clofazimine has been researched along with Great Pox in 1 studies
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In linezolid-treated animals, dark-field microscopy and qPCR assessment showed no presence of treponemes after day 3 post-treatment start, serologic test did not convert to positive, CSF had no abnormalities, and RIT was negative." | 5.62 | Efficacy of linezolid on Treponema pallidum, the syphilis agent: A preclinical study. ( Giacani, L; Haynes, AM; Mayans, MV; Mitjà, O; Nieto, C; Pérez-Mañá, C; Quintó, L; Romeis, E; Ubals, M, 2021) |
| "In linezolid-treated animals, dark-field microscopy and qPCR assessment showed no presence of treponemes after day 3 post-treatment start, serologic test did not convert to positive, CSF had no abnormalities, and RIT was negative." | 1.62 | Efficacy of linezolid on Treponema pallidum, the syphilis agent: A preclinical study. ( Giacani, L; Haynes, AM; Mayans, MV; Mitjà, O; Nieto, C; Pérez-Mañá, C; Quintó, L; Romeis, E; Ubals, M, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Haynes, AM | 1 |
| Giacani, L | 1 |
| Mayans, MV | 1 |
| Ubals, M | 1 |
| Nieto, C | 1 |
| Pérez-Mañá, C | 1 |
| Quintó, L | 1 |
| Romeis, E | 1 |
| Mitjà, O | 1 |
1 other study available for clofazimine and Great Pox
| Article | Year |
|---|---|
Efficacy of linezolid on Treponema pallidum, the syphilis agent: A preclinical study.
Topics: Animals; Area Under Curve; Clofazimine; Disease Models, Animal; Drug Evaluation, Preclinical; Linezo | 2021 |