clofazimine has been researched along with Graft vs Host Disease in 4 studies
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
Graft vs Host Disease: The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clofazimine (Lamprene) is an antimycobacterial drug that has antiinflammatory activity in a number of chronic autoimmune skin disorders." | 6.68 | Treatment of chronic graft-versus-host disease with clofazimine. ( Antin, JH; Bierer, BE; Lee, SJ; McGarigle, CJ; Wegner, SA, 1997) |
| "Clofazimine, previously used in the treatment of leprosy, is now used for treatment of Mycobacterium avium complex infection in patients with acquired immune deficiency syndrome, dermatologic disorders, and graft-versus-host disease." | 3.71 | Clofazimine enteropathy in a pediatric bone marrow transplant recipient. ( Di Lorenzo, C; Goyal, RK; Parizhskaya, M; Youssef, NN, 2001) |
| "Clofazimine (Lamprene) is an antimycobacterial drug that has antiinflammatory activity in a number of chronic autoimmune skin disorders." | 2.68 | Treatment of chronic graft-versus-host disease with clofazimine. ( Antin, JH; Bierer, BE; Lee, SJ; McGarigle, CJ; Wegner, SA, 1997) |
| "Clofazimine is a drug used to treat leprosy." | 1.34 | How can we help patients with refractory chronic graft versus host disease- single centre experience. ( Barzal, J; Oborska, S; Rzepecki, P; Sarosiek, T; Szczylik, C, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rzepecki, P | 1 |
| Barzal, J | 1 |
| Sarosiek, T | 1 |
| Oborska, S | 1 |
| Szczylik, C | 1 |
| Lee, SJ | 1 |
| Wegner, SA | 1 |
| McGarigle, CJ | 1 |
| Bierer, BE | 1 |
| Antin, JH | 1 |
| Moreira, V | 1 |
| De Medeiros, BC | 1 |
| Bonfim, CM | 1 |
| Pasquini, R | 1 |
| De Medeiros, CR | 1 |
| Parizhskaya, M | 1 |
| Youssef, NN | 1 |
| Di Lorenzo, C | 1 |
| Goyal, RK | 1 |
1 trial available for clofazimine and Graft vs Host Disease
| Article | Year |
|---|---|
Treatment of chronic graft-versus-host disease with clofazimine.
Topics: Adjuvants, Immunologic; Adult; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow Transplantation; | 1997 |
3 other studies available for clofazimine and Graft vs Host Disease
| Article | Year |
|---|---|
How can we help patients with refractory chronic graft versus host disease- single centre experience.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Clofazimine; Female; Graft vs Host | 2007 |
Methemoglobinemia secondary to clofazimine treatment for chronic graft-versus-host disease.
Topics: Child; Clofazimine; Female; Graft vs Host Disease; Humans; Methemoglobinemia | 1998 |
Clofazimine enteropathy in a pediatric bone marrow transplant recipient.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Bone Marrow Transplantation; Child; Clofazimine; Du | 2001 |