clofazimine has been researched along with Acute Disease in 6 studies
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
Acute Disease: Disease having a short and relatively severe course.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The therapeutic efficacy of liposomal clofazimine (L-CLF) was studied in mice infected with Mycobacterium tuberculosis Erdman." | 7.70 | Effective treatment of acute and chronic murine tuberculosis with liposome-encapsulated clofazimine. ( Adams, LB; Franzblau, SG; Krahenbuhl, JL; Mehta, RT; Sinha, I, 1999) |
| "The therapeutic efficacy of liposomal clofazimine (L-CLF) was studied in mice infected with Mycobacterium tuberculosis Erdman." | 3.70 | Effective treatment of acute and chronic murine tuberculosis with liposome-encapsulated clofazimine. ( Adams, LB; Franzblau, SG; Krahenbuhl, JL; Mehta, RT; Sinha, I, 1999) |
| "Two cases of acute uveitis have been reported in reversal reactions in lepromatous patients treated with anti-hansenian multidrug therapy with daily rifampicin." | 1.28 | [Acute uveitis in reversal reactions]. ( Deplus, S; Flageul, B; Spindler, E, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sheetal, S | 1 |
| Arvind, C | 1 |
| Al-Raqum, HA | 1 |
| Uppal, SS | 1 |
| El Abdalghani, RA | 1 |
| Lasheen, I | 1 |
| Kansal, RG | 1 |
| Gomez-Flores, R | 1 |
| Sinha, I | 2 |
| Mehta, RT | 2 |
| Adams, LB | 1 |
| Franzblau, SG | 1 |
| Krahenbuhl, JL | 1 |
| Browne, SG | 1 |
| Spindler, E | 1 |
| Deplus, S | 1 |
| Flageul, B | 1 |
6 other studies available for clofazimine and Acute Disease
| Article | Year |
|---|---|
Lest we forget Hansen's disease (leprosy): an unusual presentation with an acute onset of inflammatory polyarthritis and the rheumatology experience.
Topics: Acute Disease; Aged; Arthritis; Clofazimine; Dapsone; Diagnosis, Differential; Drug Therapy, Combina | 2009 |
First report of leprosy presenting as acute polyarthritis in the setting of type I downgrading lepra reaction.
Topics: Acute Disease; Adult; Arthritis; Clofazimine; Dapsone; Diagnosis, Differential; Drug Therapy, Combin | 2006 |
Therapeutic efficacy of liposomal clofazimine against Mycobacterium avium complex in mice depends on size of initial inoculum and duration of infection.
Topics: Acute Disease; Animals; Anti-Bacterial Agents; Chronic Disease; Clofazimine; Disease Models, Animal; | 1997 |
Effective treatment of acute and chronic murine tuberculosis with liposome-encapsulated clofazimine.
Topics: Acute Disease; Animals; Chronic Disease; Clofazimine; Drug Carriers; Leprostatic Agents; Liposomes; | 1999 |
The drug treatment of leprosy.
Topics: Acute Disease; Adrenal Cortex Hormones; Aniline Compounds; Clofazimine; Dapsone; Drug Therapy, Combi | 1975 |
[Acute uveitis in reversal reactions].
Topics: Acute Disease; Clofazimine; Drug Combinations; Ethionamide; Female; Humans; Leprosy, Lepromatous; Ma | 1991 |