clofazimine has been researched along with Acute Liver Injury, Drug-Induced in 9 studies
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "During treatment of multibacillary leprosy with the combination rifampin (RMP) 600 mg, ethionamide (ETH) 500 mg, and either dapsone (DDS) or clofazimine (CLO) 100 mg, hepatotoxicity was observed in 4." | 9.05 | Hepatotoxicity of the combination of rifampin-ethionamide in the treatment of multibacillary leprosy. ( Bourland, J; Davies, EM; Feracci, C; Grillone, S; Janssens, L; Pattyn, SR; Saylan, T, 1984) |
| "Side-effects of leprosy treatment with dapsone are said to be uncommon, with drug allergy occurring in only one of every several hundred patients treated with dapsone." | 7.68 | Dapsone syndrome in Vanuatu: a high incidence during multidrug treatment (MDT) of leprosy. ( Ala, J; Hall, JJ; Reeve, PA, 1992) |
| "During treatment of multibacillary leprosy with the combination rifampin (RMP) 600 mg, ethionamide (ETH) 500 mg, and either dapsone (DDS) or clofazimine (CLO) 100 mg, hepatotoxicity was observed in 4." | 5.05 | Hepatotoxicity of the combination of rifampin-ethionamide in the treatment of multibacillary leprosy. ( Bourland, J; Davies, EM; Feracci, C; Grillone, S; Janssens, L; Pattyn, SR; Saylan, T, 1984) |
| "Side-effects of leprosy treatment with dapsone are said to be uncommon, with drug allergy occurring in only one of every several hundred patients treated with dapsone." | 3.68 | Dapsone syndrome in Vanuatu: a high incidence during multidrug treatment (MDT) of leprosy. ( Ala, J; Hall, JJ; Reeve, PA, 1992) |
| "Granulomas were induced by insoluble CFZ cargo, but not by the more soluble analog, pointing to precipitation being a factor driving granulomatous inflammation." | 1.48 | An Expandable Mechanopharmaceutical Device (2): Drug Induced Granulomas Maximize the Cargo Sequestering Capacity of Macrophages in the Liver. ( Baik, J; Bergin, IL; Keswani, RK; Murashov, MD; Rosania, GR; Rzeczycki, P; Stringer, KA; Sud, S; Yoon, GS, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Morgan, RE | 2 |
| Trauner, M | 1 |
| van Staden, CJ | 2 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 2 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 2 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Aleo, MD | 1 |
| Luo, Y | 1 |
| Swiss, R | 1 |
| Bonin, PD | 1 |
| Potter, DM | 1 |
| Will, Y | 1 |
| Rzeczycki, P | 1 |
| Yoon, GS | 1 |
| Keswani, RK | 1 |
| Sud, S | 1 |
| Baik, J | 1 |
| Murashov, MD | 1 |
| Bergin, IL | 1 |
| Stringer, KA | 1 |
| Rosania, GR | 1 |
| Pattyn, SR | 1 |
| Janssens, L | 1 |
| Bourland, J | 1 |
| Saylan, T | 1 |
| Davies, EM | 1 |
| Grillone, S | 1 |
| Feracci, C | 1 |
| Saint-Marc, T | 1 |
| Marneff, E | 1 |
| Touraine, JL | 1 |
| Reeve, PA | 1 |
| Ala, J | 1 |
| Hall, JJ | 1 |
2 trials available for clofazimine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Hepatotoxicity of the combination of rifampin-ethionamide in the treatment of multibacillary leprosy.
Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; Clinical Trials as Topic; Clofazim | 1984 |
[Mycobacterium avium intracellulare infections. Treatment with a clarithromycin-clofazimine combination. 18 cases].
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Chemical and Drug | 1993 |
7 other studies available for clofazimine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2014 |
An Expandable Mechanopharmaceutical Device (2): Drug Induced Granulomas Maximize the Cargo Sequestering Capacity of Macrophages in the Liver.
Topics: Animals; Chemical and Drug Induced Liver Injury; Clofazimine; Drug Delivery Systems; Granuloma; Live | 2018 |
Dapsone syndrome in Vanuatu: a high incidence during multidrug treatment (MDT) of leprosy.
Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Clofazimine; Dapsone; Drug Eruptions; Dru | 1992 |