clofazimine has been researched along with ER-Negative PR-Negative HER2-Negative Breast Cancer in 2 studies
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ahmed, K | 1 |
| Koval, A | 1 |
| Xu, J | 1 |
| Bodmer, A | 1 |
| Katanaev, VL | 2 |
| Koval, AV | 1 |
| Vlasov, P | 1 |
| Shichkova, P | 1 |
| Khunderyakova, S | 1 |
| Markov, Y | 1 |
| Panchenko, J | 1 |
| Volodina, A | 1 |
| Kondrashov, FA | 1 |
2 other studies available for clofazimine and ER-Negative PR-Negative HER2-Negative Breast Cancer
| Article | Year |
|---|---|
Towards the first targeted therapy for triple-negative breast cancer: Repositioning of clofazimine as a chemotherapy-compatible selective Wnt pathway inhibitor.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; Cell | 2019 |
Anti-leprosy drug clofazimine inhibits growth of triple-negative breast cancer cells via inhibition of canonical Wnt signaling.
Topics: Animals; Binding Sites; Cell Line, Tumor; Clofazimine; Crystallography, X-Ray; Growth Inhibitors; HE | 2014 |