Page last updated: 2024-10-25

clofazimine and DRESS Syndrome

clofazimine has been researched along with DRESS Syndrome in 1 studies

Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.

Research Excerpts

ExcerptRelevanceReference
"Dapsone hypersensitivity syndrome (DHS) is the most serious adverse reaction associated with dapsone administration and one of the major causes of death in patients with leprosy, whose standard treatment includes multidrug therapy (MDT) with dapsone, rifampicin, and clofazimine."7.91Evaluation of Prospective HLA-B*13:01 Screening to Prevent Dapsone Hypersensitivity Syndrome in Patients With Leprosy. ( Bao, F; Cao, J; Cao, Q; Chai, Z; Chen, S; Cheng, X; Chu, T; Duan, Q; Fu, F; Fu, X; Irwanto, A; Ke, W; Krismawati, H; Kuang, Y; Lang, X; Li, J; Li, L; Li, M; Li, W; Lin, Z; Liu, D; Liu, H; Liu, J; Liu, Q; Mi, Z; Ning, Y; Pan, Q; Shang, X; Shen, J; Shen, Y; Sun, L; Sun, Y; Wang, C; Wang, H; Wang, L; Wang, X; Wang, Y; Wang, Z; Wu, W; Xiao, B; Xiao, P; Xiong, F; Xiong, J; Xiong, L; Xiong, M; Xu, Y; Yan, L; Yang, B; Yang, J; You, J; Yu, G; Yu, W; Yue, Z; Zhan, X; Zhang, F; Zhang, G; Zhang, H; Zhang, L; Zhang, Y; Zhao, Q; Zhao, W; Zheng, H, 2019)
"Dapsone hypersensitivity syndrome (DHS) is the most serious adverse reaction associated with dapsone administration and one of the major causes of death in patients with leprosy, whose standard treatment includes multidrug therapy (MDT) with dapsone, rifampicin, and clofazimine."3.91Evaluation of Prospective HLA-B*13:01 Screening to Prevent Dapsone Hypersensitivity Syndrome in Patients With Leprosy. ( Bao, F; Cao, J; Cao, Q; Chai, Z; Chen, S; Cheng, X; Chu, T; Duan, Q; Fu, F; Fu, X; Irwanto, A; Ke, W; Krismawati, H; Kuang, Y; Lang, X; Li, J; Li, L; Li, M; Li, W; Lin, Z; Liu, D; Liu, H; Liu, J; Liu, Q; Mi, Z; Ning, Y; Pan, Q; Shang, X; Shen, J; Shen, Y; Sun, L; Sun, Y; Wang, C; Wang, H; Wang, L; Wang, X; Wang, Y; Wang, Z; Wu, W; Xiao, B; Xiao, P; Xiong, F; Xiong, J; Xiong, L; Xiong, M; Xu, Y; Yan, L; Yang, B; Yang, J; You, J; Yu, G; Yu, W; Yue, Z; Zhan, X; Zhang, F; Zhang, G; Zhang, H; Zhang, L; Zhang, Y; Zhao, Q; Zhao, W; Zheng, H, 2019)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Liu, H1
Wang, Z1
Bao, F1
Wang, C1
Sun, L1
Zhang, H1
Yu, G1
Mi, Z1
Li, J3
Li, L1
Zhao, Q1
Yue, Z1
Zhao, W1
Yu, W1
Cao, J1
Xiong, F1
Wang, Y2
Chai, Z1
Cheng, X1
Zhang, Y1
Fu, F1
Lang, X1
Wang, X1
Irwanto, A1
Krismawati, H1
Fu, X1
Sun, Y1
You, J1
Liu, J2
Pan, Q1
Chu, T1
Liu, D1
Chen, S1
Shen, J1
Yan, L2
Zhang, G1
Zhang, F1
Xiong, L1
Yang, J1
Ke, W1
Li, M2
Ning, Y1
Xiong, J1
Xiong, M1
Yang, B1
Duan, Q1
Wang, H1
Li, W2
Kuang, Y1
Wang, L1
Cao, Q1
Xiao, P1
Xiao, B1
Zhang, L1
Lin, Z1
Shen, Y1
Wu, W1
Zheng, H1
Zhan, X1
Shang, X1
Xu, Y1
Liu, Q1

Other Studies

1 other study available for clofazimine and DRESS Syndrome

ArticleYear
Evaluation of Prospective HLA-B*13:01 Screening to Prevent Dapsone Hypersensitivity Syndrome in Patients With Leprosy.
    JAMA dermatology, 2019, 06-01, Volume: 155, Issue:6

    Topics: Adult; Alleles; China; Clofazimine; Cohort Studies; Dapsone; Drug Hypersensitivity Syndrome; Drug Th

2019