clofazimine has been researched along with American Trypanosomiasis in 3 studies
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Sbaraglini, ML | 2 |
| Bellera, CL | 2 |
| Quarroz Braghini, J | 1 |
| Areco, Y | 1 |
| Miranda, C | 1 |
| Carrillo, C | 2 |
| Kelly, J | 1 |
| Buchholz, B | 1 |
| Gelpi, RJ | 1 |
| Talevi, A | 2 |
| Alba Soto, CD | 2 |
| Sayé, M | 1 |
| Gauna, L | 1 |
| Valera-Vera, E | 1 |
| Reigada, C | 1 |
| Miranda, MR | 1 |
| Pereira, CA | 1 |
| Fraccaroli, L | 1 |
| Larocca, L | 1 |
3 other studies available for clofazimine and American Trypanosomiasis
| Article | Year |
|---|---|
Combined therapy with Benznidazole and repurposed drugs Clofazimine and Benidipine for chronic Chagas disease.
Topics: Animals; Chagas Disease; Chlorocebus aethiops; Chronic Disease; Clofazimine; Combined Modality Thera | 2019 |
Crystal violet structural analogues identified by in silico drug repositioning present anti-Trypanosoma cruzi activity through inhibition of proline transporter TcAAAP069.
Topics: Amino Acid Transport Systems, Neutral; Chagas Disease; Clofazimine; Computer Simulation; Drug Reposi | 2020 |
Novel cruzipain inhibitors for the chemotherapy of chronic Chagas disease.
Topics: Adult; Animals; Antiprotozoal Agents; Chagas Disease; Chronic Disease; Clofazimine; Cysteine Endopep | 2016 |