Page last updated: 2024-08-22

clodronic acid and Osteolysis

clodronic acid has been researched along with Osteolysis in 55 studies

Research

Studies (55)

Timeframe	Studies, this research(%)	All Research%
pre-1990	17 (30.91)	18.7374
1990's	26 (47.27)	18.2507
2000's	7 (12.73)	29.6817
2010's	4 (7.27)	24.3611
2020's	1 (1.82)	2.80

Authors

Authors	Studies
Adhikari, M; Amorim, T; Anderson, J; Bellido, T; Boeckman, RK; Cregor, M; Cuevas, PL; Delgado-Calle, J; Ebetino, FH; Ferrari, AJ; Helms, JA; Khan, S; Kurihara, N; Lehal, R; McAndrews, K; Roodman, GD; Sabol, HM; Srinivasan, V; Vigolo, M	1
Ashcroft, AJ; Bell, SE; Boyd, KD; Byrne, J; Child, JA; Cook, G; Davies, FE; Drayson, MT; Feyler, S; Gregory, WM; Jackson, GH; Morgan, GJ; Navarro Coy, N; Osborne, WL; Owen, RG; Roddie, H; Ross, FM; Rudin, C; Szubert, AJ; Wu, P	1
Berenson, J; Dimopoulos, MA; Terpos, E	1
Adam, Z; Hájek, R; Jakubcová, R; Klincová, M; Krejcí, M; Mayer, J; Pour, L; Szturz, P; Zahradová, L	1
Anderson, KC; Ghobrial, IM; Laubach, JP; Mahindra, A; Mitsiades, CS; Munshi, N; Raje, N; Richardson, PG; Rosenblatt, J; Schlossman, RL	1
Anderson, K; Berenson, JR; Biermann, JS; Hillner, BE; Kyle, RA; Lipton, A; Yee, GC	1
Ashcroft, AJ; Davies, FE; Morgan, GJ	1
Barth, B; Chitu, V; Grosse, J; Hanke, P; Marquardt, A; Nehls, M; Paffenholz, R; Schmittwolf, C; Schropp, P; Stanley, ER; Stumm, G; Yu, P; Zeitlmann, L	1
Clézardin, P; Daubiné, F; Gasser, J; Green, J; Le Gall, C	1
Ashammakhi, N; Huolman, R	1
Ding, Y; Markel, DC; Ren, W; Schwendener, R; Wooley, PH; Wu, B	1
Blomqvist, C; Elomaa, I; Gröhn, P; Holmström, T; Kairento, AL; Lamberg-Allardt, C; Porkka, L; Selander, K	1
Chantraine, A; Donath, A; Jung, A; Kitler, ME; Mermillod, B; Turnill, D; van Ouwenaller, C	1
Chantraine, A; Donath, A; Jung, A; van Ouwenaller, C	1
Raisz, LG	1
Barras, C; Baud, M; Courvoisier, B; Jung, A; Mermillod, B	1
Fleisch, H; Jung, A	1
Adam, Z; Hájek, D; Prokes, B; Vorlícek, J	1
Blomqvist, C; Elomaa, I	1
Houghton, F; Huss, H; Kanis, JA; McCloskey, E; O'Rourke, N	1
Aranko, K; Drake, J; Hanhijärvi, H; Humphreys, M; Lawton, WA	1
Elomaa, I; Laakso, M; Lahtinen, R; Virkkunen, P	1
Kiełbiński, M	1
Fleisch, H	2
Ashley, S; Hanson, J; Kanis, JA; McCloskey, E; Paterson, AH; Powles, TJ	1
van Rooijen, N	1
Krempien, B; Manegold, C	1
Jantunen, E; Laakso, M; Lahtinen, R	1
Bauduer, F; Delmer, A	1
Adam, Z; Hájek, D; Hejlová, N; Krejcí, M; Prokes, B; Vorlícek, J; Znojĭl, V	1
Body, JJ; Coleman, RE; Piccart, M	1
Ding, Y; Ingman, T; Konttinen, YT; Lauhio, A; Lindqvist, C; Salo, T; Santavirta, S; Sorsa, T; Teronen, O	1
Musto, P	1
Mundy, GR	1
Brion, N; Clerc, D; Paule, B	1
Barras, C; Courvoisier, B; Jung, A; Mermillod, B	1
Ashley, S; Ernst, DS; Kanis, JA; McCloskey, EV; Paterson, AH; Powles, TJ	1
Biermann, WA; Cantor, RI; Fellin, FM; Hopkins, L; Jakobowski, J; Newbold, RC	1
Powles, T	1
Conte, N; Da Rin, G; Di Virgilio, R; Foscolo, G; Legovini, P; Pavan, P; Roiter, I	1
Beuzeboc, P; Pouillart, P	1
Bonjour, JP; Rizzoli, R	1
Delmas, PD	1
Burki, F	1
Caulin, F	1
Barr, RJ; Mollan, RA; Osterberg, PH; Wallace, RG	1
Luckert, PH; Pollard, M	2
Onge, MS; Parker, B; Wink, CS	1
Bijvoet, OL; Cleton, FJ; Elte, JW; Sleeboom, HP; van Oosterom, AT	1
Luckert, PH; Pollard, M; Scheu, J	1
Blomqvist, C; Borgström, GH; Elomaa, I; Holmström, T; Lamberg-Allardt, C; Porkka, L; Taube, T	1
Warrell, RP	1
Beard, DJ; Douglas, DL; Kanis, JA; Neal, FE; Paterson, AD; Percival, RC; Russell, RG; Yates, AJ	1

Reviews

17 review(s) available for clodronic acid and Osteolysis

Article	Year
Established role of bisphosphonate therapy for prevention of skeletal complications from myeloma bone disease. Critical reviews in oncology/hematology, 2011, Volume: 77 Suppl 1 Topics: Animals; Bone and Bones; Bone Density Conservation Agents; Bone Neoplasms; Breast Neoplasms; Clinical Trials as Topic; Clodronic Acid; Diphosphonates; Female; Humans; Imidazoles; Mice; Multiple Myeloma; Osteolysis; Pamidronate; Risk Factors; Spinal Cord Compression; Zoledronic Acid	2011
The Medical Research Council Myeloma IX trial: the impact on treatment paradigms. European journal of haematology, 2012, Volume: 88, Issue:1 Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Bone Density Conservation Agents; Clinical Trials as Topic; Clodronic Acid; Diphosphonates; Disease-Free Survival; Female; Humans; Imidazoles; Infusions, Intravenous; Male; Multiple Myeloma; Osteolysis; Practice Guidelines as Topic; Zoledronic Acid	2012
Aetiology of bone disease and the role of bisphosphonates in multiple myeloma. The Lancet. Oncology, 2003, Volume: 4, Issue:5 Topics: Antineoplastic Agents; Bone and Bones; Bone Density; Bone Neoplasms; Chemokines; Clinical Trials as Topic; Clodronic Acid; Cytokines; Diphosphonates; Humans; Hypercalcemia; Imidazoles; Multiple Myeloma; Osteolysis; Patient Selection; Treatment Outcome; Zoledronic Acid	2003
Clodronate and other bisphosphonates as supportive therapy in osteolysis due to malignancy. Acta oncologica (Stockholm, Sweden), 1995, Volume: 34, Issue:5 Topics: Clodronic Acid; Diphosphonates; Humans; Neoplasms; Osteolysis	1995
[Pharmacologic therapy of bone tissue changes due to hematologic malignancies and bone metastasis]. Acta haematologica Polonica, 1994, Volume: 25, Issue:2 Topics: Bone Neoplasms; Calcitonin; Clodronic Acid; Diphosphonates; Etidronic Acid; Humans; Neoplasms; Osteolysis; Osteosclerosis; Pamidronate	1994
Extracellular and intracellular action of clodronate in osteolytic bone diseases? A hypothesis. Calcified tissue international, 1993, Volume: 52, Issue:6 Topics: Adenosine Triphosphate; Clodronic Acid; Humans; Iron; Macrophages; Osteoclasts; Osteolysis	1993
Use of clodronate in multiple myeloma. Leukemia & lymphoma, 1995, Volume: 19, Issue:3-4 Topics: Antimetabolites; Bone Diseases; Clodronic Acid; Controlled Clinical Trials as Topic; Humans; Hypercalcemia; Multicenter Studies as Topic; Multiple Myeloma; Osteolysis	1995
[Multiple myeloma and bone manifestations. Role of clodronate]. Bulletin du cancer, 1996, Volume: 83, Issue:7 Topics: Analgesics, Non-Narcotic; Bone Density; Bone Diseases; Clodronic Acid; Humans; Hypercalcemia; Magnetic Resonance Imaging; Multiple Myeloma; Osteolysis; Pain; Quality of Life; Radiography; Treatment Outcome	1996
Use of bisphosphonates in cancer patients. Cancer treatment reviews, 1996, Volume: 22, Issue:4 Topics: Alendronate; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Clodronic Acid; Diphosphonates; Etidronic Acid; Humans; Hypercalcemia; Multiple Myeloma; Osteolysis; Pain; Pamidronate; Structure-Activity Relationship	1996
The role of bisphosphonates for the treatment of bone disease in multiple myeloma. Leukemia & lymphoma, 1998, Volume: 31, Issue:5-6 Topics: Adult; Aged; Aged, 80 and over; Bone Remodeling; Clinical Trials as Topic; Clodronic Acid; Diphosphonates; Etidronic Acid; Female; Humans; Hypercalcemia; Male; Middle Aged; Multicenter Studies as Topic; Multiple Myeloma; Osteolysis; Palliative Care; Pamidronate; Prospective Studies; Randomized Controlled Trials as Topic; Treatment Outcome	1998
Bisphosphonates as cancer drugs. Hospital practice (1995), 1999, May-15, Volume: 34, Issue:5 Topics: Antineoplastic Agents; Clodronic Acid; Diphosphonates; Etidronic Acid; Humans; Neoplasm Proteins; Neoplasms; Osteolysis; Pamidronate; Parathyroid Hormone-Related Protein; Proteins; Risedronic Acid; Transforming Growth Factor beta	1999
Treatment of skeletal disease in breast cancer with clodronate. Bone, 1991, Volume: 12 Suppl 1 Topics: Administration, Oral; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Clodronic Acid; Combined Modality Therapy; Double-Blind Method; Fractures, Spontaneous; Humans; Hypercalcemia; Incidence; Injections, Intravenous; Osteolysis; Pain; Palliative Care; Prospective Studies; Spinal Fractures; Treatment Outcome	1991
An evaluation of the potential cost reductions resulting from the use of clodronate in the treatment of metastatic carcinoma of the breast to bone. Bone, 1991, Volume: 12 Suppl 1 Topics: Ambulatory Care; Analgesics; Bone Neoplasms; Breast Neoplasms; Clodronic Acid; Cost-Benefit Analysis; Costs and Cost Analysis; Epidural Space; Fractures, Spontaneous; Hospitalization; Hospitals, University; Humans; Hypercalcemia; Incidence; Length of Stay; Osteolysis; Outpatient Clinics, Hospital; Pain; Palliative Care; Philadelphia; Radiotherapy; Retrospective Studies; Spinal Neoplasms	1991
Treatment of hypercalcaemia of malignancy with clodronate. Bone, 1991, Volume: 12 Suppl 1 Topics: Calcium; Clodronic Acid; Homeostasis; Humans; Hypercalcemia; Neoplasms; Osteoclasts; Osteolysis	1991
The use of clodronate in multiple myeloma. Bone, 1991, Volume: 12 Suppl 1 Topics: Antineoplastic Agents; Bone Resorption; Calcium; Clodronic Acid; Combined Modality Therapy; Double-Blind Method; Humans; Hypercalcemia; Lymphokines; Multiple Myeloma; Neoplasm Proteins; Osteoclasts; Osteolysis	1991
Osteolytic bone metastases in breast carcinoma pathogenesis, morbidity and bisphosphonate treatment. European journal of cancer & clinical oncology, 1986, Volume: 22, Issue:4 Topics: Bone Neoplasms; Bone Resorption; Breast Neoplasms; Clodronic Acid; Diagnosis, Differential; Diphosphonates; Female; Humans; Hypercalcemia; Hyperparathyroidism; Osteolysis	1986
[Biphosphonate as a therapeutic drug--experimental studies and clinical application]. Therapeutische Umschau. Revue therapeutique, 1985, Volume: 42, Issue:6 Topics: Animals; Calcinosis; Clodronic Acid; Diphosphonates; Etidronic Acid; Humans; Hypercalcemia; Hyperparathyroidism; Myositis Ossificans; Osteitis Deformans; Osteolysis; Osteoporosis; Pamidronate; Urinary Calculi	1985

Trials

13 trial(s) available for clodronic acid and Osteolysis

Article	Year
Osteonecrosis of the jaw and renal safety in patients with newly diagnosed multiple myeloma: Medical Research Council Myeloma IX Study results. British journal of haematology, 2014, Volume: 166, Issue:1 Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conservation Agents; Clodronic Acid; Diphosphonates; Drug Administration Schedule; England; Female; Follow-Up Studies; Humans; Imidazoles; Incidence; Male; Middle Aged; Multiple Myeloma; Osteolysis; Zoledronic Acid	2014
Long-term controlled trial with diphosphonate in patients with osteolytic bone metastases. Lancet (London, England), 1983, Jan-22, Volume: 1, Issue:8317 Topics: Adult; Aged; Analgesics; Antineoplastic Agents; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Clinical Trials as Topic; Clodronic Acid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrocarbons, Chlorinated; Methylene Chloride; Middle Aged; Osteolysis; Random Allocation; Time Factors	1983
Use of dichloromethylene diphosphonate in metastatic bone disease. The New England journal of medicine, 1983, Jun-23, Volume: 308, Issue:25 Topics: Bone Neoplasms; Bone Resorption; Calcium; Clinical Trials as Topic; Clodronic Acid; Diphosphonates; Double-Blind Method; Humans; Hypercalcemia; Multiple Myeloma; Osteolysis; Random Allocation	1983
[Dichloromethylene diphosphonate in the treatment of lytic bone metastases]. Presse medicale (Paris, France : 1983), 1984, Feb-25, Volume: 13, Issue:8 Topics: Adult; Aged; Bone Neoplasms; Bone Resorption; Calcium; Clodronic Acid; Diphosphonates; Drug Evaluation; Female; Humans; Kinetics; Male; Middle Aged; Osteolysis	1984
Double-blind, placebo-controlled, dose-response trial of oral clodronate in patients with bone metastases. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1995, Volume: 13, Issue:4 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Alkaline Phosphatase; Bone and Bones; Bone Neoplasms; Calcium; Clodronic Acid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Humans; Hydroxyproline; Male; Middle Aged; Osteolysis; Patient Compliance	1995
Beneficial effects of oral clodronate in the management of malignant osteolysis and hypercalcaemia. Bone, 1995, Volume: 16, Issue:2 Topics: Biological Availability; Clodronic Acid; Cross-Over Studies; Double-Blind Method; Humans; Hypercalcemia; Osteolysis; Prospective Studies; Therapeutic Equivalency	1995
Subgroup and cost-benefit analysis of the Finnish multicentre trial of clodronate in multiple myeloma. Finnish Leukaemia Group. British journal of haematology, 1994, Volume: 87, Issue:4 Topics: Aged; Bone and Bones; Clodronic Acid; Cost-Benefit Analysis; Disease Progression; Double-Blind Method; Female; Health Care Costs; Humans; Male; Middle Aged; Multiple Myeloma; Osteolysis; Paraneoplastic Syndromes; Risk Factors	1994
[Double-blind trial of oral clodronate in breast cancer patients with bone metastases]. Bulletin du cancer, 1993, Volume: 80, Issue:10 Suppl Topics: Administration, Oral; Adult; Aged; Bone Neoplasms; Breast Neoplasms; Calcium; Clodronic Acid; Double-Blind Method; Female; Humans; Middle Aged; Osteolysis	1993
Treatment of skeletal disease in breast cancer with clodronate. Bone, 1991, Volume: 12 Suppl 1 Topics: Administration, Oral; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Clodronic Acid; Combined Modality Therapy; Double-Blind Method; Fractures, Spontaneous; Humans; Hypercalcemia; Incidence; Injections, Intravenous; Osteolysis; Pain; Palliative Care; Prospective Studies; Spinal Fractures; Treatment Outcome	1991
Clodronate treatment increases serum osteocalcin in normocalcemic osteolytic bone metastases. Oncology, 1991, Volume: 48, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Alkaline Phosphatase; Bone Neoplasms; Clodronic Acid; Female; Humans; Male; Middle Aged; Osteocalcin; Osteolysis; Parathyroid Hormone	1991
The use of clodronate in multiple myeloma. Bone, 1991, Volume: 12 Suppl 1 Topics: Antineoplastic Agents; Bone Resorption; Calcium; Clodronic Acid; Combined Modality Therapy; Double-Blind Method; Humans; Hypercalcemia; Lymphokines; Multiple Myeloma; Neoplasm Proteins; Osteoclasts; Osteolysis	1991
New French studies of clodronate in cancer-induced osteolysis. Bone, 1991, Volume: 12 Suppl 1 Topics: Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Clodronic Acid; Combined Modality Therapy; Double-Blind Method; Female; France; Hormones; Humans; Osteolysis	1991
Clodronate for osteolytic metastases due to breast cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1988, Volume: 42, Issue:2 Topics: Aged; Aged, 80 and over; Bone Neoplasms; Breast Neoplasms; Clodronic Acid; Diphosphonates; Female; Follow-Up Studies; Humans; Middle Aged; Osteolysis	1988

Other Studies

27 other study(ies) available for clodronic acid and Osteolysis

Article	Year
Targeting Notch Inhibitors to the Myeloma Bone Marrow Niche Decreases Tumor Growth and Bone Destruction without Gut Toxicity. Cancer research, 2021, 10-01, Volume: 81, Issue:19 Topics: Animals; Bone and Bones; Bone Density Conservation Agents; Bone Marrow Cells; Cell Line, Tumor; Clodronic Acid; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Humans; Mice; Multiple Myeloma; Osteolysis; Receptors, Notch; Signal Transduction; X-Ray Microtomography; Xenograft Model Antitumor Assays	2021
[Regression of an osteolytic lesion in a patient with multiple myeloma treated with clodronate after a successful therapy with bortezomib-based regimen]. Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti, 2011, Volume: 24, Issue:3 Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Density Conservation Agents; Boronic Acids; Bortezomib; Clodronic Acid; Femur; Humans; Male; Multiple Myeloma; Osteolysis; Pyrazines; Radiography; Recurrence; Remission Induction	2011
American Society of Clinical Oncology clinical practice guidelines: the role of bisphosphonates in multiple myeloma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Sep-01, Volume: 20, Issue:17 Topics: Clodronic Acid; Diphosphonates; Drug Monitoring; Humans; Imidazoles; Multiple Myeloma; Osteolysis; Pamidronate; Zoledronic Acid	2002
Mutation of mouse Mayp/Pstpip2 causes a macrophage autoinflammatory disease. Blood, 2006, Apr-15, Volume: 107, Issue:8 Topics: Adaptor Proteins, Signal Transducing; Amino Acid Substitution; Animals; Autoimmune Diseases; Bone Density Conservation Agents; Bone Marrow Transplantation; Cell Movement; Cells, Cultured; Clodronic Acid; Cytokines; Cytoskeletal Proteins; Gene Expression Regulation; Genes, Recessive; Granulocytes; Inflammation; Lipopolysaccharides; Lymphocytes; Macrophage-1 Antigen; Macrophages; Mice; Mice, Mutant Strains; Mutagenesis; Osteolysis; Point Mutation; Syndrome	2006
Antitumor effects of clinical dosing regimens of bisphosphonates in experimental breast cancer bone metastasis. Journal of the National Cancer Institute, 2007, Feb-21, Volume: 99, Issue:4 Topics: Absorptiometry, Photon; Animals; Bone and Bones; Bone Density; Bone Density Conservation Agents; Bone Neoplasms; Chemotherapy, Adjuvant; Clodronic Acid; Diphosphonates; Drug Administration Schedule; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Green Fluorescent Proteins; Imidazoles; Luciferases; Mammary Neoplasms, Experimental; Mice; Osteolysis; Research Design; Zoledronic Acid	2007
New multifunctional anti-osteolytic releasing bioabsorbable implant. The Journal of craniofacial surgery, 2007, Volume: 18, Issue:2 Topics: Absorbable Implants; Biocompatible Materials; Bone Density Conservation Agents; Clodronic Acid; Dental Stress Analysis; Drug Delivery Systems; Elasticity; Hydrogen-Ion Concentration; Lactic Acid; Materials Testing; Osteolysis; Pliability; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Shear Strength; Viscosity; Water	2007
Macrophage depletion diminishes implant-wear-induced inflammatory osteolysis in a mouse model. Journal of biomedical materials research. Part A, 2008, Jun-15, Volume: 85, Issue:4 Topics: Acid Phosphatase; Animals; Bone and Bones; Bone Resorption; Clodronic Acid; Collagen; Female; Implants, Experimental; Inflammation; Interleukin-1beta; Isoenzymes; Liposomes; Macrophages; Membranes; Mice; Mice, Inbred BALB C; Models, Animal; Molecular Weight; Osteoclasts; Osteolysis; Polyethylene; Protective Agents; Spleen; Tartrate-Resistant Acid Phosphatase; Tumor Necrosis Factor-alpha	2008
New diphosphonates to block bone resorption. The New England journal of medicine, 1980, Feb-07, Volume: 302, Issue:6 Topics: Animals; Bone Resorption; Breast Neoplasms; Clodronic Acid; Diphosphonates; Double-Blind Method; Etidronic Acid; Humans; Hypercalcemia; Hyperparathyroidism; Multiple Myeloma; Osteitis Deformans; Osteoclasts; Osteolysis; Osteomalacia; Propanolamines	1980
Inhibition by two diphosphonates of bone lysis in tumor-conditioned media. Cancer research, 1981, Volume: 41, Issue:8 Topics: Animals; Bone Resorption; Clodronic Acid; Culture Media; Diphosphonates; Etidronic Acid; Indomethacin; Kidney Neoplasms; Mammary Neoplasms, Experimental; Mice; Neoplasms, Experimental; Osteolysis	1981
[Diphosphonates in the treatment of bone metastases]. Schweizerische medizinische Wochenschrift, 1981, Dec-05, Volume: 111, Issue:49 Topics: Animals; Bone and Bones; Bone Neoplasms; Bone Resorption; Calcium; Carcinoma 256, Walker; Clodronic Acid; Diphosphonates; Humans; Neoplasm Transplantation; Neoplasms, Experimental; Osteitis Deformans; Osteolysis; Rats	1981
Increasing bone density in myeloma patients after the administration of clodronate. Acta medica Austriaca, 1995, Volume: 22, Issue:1-2 Topics: Aged; Bone Density; Clodronic Acid; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Male; Middle Aged; Multiple Myeloma; Osteolysis; Palliative Care; Tomography, X-Ray Computed	1995
[Pharmacology of clodronate and its mechanism of action on bone resorption]. Bulletin du cancer, 1993, Volume: 80, Issue:10 Suppl Topics: Bone Resorption; Clodronic Acid; Humans; Osteoblasts; Osteoclasts; Osteolysis; Osteoporosis	1993
Prophylactic treatment of skeletal metastases, tumor-induced osteolysis, and hypercalcemia in rats with the bisphosphonate Cl2MBP. Cancer, 1993, Jul-01, Volume: 72, Issue:1 Topics: Animals; Bone Neoplasms; Carcinoma 256, Walker; Clodronic Acid; Diphosphonates; Drug Administration Schedule; Drug Screening Assays, Antitumor; Hypercalcemia; Male; Osteolysis; Rats; Rats, Wistar; Tibia	1993
[The effect of clodronate on bone density in patients with multiple myeloma--a 2-year follow-up of therapeutic effects]. Vnitrni lekarstvi, 1996, Volume: 42, Issue:6 Topics: Adult; Aged; Bone Density; Clodronic Acid; Diphosphonates; Female; Follow-Up Studies; Humans; Hypercalcemia; Male; Middle Aged; Multiple Myeloma; Osteolysis	1996
Human neutrophil collagenase MMP-8 in peri-implant sulcus fluid and its inhibition by clodronate. Journal of dental research, 1997, Volume: 76, Issue:9 Topics: Adult; Anti-Bacterial Agents; Arthritis; Aurothioglucose; Biomarkers; Bone Remodeling; Bone Resorption; Calcium; Clodronic Acid; Collagenases; Connective Tissue Diseases; Dental Implants; Dental Restoration Failure; Dose-Response Relationship, Drug; Doxycycline; Enzyme Activation; Enzyme Inhibitors; Gingival Crevicular Fluid; Humans; Immunoblotting; Matrix Metalloproteinase 8; Matrix Metalloproteinase Inhibitors; Middle Aged; Osteolysis; Periodontal Diseases; Periodontal Ligament; Periodontitis; Tooth Mobility	1997
[Biosphonates in oncology]. Presse medicale (Paris, France : 1983), 2000, Apr-08, Volume: 29, Issue:13 Topics: Bone Neoplasms; Clodronic Acid; Diphosphonates; Fractures, Bone; Humans; Neoplasms; Osteolysis; Pain; Pamidronate; Spinal Cord Compression	2000
[Effect of 2 phosphonates on the osteolysis induced by tumor extracts]. Schweizerische medizinische Wochenschrift, 1979, Dec-08, Volume: 109, Issue:47 Topics: Animals; Animals, Newborn; Clodronic Acid; Diphosphonates; Etidronic Acid; Mice; Neoplasm Metastasis; Neoplasms; Osteolysis; Skull; Tissue Extracts	1979
Clodronate: the potential for the future. Bone, 1991, Volume: 12 Suppl 1 Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Breast Neoplasms; Calcitonin; Clodronic Acid; Forecasting; Humans; Incidence; Osteolysis; Palliative Care; Survival Rate	1991
[Value of Clodronate in the treatment of bone metastasis]. Bulletin du cancer, 1991, Volume: 78, Issue:8 Topics: Bone and Bones; Bone Neoplasms; Breast Neoplasms; Clodronic Acid; Female; Humans; Hypercalcemia; Male; Osteolysis; Prostatic Neoplasms	1991
[Role and use of biphosphonates in the treatment of metastatic breast cancer]. Pathologie-biologie, 1990, Volume: 38, Issue:8 Topics: Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Clodronic Acid; Female; Humans; Hypercalcemia; Organophosphonates; Osteolysis	1990
Familial expansile osteolysis. Clinical orthopaedics and related research, 1989, Issue:248 Topics: Bone Diseases, Developmental; Clodronic Acid; Deafness; Female; Genes, Dominant; Genetic Linkage; Humans; Male; Northern Ireland; Osteolysis; Pedigree; Tooth Resorption	1989
Effects of dichloromethylene diphosphonate on the osteolytic and osteoplastic effects of rat prostate adenocarcinoma cells. Journal of the National Cancer Institute, 1985, Volume: 75, Issue:5 Topics: Adenocarcinoma; Animals; Bone and Bones; Bone Resorption; Clodronic Acid; Diphosphonates; Male; Neoplasm Metastasis; Osteolysis; Prostatic Neoplasms; Rats; Rats, Inbred Strains	1985
The effects of dichloromethylene biphosphonate on osteoporotic femora of adult castrate male rats. Acta anatomica, 1985, Volume: 124, Issue:1-2 Topics: Animals; Clodronic Acid; Diphosphonates; Disease Models, Animal; Male; Orchiectomy; Osteolysis; Osteoporosis; Rats	1985
The beneficial effects of diphosphonate and piroxicam on the osteolytic and metastatic spread of rat prostate carcinoma cells. The Prostate, 1986, Volume: 8, Issue:1 Topics: Adenocarcinoma; Animals; Bone Resorption; Clodronic Acid; Diphosphonates; Drug Therapy, Combination; Female; Humans; Male; Neoplasm Transplantation; Osteolysis; Piroxicam; Prostatic Neoplasms; Rats; Rats, Inbred Strains; Thiazines	1986
Effects of diphosphonate and x-rays on bone lesions induced in rats by prostate cancer cells. Cancer, 1988, May-15, Volume: 61, Issue:10 Topics: Adenocarcinoma; Animals; Clodronic Acid; Diphosphonates; Female; Male; Neoplasm Transplantation; Osteoblasts; Osteoclasts; Osteolysis; Osteolysis, Essential; Prostatic Neoplasms; Rats; Rats, Inbred Strains; Scapula; Transplantation, Heterologous; Tumor Cells, Cultured	1988
New inhibitors of osteolysis: implications for hypercalcemia and bone metastases. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1986, Volume: 4, Issue:8 Topics: Amifostine; Bone Neoplasms; Bone Resorption; Clodronic Acid; Diphosphonates; Humans; Hypercalcemia; Osteolysis; Pamidronate; Plicamycin	1986
Treatment of malignant hypercalcaemia with clodronate. British journal of cancer, 1985, Volume: 51, Issue:5 Topics: Adult; Aged; Alkaline Phosphatase; Bone Neoplasms; Calcium; Clodronic Acid; Creatinine; Diphosphonates; Female; Humans; Hypercalcemia; Male; Middle Aged; Osteolysis	1985