clofazimine has been researched along with Innate Inflammatory Response in 6 studies
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, clinical implications may be restricted owing to poor solubility and low bioavailability rendering a suboptimal drug concentration in the target organ." | 5.91 | Clofazimine nanoclusters show high efficacy in experimental TB with amelioration in paradoxical lung inflammation. ( Jadhav, K; Jhilta, A; Ray, E; Sharma, N; Shukla, R; Singh, AK; Singh, R; Verma, RK, 2023) |
| "Type 2 lepra reaction (T2R) is a difficult-to-manage condition in leprosy, and an effective and safe steroid-sparing agent is needed for its management." | 2.80 | Effectiveness and safety of clofazimine and pentoxifylline in type 2 lepra reaction: a double-blind, randomized, controlled study. ( Bandyopadhyay, D; Das, NK; Roy, K; Sil, A, 2015) |
| " However, clinical implications may be restricted owing to poor solubility and low bioavailability rendering a suboptimal drug concentration in the target organ." | 1.91 | Clofazimine nanoclusters show high efficacy in experimental TB with amelioration in paradoxical lung inflammation. ( Jadhav, K; Jhilta, A; Ray, E; Sharma, N; Shukla, R; Singh, AK; Singh, R; Verma, RK, 2023) |
| "Clofazimine (CFZ) is a poorly soluble antibiotic and anti-inflammatory drug indicated for the treatment of leprosy." | 1.43 | Clofazimine Biocrystal Accumulation in Macrophages Upregulates Interleukin 1 Receptor Antagonist Production To Induce a Systemic Anti-Inflammatory State. ( Keswani, RK; Koehn, TA; Murashov, MD; Rosania, GR; Rzeczycki, PM; Standiford, TJ; Stringer, KA; Sud, S; Yoon, GS, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Jadhav, K | 1 |
| Jhilta, A | 1 |
| Singh, R | 1 |
| Ray, E | 1 |
| Sharma, N | 1 |
| Shukla, R | 1 |
| Singh, AK | 1 |
| Verma, RK | 1 |
| Roy, K | 1 |
| Sil, A | 1 |
| Das, NK | 1 |
| Bandyopadhyay, D | 1 |
| Hafiz, A | 1 |
| Mufeed, A | 1 |
| Kandasamy, G | 1 |
| Krishnapillai, R | 1 |
| Yoon, GS | 1 |
| Keswani, RK | 1 |
| Sud, S | 1 |
| Rzeczycki, PM | 1 |
| Murashov, MD | 1 |
| Koehn, TA | 1 |
| Standiford, TJ | 1 |
| Stringer, KA | 1 |
| Rosania, GR | 1 |
| Pfaltzgraff, RE | 1 |
1 trial available for clofazimine and Innate Inflammatory Response
| Article | Year |
|---|---|
Effectiveness and safety of clofazimine and pentoxifylline in type 2 lepra reaction: a double-blind, randomized, controlled study.
Topics: Adult; Arthritis, Reactive; Clofazimine; Double-Blind Method; Female; Humans; Inflammation; Leprosta | 2015 |
5 other studies available for clofazimine and Innate Inflammatory Response
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Clofazimine nanoclusters show high efficacy in experimental TB with amelioration in paradoxical lung inflammation.
Topics: Animals; Clofazimine; Inflammation; Mice; Pneumonia; Respiratory Aerosols and Droplets; Tuberculosis | 2023 |
Uncommon inflammatory swelling of the lips: orofacial granulomatosis.
Topics: Anti-Inflammatory Agents; Child; Clofazimine; Edema; Female; Granuloma; Granulomatosis, Orofacial; H | 2016 |
Clofazimine Biocrystal Accumulation in Macrophages Upregulates Interleukin 1 Receptor Antagonist Production To Induce a Systemic Anti-Inflammatory State.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Caspase 1; Clofazimine; Inflammasomes; Inflammation; | 2016 |
The management of reaction in leprosy.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibody Formation; Aspirin; Benzenesulfonates; Chloroquine | 1989 |