clofazimine has been researched along with Acquired Immune Deficiency Syndrome in 26 studies
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A rapid reduction in symptoms and bacteremia can be achieved as early as week 2 of therapy using an oral regimen of rifampin, ethambutol, clofazimine, and ciprofloxacin." | 9.07 | Treatment of Mycobacterium avium complex bacteremia in AIDS with a four-drug oral regimen. Rifampin, ethambutol, clofazimine, and ciprofloxacin. The California Collaborative Treatment Group. ( Bartok, AE; Chiu, J; Deresinski, SC; Feigal, DF; Kemper, CA; Leedom, JM; McCutchan, JA; Meng, TC; Nussbaum, J; Tilles, JG, 1992) |
| "This article reviews the chemistry, pharmacology, spectrum of activity, pharmacokinetics, clinical efficacy in leprosy and Mycobacterium avium complex (MAC) infection, adverse effects, drug interactions, and special considerations of clofazimine." | 8.78 | Clofazimine: a review of its use in leprosy and Mycobacterium avium complex infection. ( Garrelts, JC, 1991) |
| "We describe four additional AIDS patients with MAC disease who had a favorable clinical and microbiological response to this regimen without developing serious adverse effects after periods ranging from 4 to 12 months." | 5.28 | Successful treatment of acquired immunodeficiency syndrome-related Mycobacterium avium complex disease with a multiple drug regimen including amikacin. ( Benson, CA; Kessler, HA; Pottage, JC; Trenholme, GM, 1991) |
| " a placebo, each in combination with clofazimine and ethambutol, for the treatment of MAC bacteremia." | 5.07 | Efficacy of rifabutin in the treatment of disseminated infection due to Mycobacterium avium complex. The Rifabutin Treatment Group. ( Gordin, FM; Sullam, PM; Wynne, BA, 1994) |
| "A rapid reduction in symptoms and bacteremia can be achieved as early as week 2 of therapy using an oral regimen of rifampin, ethambutol, clofazimine, and ciprofloxacin." | 5.07 | Treatment of Mycobacterium avium complex bacteremia in AIDS with a four-drug oral regimen. Rifampin, ethambutol, clofazimine, and ciprofloxacin. The California Collaborative Treatment Group. ( Bartok, AE; Chiu, J; Deresinski, SC; Feigal, DF; Kemper, CA; Leedom, JM; McCutchan, JA; Meng, TC; Nussbaum, J; Tilles, JG, 1992) |
| "This article reviews the chemistry, pharmacology, spectrum of activity, pharmacokinetics, clinical efficacy in leprosy and Mycobacterium avium complex (MAC) infection, adverse effects, drug interactions, and special considerations of clofazimine." | 4.78 | Clofazimine: a review of its use in leprosy and Mycobacterium avium complex infection. ( Garrelts, JC, 1991) |
| "Patients with the acquired immune deficiency syndrome (AIDS) with disseminated Mycobacterium avium infection have responded poorly to treatment with rifabutine (Ansamycin) and clofazimine, in spite of the good in vitro response of M." | 3.67 | Therapeutic implications of inhibition versus killing of Mycobacterium avium complex by antimicrobial agents. ( Hadley, WK; Nassos, PS; Yajko, DM, 1987) |
| "When clarithromycin was tested against three MAC strains in combination with another drug, it showed a synergistic effect only when combined with rifampicin." | 1.28 | In vitro activity of clarithromycin alone or in combination with other antimicrobial agents against Mycobacterium avium-intracellulare. Complex strains isolated from AIDS patients. ( De Gregoris, P; Fattorini, L; Hu, CQ; Iona, E; Mascellino, MT; Orefici, G; Santoro, C, 1991) |
| "We studied patients with AIDS and DMAC and compared their survival with that of AIDS patients without DMAC but with other comparable risk factors for survival." | 1.28 | Survival of patients with acquired immune deficiency syndrome and disseminated Mycobacterium avium complex infection with and without antimycobacterial chemotherapy. ( Dubois, RE; Ellis, DA; Fann, SA; Havlik, JA; Horsburgh, CR; Kennedy, E; Thompson, SE, 1991) |
| "We describe four additional AIDS patients with MAC disease who had a favorable clinical and microbiological response to this regimen without developing serious adverse effects after periods ranging from 4 to 12 months." | 1.28 | Successful treatment of acquired immunodeficiency syndrome-related Mycobacterium avium complex disease with a multiple drug regimen including amikacin. ( Benson, CA; Kessler, HA; Pottage, JC; Trenholme, GM, 1991) |
| "Four patients with acquired immunodeficiency syndrome with bacillemia from Mycobacterium avium-intracellulare presented with early pathologic clues of a disseminated mycobacterial infection." | 1.27 | Clues to the early diagnosis of Mycobacterium avium-intracellulare infection in patients with acquired immunodeficiency syndrome. ( Polis, MA; Tuazon, CU, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (23.08) | 18.7374 |
| 1990's | 20 (76.92) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Elliott, JL | 1 |
| Hoppes, WL | 1 |
| Platt, MS | 1 |
| Thomas, JG | 1 |
| Patel, IP | 1 |
| Gansar, A | 1 |
| Sullam, PM | 1 |
| Gordin, FM | 1 |
| Wynne, BA | 1 |
| Saint-Marc, T | 1 |
| Marneff, E | 1 |
| Touraine, JL | 1 |
| Soriano, V | 1 |
| Moreno, V | 1 |
| Alba, A | 1 |
| Laguna, F | 1 |
| González-Lahoz, J | 1 |
| Ravi, S | 1 |
| Holubka, J | 1 |
| Veneri, R | 1 |
| Youn, K | 1 |
| Khatib, R | 1 |
| Abrams, DI | 1 |
| Mitchell, TF | 1 |
| Child, CC | 1 |
| Shiboski, SC | 1 |
| Brosgart, CL | 1 |
| Mass, MM | 1 |
| Dautzenberg, B | 2 |
| Olliaro, P | 1 |
| Ruf, B | 1 |
| Esposito, R | 1 |
| Opravil, M | 1 |
| Hoy, JF | 1 |
| Rozenbaum, W | 2 |
| Carosi, GP | 1 |
| Micoud, M | 1 |
| L'Age, M | 1 |
| Pirotta, N | 1 |
| Sassella, D | 1 |
| Currier, J | 1 |
| Gallais, V | 1 |
| Lacour, JP | 1 |
| Ortonne, JP | 1 |
| Cone, LA | 1 |
| Woodard, DR | 1 |
| Simmons, JC | 1 |
| Sonnenshein, MA | 1 |
| Sandler, ED | 1 |
| Ng, VL | 1 |
| Hadley, WK | 2 |
| Truffot, C | 1 |
| Mignon, A | 1 |
| Katlama, C | 1 |
| Perronne, C | 1 |
| Parrot, R | 1 |
| Grosset, J | 1 |
| Kemper, CA | 1 |
| Meng, TC | 1 |
| Nussbaum, J | 1 |
| Chiu, J | 1 |
| Feigal, DF | 1 |
| Bartok, AE | 1 |
| Leedom, JM | 1 |
| Tilles, JG | 1 |
| Deresinski, SC | 1 |
| McCutchan, JA | 1 |
| Mascellino, MT | 1 |
| Iona, E | 1 |
| Fattorini, L | 1 |
| De Gregoris, P | 1 |
| Hu, CQ | 1 |
| Santoro, C | 1 |
| Orefici, G | 1 |
| Horsburgh, CR | 1 |
| Havlik, JA | 1 |
| Ellis, DA | 1 |
| Kennedy, E | 1 |
| Fann, SA | 1 |
| Dubois, RE | 1 |
| Thompson, SE | 1 |
| Benson, CA | 1 |
| Kessler, HA | 1 |
| Pottage, JC | 1 |
| Trenholme, GM | 1 |
| Garrelts, JC | 1 |
| Hoy, J | 1 |
| Mijch, A | 1 |
| Sandland, M | 1 |
| Grayson, L | 1 |
| Lucas, R | 1 |
| Dwyer, B | 1 |
| Cunningham, CA | 1 |
| Friedberg, DN | 1 |
| Carr, RE | 1 |
| Agins, BD | 1 |
| Berman, DS | 1 |
| Spicehandler, D | 1 |
| el-Sadr, W | 1 |
| Simberkoff, MS | 1 |
| Rahal, JJ | 1 |
| Yajko, DM | 1 |
| Nassos, PS | 1 |
| Hudson, V | 1 |
| Cox, F | 1 |
| Taylor, L | 1 |
| Guill, M | 1 |
| Wray, B | 1 |
| Steele, J | 1 |
| Masur, H | 1 |
| Tuazon, C | 1 |
| Gill, V | 1 |
| Grimes, G | 1 |
| Baird, B | 1 |
| Fauci, AS | 1 |
| Lane, HC | 1 |
| Polis, MA | 1 |
| Tuazon, CU | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Controlled Prophylactic Study of Clofazimine To Prevent Mycobacterium Avium Complex Infection in HIV Disease[NCT00002058] | 0 participants | Interventional | Completed | ||||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for clofazimine and Acquired Immune Deficiency Syndrome
| Article | Year |
|---|---|
[Cutaneous pigmentation disorders in human immunodeficiency virus infection].
Topics: Acquired Immunodeficiency Syndrome; Adrenal Insufficiency; Antiviral Agents; Bleomycin; Clofazimine; | 1992 |
Clofazimine: a review of its use in leprosy and Mycobacterium avium complex infection.
Topics: Acquired Immunodeficiency Syndrome; Clofazimine; Drug Interactions; Gastrointestinal Diseases; Human | 1991 |
7 trials available for clofazimine and Acquired Immune Deficiency Syndrome
| Article | Year |
|---|---|
Efficacy of rifabutin in the treatment of disseminated infection due to Mycobacterium avium complex. The Rifabutin Treatment Group.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Opportunistic Infections; Bacteremia; Clofazimine; | 1994 |
[Mycobacterium avium intracellulare infections. Treatment with a clarithromycin-clofazimine combination. 18 cases].
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Chemical and Drug | 1993 |
Clofazimine as prophylaxis for disseminated Mycobacterium avium complex infection in AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; Clofazimine; Female; Humans; Male; Middle Aged; Mycobacte | 1993 |
Rifabutin versus placebo in combination with three drugs in the treatment of nontuberculous mycobacterial infection in patients with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Anti-Inflammatory | 1996 |
New antibiotics look good against M. avium.
Topics: Acquired Immunodeficiency Syndrome; Azithromycin; Clarithromycin; Clofazimine; Drug Therapy, Combina | 1992 |
Rifabutin in combination with clofazimine, isoniazid and ethambutol in the treatment of AIDS patients with infections due to opportunist mycobacteria. Groupe d'Etude et de Traitement des Infections à Mycobacteries Résistantes.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antitubercular Agents; Clofazimine; Drug Therapy, Combina | 1991 |
Treatment of Mycobacterium avium complex bacteremia in AIDS with a four-drug oral regimen. Rifampin, ethambutol, clofazimine, and ciprofloxacin. The California Collaborative Treatment Group.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adult; Amikacin; Anti-Infective Agents; Ba | 1992 |
17 other studies available for clofazimine and Acquired Immune Deficiency Syndrome
| Article | Year |
|---|---|
The acquired immunodeficiency syndrome and Mycobacterium avium-intracellulare bacteremia in a patient with hemophilia.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antibodies, Viral; Clofazimine; Cytomegalovirus; Hemophil | 1983 |
Kussmaul respiration and abdominal pain secondary to metabolic acidosis in AIDS patients with disseminated Mycobacterium avium complex infection receiving clofazimine.
Topics: Abdominal Pain; Acidosis; Acquired Immunodeficiency Syndrome; Clofazimine; Humans; Male; Mycobacteri | 1993 |
Clofazimine-induced eosinophilic gastroenteritis in AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Clofazimine; Eosin | 1993 |
Progress report: prophylaxis and therapy for MAC.
Topics: Acquired Immunodeficiency Syndrome; Antitubercular Agents; Azithromycin; Clarithromycin; Clofazimine | 1996 |
MAC management.
Topics: Acquired Immunodeficiency Syndrome; Amikacin; Antitubercular Agents; Ciprofloxacin; Clarithromycin; | 1996 |
Drug interactions in patients with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; Clofazimine; Drug Interactions; Humans; Male; Phenytoin; | 1992 |
Clofazimine crystals in alveolar macrophages from a patient with the acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Clofazimine; Crystallization; Humans; Macrophages, Alveol | 1992 |
In vitro activity of clarithromycin alone or in combination with other antimicrobial agents against Mycobacterium avium-intracellulare. Complex strains isolated from AIDS patients.
Topics: Acquired Immunodeficiency Syndrome; Amikacin; Anti-Bacterial Agents; Ciprofloxacin; Clarithromycin; | 1991 |
Survival of patients with acquired immune deficiency syndrome and disseminated Mycobacterium avium complex infection with and without antimycobacterial chemotherapy.
Topics: Acquired Immunodeficiency Syndrome; Anti-Bacterial Agents; Antibiotics, Antitubercular; Ciprofloxaci | 1991 |
Successful treatment of acquired immunodeficiency syndrome-related Mycobacterium avium complex disease with a multiple drug regimen including amikacin.
Topics: Acquired Immunodeficiency Syndrome; Adult; Amikacin; Antitubercular Agents; Ciprofloxacin; Clofazimi | 1991 |
Quadruple-drug therapy for Mycobacterium avium-intracellulare bacteremia in AIDS patients.
Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-Infective Agents; Clofazimine; Drug Therapy, Combina | 1990 |
Clofazamine-induced generalized retinal degeneration.
Topics: Acquired Immunodeficiency Syndrome; Adult; Clofazimine; Dark Adaptation; Electroretinography; Fluore | 1990 |
Effect of combined therapy with ansamycin, clofazimine, ethambutol, and isoniazid for Mycobacterium avium infection in patients with AIDS.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Anti-Bacterial Agents; Antitubercular Agen | 1989 |
Therapeutic implications of inhibition versus killing of Mycobacterium avium complex by antimicrobial agents.
Topics: Acquired Immunodeficiency Syndrome; Ciprofloxacin; Clofazimine; Humans; Mycobacterium avium; Rifabut | 1987 |
Pulmonary clofazimine crystals in a child with acquired immunodeficiency syndrome and disseminated Mycobacterium avium-intracellulare infection.
Topics: Acquired Immunodeficiency Syndrome; Child; Clofazimine; Crystallization; Humans; Lung; Male; Mycobac | 1988 |
Effect of combined clofazimine and ansamycin therapy on Mycobacterium avium-Mycobacterium intracellulare bacteremia in patients with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Amikacin; Anti-Bacterial Agents; Ciprofloxacin; Clofazimine; Cyc | 1987 |
Clues to the early diagnosis of Mycobacterium avium-intracellulare infection in patients with acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Amikacin; Anti-Bacterial Agents; Clofazimine; Female; Hum | 1985 |