clofazimine has been researched along with Leprosy, Borderline in 44 studies
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
Leprosy, Borderline: A form of LEPROSY in which there are clinical manifestations of both principal types (lepromatous and tuberculoid). The disease may shift toward one of these two polar or principal forms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A study was undertaken with the aim of testing the usefulness of clofazimine as a prophylactic agent against neuritis and nerve damage." | 9.08 | Does clofazimine have a prophylactic role against neuritis? ( Arunthathi, S; Satheesh, KK, 1997) |
| "A study was undertaken with the aim of testing the usefulness of clofazimine as a prophylactic agent against neuritis and nerve damage." | 5.08 | Does clofazimine have a prophylactic role against neuritis? ( Arunthathi, S; Satheesh, KK, 1997) |
| "The feasibility and effects of a 3-year treatment using rifampicin (RFP), clofazimine (B663) and dapsone (DDS) in multibacillary leprosy patients in Yangzhou Prefecture and Dongtai County (1983-1986) are reported." | 3.68 | Effect of three-year multidrug therapy in multibacillary leprosy patients. ( Ji, F; Li, W; Luo, J; Tao, M; Wang, C; Yang, Z; Ye, G, 1990) |
| "No confirmed relapse has been observed within a follow-up period of 6 months to 7 years and 3 months [59 person-years at risk (PYR)] for TT/BT patients and of 4 months to 5 years and 10 months (100 PYR) for BB/BL/LL patients." | 2.68 | Daily multidrug therapy for leprosy; results of a fourteen-year experience. ( Cottenot, F; de Carsalade, GY; Flageul, B; Pennec, J; Spindler, E; Wallach, D, 1997) |
| "Current treatment of leprosy involves use of 3 drugs: rifampicin (rifampin); clofazimine; and dapsone." | 2.41 | Leprosy. Recognition and treatment. ( Ramos-e-Silva, M; Rebello, PF, 2001) |
| "Treatment with prednisolone (60 mg/d) along with WHO MDT-MB continued." | 1.39 | Optic nerve involvement in a borderline lepromatous leprosy patient on multidrug therapy. ( Abhinav, C; Chander, B; Chauhan, PS; Khatri, G; Mahajan, VK; Mehta, KS; Prabha, N; Sharma, SK; Sharma, V; Tuli, R, 2013) |
| "Clofazimine is an important and effective constituent of multi drug therapy for leprosy." | 1.30 | Excretion of clofazimine in human milk in leprosy patients. ( Girdhar, A; Girdhar, BK; Mathur, A; Venkatesan, K, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (13.64) | 18.7374 |
| 1990's | 16 (36.36) | 18.2507 |
| 2000's | 11 (25.00) | 29.6817 |
| 2010's | 10 (22.73) | 24.3611 |
| 2020's | 1 (2.27) | 2.80 |
| Authors | Studies |
|---|---|
| Chew, R | 1 |
| Woods, ML | 1 |
| Fischer, M | 1 |
| Yang, S | 1 |
| Makredes, M | 1 |
| O'Donnell, P | 1 |
| Levin, NA | 1 |
| Khardenavis, S | 1 |
| Deshpande, A | 1 |
| El Morabite, K | 1 |
| Tbatou, F | 1 |
| Ait Ourhroui, M | 1 |
| Senouci, K | 1 |
| Hassam, B | 1 |
| Prabha, N | 1 |
| Mahajan, VK | 1 |
| Sharma, SK | 1 |
| Sharma, V | 1 |
| Chauhan, PS | 1 |
| Mehta, KS | 1 |
| Abhinav, C | 1 |
| Khatri, G | 1 |
| Chander, B | 1 |
| Tuli, R | 1 |
| Fu, X | 1 |
| Liu, H | 1 |
| Zhang, F | 1 |
| Asz-Sigall, D | 1 |
| López-García, L | 1 |
| Neme-Yunes, Y | 1 |
| Yuen-Palos, R | 1 |
| Vega-Memije, ME | 1 |
| Arenas, R | 1 |
| Manifold, R | 1 |
| Marshman, G | 1 |
| Marzano, AV | 1 |
| Tosi, D | 1 |
| Cusini, M | 1 |
| Nunzi, E | 2 |
| Massone, C | 2 |
| Crosti, C | 1 |
| Aftab, H | 1 |
| Nielsen, SD | 1 |
| Nielsen, SL | 1 |
| Due, E | 1 |
| Bygbjerg, IC | 1 |
| Thybo, S | 1 |
| Apte, G | 1 |
| Gedam, JR | 1 |
| Poojary, S | 1 |
| Nagpur, NG | 1 |
| Pai, VV | 1 |
| Ganapathi, R | 1 |
| Clapasson, A | 1 |
| Armour, KS | 1 |
| Scolyer, RA | 1 |
| Barnetson, RS | 1 |
| Miladi, MI | 1 |
| Feki, I | 1 |
| Bahloul, Z | 1 |
| Jlidi, R | 1 |
| Mhiri, C | 1 |
| Al-Raqum, HA | 1 |
| Uppal, SS | 1 |
| El Abdalghani, RA | 1 |
| Lasheen, I | 1 |
| Arora, SK | 1 |
| Meyer, M | 1 |
| Ingen-Housz-Oro, S | 1 |
| Ighilahriz, O | 1 |
| Wendling, J | 1 |
| Gaulier, A | 1 |
| Levy-Weil, F | 1 |
| Sigal-Grinberg, M | 1 |
| Flageul, B | 2 |
| Mendis, S | 1 |
| Somasiri, KG | 1 |
| Chularatna, W | 1 |
| Tyagi, PY | 1 |
| Oommen, T | 1 |
| Bhattacharya, SN | 2 |
| Chattopadhaya, D | 1 |
| Saha, K | 1 |
| Sampaio, EP | 1 |
| Malta, AM | 1 |
| Sarno, EN | 1 |
| Kaplan, G | 1 |
| de Carsalade, GY | 2 |
| Wallach, D | 1 |
| Spindler, E | 1 |
| Pennec, J | 1 |
| Cottenot, F | 1 |
| Pavithran, K | 1 |
| Satish, TC | 1 |
| Arunthathi, S | 1 |
| Satheesh, KK | 1 |
| Venkatesan, K | 1 |
| Mathur, A | 1 |
| Girdhar, A | 1 |
| Girdhar, BK | 1 |
| Moubasher, AD | 1 |
| Kamel, NA | 1 |
| Zedan, H | 1 |
| Raheem, DD | 1 |
| Young, RJ | 1 |
| Gilson, RT | 1 |
| Elston, DM | 1 |
| Bourée, P | 1 |
| de Brette, A | 1 |
| Ramos-e-Silva, M | 1 |
| Rebello, PF | 1 |
| Siccoli, M | 1 |
| Bassetti, C | 1 |
| Becx-Bleumink, M | 1 |
| Frankel, RI | 1 |
| Mita, RT | 1 |
| Kim, R | 1 |
| Dann, FJ | 1 |
| Roche, PW | 1 |
| Britton, WJ | 1 |
| Neupane, KD | 1 |
| Failbus, SS | 1 |
| Cho, SN | 1 |
| Theuvenet, WJ | 1 |
| Katoch, K | 2 |
| Natarajan, M | 1 |
| Bagga, A | 1 |
| Katoch, VM | 2 |
| Thomas, A | 1 |
| Balakrishnan, A | 1 |
| Nagarajan, M | 1 |
| Prabhakar, R | 1 |
| Tripathy, SP | 1 |
| Christian, M | 1 |
| Somasundaram, PR | 1 |
| Sehgal, VN | 1 |
| Sharma, VK | 2 |
| Mathur, RP | 1 |
| Li, W | 1 |
| Ye, G | 1 |
| Yang, Z | 1 |
| Tao, M | 1 |
| Luo, J | 1 |
| Wang, C | 1 |
| Ji, F | 1 |
| Kulkarni, V | 1 |
| Gharpuray, MB | 1 |
| Kulkarni, DS | 1 |
| Ramu, G | 1 |
| Ramanathan, U | 1 |
| Sengupta, U | 1 |
| Sharma, VD | 1 |
| Shivannavar, CT | 1 |
| Chatterjee, G | 1 |
| Kaur, S | 1 |
| Vaishnavi, C | 1 |
| Ganguly, NK | 1 |
| Rabinowitz, LG | 1 |
| Yuengel, C | 1 |
| Honig, PJ | 1 |
| Solomon, AR | 1 |
| Li, HY | 1 |
| Yu, XL | 1 |
| Zhang, MS | 1 |
| Duan, CX | 1 |
| Huang, WB | 1 |
| Zhang, SB | 1 |
| Zhu, K | 1 |
| Ma, JF | 1 |
| Ekambaram, V | 1 |
| Rao, MK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Independent Study to Establish the Efficacy of the Six Doses Uniform MDT Regimen (U-MDT) for Leprosy Patients[NCT00669643] | Phase 4 | 859 participants (Actual) | Interventional | 2007-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for clofazimine and Leprosy, Borderline
| Article | Year |
|---|---|
Leprosy - an overview of clinical features, diagnosis, and treatment.
Topics: Adult; Aged; Child; Clofazimine; Cross-Sectional Studies; Dapsone; Disease Progression; Drug Adminis | 2017 |
Leprosy. Recognition and treatment.
Topics: Adolescent; Adult; Age Factors; Biopsy; Child; Clinical Trials as Topic; Clofazimine; Dapsone; Diagn | 2001 |
Relapses among leprosy patients treated with multidrug therapy: experience in the leprosy control program of the All Africa Leprosy and Rehabilitation Training Center (ALERT) in Ethiopia; practical difficulties with diagnosing relapses; operational proced
Topics: Clofazimine; Dapsone; Epidemiologic Methods; Ethiopia; Humans; Incidence; Leprostatic Agents; Lepros | 1992 |
5 trials available for clofazimine and Leprosy, Borderline
| Article | Year |
|---|---|
Effect of rhuIFN-gamma treatment in multibacillary leprosy patients.
Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Erythema Nodosum; Humans; Interferon-gamma; Leprost | 1996 |
Daily multidrug therapy for leprosy; results of a fourteen-year experience.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Clofazimine; Dapsone; Drug Resistance, Microbial; | 1997 |
Does clofazimine have a prophylactic role against neuritis?
Topics: Adolescent; Adult; Case-Control Studies; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Hu | 1997 |
Cytokines in leprosy, II. Effect of treatment on serum cytokines in leprosy.
Topics: Adrenal Cortex Hormones; Clofazimine; Cytokines; Drug Therapy, Combination; Female; Follow-Up Studie | 1998 |
Controlled clinical trial of two multidrug regimens with and without rifampin in highly bacilliferous BL/LL south Indian patients: a five-year report.
Topics: Adolescent; Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Infant, Newborn; | 1990 |
36 other studies available for clofazimine and Leprosy, Borderline
| Article | Year |
|---|---|
Multibacillary Mid-Borderline Leprosy with Type 1 Lepra Reaction and Concurrent Latent Tuberculosis.
Topics: Abattoirs; Anti-Inflammatory Agents; Antitubercular Agents; Clofazimine; Dapsone; Diagnosis, Differe | 2021 |
A case of Hansen Disease presenting as tinea versicolor.
Topics: Clofazimine; Contraindications; Dapsone; Delayed Diagnosis; Diagnostic Errors; Humans; Hypesthesia; | 2013 |
Borderline tuberculoid leprosy with type 1/reversal reaction.
Topics: Clofazimine; Facial Nerve Diseases; Facial Paralysis; Humans; Hyperpigmentation; Leprostatic Agents; | 2014 |
[Borderline lepromatous leprosy].
Topics: Adult; Biopsy; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Leprosy, Borderline; | 2014 |
Optic nerve involvement in a borderline lepromatous leprosy patient on multidrug therapy.
Topics: Anti-Inflammatory Agents; Clofazimine; Dapsone; Drug Therapy, Combination; Humans; India; Leprostati | 2013 |
Borderline Lepromatous Leprosy with Type 1 (Reversal) Reactions in a Chinese Man.
Topics: Clofazimine; Dapsone; Humans; Leprostatic Agents; Leprosy, Borderline; Leprosy, Lepromatous; Male; M | 2015 |
Type I reaction in a borderline leprosy case successfully treated with multidrug therapy and ofloxacin.
Topics: Anti-Bacterial Agents; Clofazimine; Dapsone; Drug Therapy, Combination; Glucocorticoids; Humans; Lep | 2008 |
Leprosy: not always an easy diagnosis and often a management challenge.
Topics: Adult; Aged, 80 and over; Arm; Back; Clofazimine; Dapsone; Diagnosis, Differential; Drug Hypersensit | 2009 |
Facial reversal reaction: a dermatological emergency.
Topics: Adult; Antigens, CD; Antigens, Differentiation, Myelomonocytic; B-Lymphocytes; CD3 Complex; Clofazim | 2012 |
A case of leprosy mistaken for cutaneous sarcoidosis.
Topics: Adult; Clofazimine; Dapsone; Diagnostic Errors; Drug Therapy, Combination; Female; Humans; Leprostat | 2012 |
Chromoblastomycosis in a case of borderline lepromatous leprosy with recurrent type II lepra reaction.
Topics: Antifungal Agents; Biopsy; Chromoblastomycosis; Cladosporium; Clofazimine; Humans; Itraconazole; Lep | 2011 |
Borderline lepromatous leprosy in an Italian man.
Topics: Aged; Clofazimine; Humans; Leprosy, Borderline; Leprosy, Lepromatous; Male; Minocycline; Mycobacteri | 2013 |
Borderline lepromatous leprosy presenting as a single cutaneous plaque.
Topics: Administration, Oral; Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Forearm; Glucocorticoi | 2005 |
Chronic inflammatory joint disease revealing borderline leprosy.
Topics: Adult; Arthritis; Chronic Disease; Clofazimine; Dapsone; Diagnosis, Differential; Drug Therapy, Comb | 2006 |
First report of leprosy presenting as acute polyarthritis in the setting of type I downgrading lepra reaction.
Topics: Acute Disease; Adult; Arthritis; Clofazimine; Dapsone; Diagnosis, Differential; Drug Therapy, Combin | 2006 |
Leprosy in a preschool child--a case report.
Topics: Child, Preschool; Clofazimine; Dapsone; Drug Administration Schedule; Drug Therapy, Combination; Fem | 2007 |
[Polyarthritis and papular eruption revealing leprosy].
Topics: Administration, Oral; Adrenal Cortex Hormones; Adult; Arthritis; Biopsy; Clofazimine; Dapsone; Drug | 2008 |
Effect of drug treatment on electroneurological measures of peripheral nerve function in leprosy patients.
Topics: Adolescent; Adult; Aged; Child; Clofazimine; Dapsone; Drug Therapy, Combination; Electrophysiology; | 1993 |
Pedal edema following clofazimine therapy; a case report.
Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Edema; Foot Diseases; Humans; Leprosy, Borderline; | 1993 |
Tumor necrosis factor: status in reactions in leprosy before and after treatment.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Chloroquine; Clofazimine; Eryt | 1993 |
Dapsone-induced motor polyneuropathy in a patient with leprosy.
Topics: Adult; Anti-Inflammatory Agents; Clofazimine; Dapsone; Diagnosis, Differential; Humans; Leprostatic | 1997 |
Excretion of clofazimine in human milk in leprosy patients.
Topics: Adult; Chromatography, High Pressure Liquid; Clofazimine; Female; Humans; Leprostatic Agents; Lepros | 1997 |
Generalized annular borderline tuberculoid leprosy and update in management of Hansen's disease.
Topics: Aged; Clofazimine; Dapsone; DNA, Bacterial; Drug Therapy, Combination; Humans; Leprostatic Agents; L | 2000 |
[Late reversal leprous reaction appearing 18 months after the termination of treatment].
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Clofazimine; Coloring Age | 2001 |
[What is your diagnosis? Sensory motor polyneuropathy in borderline leprosy. Trophic skin disorders with ulcerations, local superinfection on the right foot with right inguinal lymphadenopathy].
Topics: Adolescent; Clofazimine; Dapsone; Diagnosis, Differential; Drug Therapy, Combination; Humans; Lepros | 2002 |
Resolution of type 1 reaction in multibacillary Hansen's disease as a result of treatment with cyclosporine.
Topics: Adult; Clofazimine; Cyclosporine; Drug Therapy, Combination; Humans; Leprosy, Borderline; Male; Rifa | 1992 |
The response to chemotherapy of serum Mycobacterium leprae-specific antigen in multibacillary leprosy patients.
Topics: Antibodies, Bacterial; Antigens, Bacterial; Carbohydrate Sequence; Clofazimine; Dapsone; Drug Therap | 1991 |
Clinical and bacteriological progress of highly bacillated BL-LL patients discontinuing treatment after different periods of MDT.
Topics: Adolescent; Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Humans; Leprosy, Borderline; Lep | 1991 |
Simultaneous occurrence of upgrading and downgrading type 1 (lepra) reaction.
Topics: Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Humans; Leprosy, Borderline; Male; Rifampin; | 1990 |
Effect of three-year multidrug therapy in multibacillary leprosy patients.
Topics: Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Leprosy; Leprosy, Borderline | 1990 |
Multiple cold abscesses in a borderline lepromatous patient on multidrug therapy.
Topics: Abscess; Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Ethambutol; Hip Joint; Humans; Ison | 1989 |
Results of a modified WHO regimen in highly bacilliferous BL/LL patients.
Topics: Adenosine Triphosphate; Adolescent; Adult; Animals; Clofazimine; Dapsone; Drug Therapy, Combination; | 1989 |
Bacillaemia in leprosy and effect of multidrug therapy.
Topics: Adolescent; Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Leprosy; Leprosy | 1989 |
A papulosquamous eruption in a 12-year-old cambodian boy.
Topics: Biopsy; Cambodia; Child; Clofazimine; Diagnosis, Differential; Drug Therapy, Combination; Humans; Le | 1989 |
Short-term multidrug therapy in multibacillary leprosy--review of 80 cases in two provinces of China (1983-1988).
Topics: Adult; China; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Leprostatic Agents; L | 1989 |
Changing picture of leprosy in North Arcot District, Tamil Nadu after M.D.T.
Topics: Clofazimine; Cohort Studies; Dapsone; Drug Therapy, Combination; Follow-Up Studies; Humans; India; L | 1989 |