clofazimine has been researched along with Borderline Lepromatous in 16 studies
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The World Health Organization (WHO) recommends multidrug therapy (MDT) with rifampicin, dapsone, and clofazimine for treating leprosy, which is based on very low-quality evidence." | 5.41 | Seventy years of evidence on the efficacy and safety of drugs for treating leprosy: a network meta-analysis. ( Bao, F; Chen, J; Dong, Y; Fan, Y; Gao, L; Ji, Z; Kong, J; Li, B; Liu, A; Liu, M; Luo, S; Ma, W; Peng, L; Song, J; Wu, X; Yang, J, 2023) |
| "This study sought to verify the correlation between leprosy types and the adverse effects of treatment drugs." | 2.77 | Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects. ( Almeida, PC; Bührer-Sékula, S; Cruz, R; Gonçalves, Hde S; Moraes, ME; Penna, GO; Pontes, MA, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 13 (81.25) | 24.3611 |
| 2020's | 2 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Chew, R | 1 |
| Woods, ML | 1 |
| Yang, J | 1 |
| Kong, J | 1 |
| Li, B | 1 |
| Ji, Z | 1 |
| Liu, A | 1 |
| Chen, J | 1 |
| Liu, M | 1 |
| Fan, Y | 1 |
| Peng, L | 1 |
| Song, J | 1 |
| Wu, X | 1 |
| Gao, L | 1 |
| Ma, W | 1 |
| Dong, Y | 1 |
| Luo, S | 1 |
| Bao, F | 1 |
| Lockwood, DNJ | 1 |
| Lambert, S | 1 |
| Srikantam, A | 1 |
| Darlong, J | 1 |
| Pai, VV | 1 |
| Butlin, CR | 1 |
| de Barros, B | 1 |
| Negera, E | 1 |
| Walker, SL | 1 |
| Penna, GO | 2 |
| Bührer-Sékula, S | 2 |
| Kerr, LRS | 1 |
| Stefani, MMA | 1 |
| Rodrigues, LC | 1 |
| de Araújo, MG | 1 |
| Ramos, AMC | 1 |
| de Andrade, ARC | 1 |
| Costa, MB | 1 |
| Rosa, PS | 1 |
| Gonçalves, HS | 1 |
| Cruz, R | 2 |
| Barreto, ML | 1 |
| Pontes, MAA | 1 |
| Penna, MLF | 1 |
| Pawar, M | 1 |
| Zawar, V | 1 |
| Kumavat, S | 1 |
| Daga, S | 1 |
| Weberschock, T | 1 |
| Göttig, S | 1 |
| Hossain, D | 1 |
| El Morabite, K | 1 |
| Tbatou, F | 1 |
| Ait Ourhroui, M | 1 |
| Senouci, K | 1 |
| Hassam, B | 1 |
| Shen, J | 1 |
| Yan, L | 1 |
| Yu, M | 1 |
| Li, J | 1 |
| Yu, X | 1 |
| Zhang, G | 1 |
| Ozturk, Z | 1 |
| Tatliparmak, A | 1 |
| Becker, L | 1 |
| Kowalewski, C | 1 |
| Martin, JM | 1 |
| Trindade, MA | 1 |
| Palermo, ML | 1 |
| Pagliari, C | 1 |
| Valente, N | 1 |
| Naafs, B | 1 |
| Massarollo, PC | 1 |
| D'Albuquerque, LA | 1 |
| Benard, G | 1 |
| Maghanoy, A | 1 |
| Mallari, I | 1 |
| Balagon, M | 2 |
| Saunderson, P | 1 |
| Ravanes, JM | 1 |
| Cellona, RV | 1 |
| Abalos, RM | 1 |
| Walsh, GP | 1 |
| Walsh, DS | 1 |
| Gonçalves, Hde S | 1 |
| Pontes, MA | 1 |
| Almeida, PC | 1 |
| Moraes, ME | 1 |
| Cunha, Mda G | 1 |
| Virmond, M | 1 |
| Schettini, AP | 1 |
| Cruz, RC | 1 |
| Ura, S | 1 |
| Ghuidella, C | 1 |
| Viana, Fdos R | 1 |
| Avelleira, JC | 1 |
| Campos, AA | 1 |
| Filho, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Independent Study to Establish the Efficacy of the Six Doses Uniform MDT Regimen (U-MDT) for Leprosy Patients[NCT00669643] | Phase 4 | 859 participants (Actual) | Interventional | 2007-02-28 | Completed | ||
| Methotrexate and Prednisolone Study in Erythema Nodosum Leprosum (MaPS in ENL[NCT03775460] | 550 participants (Anticipated) | Interventional | 2023-01-15 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for clofazimine and Borderline Lepromatous
| Article | Year |
|---|---|
Seventy years of evidence on the efficacy and safety of drugs for treating leprosy: a network meta-analysis.
Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Humans; Leprostatic Agents; Leprosy; Leprosy, Multi | 2023 |
Leprosy treatment during pregnancy and breastfeeding: A case report and brief review of literature.
Topics: Adult; Breast Feeding; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Leprostatic | 2017 |
Leprosy in transplant recipients: report of a case after liver transplantation and review of the literature.
Topics: Clofazimine; Drug Therapy, Combination; Glucocorticoids; Humans; Immunosuppression Therapy; Leprosta | 2011 |
5 trials available for clofazimine and Borderline Lepromatous
| Article | Year |
|---|---|
Uniform multidrug therapy for leprosy patients in Brazil (U-MDT/CT-BR): Results of an open label, randomized and controlled clinical trial, among multibacillary patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Brazil; Child; Child, Preschool; Clofazimine; Dapsone; D | 2017 |
Using methotrexate to treat patients with ENL unresponsive to steroids and clofazimine: a report on 9 patients.
Topics: Adult; Clofazimine; Drug Therapy, Combination; Erythema Nodosum; Female; Humans; Leprostatic Agents; | 2013 |
Longitudinal ocular survey of 202 Filipino patients with multi-bacillary (MB) leprosy treated with 2 year WHO-multiple drug therapy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Clofazimine; Dapsone; Drug Ther | 2011 |
Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects.
Topics: Adolescent; Adult; Aged; Child; Clofazimine; Dapsone; Drug Therapy, Combination; Humans; Leprostatic | 2012 |
OFLOXACIN multicentre trial in MB leprosy FUAM-Manaus and ILSL-Bauru, Brazil.
Topics: Adolescent; Adult; Animals; Brazil; Clofazimine; Dapsone; Double-Blind Method; Drug Therapy, Combina | 2012 |
8 other studies available for clofazimine and Borderline Lepromatous
| Article | Year |
|---|---|
Multibacillary Mid-Borderline Leprosy with Type 1 Lepra Reaction and Concurrent Latent Tuberculosis.
Topics: Abattoirs; Anti-Inflammatory Agents; Antitubercular Agents; Clofazimine; Dapsone; Diagnosis, Differe | 2021 |
Three drugs are unnecessary for treating paucibacillary leprosy-A critique of the WHO guidelines.
Topics: Anti-Bacterial Agents; Clofazimine; Drug Therapy, Combination; Guidelines as Topic; Humans; Leprosy, | 2019 |
Chronic, persistent angioedema and sinusitis-like presentation of multibacillary leprosy.
Topics: Adolescent; Angioedema; Biopsy; Chronic Disease; Clofazimine; Dapsone; Developing Countries; Diagnos | 2018 |
A young man with livid facial nodules and a loss of eyebrows.
Topics: Adult; Alopecia; Clofazimine; Dapsone; Eyebrows; Facial Dermatoses; Humans; Leprostatic Agents; Lepr | 2013 |
[Borderline lepromatous leprosy].
Topics: Adult; Biopsy; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Leprosy, Borderline; | 2014 |
Six years' follow-up of multibacillary leprosy patients treated with uniform multi-drug therapy in China.
Topics: Adolescent; Adult; Aged; Child; China; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Foll | 2015 |
Nonpruritic erythematous plaques.
Topics: Adult; Animals; Armadillos; Biopsy; Clofazimine; Dapsone; Diagnosis, Differential; Drug Therapy, Com | 2009 |
Relapse study in smear positive multibacillary (MB) leprosy after 1 year WHO-multi-drug therapy (MDT) in Cebu, Philippines.
Topics: Adolescent; Adult; Aged; Child; Clofazimine; Dapsone; Drug Therapy, Combination; Female; Humans; Lep | 2011 |