clofazimine has been researched along with Colitis, Granulomatous in 21 studies
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clofazimine, a commonly used anti-lepromatous drug, is now being prescribed for the treatment of pyoderma gangrenosum, a complication of inflammatory bowel disease." | 3.68 | Orange/black discolouration of the bowel (at laparotomy) due to clofazimine. ( Farrell, KE; Guli, E; King, RW; Merrett, MN; Zeimer, H, 1990) |
| " Ramp-up dosing was used." | 2.73 | Anti-mycobacterial therapy in Crohn's disease heals mucosa with longitudinal scars. ( Bilkey, S; Borody, TJ; Leis, S; Pang, G; Tye, S; Wettstein, AR, 2007) |
"Those in remission (Crohn's Disease Activity Index | 2.73 | Two-year combination antibiotic therapy with clarithromycin, rifabutin, and clofazimine for Crohn's disease. ( Connell, W; Crotty, B; Ee, H; Florin, T; Gibson, P; Hetzel, D; Merrett, M; Mitchell, B; Pavli, P; Radford-Smith, G; Read, R; Selby, W, 2007) | |
| "Clofazimine seems to be an effective treatment, although long-term application is necessary with frequent aggravation in the beginning." | 1.34 | Cheilitis granulomatosa and Melkersson-Rosenthal syndrome: evaluation of gastrointestinal involvement and therapeutic regimens in a series of 14 patients. ( Ratzinger, G; Sepp, N; Tilg, H; Vogetseder, W, 2007) |
| "Reversal of severe Crohn's disease has been achieved in 6/12 patients using prolonged combination anti-Mycobacterium avium subspecies paratuberculosis therapy alone." | 1.31 | Treatment of severe Crohn's disease using antimycobacterial triple therapy--approaching a cure? ( Borody, TJ; Leis, S; Surace, R; Warren, EF, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (9.52) | 18.7374 |
| 1990's | 3 (14.29) | 18.2507 |
| 2000's | 12 (57.14) | 29.6817 |
| 2010's | 4 (19.05) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dhillon, AS | 1 |
| Johnston, EL | 1 |
| Sanderson, JD | 1 |
| Savarino, E | 1 |
| Bertani, L | 1 |
| Ceccarelli, L | 1 |
| Bodini, G | 1 |
| Zingone, F | 1 |
| Buda, A | 1 |
| Facchin, S | 1 |
| Lorenzon, G | 1 |
| Marchi, S | 1 |
| Marabotto, E | 1 |
| De Bortoli, N | 1 |
| Savarino, V | 1 |
| Costa, F | 1 |
| Blandizzi, C | 1 |
| Patton, PH | 1 |
| Parker, CE | 1 |
| MacDonald, JK | 1 |
| Chande, N | 1 |
| Feller, M | 1 |
| Huwiler, K | 1 |
| Schoepfer, A | 1 |
| Shang, A | 1 |
| Furrer, H | 1 |
| Egger, M | 1 |
| Borody, TJ | 2 |
| Bilkey, S | 1 |
| Wettstein, AR | 1 |
| Leis, S | 2 |
| Pang, G | 1 |
| Tye, S | 1 |
| Selby, W | 1 |
| Pavli, P | 1 |
| Crotty, B | 1 |
| Florin, T | 1 |
| Radford-Smith, G | 1 |
| Gibson, P | 1 |
| Mitchell, B | 1 |
| Connell, W | 1 |
| Read, R | 1 |
| Merrett, M | 1 |
| Ee, H | 1 |
| Hetzel, D | 1 |
| Peyrin-Biroulet, L | 1 |
| Neut, C | 1 |
| Colombel, JF | 1 |
| Ratzinger, G | 1 |
| Sepp, N | 1 |
| Vogetseder, W | 1 |
| Tilg, H | 1 |
| Kuenstner, JT | 1 |
| Lipton, JE | 1 |
| Barash, DP | 1 |
| Gitlin, L | 1 |
| Biesecker, J | 1 |
| Chamberlin, W | 1 |
| Behr, MA | 1 |
| Hanley, J | 1 |
| Prantera, C | 1 |
| Kohn, A | 1 |
| Mangiarotti, R | 1 |
| Andreoli, A | 1 |
| Luzi, C | 1 |
| Hermon-Taylor, J | 2 |
| Warren, EF | 1 |
| Surace, R | 1 |
| Brandt, L | 1 |
| Gärtner, I | 1 |
| Nilsson, PG | 1 |
| Olofsson, T | 1 |
| Afdhal, NH | 1 |
| Long, A | 1 |
| Lennon, J | 1 |
| Crowe, J | 1 |
| O'Donoghue, DP | 1 |
| Merrett, MN | 1 |
| King, RW | 1 |
| Farrell, KE | 1 |
| Zeimer, H | 1 |
| Guli, E | 1 |
| Read, AE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Use of Autologous Adult Adipose-Derived Stem/Stromal Cells in Inflammatory Bowel Disease[NCT02952131] | Phase 1/Phase 2 | 100 participants (Anticipated) | Interventional | 2016-11-30 | Enrolling by invitation | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for clofazimine and Colitis, Granulomatous
| Article | Year |
|---|---|
Antimicrobial treatment with the fixed-dose antibiotic combination RHB-104 for Mycobacterium avium subspecies paratuberculosis in Crohn's disease: pharmacological and clinical implications.
Topics: Animals; Anti-Bacterial Agents; Clarithromycin; Clofazimine; Crohn Disease; Drug Combinations; Human | 2019 |
Anti-tuberculous therapy for maintenance of remission in Crohn's disease.
Topics: Antitubercular Agents; Clarithromycin; Clofazimine; Crohn Disease; Ethambutol; Glucocorticoids; Huma | 2016 |
Long-term antibiotic treatment for Crohn's disease: systematic review and meta-analysis of placebo-controlled trials.
Topics: Anti-Bacterial Agents; Clofazimine; Crohn Disease; Humans; Nitroimidazoles; Odds Ratio; Placebos | 2010 |
Antimycobacterial therapy in Crohn's disease: game over?
Topics: Anti-Bacterial Agents; Clarithromycin; Clofazimine; Crohn Disease; Drug Therapy, Combination; Humans | 2007 |
4 trials available for clofazimine and Colitis, Granulomatous
| Article | Year |
|---|---|
Anti-mycobacterial therapy in Crohn's disease heals mucosa with longitudinal scars.
Topics: Adolescent; Adult; Anti-Infective Agents; Clarithromycin; Clofazimine; Crohn Disease; Female; Humans | 2007 |
Two-year combination antibiotic therapy with clarithromycin, rifabutin, and clofazimine for Crohn's disease.
Topics: Adult; Anti-Bacterial Agents; Clarithromycin; Clofazimine; Crohn Disease; Double-Blind Method; Drug | 2007 |
Antimycobacterial therapy in Crohn's disease: results of a controlled, double-blind trial with a multiple antibiotic regimen.
Topics: Adult; Anti-Bacterial Agents; Antitubercular Agents; Clofazimine; Crohn Disease; Dapsone; Double-Bli | 1994 |
Controlled trial of antimycobacterial therapy in Crohn's disease. Clofazimine versus placebo.
Topics: Adult; Clofazimine; Crohn Disease; Double-Blind Method; Drug Evaluation; Female; Humans; Male; Middl | 1991 |
13 other studies available for clofazimine and Colitis, Granulomatous
| Article | Year |
|---|---|
A Case of Unusual Ileal Discoloration.
Topics: Clofazimine; Crohn Disease; Histiocytosis; Humans; Ileal Diseases; Leprostatic Agents; Male; Mycobac | 2018 |
Cheilitis granulomatosa and Melkersson-Rosenthal syndrome: evaluation of gastrointestinal involvement and therapeutic regimens in a series of 14 patients.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Capsule Endoscopy; Clo | 2007 |
The Australian antibiotic trial in Crohn's disease: alternative conclusions from the same study.
Topics: Anti-Bacterial Agents; Clarithromycin; Clofazimine; Crohn Disease; Drug Therapy, Combination; Humans | 2007 |
Flawed Australian CD study does not end MAP controversy.
Topics: Anti-Bacterial Agents; Clarithromycin; Clofazimine; Crohn Disease; Drug Therapy, Combination; Humans | 2007 |
Australian Crohn's antibiotic study opens new horizons.
Topics: Anti-Bacterial Agents; Antibodies, Monoclonal; Clarithromycin; Clofazimine; Crohn Disease; Drug Ther | 2007 |
Importance of the Australian Crohn's disease antibiotic study.
Topics: Anti-Bacterial Agents; Clarithromycin; Clofazimine; Crohn Disease; Data Interpretation, Statistical; | 2007 |
Antimycobacterial therapy for Crohn's disease: a reanalysis.
Topics: Adrenal Cortex Hormones; Antitubercular Agents; Clarithromycin; Clinical Trials as Topic; Clofazimin | 2008 |
Protagonist. Mycobacterium avium subspecies paratuberculosis is a cause of Crohn's disease.
Topics: Animals; Animals, Domestic; Cattle; Clarithromycin; Clofazimine; Crohn Disease; Disease Reservoirs; | 2001 |
Treatment of severe Crohn's disease using antimycobacterial triple therapy--approaching a cure?
Topics: Adolescent; Adult; Clarithromycin; Clofazimine; Colonoscopy; Crohn Disease; Drug Therapy, Combinatio | 2002 |
Treatment with drugs active against Mycobacterium avium subspecies paratuberculosis can heal Crohn's disease: more evidence for a neglected public health tragedy.
Topics: Clarithromycin; Clofazimine; Crohn Disease; Drug Resistance, Bacterial; Drug Therapy, Combination; H | 2002 |
Pyoderma gangrenosum associated with regional enteritis. Improvement in defective granulocyte function and healing of skin lesions during administration of clofazimine.
Topics: Adult; Clofazimine; Crohn Disease; Female; Granulocytes; Humans; Oxygen Consumption; Phagocyte Bacte | 1977 |
Orange/black discolouration of the bowel (at laparotomy) due to clofazimine.
Topics: Adult; Clofazimine; Crohn Disease; Female; Humans; Ileum; Pyoderma | 1990 |
Pyoderma gangrenosum.
Topics: Arthritis; Clofazimine; Colitis, Ulcerative; Crohn Disease; Humans; Male; Pyoderma | 1985 |