clofazimine has been researched along with Gangrene in 7 studies
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
Gangrene: Death and putrefaction of tissue usually due to a loss of blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Five patients suffering from dermatitis ulcerosa (a variant of pyoderma gangrenosum) were treated with clofazimine in a daily dosage of 200 mg orally." | 9.06 | Clofazimine in dermatitis ulcerosa (pyoderma gangrenosum). Open clinical trial. ( Mensing, H, 1988) |
| "Two patients with pyoderma gangrenosum have responded remarkably well to treatment with Clofazimine (Lamprène)." | 7.65 | [Pyoderma gangrenosum: Clofazimine therapy]. ( Beurey, J; Chaulieu, Y; Delrous, JL; Weber, M, 1977) |
| "Five patients suffering from dermatitis ulcerosa (a variant of pyoderma gangrenosum) were treated with clofazimine in a daily dosage of 200 mg orally." | 5.06 | Clofazimine in dermatitis ulcerosa (pyoderma gangrenosum). Open clinical trial. ( Mensing, H, 1988) |
| "Two patients with pyoderma gangrenosum have responded remarkably well to treatment with Clofazimine (Lamprène)." | 3.65 | [Pyoderma gangrenosum: Clofazimine therapy]. ( Beurey, J; Chaulieu, Y; Delrous, JL; Weber, M, 1977) |
| "Treatment with prednisolone and clofazimine produced an excellent clinical response." | 1.27 | Pyoderma gangrenosum associated with selective hereditary IgA deficiency. ( Bundino, S; Zina, AM, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bundino, S | 1 |
| Zina, AM | 1 |
| Cola, B | 1 |
| Porzio, F | 1 |
| Farella, S | 1 |
| Lovett, GW | 1 |
| Field, JP | 1 |
| King, LE | 1 |
| Ohela, K | 1 |
| Beurey, J | 1 |
| Weber, M | 1 |
| Delrous, JL | 1 |
| Chaulieu, Y | 1 |
| Michaëlsson, G | 1 |
| Molin, L | 1 |
| Ohmann, S | 1 |
| Gip, L | 1 |
| Lindström, B | 1 |
| Skogh, M | 1 |
| Trolin, I | 1 |
| Mensing, H | 1 |
1 trial available for clofazimine and Gangrene
| Article | Year |
|---|---|
Clofazimine in dermatitis ulcerosa (pyoderma gangrenosum). Open clinical trial.
Topics: Adult; Aged; Clinical Trials as Topic; Clofazimine; Female; Gangrene; Humans; Male; Middle Aged; Pyo | 1988 |
6 other studies available for clofazimine and Gangrene
| Article | Year |
|---|---|
Pyoderma gangrenosum associated with selective hereditary IgA deficiency.
Topics: Child, Preschool; Clofazimine; Female; Gangrene; Humans; IgA Deficiency; Prednisolone; Pyoderma; Ski | 1984 |
[Pyoderma gangrenosum: 2 cases with perineal localization].
Topics: Aged; Clofazimine; Female; Gangrene; Humans; Middle Aged; Perineum; Pyoderma; Skin Ulcer | 1980 |
Treatment of pyoderma gangrenosum with clofazimine. A case report and review of associated diseases.
Topics: Clofazimine; Diagnosis, Differential; Female; Gangrene; Humans; Middle Aged; Pyoderma | 1981 |
[Pyoderma gangrenosum treated with prednisolone and clofazimine].
Topics: Adult; Clofazimine; Female; Gangrene; Humans; Prednisolone; Pyoderma | 1981 |
[Pyoderma gangrenosum: Clofazimine therapy].
Topics: Adult; Aged; Clofazimine; Female; Gangrene; Humans; Immunity, Cellular; Pyoderma | 1977 |
Clofazimine. A new agent for the treatment of pyoderma gangrenosum.
Topics: Adult; Aged; Clofazimine; Drug Evaluation; Female; Gangrene; Humans; Male; Middle Aged; Pyoderma | 1976 |