clofazimine has been researched along with Allergy, Drug in 6 studies
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dapsone syndrome is a rare hypersensitivity reaction to dapsone and is characterized by high fever, papular or exfoliative dermatitis, progressing to liver toxicity and generalized lymphadenopathy, resembling a mononucleosis infection." | 7.73 | Dapsone syndrome with acute renal failure during leprosy treatment: case report. ( Alves-Rodrigues, EN; Fontes, CJ; Ribeiro, LC; Silva, MD; Takiuchi, A, 2005) |
| "Leprosy is a stigmatizing, chronic infection which degenerates the nervous system and often leads to incapacitation." | 5.56 | Validation study of HLA-B*13:01 as a biomarker of dapsone hypersensitivity syndrome in leprosy patients in Indonesia. ( Irwan, ID; Irwanto, A; Krismawati, H; Liu, H; Liu, J; Maladan, Y; Oktavian, A; Pongtiku, A; Sitanggang, YA; Sun, Y; Tanjung, R; Wahyuni, T; Zhang, F, 2020) |
| "Dapsone syndrome is a rare hypersensitivity reaction to dapsone and is characterized by high fever, papular or exfoliative dermatitis, progressing to liver toxicity and generalized lymphadenopathy, resembling a mononucleosis infection." | 3.73 | Dapsone syndrome with acute renal failure during leprosy treatment: case report. ( Alves-Rodrigues, EN; Fontes, CJ; Ribeiro, LC; Silva, MD; Takiuchi, A, 2005) |
| "Leprosy is a stigmatizing, chronic infection which degenerates the nervous system and often leads to incapacitation." | 1.56 | Validation study of HLA-B*13:01 as a biomarker of dapsone hypersensitivity syndrome in leprosy patients in Indonesia. ( Irwan, ID; Irwanto, A; Krismawati, H; Liu, H; Liu, J; Maladan, Y; Oktavian, A; Pongtiku, A; Sitanggang, YA; Sun, Y; Tanjung, R; Wahyuni, T; Zhang, F, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Krismawati, H | 1 |
| Irwanto, A | 1 |
| Pongtiku, A | 1 |
| Irwan, ID | 1 |
| Maladan, Y | 1 |
| Sitanggang, YA | 1 |
| Wahyuni, T | 1 |
| Tanjung, R | 1 |
| Sun, Y | 1 |
| Liu, H | 1 |
| Zhang, F | 1 |
| Oktavian, A | 1 |
| Liu, J | 1 |
| Manifold, R | 1 |
| Marshman, G | 1 |
| Alves-Rodrigues, EN | 2 |
| Ribeiro, LC | 2 |
| Silva, MD | 2 |
| Takiuchi, A | 2 |
| Fontes, CJ | 2 |
| Rabel-Filho, OC | 1 |
| Martini-Filho, D | 1 |
| Jopling, WH | 1 |
| Ramanujam, K | 1 |
| Iyer, CG | 1 |
| Ramu, G | 1 |
1 trial available for clofazimine and Allergy, Drug
| Article | Year |
|---|---|
Open trial with clofazimine in the management of recurrent lepra reaction and of sulphone sensitive cases: a preliminary report.
Topics: Adult; Clinical Trials as Topic; Clofazimine; Drug Hypersensitivity; Humans; Leprosy; Male; Sulfones | 1975 |
5 other studies available for clofazimine and Allergy, Drug
| Article | Year |
|---|---|
Validation study of HLA-B*13:01 as a biomarker of dapsone hypersensitivity syndrome in leprosy patients in Indonesia.
Topics: Adolescent; Adult; Alleles; Biomarkers; Case-Control Studies; Clofazimine; Dapsone; Drug Hypersensit | 2020 |
Leprosy: not always an easy diagnosis and often a management challenge.
Topics: Adult; Aged, 80 and over; Arm; Back; Clofazimine; Dapsone; Diagnosis, Differential; Drug Hypersensit | 2009 |
Dapsone syndrome with acute renal failure during leprosy treatment: case report.
Topics: Acute Kidney Injury; Adult; Clofazimine; Dapsone; Drug Hypersensitivity; Drug Therapy, Combination; | 2005 |
Renal hypersensitivity vasculitis associated with dapsone.
Topics: Adult; Anti-Bacterial Agents; Antitubercular Agents; Clofazimine; Cyclophosphamide; Dapsone; Drug Hy | 2005 |
Side-effects of antileprosy drugs in common use.
Topics: Clofazimine; Dapsone; Drug Hypersensitivity; Ethionamide; Humans; Leprostatic Agents; Leprosy; Rifam | 1983 |