clofazimine has been researched along with Erythema Nodosum in 42 studies
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
Erythema Nodosum: An erythematous eruption commonly associated with drug reactions or infection and characterized by inflammatory nodules that are usually tender, multiple, and bilateral. These nodules are located predominantly on the shins with less common occurrence on the thighs and forearms. They undergo characteristic color changes ending in temporary bruise-like areas. This condition usually subsides in 3-6 weeks without scarring or atrophy.
Excerpt | Relevance | Reference |
---|---|---|
"Six male patients of lepromatous leprosy with erythema nodosum leprosum reaction (ENL) reactions diagnosed clinically and by slit skin smear were treated with aspirin and clofazimine." | 7.83 | A Traditional NSAID Aspirin along with Clofazimine in Erythema Nodosum Leprosum Reaction: Study of Six Cases. ( Sharma, PK; Singh, DK, 2016) |
"Clofazimine enterophathy is a serious complication of clofazimine when used at high doses for treatment of type 2 lepra or or erythema nodosum leprosum." | 7.75 | [Persistent type 2 lepra reaction (erythema nodosum) and clofazimine-induced lethal enteropathy]. ( Gómez, Y; López, F; Pinto, R; Rodríguez, G, 2009) |
" The majority of these patients become steroid-dependent and suffer from the adverse effects of long-term corticosteroid use." | 7.01 | Comparison of the efficacy and safety of minocycline and clofazimine in chronic and recurrent erythema nodosum leprosum-A randomized clinical trial. ( Dogra, S; Hanumanthu, V; Narang, T; Thakur, V, 2021) |
"Clofazimine was administered initially 100 mg three times daily for one month and then gradually reduced to a dose of 100 mg biweekly for the last three months." | 5.27 | Effect of one year clofazimine therapy on autonomic functions in lepromatous leprosy with lepra (ENL) reaction. ( Balsara, JJ; Bulakh, PM; Burte, NP; Chandorkar, AG; Muley, MP, 1983) |
"Twenty patients of lepromatous leprosy with lepra reaction and suspected dapsone resistance were treated with tapering doses of clofazimine." | 5.05 | Clofazimine in lepra (ENL) reaction, one year clinical trial. ( Balsara, JJ; Bulakh, PM; Burte, NP; Chandorkar, AG; Muley, MP, 1983) |
" The patient responded well to fluoroquinolone, rifampicin and clofazimine, with however, the occurrence of erythema nodosum leprosum." | 4.82 | [Histoid leprosy with erythema nodosum leprosum]. ( Alioua, Z; Benomar, S; Boudi, O; Bouzidi, A; Elhaouri, M; Ghfir, M; Sbai, M; Sedrati, OL, 2003) |
"Six male patients of lepromatous leprosy with erythema nodosum leprosum reaction (ENL) reactions diagnosed clinically and by slit skin smear were treated with aspirin and clofazimine." | 3.83 | A Traditional NSAID Aspirin along with Clofazimine in Erythema Nodosum Leprosum Reaction: Study of Six Cases. ( Sharma, PK; Singh, DK, 2016) |
"Clofazimine enterophathy is a serious complication of clofazimine when used at high doses for treatment of type 2 lepra or or erythema nodosum leprosum." | 3.75 | [Persistent type 2 lepra reaction (erythema nodosum) and clofazimine-induced lethal enteropathy]. ( Gómez, Y; López, F; Pinto, R; Rodríguez, G, 2009) |
"A 66-year-old Indian male who had been treated for recurrent erythema nodosum leprosum with 300 mg of clofazimine per day for 11 months presented to hospital with a 4 week history of severe gastrointestinal upset." | 3.69 | Clofazimine induced cardiotoxicity--a case report. ( Butany, JW; Choudhri, SH; Harris, L; Keystone, JS, 1995) |
"A patient of lepromatous leprosy, who received a high dose of clofazimine as part of multidrug therapy, for chronic erythema nodosum leprosum (ENL) had frequent 'haemoptysis'." | 3.68 | Red discoloration of the sputum by clofazimine simulating haemoptysis--a case report. ( Chauhan, SL; Girdhar, A; Girdhar, BK; Malaviya, GN; Venkatesan, K, 1992) |
"Oral zinc sulfate was tried in Eight cases of recurrent Erythema Nodosum Leprosum." | 3.66 | Oral zinc in recurrent Erythema Nodosum Leprosum reaction. ( Bumb, RA; Mangal, HN; Mathur, NK, 1983) |
" Reactive episodes continue to be a serious complication, but the availability of thalidomide to control erythema nodosum leprosum has markedly improved the prognosis." | 3.65 | The diagnosis and treatment of leprosy. ( Jacobson, RR; Trautman, JR, 1976) |
" The majority of these patients become steroid-dependent and suffer from the adverse effects of long-term corticosteroid use." | 3.01 | Comparison of the efficacy and safety of minocycline and clofazimine in chronic and recurrent erythema nodosum leprosum-A randomized clinical trial. ( Dogra, S; Hanumanthu, V; Narang, T; Thakur, V, 2021) |
"No confirmed relapse has been observed within a follow-up period of 6 months to 7 years and 3 months [59 person-years at risk (PYR)] for TT/BT patients and of 4 months to 5 years and 10 months (100 PYR) for BB/BL/LL patients." | 2.68 | Daily multidrug therapy for leprosy; results of a fourteen-year experience. ( Cottenot, F; de Carsalade, GY; Flageul, B; Pennec, J; Spindler, E; Wallach, D, 1997) |
"Clofazimine treatment was superior to prednisolone (more treatment successes; RR 3." | 2.45 | Interventions for erythema nodosum leprosum. ( Lockwood, DN; Ramirez, J; Richardus, JH; van Brakel, WH; Van Veen, NH, 2009) |
"Clofazimine treatment was superior to prednisolone (more treatment successes; RR 3." | 2.45 | Interventions for erythema nodosum leprosum. A Cochrane review. ( Lockwood, DN; Ramirez, J; Richardus, JH; Van Brakel, WH; Van Veen, NH, 2009) |
"Lepromatous leprosy is associated with a high bacillary load and poor cellular immune response." | 1.56 | Lepromatous leprosy presenting with type II reaction before and type I reaction after treatment. ( Bidari-Zerehpoosh, F; Bizaval, Z; Mozafari, N; Niknejad, N; Robati, RM, 2020) |
" Prednisolone in standard dosage schedule as recommended by WHO is now being widely used in control programmes." | 1.32 | Reactions and their management. ( Ganapati, R; Pai, VV, 2004) |
"Clofazimine was administered initially 100 mg three times daily for one month and then gradually reduced to a dose of 100 mg biweekly for the last three months." | 1.27 | Effect of one year clofazimine therapy on autonomic functions in lepromatous leprosy with lepra (ENL) reaction. ( Balsara, JJ; Bulakh, PM; Burte, NP; Chandorkar, AG; Muley, MP, 1983) |
" ENL was also more frequent in regimens C and D and was not prevented by CLO in the dosage used." | 1.27 | Prospective study on the relationship between intensive bactericidal therapy and leprosy reactions. ( Coussens, L; Groenen, G; Janssens, L; Kayembe, T; Nollet, E; Pattyn, SR, 1986) |
"Only in lepromatous cases was complete ageusia seen (9." | 1.27 | Electrogustometry in Hansen's disease (study of 225 cases). ( Chaturvedi, VN; Jain, SK; Raizada, RM; Rathi, SS, 1986) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 17 (40.48) | 18.7374 |
1990's | 10 (23.81) | 18.2507 |
2000's | 7 (16.67) | 29.6817 |
2010's | 6 (14.29) | 24.3611 |
2020's | 2 (4.76) | 2.80 |
Authors | Studies |
---|---|
Hanumanthu, V | 1 |
Thakur, V | 1 |
Narang, T | 1 |
Dogra, S | 1 |
Robati, RM | 1 |
Mozafari, N | 1 |
Bidari-Zerehpoosh, F | 1 |
Niknejad, N | 1 |
Bizaval, Z | 1 |
Sharma, PK | 1 |
Singh, DK | 1 |
Hossain, D | 1 |
Van Veen, NH | 2 |
Lockwood, DN | 2 |
van Brakel, WH | 2 |
Ramirez, J | 2 |
Richardus, JH | 2 |
Rodríguez, G | 1 |
Pinto, R | 1 |
López, F | 1 |
Gómez, Y | 1 |
Raftopoulos, SC | 1 |
Fermoyle, S | 1 |
Balagon, M | 1 |
Saunderson, PR | 1 |
Gelber, RH | 1 |
Yuchua-Guillen, A | 1 |
Dofitas, BL | 1 |
Chakma, JK | 1 |
Malaviya, GN | 2 |
Girdhar, A | 2 |
Hussein, S | 1 |
BROWNE, SG | 1 |
Schreuder, PA | 1 |
Naafs, B | 2 |
Alioua, Z | 1 |
Sbai, M | 1 |
Elhaouri, M | 1 |
Bouzidi, A | 1 |
Boudi, O | 1 |
Ghfir, M | 1 |
Benomar, S | 1 |
Sedrati, OL | 1 |
Sunderkötter, CH | 1 |
Lan Ma, H | 1 |
Ganapati, R | 1 |
Pai, VV | 1 |
Anderson, R | 2 |
Burte, NP | 2 |
Chandorkar, AG | 2 |
Muley, MP | 2 |
Balsara, JJ | 2 |
Bulakh, PM | 2 |
Waters, MF | 1 |
Mathur, NK | 1 |
Bumb, RA | 1 |
Mangal, HN | 1 |
Imkamp, FM | 2 |
Gatner, EM | 1 |
Dutta, RK | 1 |
Choudhri, SH | 1 |
Harris, L | 1 |
Butany, JW | 1 |
Keystone, JS | 1 |
Bhattacharya, SN | 1 |
Chattopadhaya, D | 1 |
Saha, K | 1 |
Sampaio, EP | 1 |
Malta, AM | 1 |
Sarno, EN | 1 |
Kaplan, G | 1 |
de Carsalade, GY | 1 |
Wallach, D | 1 |
Spindler, E | 1 |
Pennec, J | 1 |
Cottenot, F | 1 |
Flageul, B | 1 |
Gálvez, J | 1 |
López-Domínguez, JM | 1 |
Navarro, A | 1 |
Creagh, R | 1 |
Casado, JL | 1 |
Chinchón Lara, I | 1 |
Vides, EA | 1 |
Cabrera, A | 1 |
Ahern, KP | 1 |
Levis, WR | 1 |
Manandhar, R | 1 |
LeMaster, JW | 1 |
Roche, PW | 1 |
Welsh, O | 1 |
Gómez, M | 1 |
Mancias, C | 1 |
Ibarra-Leal, S | 1 |
Millikan, LE | 1 |
Jacobson, RR | 2 |
Trautman, JR | 2 |
Venkatesan, K | 1 |
Chauhan, SL | 1 |
Girdhar, BK | 1 |
Garraud, O | 1 |
Ribierre, O | 1 |
Bach, MA | 1 |
Sehgal, VN | 1 |
Sharma, V | 1 |
Sharma, VK | 1 |
Chaudhary, SD | 1 |
Sen, R | 1 |
Jain, VK | 1 |
Dixit, VB | 1 |
Groenen, G | 1 |
Janssens, L | 1 |
Kayembe, T | 1 |
Nollet, E | 1 |
Coussens, L | 1 |
Pattyn, SR | 1 |
Rathi, SS | 1 |
Chaturvedi, VN | 1 |
Raizada, RM | 1 |
Jain, SK | 1 |
Lim, SD | 1 |
Kiszkiss, DF | 1 |
Choi, YS | 1 |
Good, RA | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Methotrexate and Prednisolone Study in Erythema Nodosum Leprosum (MaPS in ENL[NCT03775460] | 550 participants (Anticipated) | Interventional | 2023-01-15 | Recruiting | |||
A Pilot Study to Evaluate the Efficacy and Safety of Apremilast in Patients of Chronic and Recurrent Erythema Nodosum Leprosum[NCT04822909] | Phase 4 | 10 participants (Actual) | Interventional | 2019-09-15 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
5 reviews available for clofazimine and Erythema Nodosum
Article | Year |
---|---|
Interventions for erythema nodosum leprosum.
Topics: Aspirin; Clofazimine; Erythema Nodosum; Humans; Leprostatic Agents; Leprosy, Lepromatous; Prednisolo | 2009 |
Interventions for erythema nodosum leprosum. A Cochrane review.
Topics: Aspirin; Clofazimine; Erythema Nodosum; Humans; Leprostatic Agents; Leprosy, Lepromatous; Prednisolo | 2009 |
[Histoid leprosy with erythema nodosum leprosum].
Topics: Adult; Clofazimine; Dapsone; Erythema Nodosum; Fluoroquinolones; Histiocytes; Humans; Leprostatic Ag | 2003 |
The immunopharmacology of antileprosy agents.
Topics: Antigens, Bacterial; Clofazimine; Dapsone; Erythema Nodosum; Humans; Immune Tolerance; Immunity, Cel | 1983 |
Bangkok Workshop on Leprosy Research. Treatment of reactions and nerve damage.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Clofazimine; Cyclosporine; Drug A | 1996 |
6 trials available for clofazimine and Erythema Nodosum
Article | Year |
---|---|
Comparison of the efficacy and safety of minocycline and clofazimine in chronic and recurrent erythema nodosum leprosum-A randomized clinical trial.
Topics: Clofazimine; Erythema Nodosum; Humans; Leprostatic Agents; Leprosy, Lepromatous; Minocycline; Prospe | 2021 |
Using methotrexate to treat patients with ENL unresponsive to steroids and clofazimine: a report on 9 patients.
Topics: Adult; Clofazimine; Drug Therapy, Combination; Erythema Nodosum; Female; Humans; Leprostatic Agents; | 2013 |
Clofazimine in lepra (ENL) reaction, one year clinical trial.
Topics: Adult; Clinical Trials as Topic; Clofazimine; Erythema Nodosum; Female; Humans; Leprosy; Male; Middl | 1983 |
Effect of rhuIFN-gamma treatment in multibacillary leprosy patients.
Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Erythema Nodosum; Humans; Interferon-gamma; Leprost | 1996 |
Daily multidrug therapy for leprosy; results of a fourteen-year experience.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Clofazimine; Dapsone; Drug Resistance, Microbial; | 1997 |
Effect of zafirlukast on leprosy reactions.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Clofazimine; Cohort Studies; D | 1999 |
31 other studies available for clofazimine and Erythema Nodosum
Article | Year |
---|---|
Lepromatous leprosy presenting with type II reaction before and type I reaction after treatment.
Topics: Clofazimine; Dapsone; Disease Progression; Drug Therapy, Combination; Erythema Nodosum; Humans; Lepr | 2020 |
A Traditional NSAID Aspirin along with Clofazimine in Erythema Nodosum Leprosum Reaction: Study of Six Cases.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clofazimine; Dapsone; Drug Therapy, Combina | 2016 |
[Persistent type 2 lepra reaction (erythema nodosum) and clofazimine-induced lethal enteropathy].
Topics: Abdominal Pain; Adult; Arthritis, Rheumatoid; Child; Child, Preschool; Clofazimine; Constipation; Di | 2009 |
An unusual cause of small-intestine mucosal pigmentation.
Topics: Adult; Clofazimine; Duodenal Diseases; Endoscopy, Digestive System; Erythema Nodosum; Humans; Lepros | 2011 |
Does clofazimine prevent erythema nodosum leprosum (ENL) in leprosy? A retrospective study, comparing the experience of multibacillary patients receiving either 12 or 24 months WHO-MDT.
Topics: Adolescent; Adult; Age Distribution; Aged; Child; Clofazimine; Drug Therapy, Combination; Erythema N | 2011 |
Atypical Hansen's disease presenting as florid verrucous plaques on the lower extremities: a case report.
Topics: Biopsy; Clofazimine; Dapsone; Drug Therapy, Combination; Erythema Nodosum; Glucocorticoids; Humans; | 2012 |
Florid reactive periostitis ossificans of long bones and digits associated with reaction in a patient with leprosy.
Topics: Adolescent; Clofazimine; Dapsone; Erythema Nodosum; Humans; Leprostatic Agents; Leprosy, Lepromatous | 2012 |
'B 663' POSSIBLE ANTI-INFLAMMATORY ACTION IN LEPROMATOUS LEPROSY.
Topics: Anti-Inflammatory Agents; Antitubercular Agents; Clofazimine; Drug Resistance; Drug Resistance, Micr | 1965 |
Chronic recurrent ENL, steroid dependent: long-term treatment with high dose clofazimine.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Clofazimine; Dose-Response Relationship, D | 2003 |
[Clofazimine. Current status of therapy with clofazimine (Lampren) for leprosy, erythema leprosum , and other dermatoses after donation of the medicine to the WHO by Novartis].
Topics: Charities; Clinical Trials as Topic; Clofazimine; Erythema Nodosum; Germany; Humans; Leprosy; Skin D | 2005 |
Reactions and their management.
Topics: Arthritis; Cicatrix; Clofazimine; Dose-Response Relationship, Drug; Drug-Related Side Effects and Ad | 2004 |
The treatment of leprosy.
Topics: Adult; Animals; Clofazimine; Dapsone; Drug Resistance, Microbial; Erythema Nodosum; Ethionamide; Hum | 1983 |
Oral zinc in recurrent Erythema Nodosum Leprosum reaction.
Topics: Administration, Oral; Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Erythema Nodosum; Fema | 1983 |
Effect of one year clofazimine therapy on autonomic functions in lepromatous leprosy with lepra (ENL) reaction.
Topics: Autonomic Nervous System; Blood Pressure; Clofazimine; Erythema Nodosum; Histamine; Humans; Leprosy; | 1983 |
Possible incompatibility of dapsone with clofazimine in the treatment of patients with erythema nodosum leprosum.
Topics: Clofazimine; Dapsone; Erythema Nodosum; Female; Humans; Leprosy; Male | 1982 |
Clofazimine and dapsone--a combination therapy in erythema nodosum leprosum syndrome.
Topics: Adolescent; Adult; Clofazimine; Dapsone; Drug Therapy, Combination; Erythema Nodosum; Female; Humans | 1980 |
Clofazimine induced cardiotoxicity--a case report.
Topics: Aged; Arrhythmias, Cardiac; Clofazimine; Erythema Nodosum; Humans; Leprosy, Lepromatous; Male | 1995 |
Tumor necrosis factor: status in reactions in leprosy before and after treatment.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Chloroquine; Clofazimine; Eryt | 1993 |
[Patient with Hansen disease and lepromatous reaction with predominant neural involvement].
Topics: Biopsy; Clofazimine; Dapsone; Erythema Nodosum; Humans; Leprostatic Agents; Leprosy, Lepromatous; Ma | 1998 |
Risk factors for erythema nodosum leprosum.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Child; Child, Preschool; Clofazimine; Cohor | 1999 |
A new therapeutic approach to type II leprosy reaction.
Topics: Adult; Aged; Clofazimine; Drug Therapy, Combination; Erythema Nodosum; Female; Humans; Leprostatic A | 1999 |
The diagnosis and treatment of leprosy.
Topics: Biopsy; Clofazimine; Dapsone; Erythema Nodosum; Humans; Immunotherapy; Leprosy; Recurrence; Rifampin | 1976 |
Treatment of Hansen's disease.
Topics: Chloroquine; Clofazimine; Dapsone; Drug Resistance, Microbial; Erythema Nodosum; Humans; Leprosy; Pr | 1976 |
Red discoloration of the sputum by clofazimine simulating haemoptysis--a case report.
Topics: Adolescent; Clofazimine; Diagnostic Errors; Erythema Nodosum; Hemoptysis; Humans; Leprosy, Lepromato | 1992 |
A follow up of T-cell subsets and of anti-M. leprae antibody titer as measured by the FLA-ABS test in Melanesian leprosy patients under polychemotherapy.
Topics: Adolescent; Adult; Antibodies, Bacterial; Child; Clofazimine; Dapsone; Drug Therapy, Combination; Er | 1986 |
The effect of anti-reactional drugs on complement components in the type II, erythema nodosum leprosum, reaction.
Topics: Chloroquine; Clofazimine; Complement C3; Complement Factor B; Complement System Proteins; Erythema N | 1988 |
Leukemoid reaction in erythema nodosum leprosum in a leprosy patient.
Topics: Adult; Clofazimine; Erythema Nodosum; Ferritins; Humans; Leprosy, Lepromatous; Leukemoid Reaction; M | 1988 |
Prospective study on the relationship between intensive bactericidal therapy and leprosy reactions.
Topics: Adult; Child; Clofazimine; Dapsone; Drug Therapy, Combination; Edema; Erythema Nodosum; Ethionamide; | 1986 |
Electrogustometry in Hansen's disease (study of 225 cases).
Topics: Adolescent; Adult; Ageusia; Clofazimine; Dapsone; Erythema Nodosum; Facial Paralysis; Female; Humans | 1986 |
Thymus-dependent lymphocytes of peripheral blood in leprosy patients.
Topics: Adult; Aged; Animals; Blood Cell Count; Clofazimine; Dapsone; Erythema Nodosum; Erythrocytes; Humans | 1974 |
The treatment of corticosteroid-dependent lepromatous patients in persistent Erythema nodosum leprosum with clofazimine.
Topics: Adrenal Cortex Hormones; Clofazimine; Erythema Nodosum; Female; Follow-Up Studies; Humans; Leprosy; | 1973 |