clofazimine has been researched along with HIV in 4 studies
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
HIV: Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We evaluated the efficacy, pharmacokinetics (PK), and safety of clofazimine (CFZ) in patients living with human immunodeficiency virus (HIV) with cryptosporidiosis." | 9.41 | Clofazimine for Treatment of Cryptosporidiosis in Human Immunodeficiency Virus Infected Adults: An Experimental Medicine, Randomized, Double-blind, Placebo-controlled Phase 2a Trial. ( Arnold, SLM; Barrett, LK; Chen, CR; Conrad, TM; Douglas, E; Gordon, MA; Hebert, D; Henrion, M; Hermann, D; Hollingsworth, B; Houpt, E; Iroh Tam, P; Jere, KC; Lindblad, R; Love, MS; Makhaza, L; McNamara, CW; Nedi, W; Nyirenda, J; Operario, DJ; Phulusa, J; Quinnan, GV; Sawyer, LA; Thole, H; Toto, N; Van Voorhis, WC; Winter, A, 2021) |
| "We evaluated the efficacy, pharmacokinetics (PK), and safety of clofazimine (CFZ) in patients living with human immunodeficiency virus (HIV) with cryptosporidiosis." | 5.41 | Clofazimine for Treatment of Cryptosporidiosis in Human Immunodeficiency Virus Infected Adults: An Experimental Medicine, Randomized, Double-blind, Placebo-controlled Phase 2a Trial. ( Arnold, SLM; Barrett, LK; Chen, CR; Conrad, TM; Douglas, E; Gordon, MA; Hebert, D; Henrion, M; Hermann, D; Hollingsworth, B; Houpt, E; Iroh Tam, P; Jere, KC; Lindblad, R; Love, MS; Makhaza, L; McNamara, CW; Nedi, W; Nyirenda, J; Operario, DJ; Phulusa, J; Quinnan, GV; Sawyer, LA; Thole, H; Toto, N; Van Voorhis, WC; Winter, A, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Iroh Tam, P | 1 |
| Arnold, SLM | 1 |
| Barrett, LK | 1 |
| Chen, CR | 1 |
| Conrad, TM | 1 |
| Douglas, E | 1 |
| Gordon, MA | 1 |
| Hebert, D | 1 |
| Henrion, M | 1 |
| Hermann, D | 1 |
| Hollingsworth, B | 1 |
| Houpt, E | 1 |
| Jere, KC | 1 |
| Lindblad, R | 1 |
| Love, MS | 1 |
| Makhaza, L | 1 |
| McNamara, CW | 1 |
| Nedi, W | 1 |
| Nyirenda, J | 1 |
| Operario, DJ | 1 |
| Phulusa, J | 1 |
| Quinnan, GV | 1 |
| Sawyer, LA | 1 |
| Thole, H | 1 |
| Toto, N | 1 |
| Winter, A | 1 |
| Van Voorhis, WC | 1 |
| Singh, DK | 1 |
| Dwivedi, VP | 1 |
| Ranganathan, A | 1 |
| Bishai, WR | 1 |
| Van Kaer, L | 1 |
| Das, G | 1 |
| Levis, W | 1 |
| Rendini, T | 1 |
| Fattorini, L | 1 |
| Vincent, V | 1 |
| Li, B | 1 |
| Xiao, Y | 1 |
| Varnerot, A | 1 |
| Tortoli, E | 1 |
| Piersimoni, C | 1 |
| Mandler, F | 1 |
| Mascellino, MT | 1 |
| Iona, E | 1 |
| Orefici, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 2A, Randomized, Double-Blind, Placebo-Controlled Evaluation of the Safety, Tolerability, Pharmacokinetics and Efficacy of Clofazimine (CFZ) in Cryptosporidiosis[NCT03341767] | Phase 2 | 33 participants (Actual) | Interventional | 2017-12-14 | Terminated (stopped due to Insufficient accrual rate) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for clofazimine and HIV
| Article | Year |
|---|---|
Clofazimine for Treatment of Cryptosporidiosis in Human Immunodeficiency Virus Infected Adults: An Experimental Medicine, Randomized, Double-blind, Placebo-controlled Phase 2a Trial.
Topics: Adult; Biomedical Research; Clofazimine; Cryptosporidiosis; Cryptosporidium; Diarrhea; HIV; HIV Infe | 2021 |
3 other studies available for clofazimine and HIV
| Article | Year |
|---|---|
Reply to Levis and Rendini.
Topics: Clofazimine; HIV; Humans; Mycobacterium; Neoplasms | 2017 |
Clofazimine Mechanisms of Action in Mycobacteria, HIV, and Cancer.
Topics: BCG Vaccine; Clofazimine; HIV; Humans; Mycobacterium; Neoplasms; T-Lymphocytes | 2017 |
Type frequency and antimicrobial susceptibility of Mycobacterium avium-intracellulare complex strains isolated in Italy from AIDS and non-AIDS patients.
Topics: Adolescent; Adult; AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Anti-Infective Agen | 1996 |