; Carbohydrate Sequence; Clofazimine; Dapsone; Drug Therap | 1991 |
[Acute uveitis in reversal reactions].
Topics: Acute Disease; Clofazimine; Drug Combinations; Ethionamide; Female; Humans; Leprosy, Lepromatous; Ma | 1991 |
Clinical and bacteriological progress of highly bacillated BL-LL patients discontinuing treatment after different periods of MDT.
Topics: Adolescent; Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Humans; Leprosy, Borderline; Lep | 1991 |
Skin pigmentation from clofazimine therapy in leprosy patients: a reappraisal.
Topics: Aged; Aged, 80 and over; Clofazimine; Drug Eruptions; Female; Humans; Leprosy, Lepromatous; Male; Ne | 1990 |
Effect of three-year multidrug therapy in multibacillary leprosy patients.
Topics: Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Leprosy; Leprosy, Borderline | 1990 |
Multiple cold abscesses in a borderline lepromatous patient on multidrug therapy.
Topics: Abscess; Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Ethambutol; Hip Joint; Humans; Ison | 1989 |
Clofazimine induced nail changes.
Topics: Clofazimine; Humans; Leprosy, Lepromatous; Nail Diseases; Skin Diseases | 1989 |
Evaluation of Mycobacterium leprae antigens in the serological monitoring of a clofazimine-based chemotherapeutic study of dapsone resistant lepromatous leprosy patients in Cebu, Philippines.
Topics: Adult; Antigens, Bacterial; Clofazimine; Colony Count, Microbial; Dapsone; Drug Resistance, Microbia | 1989 |
Results of a modified WHO regimen in highly bacilliferous BL/LL patients.
Topics: Adenosine Triphosphate; Adolescent; Adult; Animals; Clofazimine; Dapsone; Drug Therapy, Combination; | 1989 |
Bacillaemia in leprosy and effect of multidrug therapy.
Topics: Adolescent; Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Leprosy; Leprosy | 1989 |
Vitiligo following type II lepra reaction.
Topics: Autoimmune Diseases; Clofazimine; Dapsone; Drug Therapy, Combination; Follow-Up Studies; Humans; Lep | 1989 |
Polychromatic corneal and conjunctival crystals secondary to clofazimine therapy in a leper.
Topics: Aged; Biopsy; Clofazimine; Conjunctiva; Conjunctival Diseases; Corneal Opacity; Crystallization; Hum | 1989 |
Short-term multidrug therapy in multibacillary leprosy--review of 80 cases in two provinces of China (1983-1988).
Topics: Adult; China; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Leprostatic Agents; L | 1989 |
Changing picture of leprosy in North Arcot District, Tamil Nadu after M.D.T.
Topics: Clofazimine; Cohort Studies; Dapsone; Drug Therapy, Combination; Follow-Up Studies; Humans; India; L | 1989 |
Clofazimine and dapsone compliance in leprosy.
Topics: Clofazimine; Dapsone; Humans; Leprosy, Lepromatous; Patient Compliance; Pilot Projects; Rifampin; Se | 1988 |
Effect of multidrug therapy on the levels of antibodies to Mycobacterium leprae glycolipid-1 in the leprosy spectrum.
Topics: Antibodies, Bacterial; Antigens, Bacterial; Clofazimine; Dapsone; Drug Therapy, Combination; Glycoli | 1988 |
Leukemoid reaction in erythema nodosum leprosum in a leprosy patient.
Topics: Adult; Clofazimine; Erythema Nodosum; Ferritins; Humans; Leprosy, Lepromatous; Leukemoid Reaction; M | 1988 |
New multidrug regimen with indigenous drugs and dapsone in the treatment of lepromatous leprosy (preliminary report).
Topics: Animals; Anti-Infective Agents; Clofazimine; Dapsone; Drug Therapy, Combination; Fatty Acids; Humans | 1987 |