clofazimine has been researched along with Disease Exacerbation in 5 studies
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lepromatous leprosy is associated with a high bacillary load and poor cellular immune response." | 1.56 | Lepromatous leprosy presenting with type II reaction before and type I reaction after treatment. ( Bidari-Zerehpoosh, F; Bizaval, Z; Mozafari, N; Niknejad, N; Robati, RM, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Robati, RM | 1 |
| Mozafari, N | 1 |
| Bidari-Zerehpoosh, F | 1 |
| Niknejad, N | 1 |
| Bizaval, Z | 1 |
| Scagliola, A | 1 |
| Miluzio, A | 1 |
| Ventura, G | 1 |
| Oliveto, S | 1 |
| Cordiglieri, C | 1 |
| Manfrini, N | 1 |
| Cirino, D | 1 |
| Ricciardi, S | 1 |
| Valenti, L | 1 |
| Baselli, G | 1 |
| D'Ambrosio, R | 1 |
| Maggioni, M | 1 |
| Brina, D | 1 |
| Bresciani, A | 1 |
| Biffo, S | 1 |
| Fischer, M | 1 |
| Goulart, IM | 1 |
| Reis, AC | 1 |
| De Rezende, TM | 1 |
| Borges, AS | 1 |
| Ferreira, MS | 1 |
| Nishioka, SA | 1 |
| Wollina, U | 1 |
| Karte, K | 1 |
| Geyer, A | 1 |
| Stuhlert, A | 1 |
| Bocker, T | 1 |
1 review available for clofazimine and Disease Exacerbation
| Article | Year |
|---|---|
Leprosy - an overview of clinical features, diagnosis, and treatment.
Topics: Adult; Aged; Child; Clofazimine; Cross-Sectional Studies; Dapsone; Disease Progression; Drug Adminis | 2017 |
4 other studies available for clofazimine and Disease Exacerbation
| Article | Year |
|---|---|
Lepromatous leprosy presenting with type II reaction before and type I reaction after treatment.
Topics: Clofazimine; Dapsone; Disease Progression; Drug Therapy, Combination; Erythema Nodosum; Humans; Lepr | 2020 |
Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; CCAAT-Enhancer-Binding Protein-beta; Cell Line; Cell Transformat | 2021 |
Aplastic anaemia associated with multidrug therapy (dapsone, rifampicin and clofazimine) in a patient with lepromatous leprosy.
Topics: Adult; Anemia, Aplastic; Brazil; Clofazimine; Dapsone; Disease Progression; Drug Therapy, Combinatio | 2005 |
Clofazimine in inflammatory facial dermatosis--granuloma faciale and lipogranulomatosis subcutanea (Rothmann-Makai)
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Clofazimine; Disease Progression; Facial Dermatoses; | 1996 |