clofazimine has been researched along with Arrhythmias, Cardiac in 3 studies
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 66-year-old Indian male who had been treated for recurrent erythema nodosum leprosum with 300 mg of clofazimine per day for 11 months presented to hospital with a 4 week history of severe gastrointestinal upset." | 3.69 | Clofazimine induced cardiotoxicity--a case report. ( Butany, JW; Choudhri, SH; Harris, L; Keystone, JS, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Radigan, A | 1 |
| Jevert-Eichorn, S | 1 |
| Zweijpfenning, SMH | 1 |
| van Groningen, H | 1 |
| van Ingen, J | 1 |
| Magis-Escurra, C | 1 |
| Boeree, MJ | 1 |
| Wagner, D | 1 |
| Bax, H | 1 |
| Andrejak, C | 1 |
| Wener, R | 1 |
| Rahman, A | 1 |
| Kunst, H | 1 |
| Lorent, N | 1 |
| Brouwer, MA | 1 |
| Hoefsloot, W | 1 |
| Choudhri, SH | 1 |
| Harris, L | 1 |
| Butany, JW | 1 |
| Keystone, JS | 1 |
3 other studies available for clofazimine and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Rare case of pacemaker infection with
Topics: Amikacin; Anti-Bacterial Agents; Anti-Infective Agents; Arrhythmias, Cardiac; Cefoxitin; Clarithromy | 2019 |
Clofazimine does not lead to significant QT interval prolongation: a multicentre study.
Topics: Arrhythmias, Cardiac; Clofazimine; Diarylquinolines; Heart; Humans; Long QT Syndrome | 2018 |
Clofazimine induced cardiotoxicity--a case report.
Topics: Aged; Arrhythmias, Cardiac; Clofazimine; Erythema Nodosum; Humans; Leprosy, Lepromatous; Male | 1995 |