Page last updated: 2024-09-03

clofarabine and Neoplasms

clofarabine has been researched along with Neoplasms in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (45.00)29.6817
2010's7 (35.00)24.3611
2020's4 (20.00)2.80

Authors

AuthorsStudies
Chen, XB; Wang, S; Wang, SQ; Yu, B; Yuan, XH; Zhao, W1
Ma, Y; Yang, J; Zhang, C; Zhu, L; Zhu, X1
Chen, M; Chen, Z; Fan, H; Liu, R; Zhang, J1
Fan, Z; Hou, Z; Li, Y; Tian, H; Wang, F; Xue, K; Zhao, Q; Zhu, F1
Cros-Perrial, E; Dumontet, C; Jordheim, LP; Lefebvre-Tournier, I; Peyrottes, S; Puy, JY1
Deng, H; Liu, B; Ma, Y; Mou, Q; Wang, D; Wang, R; Wu, C; Yan, D; Zhang, C; Zhu, X1
Liu, H; Shi, L; Tong, G; Wang, D; Wu, J; Xu, L; Yan, D; Yu, C; Zhu, X1
Chen, X; Lu, Y; Tu, X; Zhang, Y; Zhong, D1
Abt, ER; Austin, WR; Bazzy, J; Cabebe, AE; Capri, JR; Czernin, J; Donahue, TR; Faull, KF; Gipson, RM; Herrmann, K; Herschman, HR; Kim, W; Lavie, A; Le, TM; Lee, JT; Phelps, ME; Poddar, S; Radu, CG; Sadeghi, S; Slavik, R; Steele, D; Taechariyakul, T; Uong, NT; Van Valkenburgh, JS; Wang, X; Wei, L; Witte, ON; Yaghoubi, SS1
Bohannan, Z; Borthakur, G; Bueso-Ramos, C; Daver, N; Faderl, S; Garcia-Manero, G; Hosing, C; Jabbour, E; Kadia, T; Kantarjian, HM; Khoury, JD; Maduike, R; Miller, D; Patel, K; Pemmaraju, N; Ravandi, F; Sasaki, K; Verstovsek, S1
Bagley, RG; Crawford, J; Krumbholz, R; Kurtzberg, LS; Lovett, D; Roth, S; Rouleau, C; Schmid, S; Teicher, BA; Yao, M1
Albertioni, F; Juliusson, G; Lotfi, K; Zhenchuk, A1
Bonate, PL; Cunningham, CC; Gaynon, P; Jeha, S; Kadota, R; Lam, GN; Razzouk, B; Rytting, M; Steinherz, P; Weitman, S1
Cortes, J; Du, M; Faderl, S; Gandhi, V; Giles, F; Ibrahim, N; Jeha, S; Kantarjian, HM; Keating, M; Khuri, F; Kozuch, P; McLaughlin, P; O'Brien, S; Plunkett, W; Rios, MB1
Sternberg, A1
Cooper, T; Gandhi, V; Kantarjian, H; Plunkett, W1
Faderl, S; Gandhi, V; Jeha, S; Kantarjian, HM; Keating, MJ; Plunkett, W1
Arthaud, L; Bonate, PL; Cantrell, WR; Secrist, JA; Stephenson, K; Weitman, S1

Reviews

5 review(s) available for clofarabine and Neoplasms

ArticleYear
FDA-approved pyrimidine-fused bicyclic heterocycles for cancer therapy: Synthesis and clinical application.
    European journal of medicinal chemistry, 2021, Mar-15, Volume: 214

    Topics: Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Humans; Molecular Structure; Neoplasms; Pyrimidines; United States; United States Food and Drug Administration

2021
Mechanisms of anti-cancer action and pharmacology of clofarabine.
    Biochemical pharmacology, 2009, Dec-01, Volume: 78, Issue:11

    Topics: Adenine Nucleotides; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Arabinonucleosides; Clofarabine; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Hematologic Neoplasms; Humans; Myelodysplastic Syndromes; Neoplasms

2009
Clofarabine. Bioenvision/ILEX.
    Current opinion in investigational drugs (London, England : 2000), 2003, Volume: 4, Issue:12

    Topics: Adenine Nucleotides; Animals; Arabinonucleosides; Clinical Trials as Topic; Clofarabine; Drugs, Investigational; Humans; Neoplasms; Technology, Pharmaceutical

2003
The role of clofarabine in hematologic and solid malignancies--development of a next-generation nucleoside analog.
    Cancer, 2005, May-15, Volume: 103, Issue:10

    Topics: Adenine Nucleotides; Adult; Aged; Antineoplastic Agents; Arabinonucleosides; Child; Clofarabine; Hematologic Neoplasms; Humans; Leukemia; Lymphoproliferative Disorders; Neoplasms

2005
Discovery and development of clofarabine: a nucleoside analogue for treating cancer.
    Nature reviews. Drug discovery, 2006, Volume: 5, Issue:10

    Topics: Adenine Nucleotides; Antineoplastic Agents; Arabinonucleosides; Clinical Trials as Topic; Clofarabine; Drug Approval; Drug Design; Humans; Leukemia, Myeloid, Acute; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2006

Trials

4 trial(s) available for clofarabine and Neoplasms

ArticleYear
Phase 2 study of low-dose clofarabine plus cytarabine for patients with higher-risk myelodysplastic syndrome who have relapsed or are refractory to hypomethylating agents.
    Cancer, 2017, Feb-15, Volume: 123, Issue:4

    Topics: Adenine Nucleotides; Adult; Aged; Aged, 80 and over; Arabinonucleosides; Clofarabine; Cytarabine; Disease-Free Survival; DNA Methylation; Female; Humans; Male; Middle Aged; Myelodysplastic Syndromes; Neoplasm Proteins; Neoplasms; Treatment Outcome

2017
Population pharmacokinetics of clofarabine and its metabolite 6-ketoclofarabine in adult and pediatric patients with cancer.
    Cancer chemotherapy and pharmacology, 2011, Volume: 67, Issue:4

    Topics: Adenine Nucleotides; Administration, Oral; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents; Arabinonucleosides; Biological Availability; Body Weight; Child; Child, Preschool; Clofarabine; Creatinine; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Male; Middle Aged; Models, Biological; Neoplasms; Young Adult

2011
Phase I clinical and pharmacology study of clofarabine in patients with solid and hematologic cancers.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Mar-15, Volume: 21, Issue:6

    Topics: Adenine Nucleotides; Adult; Aged; Antineoplastic Agents; Arabinonucleosides; Bone Marrow; Breast Neoplasms; Clofarabine; Drug Administration Schedule; Female; Gastrointestinal Neoplasms; Hematologic Neoplasms; Humans; Infusions, Intravenous; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Liver; Lung Neoplasms; Male; Middle Aged; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome

2003
Clofarabine in adult acute leukemias: clinical success and pharmacokinetics.
    Nucleosides, nucleotides & nucleic acids, 2004, Volume: 23, Issue:8-9

    Topics: Adenine Nucleotides; Adult; Antimetabolites, Antineoplastic; Arabinonucleosides; Clinical Trials as Topic; Clofarabine; Cohort Studies; Cytarabine; Dose-Response Relationship, Drug; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Models, Chemical; Myelodysplastic Syndromes; Neoplasm Metastasis; Neoplasms; Nucleosides; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome

2004

Other Studies

11 other study(ies) available for clofarabine and Neoplasms

ArticleYear
Aptamers Entirely Built from Therapeutic Nucleoside Analogues for Targeted Cancer Therapy.
    Journal of the American Chemical Society, 2022, 02-02, Volume: 144, Issue:4

    Topics: Animals; Antineoplastic Agents; Apoptosis; Aptamers, Nucleotide; Cell Line, Tumor; Clofarabine; Drug Carriers; Floxuridine; Humans; Mice; Mucin-1; Neoplasms; Nucleosides; Tissue Distribution; Transplantation, Heterologous

2022
A cocktail therapeutic strategy based on clofarabine-containing aptamer-PROTAC for enhanced cancer therapy.
    Chemical communications (Cambridge, England), 2023, Sep-26, Volume: 59, Issue:77

    Topics: Clofarabine; Combined Modality Therapy; Endonucleases; Humans; Neoplasms; Nucleosides; Oligonucleotides

2023
Ultralong-Circulating and Self-Targeting "Watson-Crick A = T"-Inspired Supramolecular Nanotheranostics for NIR-II Imaging-Guided Photochemotherapy.
    ACS applied materials & interfaces, 2020, Jul-22, Volume: 12, Issue:29

    Topics: Animals; Antimetabolites, Antineoplastic; Clofarabine; Drug Liberation; Humans; Indocyanine Green; Infrared Rays; Macromolecular Substances; Methotrexate; Mice; Neoplasms; Optical Imaging; Particle Size; Photochemotherapy; Surface Properties; Theranostic Nanomedicine; Tumor Cells, Cultured

2020
Determination and quantification of intracellular fludarabine triphosphate, cladribine triphosphate and clofarabine triphosphate by LC-MS/MS in human cancer cells.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2017, May-15, Volume: 1053

    Topics: Adenine Nucleotides; Adenosine Triphosphate; Antineoplastic Agents; Arabinonucleosides; Cell Line, Tumor; Chromatography, High Pressure Liquid; Cladribine; Clofarabine; Humans; Limit of Detection; Neoplasms; Polyphosphates; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Vidarabine

2017
A Molecular Recognition Approach To Synthesize Nucleoside Analogue Based Multifunctional Nanoparticles for Targeted Cancer Therapy.
    Journal of the American Chemical Society, 2017, 10-11, Volume: 139, Issue:40

    Topics: Adenine Nucleotides; Animals; Aptamers, Nucleotide; Arabinonucleosides; Cell Line, Tumor; Clofarabine; Delayed-Action Preparations; Drug Delivery Systems; Drug Liberation; Fluorescent Dyes; Humans; Mice; Nanoparticles; Neoplasms; Nucleosides; Optical Imaging; Prodrugs

2017
Nucleoside Analogue-Based Supramolecular Nanodrugs Driven by Molecular Recognition for Synergistic Cancer Therapy.
    Journal of the American Chemical Society, 2018, 07-18, Volume: 140, Issue:28

    Topics: Animals; Antineoplastic Agents; Clofarabine; Folic Acid; Folic Acid Antagonists; HeLa Cells; Humans; Hydrophobic and Hydrophilic Interactions; Mice, Inbred BALB C; Mice, Nude; Molecular Dynamics Simulation; Nanoparticles; Neoplasms; Quinazolines; Rats; Thiophenes

2018
A sensitive LC-MS/MS method for quantifying clofarabine triphosphate concentrations in human peripheral blood mononuclear cells.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2014, Aug-01, Volume: 964

    Topics: Adenine Nucleotides; Antimetabolites, Antineoplastic; Arabinonucleosides; Chromatography, Liquid; Clofarabine; Drug Monitoring; Humans; Leukocytes, Mononuclear; Limit of Detection; Neoplasms; Polyphosphates; Tandem Mass Spectrometry

2014
[18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity.
    Proceedings of the National Academy of Sciences of the United States of America, 2016, Apr-12, Volume: 113, Issue:15

    Topics: Adenine Nucleotides; Animals; Antineoplastic Agents; Arabinonucleosides; Biomarkers, Tumor; Cell Line, Tumor; Clofarabine; Contrast Media; Deoxycytidine Kinase; Humans; Leukemia; Mice; Neoplasms; Positron-Emission Tomography; Prodrugs; Rats

2016
Bone marrow CFU-GM and human tumor xenograft efficacy of three antitumor nucleoside analogs.
    International journal of oncology, 2009, Volume: 34, Issue:5

    Topics: Adenine Nucleotides; Animals; Antimetabolites, Antineoplastic; Arabinonucleosides; Bone Marrow Cells; Cells, Cultured; Cladribine; Clofarabine; Granulocyte-Macrophage Progenitor Cells; HT29 Cells; Humans; Male; Mice; Mice, Inbred BALB C; Mice, SCID; Models, Biological; Neoplasms; Treatment Outcome; Vidarabine Phosphate; Xenograft Model Antitumor Assays

2009
Bibliography. Current world literature. Therapeutic modalities.
    Current opinion in oncology, 2004, Volume: 16, Issue:6

    Topics: Adenine Nucleotides; Antineoplastic Agents; Arabinonucleosides; Cancer Vaccines; Clofarabine; Cytokines; Epidermal Growth Factor; Glucocorticoids; Humans; Interleukin-2; Metalloporphyrins; Neoplasms; Proto-Oncogene Proteins c-bcl-2; Sirolimus

2004
A tale of two drugs.
    Nature reviews. Drug discovery, 2006, Volume: 5, Issue:10

    Topics: Adenine Nucleotides; Antineoplastic Agents; Arabinonucleosides; Benzenesulfonates; Clofarabine; Drug Approval; Drug Design; Humans; Neoplasms; Niacinamide; Phenylurea Compounds; Pyridines; Sorafenib

2006