clofazimine has been researched along with Experimental Neoplasms in 2 studies
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In patients with multiple myeloma (MM), AHR levels were inversely correlated with survival, suggesting that AHR inhibition may be beneficial for the treatment of this disease." | 1.48 | Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma. ( Affronti, HC; Bagati, A; Bergsagel, PL; Bianchi-Smiraglia, A; Fink, EE; Gitlin, II; Gudkov, AV; Han, Z; Kandel, ES; Lee, KP; Leonova, KI; Lightman, SM; Lipchick, BC; Long, MD; Moparthy, K; Moparthy, S; Nikiforov, MA; Polechetti, A; Roll, MV; Rosario, SR; Rowsam, AM; Smiraglia, DJ; Wolff, DW; Yun, DH, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bianchi-Smiraglia, A | 1 |
| Bagati, A | 1 |
| Fink, EE | 1 |
| Affronti, HC | 1 |
| Lipchick, BC | 1 |
| Moparthy, S | 1 |
| Long, MD | 1 |
| Rosario, SR | 1 |
| Lightman, SM | 1 |
| Moparthy, K | 1 |
| Wolff, DW | 1 |
| Yun, DH | 1 |
| Han, Z | 1 |
| Polechetti, A | 1 |
| Roll, MV | 1 |
| Gitlin, II | 1 |
| Leonova, KI | 1 |
| Rowsam, AM | 1 |
| Kandel, ES | 1 |
| Gudkov, AV | 1 |
| Bergsagel, PL | 1 |
| Lee, KP | 1 |
| Smiraglia, DJ | 1 |
| Nikiforov, MA | 1 |
| Wilkie, D | 1 |
2 other studies available for clofazimine and Experimental Neoplasms
| Article | Year |
|---|---|
Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma.
Topics: Animals; Biogenic Polyamines; Cell Line, Tumor; Clofazimine; HEK293 Cells; Humans; Mice; Multiple My | 2018 |
Antimitochondrial drugs in cancer chemotherapy: preliminary communication.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Clofazimine; Clomipramine; Cricetinae; Lung Neoplas | 1979 |