clofazimine has been researched along with Chronic Disease in 18 studies
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Seven patients with pyoderma gangrenosum have been treated with clofazimine." | 9.05 | Pyoderma gangrenosum treated with clofazimine: clinical evaluation of 7 cases. ( Rasmussen, I, 1983) |
| "The therapeutic efficacy of liposomal clofazimine (L-CLF) was studied in mice infected with Mycobacterium tuberculosis Erdman." | 7.70 | Effective treatment of acute and chronic murine tuberculosis with liposome-encapsulated clofazimine. ( Adams, LB; Franzblau, SG; Krahenbuhl, JL; Mehta, RT; Sinha, I, 1999) |
| "Clofazimine-induced crystal-storing histiocytosis is a rare but well-recognized condition in the literature." | 7.70 | Clofazimine-induced crystal-storing histiocytosis producing chronic abdominal pain in a leprosy patient. ( Akaraviputh, T; Chanchairujira, T; Hargrove, NS; Kachintorn, U; Manatsathit, S; Siritanaratkul, N; Sukpanichnant, S; Thakerngpol, K, 2000) |
| "Three cases of pyoderma gangrenosum (PG) responsive to clofazimine are reported." | 7.66 | Pyoderma gangrenosum treated with clofazimine. Report of three cases. ( Davis, BR; Kark, EC; Pomeranz, JR, 1981) |
| "Clofazimine (Lamprene) is an antimycobacterial drug that has antiinflammatory activity in a number of chronic autoimmune skin disorders." | 6.68 | Treatment of chronic graft-versus-host disease with clofazimine. ( Antin, JH; Bierer, BE; Lee, SJ; McGarigle, CJ; Wegner, SA, 1997) |
| "Seven patients with pyoderma gangrenosum have been treated with clofazimine." | 5.05 | Pyoderma gangrenosum treated with clofazimine: clinical evaluation of 7 cases. ( Rasmussen, I, 1983) |
| "The therapeutic efficacy of liposomal clofazimine (L-CLF) was studied in mice infected with Mycobacterium tuberculosis Erdman." | 3.70 | Effective treatment of acute and chronic murine tuberculosis with liposome-encapsulated clofazimine. ( Adams, LB; Franzblau, SG; Krahenbuhl, JL; Mehta, RT; Sinha, I, 1999) |
| "Clofazimine-induced crystal-storing histiocytosis is a rare but well-recognized condition in the literature." | 3.70 | Clofazimine-induced crystal-storing histiocytosis producing chronic abdominal pain in a leprosy patient. ( Akaraviputh, T; Chanchairujira, T; Hargrove, NS; Kachintorn, U; Manatsathit, S; Siritanaratkul, N; Sukpanichnant, S; Thakerngpol, K, 2000) |
| "Three cases of pyoderma gangrenosum (PG) responsive to clofazimine are reported." | 3.66 | Pyoderma gangrenosum treated with clofazimine. Report of three cases. ( Davis, BR; Kark, EC; Pomeranz, JR, 1981) |
| "Clofazimine (Lamprene) is an antimycobacterial drug that has antiinflammatory activity in a number of chronic autoimmune skin disorders." | 2.68 | Treatment of chronic graft-versus-host disease with clofazimine. ( Antin, JH; Bierer, BE; Lee, SJ; McGarigle, CJ; Wegner, SA, 1997) |
| "Clofazimine is a drug used to treat leprosy." | 1.34 | How can we help patients with refractory chronic graft versus host disease- single centre experience. ( Barzal, J; Oborska, S; Rzepecki, P; Sarosiek, T; Szczylik, C, 2007) |
| " If chemotherapy is initiated 3 wk after challenge (established infections), the activity of this double drug combination is less effective." | 1.27 | Activity of rifabutin alone or in combination with clofazimine or ethambutol or both against acute and chronic experimental Mycobacterium intracellulare infections. ( Farhi, DC; Gangadharam, PR; Iseman, MD; Jairam, BT; Nguyen, AK; Perumal, VK; Rao, PN, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (27.78) | 18.7374 |
| 1990's | 4 (22.22) | 18.2507 |
| 2000's | 4 (22.22) | 29.6817 |
| 2010's | 4 (22.22) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Sbaraglini, ML | 2 |
| Bellera, CL | 2 |
| Quarroz Braghini, J | 1 |
| Areco, Y | 1 |
| Miranda, C | 1 |
| Carrillo, C | 2 |
| Kelly, J | 1 |
| Buchholz, B | 1 |
| Gelpi, RJ | 1 |
| Talevi, A | 2 |
| Alba Soto, CD | 2 |
| Duran Merino, CE | 1 |
| Ortiz Úsuga, MC | 1 |
| Jaramillo, MJ | 1 |
| Rodríguez, AM | 1 |
| Pawar, M | 1 |
| Zawar, V | 1 |
| Kumavat, S | 1 |
| Daga, S | 1 |
| Fraccaroli, L | 1 |
| Larocca, L | 1 |
| Xu, J | 1 |
| Lu, Y | 1 |
| Fu, L | 1 |
| Zhu, H | 1 |
| Wang, B | 1 |
| Mdluli, K | 1 |
| Upton, AM | 1 |
| Jin, H | 1 |
| Zheng, M | 1 |
| Zhao, W | 1 |
| Li, P | 1 |
| Schreuder, PA | 1 |
| Naafs, B | 1 |
| Miladi, MI | 1 |
| Feki, I | 1 |
| Bahloul, Z | 1 |
| Jlidi, R | 1 |
| Mhiri, C | 1 |
| Rzepecki, P | 1 |
| Barzal, J | 1 |
| Sarosiek, T | 1 |
| Oborska, S | 1 |
| Szczylik, C | 1 |
| Rasmussen, I | 1 |
| Kark, EC | 1 |
| Davis, BR | 1 |
| Pomeranz, JR | 1 |
| Michałowska-Mitczuk, D | 1 |
| Kansal, RG | 1 |
| Gomez-Flores, R | 1 |
| Sinha, I | 2 |
| Mehta, RT | 2 |
| Lee, SJ | 1 |
| Wegner, SA | 1 |
| McGarigle, CJ | 1 |
| Bierer, BE | 1 |
| Antin, JH | 1 |
| Adams, LB | 1 |
| Franzblau, SG | 1 |
| Krahenbuhl, JL | 1 |
| Sukpanichnant, S | 1 |
| Hargrove, NS | 1 |
| Kachintorn, U | 1 |
| Manatsathit, S | 1 |
| Chanchairujira, T | 1 |
| Siritanaratkul, N | 1 |
| Akaraviputh, T | 1 |
| Thakerngpol, K | 1 |
| Dupré, A | 1 |
| Bonafé, JL | 1 |
| Lassère, J | 1 |
| Albarel, N | 1 |
| Christol, B | 1 |
| Gangadharam, PR | 1 |
| Perumal, VK | 1 |
| Jairam, BT | 1 |
| Rao, PN | 1 |
| Nguyen, AK | 1 |
| Farhi, DC | 1 |
| Iseman, MD | 1 |
| Davy, C | 1 |
| Riveau, E | 1 |
| Bousquet, JC | 1 |
| Curet, P | 1 |
| Vayre, P | 1 |
| Cortez, A | 1 |
| Grellet, J | 1 |
2 reviews available for clofazimine and Chronic Disease
| Article | Year |
|---|---|
Chronic Unilateral Uveitis as a Manifestation of Leprosy: A Case Report and Literature Review.
Topics: Aged; Atrophy; Biopsy; Chronic Disease; Clofazimine; Dapsone; Drug Therapy, Combination; Eye Infecti | 2021 |
[Patients with chronic sputum positive tuberculosis-a therapeutic problem].
Topics: Amikacin; Amoxicillin; Antitubercular Agents; Chronic Disease; Clarithromycin; Clofazimine; Humans; | 1995 |
2 trials available for clofazimine and Chronic Disease
| Article | Year |
|---|---|
Pyoderma gangrenosum treated with clofazimine: clinical evaluation of 7 cases.
Topics: Adult; Aged; Chronic Disease; Clinical Trials as Topic; Clofazimine; Female; Humans; Male; Middle Ag | 1983 |
Treatment of chronic graft-versus-host disease with clofazimine.
Topics: Adjuvants, Immunologic; Adult; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow Transplantation; | 1997 |
14 other studies available for clofazimine and Chronic Disease
| Article | Year |
|---|---|
Combined therapy with Benznidazole and repurposed drugs Clofazimine and Benidipine for chronic Chagas disease.
Topics: Animals; Chagas Disease; Chlorocebus aethiops; Chronic Disease; Clofazimine; Combined Modality Thera | 2019 |
Chronic, persistent angioedema and sinusitis-like presentation of multibacillary leprosy.
Topics: Adolescent; Angioedema; Biopsy; Chronic Disease; Clofazimine; Dapsone; Developing Countries; Diagnos | 2018 |
Novel cruzipain inhibitors for the chemotherapy of chronic Chagas disease.
Topics: Adult; Animals; Antiprotozoal Agents; Chagas Disease; Chronic Disease; Clofazimine; Cysteine Endopep | 2016 |
In vitro and in vivo activity of clofazimine against Mycobacterium tuberculosis persisters.
Topics: Animals; Antitubercular Agents; Aza Compounds; Chronic Disease; Clofazimine; Disease Models, Animal; | 2012 |
Chronic recurrent ENL, steroid dependent: long-term treatment with high dose clofazimine.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Clofazimine; Dose-Response Relationship, D | 2003 |
Chronic inflammatory joint disease revealing borderline leprosy.
Topics: Adult; Arthritis; Chronic Disease; Clofazimine; Dapsone; Diagnosis, Differential; Drug Therapy, Comb | 2006 |
How can we help patients with refractory chronic graft versus host disease- single centre experience.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Clofazimine; Female; Graft vs Host | 2007 |
Pyoderma gangrenosum treated with clofazimine. Report of three cases.
Topics: Chronic Disease; Clofazimine; Female; Humans; Male; Middle Aged; Pyoderma; Skin Ulcer; Wound Healing | 1981 |
Therapeutic efficacy of liposomal clofazimine against Mycobacterium avium complex in mice depends on size of initial inoculum and duration of infection.
Topics: Acute Disease; Animals; Anti-Bacterial Agents; Chronic Disease; Clofazimine; Disease Models, Animal; | 1997 |
Effective treatment of acute and chronic murine tuberculosis with liposome-encapsulated clofazimine.
Topics: Acute Disease; Animals; Chronic Disease; Clofazimine; Drug Carriers; Leprostatic Agents; Liposomes; | 1999 |
Clofazimine-induced crystal-storing histiocytosis producing chronic abdominal pain in a leprosy patient.
Topics: Abdominal Pain; Adult; Biopsy; Chronic Disease; Clofazimine; Crystallization; Cytoplasm; Diagnosis, | 2000 |
[Lamprene (Clofazimine) treatment of chronic lupus erythematoides (author's transl)].
Topics: Adult; Chronic Disease; Clofazimine; Dose-Response Relationship, Drug; Drug Evaluation; Female; Huma | 1978 |
Activity of rifabutin alone or in combination with clofazimine or ethambutol or both against acute and chronic experimental Mycobacterium intracellulare infections.
Topics: Animals; Chronic Disease; Clofazimine; Drug Therapy, Combination; Ethambutol; Male; Mice; Mice, Inbr | 1987 |
[Small intestine transit anomalies in a patient with chronic abdominal pain and treated for Hansen's disease].
Topics: Abdomen; Chronic Disease; Clofazimine; Female; Gastrointestinal Motility; Humans; Intestinal Disease | 1986 |