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clofazimine and Infections, Mycobacterium

clofazimine has been researched along with Infections, Mycobacterium in 31 studies

Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.

Research Excerpts

ExcerptRelevanceReference
"The usefulness of clofazimine (CLO, CAS 2030-63-9) in the treatment of mycobacterial infections with special emphasis on treatment of leprosy is critically discussed."8.78Critical comments on the treatment of leprosy and other mycobacterial infections with clofazimine. ( Freerksen, E; Seydel, JK, 1992)
"The usefulness of clofazimine (CLO, CAS 2030-63-9) in the treatment of mycobacterial infections with special emphasis on treatment of leprosy is critically discussed."4.78Critical comments on the treatment of leprosy and other mycobacterial infections with clofazimine. ( Freerksen, E; Seydel, JK, 1992)
" A diagnosis of mycobacterial neuritis was made and the cat was treated with clofazimine and enrofloxacin for extended periods."3.70Mycobacterial neuritis in a cat. ( Kern, MR; Paulsen, DB; Weigand, CM, 2000)
"Those in remission (Crohn's Disease Activity Index 2.73Two-year combination antibiotic therapy with clarithromycin, rifabutin, and clofazimine for Crohn's disease. ( Connell, W; Crotty, B; Ee, H; Florin, T; Gibson, P; Hetzel, D; Merrett, M; Mitchell, B; Pavli, P; Radford-Smith, G; Read, R; Selby, W, 2007)
"Clofazimine has been in clinical use for almost 40 years, but little is known of its mechanism of action."2.39Clofazimine: a review of its medical uses and mechanisms of action. ( Arbiser, JL; Moschella, SL, 1995)
"PBTZ169 appears to be a candidate for treating four common NTM infections."1.91Efficacy of PBTZ169 and pretomanid against Mycobacterium avium, ( Chen, X; Fu, L; Lu, Y; Qi, X; Wang, B; Wang, H; Zhang, W; Zheng, L, 2023)
"Reversal of severe Crohn's disease has been achieved in 6/12 patients using prolonged combination anti-Mycobacterium avium subspecies paratuberculosis therapy alone."1.31Treatment of severe Crohn's disease using antimycobacterial triple therapy--approaching a cure? ( Borody, TJ; Leis, S; Surace, R; Warren, EF, 2002)
"Four patients with acquired immunodeficiency syndrome with bacillemia from Mycobacterium avium-intracellulare presented with early pathologic clues of a disseminated mycobacterial infection."1.27Clues to the early diagnosis of Mycobacterium avium-intracellulare infection in patients with acquired immunodeficiency syndrome. ( Polis, MA; Tuazon, CU, 1985)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-199013 (41.94)18.7374
1990's9 (29.03)18.2507
2000's6 (19.35)29.6817
2010's2 (6.45)24.3611
2020's1 (3.23)2.80

Authors

AuthorsStudies
Zheng, L1
Qi, X1
Zhang, W1
Wang, H1
Fu, L1
Wang, B1
Chen, X2
Lu, Y1
Obregón-Henao, A1
Arnett, KA1
Henao-Tamayo, M1
Massoudi, L1
Creissen, E1
Andries, K1
Lenaerts, AJ1
Ordway, DJ1
van Ingen, J1
Totten, SE1
Helstrom, NK1
Heifets, LB1
Boeree, MJ1
Daley, CL1
LUNN, HF1
REE, RJ1
BARRY, VC1
CONALTY, ML1
Selby, W1
Pavli, P1
Crotty, B1
Florin, T1
Radford-Smith, G1
Gibson, P1
Mitchell, B1
Connell, W1
Read, R1
Merrett, M1
Ee, H1
Hetzel, D1
Peyrin-Biroulet, L1
Neut, C1
Colombel, JF1
Elliott, JL1
Hoppes, WL1
Platt, MS1
Thomas, JG1
Patel, IP1
Gansar, A1
Watson, SR1
Auclair, LK1
Collins, FM1
de Bergeyck, E1
Janssens, PG1
de Muynck, A1
Arbiser, JL1
Moschella, SL1
Dautzenberg, B2
Olliaro, P1
Ruf, B1
Esposito, R1
Opravil, M1
Hoy, JF1
Rozenbaum, W2
Carosi, GP1
Micoud, M1
L'Age, M1
Pirotta, N1
Sassella, D1
Alford, PL1
Lee, DR1
Binhazim, AA1
Hubbard, GB1
Matherne, CM1
Fisher, M1
Tomlinson, DR1
Coker, RJ1
O'Connor, R1
O'Sullivan, JF2
O'Kennedy, R1
Reddy, VM1
Gangadharam, PR2
Paulsen, DB1
Kern, MR1
Weigand, CM1
Lucas, J1
Lucas, A1
Furber, H1
James, G1
Hughes, MS1
Martin, P1
Chen, SC1
Mitchell, DH1
Love, DN1
Malik, R1
Borody, TJ1
Leis, S1
Warren, EF1
Surace, R1
Damle, P1
McClatchy, JK1
Davidson, PT1
Ellis, BP1
Cruickshank, JG1
Banerjee, DK1
Holmes, IB1
Freerksen, E1
Seydel, JK1
Truffot, C1
Mignon, A1
Katlama, C1
Perronne, C1
Parrot, R1
Grosset, J1
Wheeler, PR1
Bulmer, K1
Ratledge, C1
Bodemer, C1
Durand, C1
Blanche, S1
Teillac, D1
De Prost, Y1
Masur, H1
Tuazon, C1
Gill, V1
Grimes, G1
Baird, B1
Fauci, AS1
Lane, HC1
Polis, MA1
Tuazon, CU1
Revill, WD1
Morrow, RH1
Pike, MC1
Ateng, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Beta-Lactam Containing Regimen for the Shortening of Buruli Ulcer Disease Therapy: Comparison of 8 Weeks Standard Therapy (Rifampicin Plus Clarithromycin) vs. 4 Weeks Standard Plus Amoxicillin/Clavulanate Therapy [RC8 vs. RCA4][NCT05169554]Phase 2140 participants (Anticipated)Interventional2021-12-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

8 reviews available for clofazimine and Infections, Mycobacterium

ArticleYear
THE ANTIMYCOBACTERIAL ACTIVITY OF B 663.
    Leprosy review, 1965, Volume: 36

    Topics: Animals; Anti-Bacterial Agents; Antitubercular Agents; Clofazimine; Cricetinae; Drug Resistance; Dru

1965
Antimycobacterial therapy in Crohn's disease: game over?
    Gastroenterology, 2007, Volume: 132, Issue:7

    Topics: Anti-Bacterial Agents; Clarithromycin; Clofazimine; Crohn Disease; Drug Therapy, Combination; Humans

2007
Clofazimine: a review of its medical uses and mechanisms of action.
    Journal of the American Academy of Dermatology, 1995, Volume: 32, Issue:2 Pt 1

    Topics: Clofazimine; DNA, Bacterial; Humans; Intercalating Agents; Mycobacterium Infections; Mycobacterium I

1995
Naturally acquired leprosy in two wild-born chimpanzees.
    Laboratory animal science, 1996, Volume: 46, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Ape Diseases; Aspirin; Clofazimine; Fatal Outcome; Leprostatic Ag

1996
The pharmacology, metabolism, and chemistry of clofazimine.
    Drug metabolism reviews, 1995, Volume: 27, Issue:4

    Topics: Absorption; Animals; Biological Availability; Chromatography, High Pressure Liquid; Clofazimine; Hal

1995
Antimycobacterial activities of riminophenazines.
    The Journal of antimicrobial chemotherapy, 1999, Volume: 43, Issue:5

    Topics: Animals; Antitubercular Agents; Clofazimine; Humans; Leprostatic Agents; Mycobacterium; Mycobacteriu

1999
Leprosy.
    Indian journal of medical sciences, 2001, Volume: 55, Issue:5

    Topics: Clofazimine; Cost-Benefit Analysis; Dapsone; Drug Therapy, Combination; Global Health; Humans; Inter

2001
Critical comments on the treatment of leprosy and other mycobacterial infections with clofazimine.
    Arzneimittel-Forschung, 1992, Volume: 42, Issue:10

    Topics: Clofazimine; Humans; Leprosy; Mycobacterium Infections

1992

Trials

4 trials available for clofazimine and Infections, Mycobacterium

ArticleYear
Two-year combination antibiotic therapy with clarithromycin, rifabutin, and clofazimine for Crohn's disease.
    Gastroenterology, 2007, Volume: 132, Issue:7

    Topics: Adult; Anti-Bacterial Agents; Clarithromycin; Clofazimine; Crohn Disease; Double-Blind Method; Drug

2007
Rifabutin versus placebo in combination with three drugs in the treatment of nontuberculous mycobacterial infection in patients with AIDS.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1996, Volume: 22, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Anti-Inflammatory

1996
Rifabutin in combination with clofazimine, isoniazid and ethambutol in the treatment of AIDS patients with infections due to opportunist mycobacteria. Groupe d'Etude et de Traitement des Infections à Mycobacteries Résistantes.
    Tubercle, 1991, Volume: 72, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antitubercular Agents; Clofazimine; Drug Therapy, Combina

1991
A controlled trial of the treatment of Mycobacterium ulcerans infection with clofazimine.
    Lancet (London, England), 1973, Oct-20, Volume: 2, Issue:7834

    Topics: Clinical Trials as Topic; Clofazimine; Culture Media; Drug Evaluation; Humans; Mycobacterium; Mycoba

1973

Other Studies

19 other studies available for clofazimine and Infections, Mycobacterium

ArticleYear
Efficacy of PBTZ169 and pretomanid against Mycobacterium avium,
    Frontiers in cellular and infection microbiology, 2023, Volume: 13

    Topics: Animals; Anti-Bacterial Agents; Clofazimine; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests;

2023
Susceptibility of Mycobacterium abscessus to antimycobacterial drugs in preclinical models.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:11

    Topics: Animals; Anti-Bacterial Agents; Clarithromycin; Clofazimine; Diarylquinolines; Granulocyte-Macrophag

2015
In vitro synergy between clofazimine and amikacin in treatment of nontuberculous mycobacterial disease.
    Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:12

    Topics: Amikacin; Anti-Bacterial Agents; Clofazimine; Drug Synergism; Microbial Sensitivity Tests; Mycobacte

2012
TREATMENT OF MYCOBACTERIAL SKIN ULCERS IN UGANDA WITH A RIMINOPHENAZINE DERIVATIVE (B.663).
    Lancet (London, England), 1964, Feb-01, Volume: 1, Issue:7327

    Topics: Antitubercular Agents; Clofazimine; Mice; Mycobacterium Infections; Phenazines; Skin Ulcer; Uganda

1964
The acquired immunodeficiency syndrome and Mycobacterium avium-intracellulare bacteremia in a patient with hemophilia.
    Annals of internal medicine, 1983, Volume: 98, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antibodies, Viral; Clofazimine; Cytomegalovirus; Hemophil

1983
The effect of combined chemotherapy on suppressor T-cell activity in Mycobacterium simiae-infected mice.
    Immunology, 1981, Volume: 43, Issue:3

    Topics: Amikacin; Animals; Clofazimine; Drug Therapy, Combination; Lymphocyte Activation; Mice; Mycobacteriu

1981
Radiological abnormalities of the ileum associated with the use of clofazimine (Lamprene; B663) in the treatment of skin ulceration due to Mycobacterium ulcerans.
    Leprosy review, 1980, Volume: 51, Issue:3

    Topics: Adult; Clofazimine; Female; Humans; Ileal Diseases; Mycobacterium Infections; Radiography; Skin Ulce

1980
The management of mycobacterial infections in HIV seropositive individuals. Jefferiss Wing Therapeutics and Protocols Group.
    International journal of STD & AIDS, 1996, Volume: 7, Issue:4

    Topics: Adrenal Cortex Hormones; Amikacin; Anti-Bacterial Agents; Anti-Infective Agents; Antibiotics, Antitu

1996
Mycobacterial neuritis in a cat.
    Journal of the American Veterinary Medical Association, 2000, May-15, Volume: 216, Issue:10

    Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Anti-Infective Agents; Anti-Inflammatory Agents

2000
Mycobacterium genavense infection in two aged ferrets with conjunctival lesions.
    Australian veterinary journal, 2000, Volume: 78, Issue:10

    Topics: Animals; Clarithromycin; Clofazimine; Conjunctivitis, Bacterial; Diagnosis, Differential; DNA Primer

2000
Treatment of severe Crohn's disease using antimycobacterial triple therapy--approaching a cure?
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2002, Volume: 34, Issue:1

    Topics: Adolescent; Adult; Clarithromycin; Clofazimine; Colonoscopy; Crohn Disease; Drug Therapy, Combinatio

2002
Antimycobacterial activity of some potential chemotherapeutic compounds.
    Tubercle, 1978, Volume: 59, Issue:2

    Topics: Clofazimine; Cyclopentanes; Fatty Acids; Mycobacterium; Mycobacterium Infections; Oils

1978
Letter: Topical clofazimine and atypical mycobacteria.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1976, May-08, Volume: 50, Issue:20

    Topics: Administration, Topical; Clofazimine; Humans; Mycobacterium Infections; Skin Ulcer

1976
In vitro and in vivo studies of the action of rifampicin, clofazimine and B1912 on Mycobacterium marinum.
    Chemotherapy, 1976, Volume: 22, Issue:3-4

    Topics: Animals; Clofazimine; Mice; Mycobacterium; Mycobacterium Infections; Phenazines; Rifampin

1976
Fatty acid oxidation and the beta-oxidation complex in Mycobacterium leprae and two axenically cultivable mycobacteria that are pathogens.
    Journal of general microbiology, 1991, Volume: 137, Issue:4

    Topics: Acetyl Coenzyme A; Clofazimine; Dapsone; Fatty Acids; Laurates; Mycobacterium; Mycobacterium avium;

1991
[Disseminated Mycobacterium marinum infection].
    Annales de dermatologie et de venereologie, 1989, Volume: 116, Issue:11

    Topics: Child, Preschool; Clofazimine; Consanguinity; Drug Therapy, Combination; Ethambutol; Female; Hepatom

1989
Clofazimine for leprosy and Mycobacterium avium complex infections.
    The Medical letter on drugs and therapeutics, 1987, Aug-14, Volume: 29, Issue:746

    Topics: Clofazimine; Humans; Leprosy; Mycobacterium avium; Mycobacterium Infections

1987
Effect of combined clofazimine and ansamycin therapy on Mycobacterium avium-Mycobacterium intracellulare bacteremia in patients with AIDS.
    The Journal of infectious diseases, 1987, Volume: 155, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Amikacin; Anti-Bacterial Agents; Ciprofloxacin; Clofazimine; Cyc

1987
Clues to the early diagnosis of Mycobacterium avium-intracellulare infection in patients with acquired immunodeficiency syndrome.
    Archives of pathology & laboratory medicine, 1985, Volume: 109, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Adult; Amikacin; Anti-Bacterial Agents; Clofazimine; Female; Hum

1985