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clofazimine and Leprosy, Borderline

clofazimine has been researched along with Leprosy, Borderline in 44 studies

Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.

Leprosy, Borderline: A form of LEPROSY in which there are clinical manifestations of both principal types (lepromatous and tuberculoid). The disease may shift toward one of these two polar or principal forms.

Research Excerpts

ExcerptRelevanceReference
"A study was undertaken with the aim of testing the usefulness of clofazimine as a prophylactic agent against neuritis and nerve damage."9.08Does clofazimine have a prophylactic role against neuritis? ( Arunthathi, S; Satheesh, KK, 1997)
"A study was undertaken with the aim of testing the usefulness of clofazimine as a prophylactic agent against neuritis and nerve damage."5.08Does clofazimine have a prophylactic role against neuritis? ( Arunthathi, S; Satheesh, KK, 1997)
"The feasibility and effects of a 3-year treatment using rifampicin (RFP), clofazimine (B663) and dapsone (DDS) in multibacillary leprosy patients in Yangzhou Prefecture and Dongtai County (1983-1986) are reported."3.68Effect of three-year multidrug therapy in multibacillary leprosy patients. ( Ji, F; Li, W; Luo, J; Tao, M; Wang, C; Yang, Z; Ye, G, 1990)
"No confirmed relapse has been observed within a follow-up period of 6 months to 7 years and 3 months [59 person-years at risk (PYR)] for TT/BT patients and of 4 months to 5 years and 10 months (100 PYR) for BB/BL/LL patients."2.68Daily multidrug therapy for leprosy; results of a fourteen-year experience. ( Cottenot, F; de Carsalade, GY; Flageul, B; Pennec, J; Spindler, E; Wallach, D, 1997)
"Current treatment of leprosy involves use of 3 drugs: rifampicin (rifampin); clofazimine; and dapsone."2.41Leprosy. Recognition and treatment. ( Ramos-e-Silva, M; Rebello, PF, 2001)
"Treatment with prednisolone (60 mg/d) along with WHO MDT-MB continued."1.39Optic nerve involvement in a borderline lepromatous leprosy patient on multidrug therapy. ( Abhinav, C; Chander, B; Chauhan, PS; Khatri, G; Mahajan, VK; Mehta, KS; Prabha, N; Sharma, SK; Sharma, V; Tuli, R, 2013)
"Clofazimine is an important and effective constituent of multi drug therapy for leprosy."1.30Excretion of clofazimine in human milk in leprosy patients. ( Girdhar, A; Girdhar, BK; Mathur, A; Venkatesan, K, 1997)

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-19906 (13.64)18.7374
1990's16 (36.36)18.2507
2000's11 (25.00)29.6817
2010's10 (22.73)24.3611
2020's1 (2.27)2.80

Authors

AuthorsStudies
Chew, R1
Woods, ML1
Fischer, M1
Yang, S1
Makredes, M1
O'Donnell, P1
Levin, NA1
Khardenavis, S1
Deshpande, A1
El Morabite, K1
Tbatou, F1
Ait Ourhroui, M1
Senouci, K1
Hassam, B1
Prabha, N1
Mahajan, VK1
Sharma, SK1
Sharma, V1
Chauhan, PS1
Mehta, KS1
Abhinav, C1
Khatri, G1
Chander, B1
Tuli, R1
Fu, X1
Liu, H1
Zhang, F1
Asz-Sigall, D1
López-García, L1
Neme-Yunes, Y1
Yuen-Palos, R1
Vega-Memije, ME1
Arenas, R1
Manifold, R1
Marshman, G1
Marzano, AV1
Tosi, D1
Cusini, M1
Nunzi, E2
Massone, C2
Crosti, C1
Aftab, H1
Nielsen, SD1
Nielsen, SL1
Due, E1
Bygbjerg, IC1
Thybo, S1
Apte, G1
Gedam, JR1
Poojary, S1
Nagpur, NG1
Pai, VV1
Ganapathi, R1
Clapasson, A1
Armour, KS1
Scolyer, RA1
Barnetson, RS1
Miladi, MI1
Feki, I1
Bahloul, Z1
Jlidi, R1
Mhiri, C1
Al-Raqum, HA1
Uppal, SS1
El Abdalghani, RA1
Lasheen, I1
Arora, SK1
Meyer, M1
Ingen-Housz-Oro, S1
Ighilahriz, O1
Wendling, J1
Gaulier, A1
Levy-Weil, F1
Sigal-Grinberg, M1
Flageul, B2
Mendis, S1
Somasiri, KG1
Chularatna, W1
Tyagi, PY1
Oommen, T1
Bhattacharya, SN2
Chattopadhaya, D1
Saha, K1
Sampaio, EP1
Malta, AM1
Sarno, EN1
Kaplan, G1
de Carsalade, GY2
Wallach, D1
Spindler, E1
Pennec, J1
Cottenot, F1
Pavithran, K1
Satish, TC1
Arunthathi, S1
Satheesh, KK1
Venkatesan, K1
Mathur, A1
Girdhar, A1
Girdhar, BK1
Moubasher, AD1
Kamel, NA1
Zedan, H1
Raheem, DD1
Young, RJ1
Gilson, RT1
Elston, DM1
Bourée, P1
de Brette, A1
Ramos-e-Silva, M1
Rebello, PF1
Siccoli, M1
Bassetti, C1
Becx-Bleumink, M1
Frankel, RI1
Mita, RT1
Kim, R1
Dann, FJ1
Roche, PW1
Britton, WJ1
Neupane, KD1
Failbus, SS1
Cho, SN1
Theuvenet, WJ1
Katoch, K2
Natarajan, M1
Bagga, A1
Katoch, VM2
Thomas, A1
Balakrishnan, A1
Nagarajan, M1
Prabhakar, R1
Tripathy, SP1
Christian, M1
Somasundaram, PR1
Sehgal, VN1
Sharma, VK2
Mathur, RP1
Li, W1
Ye, G1
Yang, Z1
Tao, M1
Luo, J1
Wang, C1
Ji, F1
Kulkarni, V1
Gharpuray, MB1
Kulkarni, DS1
Ramu, G1
Ramanathan, U1
Sengupta, U1
Sharma, VD1
Shivannavar, CT1
Chatterjee, G1
Kaur, S1
Vaishnavi, C1
Ganguly, NK1
Rabinowitz, LG1
Yuengel, C1
Honig, PJ1
Solomon, AR1
Li, HY1
Yu, XL1
Zhang, MS1
Duan, CX1
Huang, WB1
Zhang, SB1
Zhu, K1
Ma, JF1
Ekambaram, V1
Rao, MK1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Independent Study to Establish the Efficacy of the Six Doses Uniform MDT Regimen (U-MDT) for Leprosy Patients[NCT00669643]Phase 4859 participants (Actual)Interventional2007-02-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for clofazimine and Leprosy, Borderline

ArticleYear
Leprosy - an overview of clinical features, diagnosis, and treatment.
    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2017, Volume: 15, Issue:8

    Topics: Adult; Aged; Child; Clofazimine; Cross-Sectional Studies; Dapsone; Disease Progression; Drug Adminis

2017
Leprosy. Recognition and treatment.
    American journal of clinical dermatology, 2001, Volume: 2, Issue:4

    Topics: Adolescent; Adult; Age Factors; Biopsy; Child; Clinical Trials as Topic; Clofazimine; Dapsone; Diagn

2001
Relapses among leprosy patients treated with multidrug therapy: experience in the leprosy control program of the All Africa Leprosy and Rehabilitation Training Center (ALERT) in Ethiopia; practical difficulties with diagnosing relapses; operational proced
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1992, Volume: 60, Issue:3

    Topics: Clofazimine; Dapsone; Epidemiologic Methods; Ethiopia; Humans; Incidence; Leprostatic Agents; Lepros

1992

Trials

5 trials available for clofazimine and Leprosy, Borderline

ArticleYear
Effect of rhuIFN-gamma treatment in multibacillary leprosy patients.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1996, Volume: 64, Issue:3

    Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Erythema Nodosum; Humans; Interferon-gamma; Leprost

1996
Daily multidrug therapy for leprosy; results of a fourteen-year experience.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1997, Volume: 65, Issue:1

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Clofazimine; Dapsone; Drug Resistance, Microbial;

1997
Does clofazimine have a prophylactic role against neuritis?
    Leprosy review, 1997, Volume: 68, Issue:3

    Topics: Adolescent; Adult; Case-Control Studies; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Hu

1997
Cytokines in leprosy, II. Effect of treatment on serum cytokines in leprosy.
    International journal of dermatology, 1998, Volume: 37, Issue:10

    Topics: Adrenal Cortex Hormones; Clofazimine; Cytokines; Drug Therapy, Combination; Female; Follow-Up Studie

1998
Controlled clinical trial of two multidrug regimens with and without rifampin in highly bacilliferous BL/LL south Indian patients: a five-year report.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1990, Volume: 58, Issue:2

    Topics: Adolescent; Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Infant, Newborn;

1990

Other Studies

36 other studies available for clofazimine and Leprosy, Borderline

ArticleYear
Multibacillary Mid-Borderline Leprosy with Type 1 Lepra Reaction and Concurrent Latent Tuberculosis.
    The American journal of tropical medicine and hygiene, 2021, 10-25, Volume: 106, Issue:2

    Topics: Abattoirs; Anti-Inflammatory Agents; Antitubercular Agents; Clofazimine; Dapsone; Diagnosis, Differe

2021
A case of Hansen Disease presenting as tinea versicolor.
    Dermatology online journal, 2013, Apr-15, Volume: 19, Issue:4

    Topics: Clofazimine; Contraindications; Dapsone; Delayed Diagnosis; Diagnostic Errors; Humans; Hypesthesia;

2013
Borderline tuberculoid leprosy with type 1/reversal reaction.
    BMJ case reports, 2014, Jan-30, Volume: 2014

    Topics: Clofazimine; Facial Nerve Diseases; Facial Paralysis; Humans; Hyperpigmentation; Leprostatic Agents;

2014
[Borderline lepromatous leprosy].
    Presse medicale (Paris, France : 1983), 2014, Volume: 43, Issue:6 Pt 1

    Topics: Adult; Biopsy; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Leprosy, Borderline;

2014
Optic nerve involvement in a borderline lepromatous leprosy patient on multidrug therapy.
    Leprosy review, 2013, Volume: 84, Issue:4

    Topics: Anti-Inflammatory Agents; Clofazimine; Dapsone; Drug Therapy, Combination; Humans; India; Leprostati

2013
Borderline Lepromatous Leprosy with Type 1 (Reversal) Reactions in a Chinese Man.
    The American journal of tropical medicine and hygiene, 2015, Volume: 93, Issue:2

    Topics: Clofazimine; Dapsone; Humans; Leprostatic Agents; Leprosy, Borderline; Leprosy, Lepromatous; Male; M

2015
Type I reaction in a borderline leprosy case successfully treated with multidrug therapy and ofloxacin.
    International journal of dermatology, 2008, Volume: 47, Issue:10

    Topics: Anti-Bacterial Agents; Clofazimine; Dapsone; Drug Therapy, Combination; Glucocorticoids; Humans; Lep

2008
Leprosy: not always an easy diagnosis and often a management challenge.
    The Australasian journal of dermatology, 2009, Volume: 50, Issue:1

    Topics: Adult; Aged, 80 and over; Arm; Back; Clofazimine; Dapsone; Diagnosis, Differential; Drug Hypersensit

2009
Facial reversal reaction: a dermatological emergency.
    The Journal of dermatology, 2012, Volume: 39, Issue:2

    Topics: Adult; Antigens, CD; Antigens, Differentiation, Myelomonocytic; B-Lymphocytes; CD3 Complex; Clofazim

2012
A case of leprosy mistaken for cutaneous sarcoidosis.
    Acta dermato-venereologica, 2012, Volume: 92, Issue:2

    Topics: Adult; Clofazimine; Dapsone; Diagnostic Errors; Drug Therapy, Combination; Female; Humans; Leprostat

2012
Chromoblastomycosis in a case of borderline lepromatous leprosy with recurrent type II lepra reaction.
    Leprosy review, 2011, Volume: 82, Issue:3

    Topics: Antifungal Agents; Biopsy; Chromoblastomycosis; Cladosporium; Clofazimine; Humans; Itraconazole; Lep

2011
Borderline lepromatous leprosy in an Italian man.
    The American journal of tropical medicine and hygiene, 2013, Volume: 88, Issue:2

    Topics: Aged; Clofazimine; Humans; Leprosy, Borderline; Leprosy, Lepromatous; Male; Minocycline; Mycobacteri

2013
Borderline lepromatous leprosy presenting as a single cutaneous plaque.
    The Australasian journal of dermatology, 2005, Volume: 46, Issue:3

    Topics: Administration, Oral; Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Forearm; Glucocorticoi

2005
Chronic inflammatory joint disease revealing borderline leprosy.
    Joint bone spine, 2006, Volume: 73, Issue:3

    Topics: Adult; Arthritis; Chronic Disease; Clofazimine; Dapsone; Diagnosis, Differential; Drug Therapy, Comb

2006
First report of leprosy presenting as acute polyarthritis in the setting of type I downgrading lepra reaction.
    Clinical rheumatology, 2006, Volume: 25, Issue:1

    Topics: Acute Disease; Adult; Arthritis; Clofazimine; Dapsone; Diagnosis, Differential; Drug Therapy, Combin

2006
Leprosy in a preschool child--a case report.
    Journal of the Indian Medical Association, 2007, Volume: 105, Issue:3

    Topics: Child, Preschool; Clofazimine; Dapsone; Drug Administration Schedule; Drug Therapy, Combination; Fem

2007
[Polyarthritis and papular eruption revealing leprosy].
    La Revue de medecine interne, 2008, Volume: 29, Issue:3

    Topics: Administration, Oral; Adrenal Cortex Hormones; Adult; Arthritis; Biopsy; Clofazimine; Dapsone; Drug

2008
Effect of drug treatment on electroneurological measures of peripheral nerve function in leprosy patients.
    The Ceylon medical journal, 1993, Volume: 38, Issue:4

    Topics: Adolescent; Adult; Aged; Child; Clofazimine; Dapsone; Drug Therapy, Combination; Electrophysiology;

1993
Pedal edema following clofazimine therapy; a case report.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1993, Volume: 61, Issue:4

    Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Edema; Foot Diseases; Humans; Leprosy, Borderline;

1993
Tumor necrosis factor: status in reactions in leprosy before and after treatment.
    International journal of dermatology, 1993, Volume: 32, Issue:6

    Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Chloroquine; Clofazimine; Eryt

1993
Dapsone-induced motor polyneuropathy in a patient with leprosy.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1997, Volume: 65, Issue:2

    Topics: Adult; Anti-Inflammatory Agents; Clofazimine; Dapsone; Diagnosis, Differential; Humans; Leprostatic

1997
Excretion of clofazimine in human milk in leprosy patients.
    Leprosy review, 1997, Volume: 68, Issue:3

    Topics: Adult; Chromatography, High Pressure Liquid; Clofazimine; Female; Humans; Leprostatic Agents; Lepros

1997
Generalized annular borderline tuberculoid leprosy and update in management of Hansen's disease.
    Cutis, 2000, Volume: 65, Issue:4

    Topics: Aged; Clofazimine; Dapsone; DNA, Bacterial; Drug Therapy, Combination; Humans; Leprostatic Agents; L

2000
[Late reversal leprous reaction appearing 18 months after the termination of treatment].
    Presse medicale (Paris, France : 1983), 2001, Mar-03, Volume: 30, Issue:8

    Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Clofazimine; Coloring Age

2001
[What is your diagnosis? Sensory motor polyneuropathy in borderline leprosy. Trophic skin disorders with ulcerations, local superinfection on the right foot with right inguinal lymphadenopathy].
    Praxis, 2002, Jan-16, Volume: 91, Issue:3

    Topics: Adolescent; Clofazimine; Dapsone; Diagnosis, Differential; Drug Therapy, Combination; Humans; Lepros

2002
Resolution of type 1 reaction in multibacillary Hansen's disease as a result of treatment with cyclosporine.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1992, Volume: 60, Issue:1

    Topics: Adult; Clofazimine; Cyclosporine; Drug Therapy, Combination; Humans; Leprosy, Borderline; Male; Rifa

1992
The response to chemotherapy of serum Mycobacterium leprae-specific antigen in multibacillary leprosy patients.
    The American journal of tropical medicine and hygiene, 1991, Volume: 44, Issue:6

    Topics: Antibodies, Bacterial; Antigens, Bacterial; Carbohydrate Sequence; Clofazimine; Dapsone; Drug Therap

1991
Clinical and bacteriological progress of highly bacillated BL-LL patients discontinuing treatment after different periods of MDT.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1991, Volume: 59, Issue:2

    Topics: Adolescent; Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Humans; Leprosy, Borderline; Lep

1991
Simultaneous occurrence of upgrading and downgrading type 1 (lepra) reaction.
    International journal of dermatology, 1990, Volume: 29, Issue:5

    Topics: Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Humans; Leprosy, Borderline; Male; Rifampin;

1990
Effect of three-year multidrug therapy in multibacillary leprosy patients.
    Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao, 1990, Volume: 5, Issue:1

    Topics: Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Leprosy; Leprosy, Borderline

1990
Multiple cold abscesses in a borderline lepromatous patient on multidrug therapy.
    Indian journal of leprosy, 1989, Volume: 61, Issue:4

    Topics: Abscess; Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Ethambutol; Hip Joint; Humans; Ison

1989
Results of a modified WHO regimen in highly bacilliferous BL/LL patients.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1989, Volume: 57, Issue:2

    Topics: Adenosine Triphosphate; Adolescent; Adult; Animals; Clofazimine; Dapsone; Drug Therapy, Combination;

1989
Bacillaemia in leprosy and effect of multidrug therapy.
    Leprosy review, 1989, Volume: 60, Issue:3

    Topics: Adolescent; Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Leprosy; Leprosy

1989
A papulosquamous eruption in a 12-year-old cambodian boy.
    Pediatric dermatology, 1989, Volume: 6, Issue:2

    Topics: Biopsy; Cambodia; Child; Clofazimine; Diagnosis, Differential; Drug Therapy, Combination; Humans; Le

1989
Short-term multidrug therapy in multibacillary leprosy--review of 80 cases in two provinces of China (1983-1988).
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1989, Volume: 57, Issue:3

    Topics: Adult; China; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Leprostatic Agents; L

1989
Changing picture of leprosy in North Arcot District, Tamil Nadu after M.D.T.
    Indian journal of leprosy, 1989, Volume: 61, Issue:1

    Topics: Clofazimine; Cohort Studies; Dapsone; Drug Therapy, Combination; Follow-Up Studies; Humans; India; L

1989