Page last updated: 2024-09-03

clofarabine and Leukemia

clofarabine has been researched along with Leukemia in 30 studies

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (6.67)18.2507
2000's12 (40.00)29.6817
2010's15 (50.00)24.3611
2020's1 (3.33)2.80

Authors

AuthorsStudies
Abou Dalle, I; Atoui, A; Bazarbachi, A; Bidaoui, G; Dulery, R; El Cheikh, J; Mohty, M; Moukalled, N; Sharrouf, L; Terro, K; Zahreddine, A1
Bridges, AG; El-Azhary, RA; Hashmi, SK; Hunjan, MK; Lehman, JS; Nowsheen, S; Ramos-Rodriguez, AJ1
Shigemi, H; Tanaka, Y; Ueda, T; Yamauchi, T1
Asano, T; Narazaki, H; Yamanishi, M1
Abt, ER; Austin, WR; Bazzy, J; Cabebe, AE; Capri, JR; Czernin, J; Donahue, TR; Faull, KF; Gipson, RM; Herrmann, K; Herschman, HR; Kim, W; Lavie, A; Le, TM; Lee, JT; Phelps, ME; Poddar, S; Radu, CG; Sadeghi, S; Slavik, R; Steele, D; Taechariyakul, T; Uong, NT; Van Valkenburgh, JS; Wang, X; Wei, L; Witte, ON; Yaghoubi, SS1
Gerber, JM; Grunwald, MR; Induru, R; McDonnell, MH1
Boulad, F; Castro-Malaspina, H; Giralt, SA; Kernan, NA; Kobos, R; O'Reilly, RJ; Papadopoulos, EB; Perales, MA; Prockop, SE; Scaradavou, A; Spitzer, B; Webb, N; Young, JW; Zabor, EC1
Aoki, Y; Fujimura, J; Hoshino, A; Imai, K; Ishiwata, Y; Kajiwara, M; Kanegane, H; Mae, T; Matsumoto, K; Mitsuiki, N; Miyamoto, S; Mizutani, S; Morio, T; Nishimura, A; Takagi, M; Takikawa, K; Tanaka, M; Tomita, O; Tomizawa, D; Yanagimachi, M; Yasuhara, M1
Vij, R1
Badowska, W; Balcerska, A; Balwierz, W; Derwich, K; Gil, L; Komarnicki, M; Kowalczyk, J; Krawczuk-Rybak, M; Matysiak, M; Sobol, G; Sonta-Jakimczyk, D; Stefaniak, J; Styczynski, J; Urasinski, T; Wachowiak, J; Wieczorek, M; Wysocki, M1
Borthakur, G; Kantarjian, H; Sampat, K1
Abichandani, R; Barry, E; Carroll, WL; Chu, R; Cooper, T; Gaynon, P; Hijiya, N; Jeha, S; Kadota, R; Rytting, M; Shen, V; Silverman, L; Steinherz, P; Thomson, B1
Einsele, H; Grigoleit, GU; Kapp, M; Mielke, S; Stuhler, G; Tan, SM; Topp, MS; Unzicker, C1
Faderl, S1
Faderl, S; Ghandhi, V; Ghanem, H; Jabbour, E; Kantarjian, H; Plunkett, W1
Chastagner, P; Clement, L; Contet, A; Kimmoun, A; Salmon, A; Schmitt, C; Sudour, H1
Baker, SD; Campana, D; Christensen, R; Coustan-Smith, E; Furmanski, BD; Heym, KM; Inaba, H; Li, L; Mascara, GP; Onciu, M; Pounds, SB; Pui, CH; Ribeiro, RC; Rubnitz, JE; Shurtleff, SA1
Braun, T; Choi, S; Elenitoba-Johnson, K; Erba, H; Ferrara, J; Frame, D; Harris, A; Jones, D; Kitko, C; Kujawski, L; Levine, J; Magenau, J; Mineishi, S; Paczesny, S; Pawarode, A; Peres, E; Reddy, P; Sanks, J; Tobai, H; Yanik, G1
Nishi, R; Ueda, T; Yamauchi, T1
Abd Elmoneim, A; Arceci, RJ; Boklan, J; Cooper, T; Gore, L; Narendran, A; Ricklis, RM; Rolla, K; Scott, T1
Ahmed, AB; Bruserud, O; Hatfield, KJ; Kittang, AO; Reikvam, H; Sjo, M; Tvedt, TH1
Bhamidipati, PK; Cortes, J; Daver, N; Estrov, Z; Jabbour, E; Konoplev, S1
Albertioni, F; Elford, H; Eriksson, S; Flordal, E; Lagercrantz, S; Liliemark, J; Månsson, E; Spasokoukotskaja, T1
Ayres, M; Bonate, P; Du, M; Faderl, S; Gandhi, V; Kantarjian, H; Keating, MJ; Plunkett, W; Rios, MB1
Beran, M; Bonate, P; Cortes, J; Du, M; Estey, E; Estrov, Z; Faderl, S; Ferrajoli, A; Gandhi, V; Garcia-Manero, G; Giles, FJ; Kantarjian, H; Keating, M; Kwari, M; O'Brien, S; Plunkett, W; Wierda, W1
Faderl, S; Gandhi, V; Jeha, S; Kantarjian, HM; Keating, MJ; Plunkett, W1
Gandhi, V; Plunkett, W1
Albertioni, F; Eriksson, S; Hullán, L; Sasvári-Székely, M; Spasokoukotskaja, T; Staub, M1
Albertioni, F; Eriksson, S; Liliemark, J; Lotfi, K; Månsson, E; Peterson, C; Pettersson, B; Spasokoukotskaja, T1

Reviews

6 review(s) available for clofarabine and Leukemia

ArticleYear
Cutaneous manifestations in leukemia patients.
    Seminars in oncology, 2016, Volume: 43, Issue:3

    Topics: Adenine Nucleotides; Antineoplastic Agents; Arabinonucleosides; Clofarabine; Cytarabine; Dermatomycoses; Etoposide; Humans; Leukemia; Mastocytosis; Niacinamide; Paraneoplastic Syndromes; Phenylurea Compounds; Skin Diseases, Bacterial; Skin Neoplasms; Sorafenib

2016
Clofarabine in leukemia.
    Expert review of hematology, 2010, Volume: 3, Issue:1

    Topics: Adenine Nucleotides; Antineoplastic Agents; Arabinonucleosides; Clinical Trials as Topic; Clofarabine; Cytarabine; Drug Therapy, Combination; Humans; Leukemia; Lymphoproliferative Disorders

2010
High-dose etoposide in allogeneic stem cell transplantation.
    Cancer chemotherapy and pharmacology, 2012, Volume: 70, Issue:6

    Topics: Adenine Nucleotides; Anthracyclines; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Arabinonucleosides; Busulfan; Carboplatin; Carmustine; Clinical Trials as Topic; Clofarabine; Cyclophosphamide; Dose Fractionation, Radiation; Drug Administration Schedule; Etoposide; Humans; Ifosfamide; Leukemia; Leukemia, Myeloid, Acute; Lomustine; Mucositis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy, Adjuvant; Severity of Illness Index; Stem Cell Transplantation; Transplantation Conditioning; Transplantation, Homologous; Whole-Body Irradiation

2012
Clofarabine.
    Drugs in R&D, 2004, Volume: 5, Issue:4

    Topics: Adenine Nucleotides; Antineoplastic Agents; Arabinonucleosides; Clinical Trials as Topic; Clofarabine; Humans; Leukemia

2004
The role of clofarabine in hematologic and solid malignancies--development of a next-generation nucleoside analog.
    Cancer, 2005, May-15, Volume: 103, Issue:10

    Topics: Adenine Nucleotides; Adult; Aged; Antineoplastic Agents; Arabinonucleosides; Child; Clofarabine; Hematologic Neoplasms; Humans; Leukemia; Lymphoproliferative Disorders; Neoplasms

2005
Clofarabine and nelarabine: two new purine nucleoside analogs.
    Current opinion in oncology, 2006, Volume: 18, Issue:6

    Topics: Adenine Nucleotides; Antineoplastic Agents; Arabinonucleosides; Clofarabine; Humans; Leukemia; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2006

Trials

7 trial(s) available for clofarabine and Leukemia

ArticleYear
Second Allogeneic Stem Cell Transplantation for Acute Leukemia Using a Chemotherapy-Only Cytoreduction with Clofarabine, Melphalan, and Thiotepa.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2016, Volume: 22, Issue:8

    Topics: Acute Disease; Adenine Nucleotides; Adolescent; Adult; Arabinonucleosides; Child; Child, Preschool; Clofarabine; Hematopoietic Stem Cell Transplantation; Humans; Leukemia; Melphalan; Myeloablative Agonists; Remission Induction; Salvage Therapy; Survival Analysis; Thiotepa; Transplantation, Homologous; Young Adult

2016
A multi-center phase I study of clofarabine, etoposide and cyclophosphamide in combination in pediatric patients with refractory or relapsed acute leukemia.
    Leukemia, 2009, Volume: 23, Issue:12

    Topics: Acute Disease; Adenine Nucleotides; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Arabinonucleosides; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Clofarabine; Cyclophosphamide; Etoposide; Hematopoietic Stem Cell Transplantation; Humans; Infant; Leukemia; Leukemia, Myeloid, Acute; Maximum Tolerated Dose; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Salvage Therapy; Treatment Outcome; Young Adult

2009
Phase I pharmacokinetic and pharmacodynamic study of the multikinase inhibitor sorafenib in combination with clofarabine and cytarabine in pediatric relapsed/refractory leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011, Aug-20, Volume: 29, Issue:24

    Topics: Adenine Nucleotides; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Arabinonucleosides; Benzenesulfonates; Child; Clofarabine; Cytarabine; Drug Administration Schedule; Drug Resistance, Neoplasm; Female; Humans; Leukemia; Leukemia, Myeloid, Acute; Male; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Pyridines; Recurrence; Sorafenib

2011
Clofarabine and busulfan conditioning facilitates engraftment and provides significant antitumor activity in nonremission hematologic malignancies.
    Blood, 2011, Oct-13, Volume: 118, Issue:15

    Topics: Adenine Nucleotides; Adolescent; Adult; Aged; Antineoplastic Agents; Arabinonucleosides; Busulfan; Child, Preschool; Clofarabine; Disease-Free Survival; Graft Survival; Hematopoietic Stem Cell Transplantation; Humans; Infant; Leukemia; Male; Middle Aged; Myeloablative Agonists; Remission Induction; Survival Rate; Time Factors; Transplantation Conditioning; Transplantation, Homologous

2011
Phase I dose-escalation trial of clofarabine followed by escalating doses of fractionated cyclophosphamide in children with relapsed or refractory acute leukemias.
    Pediatric blood & cancer, 2012, Dec-15, Volume: 59, Issue:7

    Topics: Acute Disease; Adenine Nucleotides; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Arabinonucleosides; Child; Child, Preschool; Clofarabine; Cyclophosphamide; DNA Damage; Drug Administration Schedule; Female; Humans; Leukemia; Leukemia, Myeloid, Acute; Male; Maximum Tolerated Dose; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Young Adult

2012
Pharmacokinetics and pharmacodynamics of plasma clofarabine and cellular clofarabine triphosphate in patients with acute leukemias.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Dec-15, Volume: 9, Issue:17

    Topics: Adenine Nucleotides; Antineoplastic Agents; Arabinonucleosides; Clofarabine; DNA; Dose-Response Relationship, Drug; Humans; Leukemia; Leukemia, Myeloid, Acute; Maximum Tolerated Dose; Models, Chemical; Neoplastic Cells, Circulating; Oligonucleotides; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors

2003
Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemias.
    Blood, 2005, Feb-01, Volume: 105, Issue:3

    Topics: Acute Disease; Adenine Nucleotides; Aged; Antineoplastic Combined Chemotherapy Protocols; Arabinonucleosides; Clofarabine; Cytarabine; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Karyotyping; Leukemia; Male; Middle Aged; Recurrence; Treatment Outcome

2005

Other Studies

17 other study(ies) available for clofarabine and Leukemia

ArticleYear
Clofarabine and total body irradiation (TBI) as conditioning regimen for allogeneic stem cell transplantation in high-risk acute leukemia patients: a two-center retrospective cohort study.
    Bone marrow transplantation, 2023, Volume: 58, Issue:6

    Topics: Adult; Aged; Clofarabine; Graft vs Host Disease; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Humans; Leukemia; Middle Aged; Retrospective Studies; Transplantation Conditioning; Whole-Body Irradiation; Young Adult

2023
Chemotherapy-induced skin toxicity and capillary leak syndrome.
    International journal of dermatology, 2019, Volume: 58, Issue:7

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capillary Leak Syndrome; Clofarabine; Cytarabine; Erythema; Female; Humans; Leukemia; Male; Middle Aged; Skin; Stevens-Johnson Syndrome

2019
Novel leukemic cell lines resistant to clofarabine by mechanisms of decreased active metabolite and increased antiapoptosis.
    Cancer science, 2013, Volume: 104, Issue:6

    Topics: Adenine Nucleotides; Antineoplastic Agents; Arabinonucleosides; Blotting, Western; Cell Line, Tumor; Clofarabine; Drug Resistance, Neoplasm; HL-60 Cells; Humans; Leukemia; Reverse Transcriptase Polymerase Chain Reaction

2013
Melatonin overcomes resistance to clofarabine in two leukemic cell lines by increased expression of deoxycytidine kinase.
    Experimental hematology, 2015, Volume: 43, Issue:3

    Topics: Adenine Nucleotides; Antineoplastic Agents; Arabinonucleosides; Cell Line, Tumor; Clofarabine; Deoxycytidine Kinase; Drug Resistance, Neoplasm; Flow Cytometry; Gene Expression Regulation, Enzymologic; Humans; Inhibitory Concentration 50; Leukemia; Melatonin; Real-Time Polymerase Chain Reaction

2015
[18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity.
    Proceedings of the National Academy of Sciences of the United States of America, 2016, Apr-12, Volume: 113, Issue:15

    Topics: Adenine Nucleotides; Animals; Antineoplastic Agents; Arabinonucleosides; Biomarkers, Tumor; Cell Line, Tumor; Clofarabine; Contrast Media; Deoxycytidine Kinase; Humans; Leukemia; Mice; Neoplasms; Positron-Emission Tomography; Prodrugs; Rats

2016
HLA haploidentical hematopoietic cell transplantation using clofarabine and busulfan for refractory pediatric hematological malignancy.
    International journal of hematology, 2017, Volume: 105, Issue:5

    Topics: Adenine Nucleotides; Arabinonucleosides; Busulfan; Child; Clofarabine; Female; Follow-Up Studies; Haploidy; Hematopoietic Stem Cell Transplantation; HLA Antigens; Humans; Leukemia; Male; Recurrence; Remission Induction; Time Factors; Transplantation Conditioning; Treatment Outcome

2017
Clofarabine: a size that fits all, may not fit all.
    Leukemia & lymphoma, 2009, Volume: 50, Issue:3

    Topics: Adenine Nucleotides; Arabinonucleosides; Clofarabine; Drug Administration Schedule; Humans; Leukemia; Leukemia, Myeloid, Acute; Maximum Tolerated Dose; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome

2009
Comparison of clofarabine activity in childhood and adult acute leukemia: individual tumor response study.
    Anticancer research, 2009, Volume: 29, Issue:5

    Topics: Acute Disease; Adenine Nucleotides; Adolescent; Adult; Antineoplastic Agents; Arabinonucleosides; Child; Child, Preschool; Clofarabine; Humans; Infant; Leukemia; Middle Aged; Treatment Outcome; Young Adult

2009
Clofarabine: emerging role in leukemias.
    Expert opinion on investigational drugs, 2009, Volume: 18, Issue:10

    Topics: Adenine Nucleotides; Adult; Aged; Antineoplastic Agents; Arabinonucleosides; Child; Clinical Trials as Topic; Clofarabine; Drug Evaluation, Preclinical; Humans; Leukemia; Middle Aged; Prognosis

2009
Clofarabine-based salvage chemotherapy for relapsed or refractory acute leukemia before allogeneic stem cell transplantation: results from a case series.
    Leukemia & lymphoma, 2009, Volume: 50, Issue:12

    Topics: Acute Disease; Adenine Nucleotides; Antineoplastic Combined Chemotherapy Protocols; Arabinonucleosides; Clofarabine; Cyclophosphamide; Cytarabine; Drug Resistance, Neoplasm; Female; Humans; Leukemia; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Leukemia, Myelomonocytic, Acute; Male; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Salvage Therapy; Stem Cell Transplantation; Transplantation, Homologous; Treatment Outcome

2009
Last exit clofarabine?
    Leukemia & lymphoma, 2009, Volume: 50, Issue:12

    Topics: Acute Disease; Adenine Nucleotides; Antineoplastic Combined Chemotherapy Protocols; Arabinonucleosides; Clofarabine; Cyclophosphamide; Cytarabine; Humans; Leukemia; Leukemia, Myeloid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Salvage Therapy; Stem Cell Transplantation; Transplantation, Homologous; Treatment Outcome

2009
Successful management with clofarabine for refractory leukaemia in a young adult with chronic renal failure.
    American journal of hematology, 2011, Volume: 86, Issue:3

    Topics: Adenine Nucleotides; Antineoplastic Combined Chemotherapy Protocols; Arabinonucleosides; Clofarabine; Cytarabine; Disease Management; Humans; Kidney Failure, Chronic; Leukemia; Male; Renal Dialysis; Salvage Therapy; Treatment Outcome; Young Adult

2011
Determination of clofarabine triphosphate concentrations in leukemia cells using sensitive, isocratic high-performance liquid chromatography.
    Anticancer research, 2011, Volume: 31, Issue:9

    Topics: Adenine Nucleotides; Antineoplastic Agents; Arabinonucleosides; Chromatography, High Pressure Liquid; Clofarabine; HL-60 Cells; Humans; Leukemia; Reproducibility of Results

2011
Epstein-Barr virus-induced CD30-positive diffuse large B-cell lymphoma in a patient with mixed-phenotypic leukemia treated with clofarabine.
    Clinical lymphoma, myeloma & leukemia, 2013, Volume: 13, Issue:3

    Topics: Adenine Nucleotides; Antimetabolites, Antineoplastic; Arabinonucleosides; Clofarabine; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Ki-1 Antigen; Leukemia; Lymphoma, Large B-Cell, Diffuse; Male; Middle Aged

2013
Down-regulation of deoxycytidine kinase in human leukemic cell lines resistant to cladribine and clofarabine and increased ribonucleotide reductase activity contributes to fludarabine resistance.
    Biochemical pharmacology, 2003, Jan-15, Volume: 65, Issue:2

    Topics: Adenine Nucleotides; Antineoplastic Agents; Arabinonucleosides; Cell Line; Cladribine; Clofarabine; Cytogenetics; Deoxycytidine Kinase; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Activation; Humans; Leukemia; Phenotype; Phosphorylation; Ribonucleotide Reductases; Vidarabine

2003
Activation of deoxycytidine kinase by various nucleoside analogues.
    Advances in experimental medicine and biology, 1998, Volume: 431

    Topics: Adenine Nucleotides; Antimetabolites, Antineoplastic; Arabinonucleosides; Cell Cycle; Cells, Cultured; Cladribine; Clofarabine; Cytarabine; Deoxycytidine Kinase; Enzyme Activation; HL-60 Cells; Humans; Leukemia; Lymphocytes; Palatine Tonsil; Thymidine Kinase; Tumor Cells, Cultured; Vidarabine

1998
Biochemical pharmacology and resistance to 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine, a novel analogue of cladribine in human leukemic cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:9

    Topics: Adenine Nucleotides; Antineoplastic Agents; Arabinonucleosides; Cladribine; Clofarabine; Deoxycytidine Kinase; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Leukemia, T-Cell; Phosphorylation; Recombinant Proteins; Tumor Cells, Cultured

1999