clofazimine has been researched along with Granulomas in 13 studies
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty patients, ten suffering from disseminated granuloma anulare and ten from necrobiosis lipoidica, were treated with clofazimine 200 mg p." | 7.67 | [Clofazimine--therapeutic alternative in necrobiosis lipoidica and granuloma anulare]. ( Mensing, H, 1989) |
| "Twenty patients, ten suffering from disseminated granuloma anulare and ten from necrobiosis lipoidica, were treated with clofazimine 200 mg p." | 3.67 | [Clofazimine--therapeutic alternative in necrobiosis lipoidica and granuloma anulare]. ( Mensing, H, 1989) |
| "Granulomas were induced by insoluble CFZ cargo, but not by the more soluble analog, pointing to precipitation being a factor driving granulomatous inflammation." | 1.48 | An Expandable Mechanopharmaceutical Device (2): Drug Induced Granulomas Maximize the Cargo Sequestering Capacity of Macrophages in the Liver. ( Baik, J; Bergin, IL; Keswani, RK; Murashov, MD; Rosania, GR; Rzeczycki, P; Stringer, KA; Sud, S; Yoon, GS, 2018) |
| " Recurrences have been suppressed with a reduced maintenance dosage of this agent." | 1.29 | Granulomatous glossitis as an unusual manifestation of Melkersson-Rosenthal syndrome. ( Boateng, BI; Hornstein, OP; Kiesewetter, FF; Mahler, VB, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (30.77) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Kokesch-Himmelreich, J | 1 |
| Treu, A | 1 |
| Race, AM | 1 |
| Walter, K | 1 |
| Hölscher, C | 1 |
| Römpp, A | 1 |
| Rzeczycki, P | 1 |
| Yoon, GS | 1 |
| Keswani, RK | 1 |
| Sud, S | 1 |
| Baik, J | 1 |
| Murashov, MD | 1 |
| Bergin, IL | 1 |
| Stringer, KA | 1 |
| Rosania, GR | 1 |
| Tirhazouine, I | 1 |
| Chiheb, S | 1 |
| Hali, F | 1 |
| Rifki, A | 1 |
| Benchikhi, H | 1 |
| Paniz Mondolfi, AE | 1 |
| Cressey, BD | 1 |
| Ahmad, A | 1 |
| Tapia-Centola, B | 1 |
| Cohen, LM | 1 |
| Mahmoodi, M | 1 |
| Irwin, SM | 1 |
| Gruppo, V | 1 |
| Brooks, E | 1 |
| Gilliland, J | 1 |
| Scherman, M | 1 |
| Reichlen, MJ | 1 |
| Leistikow, R | 1 |
| Kramnik, I | 1 |
| Nuermberger, EL | 1 |
| Voskuil, MI | 1 |
| Lenaerts, AJ | 1 |
| Hafiz, A | 1 |
| Mufeed, A | 1 |
| Kandasamy, G | 1 |
| Krishnapillai, R | 1 |
| Jacyk, WK | 1 |
| Kaufman, AC | 1 |
| Greene, CE | 1 |
| Rakich, PM | 1 |
| Weigner, DD | 1 |
| Mahler, VB | 1 |
| Hornstein, OP | 1 |
| Boateng, BI | 1 |
| Kiesewetter, FF | 1 |
| Wollina, U | 1 |
| Karte, K | 1 |
| Geyer, A | 1 |
| Stuhlert, A | 1 |
| Bocker, T | 1 |
| Mensing, H | 1 |
| Levine, S | 1 |
| Saltzman, A | 1 |
| Rister, M | 1 |
| Fröhlich, G | 1 |
| Seiferth, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacometrics to Advance Novel Regimens for Drug-resistant Tuberculosis[NCT03827811] | 625 participants (Anticipated) | Observational | 2020-01-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 other studies available for clofazimine and Granulomas
| Article | Year |
|---|---|
Do Anti-tuberculosis Drugs Reach Their Target?─High-Resolution Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Provides Information on Drug Penetration into Necrotic Granulomas.
Topics: Animals; Antitubercular Agents; Clofazimine; Granuloma; Humans; Lasers; Mice; Mycobacterium tubercul | 2022 |
An Expandable Mechanopharmaceutical Device (2): Drug Induced Granulomas Maximize the Cargo Sequestering Capacity of Macrophages in the Liver.
Topics: Animals; Chemical and Drug Induced Liver Injury; Clofazimine; Drug Delivery Systems; Granuloma; Live | 2018 |
[Histoid leprosy].
Topics: Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Granuloma; Guinea; Histiocytes; Humans; Lepr | 2013 |
Granulomatous alopecia: a variant of alopecia areata?
Topics: Adult; Aged; Alopecia Areata; Anti-Inflammatory Agents, Non-Steroidal; Clofazimine; Female; Glucocor | 2013 |
Limited activity of clofazimine as a single drug in a mouse model of tuberculosis exhibiting caseous necrotic granulomas.
Topics: Animals; Antitubercular Agents; Bacterial Load; Clofazimine; Disease Models, Animal; Female; Granulo | 2014 |
Uncommon inflammatory swelling of the lips: orofacial granulomatosis.
Topics: Anti-Inflammatory Agents; Child; Clofazimine; Edema; Female; Granuloma; Granulomatosis, Orofacial; H | 2016 |
Facial granuloma in a patient treated with clofazimine.
Topics: Adult; Clofazimine; Facial Dermatoses; Granuloma; Humans; Male | 1981 |
Treatment of localized Mycobacterium avium complex infection with clofazimine and doxycycline in a cat.
Topics: Animals; Anti-Bacterial Agents; Cat Diseases; Cats; Clofazimine; Doxycycline; Granuloma; Leprostatic | 1995 |
Granulomatous glossitis as an unusual manifestation of Melkersson-Rosenthal syndrome.
Topics: Clofazimine; Diagnosis, Differential; Edema; Glossitis; Granuloma; Humans; Lip Diseases; Male; Melke | 1995 |
Clofazimine in inflammatory facial dermatosis--granuloma faciale and lipogranulomatosis subcutanea (Rothmann-Makai)
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Clofazimine; Disease Progression; Facial Dermatoses; | 1996 |
[Clofazimine--therapeutic alternative in necrobiosis lipoidica and granuloma anulare].
Topics: Administration, Oral; Adult; Clofazimine; Drug Administration Schedule; Female; Granuloma; Humans; M | 1989 |
Clofazimine enteropathy: possible relation to Peyer's patches.
Topics: Animals; Clofazimine; Female; Granuloma; Intestinal Diseases; Lymph Nodes; Male; Mice; Peyer's Patch | 1986 |
[Chronic septic granulomatous disease in two brothers (author's transl)].
Topics: Adrenal Cortex Hormones; Bronchopneumonia; Child; Child, Preschool; Clofazimine; Dermatitis; Granulo | 1974 |