clofazimine has been researched along with Infections, Mycobacterium in 31 studies
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The usefulness of clofazimine (CLO, CAS 2030-63-9) in the treatment of mycobacterial infections with special emphasis on treatment of leprosy is critically discussed." | 8.78 | Critical comments on the treatment of leprosy and other mycobacterial infections with clofazimine. ( Freerksen, E; Seydel, JK, 1992) |
| "The usefulness of clofazimine (CLO, CAS 2030-63-9) in the treatment of mycobacterial infections with special emphasis on treatment of leprosy is critically discussed." | 4.78 | Critical comments on the treatment of leprosy and other mycobacterial infections with clofazimine. ( Freerksen, E; Seydel, JK, 1992) |
| " A diagnosis of mycobacterial neuritis was made and the cat was treated with clofazimine and enrofloxacin for extended periods." | 3.70 | Mycobacterial neuritis in a cat. ( Kern, MR; Paulsen, DB; Weigand, CM, 2000) |
"Those in remission (Crohn's Disease Activity Index | 2.73 | Two-year combination antibiotic therapy with clarithromycin, rifabutin, and clofazimine for Crohn's disease. ( Connell, W; Crotty, B; Ee, H; Florin, T; Gibson, P; Hetzel, D; Merrett, M; Mitchell, B; Pavli, P; Radford-Smith, G; Read, R; Selby, W, 2007) | |
| "Clofazimine has been in clinical use for almost 40 years, but little is known of its mechanism of action." | 2.39 | Clofazimine: a review of its medical uses and mechanisms of action. ( Arbiser, JL; Moschella, SL, 1995) |
| "PBTZ169 appears to be a candidate for treating four common NTM infections." | 1.91 | Efficacy of PBTZ169 and pretomanid against Mycobacterium avium, ( Chen, X; Fu, L; Lu, Y; Qi, X; Wang, B; Wang, H; Zhang, W; Zheng, L, 2023) |
| "Reversal of severe Crohn's disease has been achieved in 6/12 patients using prolonged combination anti-Mycobacterium avium subspecies paratuberculosis therapy alone." | 1.31 | Treatment of severe Crohn's disease using antimycobacterial triple therapy--approaching a cure? ( Borody, TJ; Leis, S; Surace, R; Warren, EF, 2002) |
| "Four patients with acquired immunodeficiency syndrome with bacillemia from Mycobacterium avium-intracellulare presented with early pathologic clues of a disseminated mycobacterial infection." | 1.27 | Clues to the early diagnosis of Mycobacterium avium-intracellulare infection in patients with acquired immunodeficiency syndrome. ( Polis, MA; Tuazon, CU, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (41.94) | 18.7374 |
| 1990's | 9 (29.03) | 18.2507 |
| 2000's | 6 (19.35) | 29.6817 |
| 2010's | 2 (6.45) | 24.3611 |
| 2020's | 1 (3.23) | 2.80 |
| Authors | Studies |
|---|---|
| Zheng, L | 1 |
| Qi, X | 1 |
| Zhang, W | 1 |
| Wang, H | 1 |
| Fu, L | 1 |
| Wang, B | 1 |
| Chen, X | 2 |
| Lu, Y | 1 |
| Obregón-Henao, A | 1 |
| Arnett, KA | 1 |
| Henao-Tamayo, M | 1 |
| Massoudi, L | 1 |
| Creissen, E | 1 |
| Andries, K | 1 |
| Lenaerts, AJ | 1 |
| Ordway, DJ | 1 |
| van Ingen, J | 1 |
| Totten, SE | 1 |
| Helstrom, NK | 1 |
| Heifets, LB | 1 |
| Boeree, MJ | 1 |
| Daley, CL | 1 |
| LUNN, HF | 1 |
| REE, RJ | 1 |
| BARRY, VC | 1 |
| CONALTY, ML | 1 |
| Selby, W | 1 |
| Pavli, P | 1 |
| Crotty, B | 1 |
| Florin, T | 1 |
| Radford-Smith, G | 1 |
| Gibson, P | 1 |
| Mitchell, B | 1 |
| Connell, W | 1 |
| Read, R | 1 |
| Merrett, M | 1 |
| Ee, H | 1 |
| Hetzel, D | 1 |
| Peyrin-Biroulet, L | 1 |
| Neut, C | 1 |
| Colombel, JF | 1 |
| Elliott, JL | 1 |
| Hoppes, WL | 1 |
| Platt, MS | 1 |
| Thomas, JG | 1 |
| Patel, IP | 1 |
| Gansar, A | 1 |
| Watson, SR | 1 |
| Auclair, LK | 1 |
| Collins, FM | 1 |
| de Bergeyck, E | 1 |
| Janssens, PG | 1 |
| de Muynck, A | 1 |
| Arbiser, JL | 1 |
| Moschella, SL | 1 |
| Dautzenberg, B | 2 |
| Olliaro, P | 1 |
| Ruf, B | 1 |
| Esposito, R | 1 |
| Opravil, M | 1 |
| Hoy, JF | 1 |
| Rozenbaum, W | 2 |
| Carosi, GP | 1 |
| Micoud, M | 1 |
| L'Age, M | 1 |
| Pirotta, N | 1 |
| Sassella, D | 1 |
| Alford, PL | 1 |
| Lee, DR | 1 |
| Binhazim, AA | 1 |
| Hubbard, GB | 1 |
| Matherne, CM | 1 |
| Fisher, M | 1 |
| Tomlinson, DR | 1 |
| Coker, RJ | 1 |
| O'Connor, R | 1 |
| O'Sullivan, JF | 2 |
| O'Kennedy, R | 1 |
| Reddy, VM | 1 |
| Gangadharam, PR | 2 |
| Paulsen, DB | 1 |
| Kern, MR | 1 |
| Weigand, CM | 1 |
| Lucas, J | 1 |
| Lucas, A | 1 |
| Furber, H | 1 |
| James, G | 1 |
| Hughes, MS | 1 |
| Martin, P | 1 |
| Chen, SC | 1 |
| Mitchell, DH | 1 |
| Love, DN | 1 |
| Malik, R | 1 |
| Borody, TJ | 1 |
| Leis, S | 1 |
| Warren, EF | 1 |
| Surace, R | 1 |
| Damle, P | 1 |
| McClatchy, JK | 1 |
| Davidson, PT | 1 |
| Ellis, BP | 1 |
| Cruickshank, JG | 1 |
| Banerjee, DK | 1 |
| Holmes, IB | 1 |
| Freerksen, E | 1 |
| Seydel, JK | 1 |
| Truffot, C | 1 |
| Mignon, A | 1 |
| Katlama, C | 1 |
| Perronne, C | 1 |
| Parrot, R | 1 |
| Grosset, J | 1 |
| Wheeler, PR | 1 |
| Bulmer, K | 1 |
| Ratledge, C | 1 |
| Bodemer, C | 1 |
| Durand, C | 1 |
| Blanche, S | 1 |
| Teillac, D | 1 |
| De Prost, Y | 1 |
| Masur, H | 1 |
| Tuazon, C | 1 |
| Gill, V | 1 |
| Grimes, G | 1 |
| Baird, B | 1 |
| Fauci, AS | 1 |
| Lane, HC | 1 |
| Polis, MA | 1 |
| Tuazon, CU | 1 |
| Revill, WD | 1 |
| Morrow, RH | 1 |
| Pike, MC | 1 |
| Ateng, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Beta-Lactam Containing Regimen for the Shortening of Buruli Ulcer Disease Therapy: Comparison of 8 Weeks Standard Therapy (Rifampicin Plus Clarithromycin) vs. 4 Weeks Standard Plus Amoxicillin/Clavulanate Therapy [RC8 vs. RCA4][NCT05169554] | Phase 2 | 140 participants (Anticipated) | Interventional | 2021-12-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for clofazimine and Infections, Mycobacterium
| Article | Year |
|---|---|
THE ANTIMYCOBACTERIAL ACTIVITY OF B 663.
Topics: Animals; Anti-Bacterial Agents; Antitubercular Agents; Clofazimine; Cricetinae; Drug Resistance; Dru | 1965 |
Antimycobacterial therapy in Crohn's disease: game over?
Topics: Anti-Bacterial Agents; Clarithromycin; Clofazimine; Crohn Disease; Drug Therapy, Combination; Humans | 2007 |
Clofazimine: a review of its medical uses and mechanisms of action.
Topics: Clofazimine; DNA, Bacterial; Humans; Intercalating Agents; Mycobacterium Infections; Mycobacterium I | 1995 |
Naturally acquired leprosy in two wild-born chimpanzees.
Topics: Animals; Anti-Inflammatory Agents; Ape Diseases; Aspirin; Clofazimine; Fatal Outcome; Leprostatic Ag | 1996 |
The pharmacology, metabolism, and chemistry of clofazimine.
Topics: Absorption; Animals; Biological Availability; Chromatography, High Pressure Liquid; Clofazimine; Hal | 1995 |
Antimycobacterial activities of riminophenazines.
Topics: Animals; Antitubercular Agents; Clofazimine; Humans; Leprostatic Agents; Mycobacterium; Mycobacteriu | 1999 |
Leprosy.
Topics: Clofazimine; Cost-Benefit Analysis; Dapsone; Drug Therapy, Combination; Global Health; Humans; Inter | 2001 |
Critical comments on the treatment of leprosy and other mycobacterial infections with clofazimine.
Topics: Clofazimine; Humans; Leprosy; Mycobacterium Infections | 1992 |
4 trials available for clofazimine and Infections, Mycobacterium
| Article | Year |
|---|---|
Two-year combination antibiotic therapy with clarithromycin, rifabutin, and clofazimine for Crohn's disease.
Topics: Adult; Anti-Bacterial Agents; Clarithromycin; Clofazimine; Crohn Disease; Double-Blind Method; Drug | 2007 |
Rifabutin versus placebo in combination with three drugs in the treatment of nontuberculous mycobacterial infection in patients with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Anti-Inflammatory | 1996 |
Rifabutin in combination with clofazimine, isoniazid and ethambutol in the treatment of AIDS patients with infections due to opportunist mycobacteria. Groupe d'Etude et de Traitement des Infections à Mycobacteries Résistantes.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antitubercular Agents; Clofazimine; Drug Therapy, Combina | 1991 |
A controlled trial of the treatment of Mycobacterium ulcerans infection with clofazimine.
Topics: Clinical Trials as Topic; Clofazimine; Culture Media; Drug Evaluation; Humans; Mycobacterium; Mycoba | 1973 |
19 other studies available for clofazimine and Infections, Mycobacterium
| Article | Year |
|---|---|
Efficacy of PBTZ169 and pretomanid against Mycobacterium avium,
Topics: Animals; Anti-Bacterial Agents; Clofazimine; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; | 2023 |
Susceptibility of Mycobacterium abscessus to antimycobacterial drugs in preclinical models.
Topics: Animals; Anti-Bacterial Agents; Clarithromycin; Clofazimine; Diarylquinolines; Granulocyte-Macrophag | 2015 |
In vitro synergy between clofazimine and amikacin in treatment of nontuberculous mycobacterial disease.
Topics: Amikacin; Anti-Bacterial Agents; Clofazimine; Drug Synergism; Microbial Sensitivity Tests; Mycobacte | 2012 |
TREATMENT OF MYCOBACTERIAL SKIN ULCERS IN UGANDA WITH A RIMINOPHENAZINE DERIVATIVE (B.663).
Topics: Antitubercular Agents; Clofazimine; Mice; Mycobacterium Infections; Phenazines; Skin Ulcer; Uganda | 1964 |
The acquired immunodeficiency syndrome and Mycobacterium avium-intracellulare bacteremia in a patient with hemophilia.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antibodies, Viral; Clofazimine; Cytomegalovirus; Hemophil | 1983 |
The effect of combined chemotherapy on suppressor T-cell activity in Mycobacterium simiae-infected mice.
Topics: Amikacin; Animals; Clofazimine; Drug Therapy, Combination; Lymphocyte Activation; Mice; Mycobacteriu | 1981 |
Radiological abnormalities of the ileum associated with the use of clofazimine (Lamprene; B663) in the treatment of skin ulceration due to Mycobacterium ulcerans.
Topics: Adult; Clofazimine; Female; Humans; Ileal Diseases; Mycobacterium Infections; Radiography; Skin Ulce | 1980 |
The management of mycobacterial infections in HIV seropositive individuals. Jefferiss Wing Therapeutics and Protocols Group.
Topics: Adrenal Cortex Hormones; Amikacin; Anti-Bacterial Agents; Anti-Infective Agents; Antibiotics, Antitu | 1996 |
Mycobacterial neuritis in a cat.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Anti-Infective Agents; Anti-Inflammatory Agents | 2000 |
Mycobacterium genavense infection in two aged ferrets with conjunctival lesions.
Topics: Animals; Clarithromycin; Clofazimine; Conjunctivitis, Bacterial; Diagnosis, Differential; DNA Primer | 2000 |
Treatment of severe Crohn's disease using antimycobacterial triple therapy--approaching a cure?
Topics: Adolescent; Adult; Clarithromycin; Clofazimine; Colonoscopy; Crohn Disease; Drug Therapy, Combinatio | 2002 |
Antimycobacterial activity of some potential chemotherapeutic compounds.
Topics: Clofazimine; Cyclopentanes; Fatty Acids; Mycobacterium; Mycobacterium Infections; Oils | 1978 |
Letter: Topical clofazimine and atypical mycobacteria.
Topics: Administration, Topical; Clofazimine; Humans; Mycobacterium Infections; Skin Ulcer | 1976 |
In vitro and in vivo studies of the action of rifampicin, clofazimine and B1912 on Mycobacterium marinum.
Topics: Animals; Clofazimine; Mice; Mycobacterium; Mycobacterium Infections; Phenazines; Rifampin | 1976 |
Fatty acid oxidation and the beta-oxidation complex in Mycobacterium leprae and two axenically cultivable mycobacteria that are pathogens.
Topics: Acetyl Coenzyme A; Clofazimine; Dapsone; Fatty Acids; Laurates; Mycobacterium; Mycobacterium avium; | 1991 |
[Disseminated Mycobacterium marinum infection].
Topics: Child, Preschool; Clofazimine; Consanguinity; Drug Therapy, Combination; Ethambutol; Female; Hepatom | 1989 |
Clofazimine for leprosy and Mycobacterium avium complex infections.
Topics: Clofazimine; Humans; Leprosy; Mycobacterium avium; Mycobacterium Infections | 1987 |
Effect of combined clofazimine and ansamycin therapy on Mycobacterium avium-Mycobacterium intracellulare bacteremia in patients with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Amikacin; Anti-Bacterial Agents; Ciprofloxacin; Clofazimine; Cyc | 1987 |
Clues to the early diagnosis of Mycobacterium avium-intracellulare infection in patients with acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Amikacin; Anti-Bacterial Agents; Clofazimine; Female; Hum | 1985 |