clodronic acid has been researched along with Innate Inflammatory Response in 64 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (10.94) | 18.2507 |
| 2000's | 19 (29.69) | 29.6817 |
| 2010's | 28 (43.75) | 24.3611 |
| 2020's | 10 (15.63) | 2.80 |
| Authors | Studies |
|---|---|
| Aspar, DG; Dunn, CJ; Galinet, LA; Nugent, RA; Schlachter, ST; Shields, SK; Staite, ND | 1 |
| Abdou, WM; Geronikaki, A; Kamel, AA | 1 |
| Casabella, A; Molfetta, L; Palermo, A; Rosini, S; Saviola, G | 1 |
| Ayares, D; Azimzadeh, AM; Barth, RN; Burdorf, L; Cimeno, A; Dandro, A; Eyestone, W; Kuravi, K; LaMattina, JC; Parsell, DM; Phelps, C; Pierson, RN; Sendil, S; Sorrells, L | 1 |
| Ackermann, J; Crainiciuc, G; Culemann, S; Euler, M; Fischer, K; Garibagaoglu, H; Grüneboom, A; Hahn, J; Hidalgo, A; Hoffmann, MH; Kienhöfer, D; Knab, K; Krönke, G; Nimmerjahn, F; Schett, G; Uderhardt, S; Wegner, A | 1 |
| Basta-Kaim, A; Ghafir El Idrissi, I; Lacivita, E; Leopoldo, M; Leśkiewicz, M; Trojan, E; Tylek, K | 1 |
| Boudaka, A; Mihara, H; Sugiyama, T; Tominaga, M | 1 |
| Bando, K; Deng, X; Endo, Y; Funayama, H; Kim, S; Kiyama, T; Monma, Y; Oizumi, T; Okada, S; Shikama, Y; Shima, K; Suzuki, H; Takahashi, T; Tanaka, Y; Yamaguchi, K; Yu, Z | 1 |
| Mert, T; Sahin, E; Sahin, M; Yaman, S | 2 |
| Hasuzawa, N; Moriyama, S; Moriyama, Y; Nomura, M | 1 |
| Gao Smith, F; Jin, SW; Mei, HX; Wang, Q; Xiang, SY; Xu, HR; Yang, Q; Ye, Y; Zhang, HW; Zheng, SX | 1 |
| Ashida, K; Hasuzawa, N; Kabashima, M; Moriyama, Y; Nagayama, A; Nomura, M; Ogawa, Y; Tatsushima, K; Tokubuchi, R; Wang, L | 1 |
| Bertin, FR; Blostein, MD; Ebrahimian, T; Kassim, Y; Laurance, S; Lehoux, S; Lemarié, CA; Rys, RN | 1 |
| He, L; Li, Q; Li, Y; Shu, Z; Song, P; Wang, H; Xu, P; Yang, C; Zhang, J; Zhang, Y | 1 |
| Kapás, L; Szentirmai, É | 1 |
| Brignole, C; Di Paolo, D; Pastorino, F; Perri, P; Ponzoni, M | 1 |
| Ali, N; Andre, R; Bates, GP; Benjamin, AC; Farag, S; Pido-Lopez, J; Tabrizi, SJ | 1 |
| Bando, K; Endo, Y; Funayama, H; Kiyama, T; Oizumi, T; Sugawara, S; Suzuki, H; Tada, H; Takahashi, T | 1 |
| Kozicky, LK; Sly, LM | 1 |
| Brunelli, S; Donè, E; Giovenzana, A; Manfredi, AA; Maugeri, N; Meneveri, R; Nicolosi, PA; Pulcinelli, E; Rovere-Querini, P; Tirone, M; Tombetti, E | 1 |
| Godai, K; Hasegawa-Moriyama, M; Kanmura, Y; Kojima, M; Kurimoto, T; Kuwaki, T; Nakama, M | 1 |
| Akiyoshi, K; Aoe, S; Fukaishi, T; Hamaguchi, M; Itoh, M; Kanai, S; Kato, H; Komohara, Y; Konuma, K; Marumoto, Y; Ogawa, Y; Sakaida, I; Sakugawa, H; Suganami, T; Takeya, M; Terai, S | 1 |
| Ahn, CH; Byun, Y; Haque, MR; Jeong, JH; Lee, DY | 1 |
| Haribhai, D; Hwang, ST; Mackinnon, AC; Plaza, JA; Schulte, BC; Williams, CB; Wu, X; Zhou, Y | 1 |
| Aghaei, M; Downey, CM; Jirik, FR; Schwendener, RA | 1 |
| Moore, BB; Osterholzer, JJ; Peters-Golden, M; Przybranowski, S; Teitz-Tennenbaum, S; van Rooijen, N; Wilke, C; Wilkinson, JE; Zasłona, Z | 1 |
| Cengia, L; Chae, JJ; Croker, BA; De Nardo, D; DiRago, L; Kastner, DL; Kile, BT; Kim, ML; Ko, HJ; Lew, AM; Lyras, D; Masters, SL; Metcalf, D; Park, YH; Roberts, AW; Stirzaker, RA; Tye, H | 1 |
| Dam, W; Hijmans, RS; Navis, G; Poosti, F; van den Born, J; van Goor, H; Yazdani, S | 1 |
| Fujii, H; Hayashi, Y; Hiyama, S; Iijima, H; Inoue, T; Ishii, M; Kamada, Y; Kawai, S; Kuwahara, R; Miyoshi, E; Morii, E; Shinzaki, S; Shiraishi, E; Takamatsu, S; Takehara, T; Tsujii, M; Wakamatsu, K | 1 |
| Busuttil, RW; Kupiec-Weglinski, JW; Wang, X; Yue, S; Zhai, Y; Zhou, H | 1 |
| Bem, RA; Farnand, AW; Frevert, CW; Koski, A; Martin, TR; Matute-Bello, G; Rosenfeld, ME; van Rooijen, N; Wong, V | 1 |
| Oh, DJ; Yu, SH; Yu, SJ | 1 |
| Christophi, GP; Gruber, RC; Hudson, CA; Massa, PT; Panos, M | 1 |
| Cmarik, JL; Hanson, C; Li, X; Ruscetti, S | 1 |
| Lewis, JF; McCaig, L; Tessolini, JM; Veldhuizen, RA; Walker, MG; Yao, LJ | 1 |
| Felder, RB; Serrats, J; Wei, SG; Weiss, RM; Yu, Y; Zhang, ZH | 1 |
| Alexander, KA; Chang, MK; Hume, DA; Kohler, T; Maylin, ER; Müller, R; Pettit, AR; Raggatt, LJ; Sweet, MJ; Van Rooijen, N; Wu, AC | 1 |
| Cani, PD; Horsmans, Y; Lanthier, N; Leclercq, IA; Molendi-Coste, O; van Rooijen, N | 1 |
| Allavena, P; Mantovani, A | 1 |
| Said, N; Sanchez-Carbayo, M; Smith, SC; Theodorescu, D | 1 |
| Berk, M; Dixon, LJ; Feldstein, AE; Papouchado, BG; Thapaliya, S | 1 |
| Bianco, AM; Crovella, S; Decorti, G; Marcuzzi, A; Monasta, L; Piscianz, E; Vuch, J; Zanin, V | 1 |
| Bauersachs, J; Bayer, B; Bobinger, T; Ertl, G; Fraccarollo, D; Frantz, S; Hagedorn, I; Hofmann, U; Kneitz, S; Kranepuhl, S; Nahrendorf, M; Nieswandt, B; Pachel, C; Schäfer, A; Schön, MP; Wagner, H; Weidemann, F | 1 |
| Emerson, SG; Giannola, D; Joe, G; Louboutin, JP; Rivera, A; Shlomchik, WD; Zhang, Y; Zhu, J | 1 |
| Egawa, S; Endo, Y; Matsuno, S; Mikami, Y; Qiu-Feng, H; Shibuya, K; Shimamura, H; Sunamura, M; Takeda, K; Yagi, H; Yamauchi, J | 1 |
| Brack, A; Labuz, D; Machelska, H; Reszka, R; Rittner, HL; Schäfer, M; Schiltz, A; Stein, C | 1 |
| Endo, Y; Funayama, H; Mayanagi, H; Monma, Y; Ohsako, M; Sugawara, S | 1 |
| Deng, X; Endo, Y; Funayama, H; Kuroishi, T; Sasano, T; Sugawara, S; Yu, Z | 1 |
| Barth, B; Chitu, V; Grosse, J; Hanke, P; Marquardt, A; Nehls, M; Paffenholz, R; Schmittwolf, C; Schropp, P; Stanley, ER; Stumm, G; Yu, P; Zeitlmann, L | 1 |
| Haase, I; Hartmann, K; Krieg, T; Markur, D; Pasparakis, M; Peters, T; Rupec, RA; Scharffetter-Kochanek, K; Stratis, A; van Rooijen, N | 1 |
| Deng, X; Endo, Y; Funayama, H; Sasano, T; Sugawara, S; Yamaguchi, K; Yu, Z | 1 |
| Huard, J; Li, Y; Schwendener, R; Shen, W; Zhu, J | 1 |
| Fotovati, A; Hosoi, F; Iguchi, H; Izumi, H; Kimura, YN; Kohno, K; Kuwano, M; Ono, M; Shirouzu, K; Takamori, S; Umezawa, K; Watari, K; Yasumoto, K | 1 |
| Ding, Y; Markel, DC; Ren, W; Schwendener, R; Wooley, PH; Wu, B | 1 |
| Bénard, T; Berna, P; Bertrand, CP; Boichot, E; Hitier, S; Lagente, V; Nénan, S; Planquois, JM | 1 |
| Cantatore, FP; Longo, V; Mangieri, D; Maruotti, N; Nico, B; Ribatti, D; Vacca, A | 1 |
| Amos, N; Camilleri, JP; Douglas-Jones, AG; Love, WG; Williams, AS; Williams, BD | 1 |
| Berg, RD; Deitch, EA; Goris, RJ; Haskel, Y; Lu, Q; Nieuwenhuijzen, GA; van Rooijen, N | 1 |
| Bergh, A; Damber, JE; van Rooijen, N | 1 |
| Hannuniemi, R; Kippo, K; Laurén, L; Osterman, T; Pasanen, I; Sellman, R; Väänänen, K; Virtamo, T | 1 |
| Bowen, LK; Brown, JW; Cummings, OW; Heidler, KM; Sekine, Y; Van Rooijen, N; Wilkes, DS | 1 |
| Guan, Z; Huitinga, I; Popovich, PG; Stokes, BT; van Rooijen, N; Wei, P | 1 |
| Inman, MD; Matsumoto, K; O'Byrne, PM; Shen, H; Tang, C; van Rooijen, N; Yang, P | 1 |
6 review(s) available for clodronic acid and Innate Inflammatory Response
| Article | Year |
|---|---|
Role of the Osteochondral Unit in the Pathogenesis of Osteoarthritis: Focus on the Potential Use of Clodronate.
Topics: Bone and Bones; Cartilage, Articular; Clodronic Acid; Humans; Inflammation; Osteoarthritis | 2022 |
Transient Receptor Potential Vanilloid 4 Regulation of Adenosine Triphosphate Release by the Adenosine Triphosphate Transporter Vesicular Nucleotide Transporter, a Novel Therapeutic Target for Gastrointestinal Baroreception and Chronic Inflammation.
Topics: Abdominal Pain; Adenosine Triphosphate; Analgesics; Animals; Chronic Disease; Clodronic Acid; Gastrointestinal Tract; Humans; Inflammation; Mice; Mucous Membrane; Nucleotide Transport Proteins; Pressoreceptors; Receptors, Purinergic P2; TRPV Cation Channels | 2020 |
[Basic Studies on the Mechanism, Prevention, and Treatment of Osteonecrosis of the Jaw Induced by Bisphosphonates].
Topics: Animals; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conservation Agents; Clinical Trials as Topic; Clodronic Acid; Diphosphonates; Etidronic Acid; Humans; Inflammation; Jaw; Mice; Nitrogen; Phosphate Transport Proteins; Rats | 2020 |
Physiopathological roles of vesicular nucleotide transporter (VNUT), an essential component for vesicular ATP release.
Topics: Adenosine Triphosphate; Animals; Circadian Rhythm; Clodronic Acid; Humans; Inflammation; Neurons; Nucleotide Transport Proteins; Pain Perception; Porokeratosis | 2020 |
Targeting Macrophages as a Potential Therapeutic Intervention: Impact on Inflammatory Diseases and Cancer.
Topics: Animals; Clodronic Acid; Disease Models, Animal; Drug Delivery Systems; Humans; Inflammation; Liposomes; Macrophages; Mice; Nanotechnology; Neoplasms | 2018 |
Immunology in the clinic review series; focus on cancer: tumour-associated macrophages: undisputed stars of the inflammatory tumour microenvironment.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzenesulfonates; Chemotaxis; Clodronic Acid; Cytokines; Dioxoles; Disease Progression; Humans; Immunity, Innate; Inflammation; Liposomes; Macrophages; Mice; Molecular Targeted Therapy; Neoplasm Invasiveness; Neoplasm Proteins; Neoplasms; Neovascularization, Pathologic; Niacinamide; Phenylurea Compounds; Prognosis; Pyridines; Sorafenib; Tetrahydroisoquinolines; Trabectedin; Tumor Escape; Tumor Microenvironment | 2012 |
58 other study(ies) available for clodronic acid and Innate Inflammatory Response
| Article | Year |
|---|---|
Anti-inflammatory/antiarthritic ketonic bisphosphonic acid esters.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Diphosphonates; Drug Design; Granuloma; Hypersensitivity, Delayed; Indicators and Reagents; Inflammation; Mice; Molecular Structure; Structure-Activity Relationship | 1998 |
Inhibitory effect of novel S,N-bisphosphonates on some carcinoma cell lines, osteoarthritis, and chronic inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Biological Assay; Cell Line, Tumor; Chronic Disease; Computer-Aided Design; Diphosphonates; Female; Granuloma; Humans; Inflammation; Male; Mice; Osteoarthritis; Rats; Structure-Activity Relationship; Toxicity Tests | 2012 |
hEPCR.hTBM.hCD47.hHO-1 with donor clodronate and DDAVP treatment improves perfusion and function of GalTKO.hCD46 porcine livers perfused with human blood.
Topics: Animals; Animals, Genetically Modified; Clodronic Acid; Deamino Arginine Vasopressin; Graft Survival; Heme Oxygenase-1; Humans; Inflammation; Liver; Perfusion; Swine; Thrombocytopenia; Transplantation, Heterologous | 2022 |
Stunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes.
Topics: Anti-Inflammatory Agents; Clodronic Acid; Humans; Inflammation; Liposomes; Neutrophils | 2023 |
Microglia Depletion Attenuates the Pro-Resolving Activity of the Formyl Peptide Receptor 2 Agonist AMS21 Related to Inhibition of Inflammasome NLRP3 Signalling Pathway: A Study of Organotypic Hippocampal Cultures.
Topics: Anti-Inflammatory Agents; Clodronic Acid; Hippocampus; Humans; Inflammasomes; Inflammation; Lipopolysaccharides; Microglia; NLR Family, Pyrin Domain-Containing 3 Protein; Receptors, Formyl Peptide | 2023 |
Effects of immune cell-targeted treatments result from the suppression of neuronal oxidative stress and inflammation in experimental diabetic rats.
Topics: Animals; Antigens, Ly; Antioxidants; Blood Glucose; Chemokines; Clodronic Acid; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Inflammation; Liposomes; Male; Minocycline; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar; Streptozocin | 2020 |
PDX regulates inflammatory cell infiltration via resident macrophage in LPS-induced lung injury.
Topics: Acute Lung Injury; Administration, Intranasal; Animals; Chemokine CCL2; Chemokine CXCL2; Chemotaxis, Leukocyte; Clodronic Acid; Docosahexaenoic Acids; Inflammation; Injections, Intraperitoneal; Lipopolysaccharides; Liposomes; Macrophages; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Neutrophils; Receptors, CCR2; Receptors, Interleukin-8B; Signal Transduction; Transendothelial and Transepithelial Migration; Tumor Necrosis Factor-alpha | 2020 |
Clodronate, an inhibitor of the vesicular nucleotide transporter, ameliorates steatohepatitis and acute liver injury.
Topics: Adenosine Triphosphate; Animals; Chemical and Drug Induced Liver Injury; Clodronic Acid; Diet; Disease Models, Animal; Fatty Liver; Humans; Inflammation; Lipopolysaccharides; Mice; Nucleotide Transport Proteins; Receptors, Purinergic | 2021 |
Gas6 Promotes Inflammatory (CCR2
Topics: Animals; Cells, Cultured; Chemokine CCL2; Chemotaxis, Leukocyte; Clodronic Acid; CX3C Chemokine Receptor 1; Disease Models, Animal; Endothelial Cells; Genetic Predisposition to Disease; Inflammation; Intercellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Male; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Paracrine Communication; Phenotype; Receptors, CCR2; Receptors, Chemokine; Signal Transduction; Vena Cava, Inferior; Venous Thrombosis | 2017 |
Hepatic recruitment of CD11b+Ly6C+ inflammatory monocytes promotes hepatic ischemia/reperfusion injury.
Topics: Animals; Antigens, Ly; CD11b Antigen; Chemokine CCL2; Clodronic Acid; Flow Cytometry; Inflammation; Liver; Male; Mice; Mice, Inbred C57BL; Monocytes; Receptors, CCR2; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction | 2018 |
Brown adipose tissue plays a central role in systemic inflammation-induced sleep responses.
Topics: Adipocytes, Brown; Adipose Tissue, Brown; Animals; Body Temperature; Clodronic Acid; Electroencephalography; Electromyography; Genotype; Inflammation; Interleukin-1beta; Ion Channels; Lipopolysaccharides; Liposomes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondrial Proteins; Sleep; Telemetry; Temperature; Thermogenesis; Tumor Necrosis Factor-alpha; Uncoupling Protein 1 | 2018 |
In vivo neutralization of the protagonist role of macrophages during the chronic inflammatory stage of Huntington's disease.
Topics: Animals; Brain; Chronic Disease; Clodronic Acid; Cytokines; Dendritic Cells; Female; Huntington Disease; Inflammation; Liposomes; Macrophages; Male; Mice, Inbred C57BL; Spleen | 2018 |
Anti-inflammatory properties of Liposome-encapsulated clodronate or Anti-Ly6G can be modulated by peripheral or central inflammatory markers in carrageenan-induced inflammation model.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Carrageenan; Clodronic Acid; Disease Models, Animal; Edema; Hyperalgesia; Inflammation; Liposomes; Macrophages; Male; Neutrophils; Pain; Rats; Rats, Wistar; Spinal Cord | 2019 |
Augmentation of Lipopolysaccharide-Induced Production of IL-1α and IL-1β in Mice Given Intravenous Zoledronate (a Nitrogen-Containing Bisphosphonate) and Its Prevention by Clodronate (a Non-nitrogen-containing Bisphosphonate).
Topics: Animals; Bone Density Conservation Agents; Clodronic Acid; Drug Synergism; Inflammation; Interleukin-1beta; Lipopolysaccharides; Liver; Male; Mice; Pectoralis Muscles; Spleen; Zoledronic Acid | 2019 |
Depletion and Reconstitution of Macrophages in Mice.
Topics: Animals; Clodronic Acid; Inflammation; Interferon-gamma; Interleukin-10; Interleukin-13; Interleukin-4; Lipopolysaccharides; Liposomes; Macrophages; Mice | 2019 |
Macrophages Guard Endothelial Lineage by Hindering Endothelial-to-Mesenchymal Transition: Implications for the Pathogenesis of Systemic Sclerosis.
Topics: Animals; Autoantibodies; Cell Differentiation; Cell Lineage; Cell Plasticity; Cells, Cultured; Clodronic Acid; DNA Topoisomerases, Type I; Endothelium; Fibrosis; Humans; Immunity, Innate; Inflammation; Lung; Macrophages; Mesenchymal Stem Cells; Mice; Mice, Transgenic; Neovascularization, Pathologic; Nuclear Proteins; Scleroderma, Systemic | 2019 |
Peroxisome proliferator-activated receptor-gamma agonist rosiglitazone attenuates inflammatory pain through the induction of heme oxygenase-1 in macrophages.
Topics: Animals; Anti-Inflammatory Agents; Antigens, Differentiation; Clodronic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Freund's Adjuvant; Gene Expression Regulation; Heme Oxygenase-1; Hyperalgesia; Inflammation; Lectins, C-Type; Macrophages, Peritoneal; Male; Mannose Receptor; Mannose-Binding Lectins; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Pain; Pain Measurement; Pain Threshold; Receptors, Cell Surface; Rosiglitazone; Thiazolidinediones; Time Factors | 2013 |
Hepatic crown-like structure: a unique histological feature in non-alcoholic steatohepatitis in mice and humans.
Topics: Animals; Chronic Disease; Clodronic Acid; Fatty Liver; Female; Hepatitis, Viral, Human; Humans; Inflammation; Lipid Metabolism; Liposomes; Liver; Liver Cirrhosis; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Non-alcoholic Fatty Liver Disease; Phenotype; Receptor, Melanocortin, Type 4 | 2013 |
Local co-delivery of pancreatic islets and liposomal clodronate using injectable hydrogel to prevent acute immune reactions in a type 1 diabetes.
Topics: Animals; Clodronic Acid; Collagen; Diabetes Mellitus, Type 1; Drug Combinations; Inflammation; Injections; Islets of Langerhans Transplantation; Laminin; Liposomes; Macrophages; Male; Mice, Inbred C57BL; Proteoglycans; Rats, Sprague-Dawley | 2014 |
Depletion of M2-like tumor-associated macrophages delays cutaneous T-cell lymphoma development in vivo.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Bone Marrow Cells; Cell Line, Tumor; Clodronic Acid; Cytokines; Disease Models, Animal; Humans; Inflammation; Liposomes; Lymphoma, T-Cell, Cutaneous; Macrophages; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, SCID; Mycosis Fungoides; Neoplasm Transplantation; Phenotype; Platelet Endothelial Cell Adhesion Molecule-1; Receptors, Cell Surface; Skin Neoplasms | 2014 |
DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarization.
Topics: Adenocarcinoma; Animals; Carcinoma, Non-Small-Cell Lung; Cell Membrane Permeability; Cell Polarity; Clodronic Acid; Humans; Inflammation; Liposomes; Lung Neoplasms; Macrophages; Male; Membrane Proteins; Mice, Transgenic; Necrosis; Neovascularization, Pathologic; Nucleotides, Cyclic; Phenotype; ras Proteins; Subcutaneous Tissue; Tumor Suppressor Protein p53; Xanthones; Xenograft Model Antitumor Assays | 2014 |
Resident alveolar macrophages suppress, whereas recruited monocytes promote, allergic lung inflammation in murine models of asthma.
Topics: Allergens; Alveolitis, Extrinsic Allergic; Animals; Antigens, Ly; Asthma; Bronchoalveolar Lavage Fluid; CD11b Antigen; Cell Proliferation; Clodronic Acid; Cytokines; Disease Models, Animal; Eosinophils; Inflammation; Leukocyte Common Antigens; Lung; Macrophages, Alveolar; Mice; Mice, Inbred C57BL; Monocytes; Ovalbumin; Pneumonia; Pyroglyphidae | 2014 |
Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β.
Topics: Actins; Animals; Bone Marrow Cells; Caspase 1; Caspases; Clodronic Acid; Crosses, Genetic; Culture Media, Conditioned; Cytoskeletal Proteins; Enzyme-Linked Immunosorbent Assay; Hereditary Autoinflammatory Diseases; Inflammation; Interleukin-18; Interleukin-1beta; Lipopolysaccharides; Liposomes; Liver; Macrophage Colony-Stimulating Factor; Macrophages; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Microscopy, Fluorescence; Monocytes; Pyrin; Signal Transduction | 2015 |
Targeting tubulointerstitial remodeling in proteinuric nephropathy in rats.
Topics: Animals; Antibodies; Biomarkers; Clodronic Acid; Collagen Type III; Disease Models, Animal; Doxorubicin; Fibrosis; Fingolimod Hydrochloride; Inflammation; Kidney Diseases; Kidney Tubules; Leukocyte Count; Liposomes; Lymphangiogenesis; Lymphatic Vessels; Macrophages; Male; Myofibroblasts; Proteinuria; Rats, Wistar; RNA, Messenger; T-Lymphocytes; Vascular Endothelial Growth Factor Receptor-3 | 2015 |
N-Acetylglucosaminyltransferase V exacerbates murine colitis with macrophage dysfunction and enhances colitic tumorigenesis.
Topics: Animals; Clodronic Acid; Colitis; Colonic Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Flow Cytometry; Inflammation; Interleukin-10; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; N-Acetylglucosaminyltransferases; Severity of Illness Index; Trinitrobenzenesulfonic Acid | 2016 |
Prolonged Ischemia Triggers Necrotic Depletion of Tissue-Resident Macrophages To Facilitate Inflammatory Immune Activation in Liver Ischemia Reperfusion Injury.
Topics: Animals; Cells, Cultured; Clodronic Acid; Disease Models, Animal; GTPase-Activating Proteins; Humans; Imidazoles; Immunity; Indoles; Inflammation; Kupffer Cells; Liver; Male; Mice; Mice, Inbred C57BL; Necrosis; Reperfusion Injury; Signal Transduction | 2017 |
Depletion of resident alveolar macrophages does not prevent Fas-mediated lung injury in mice.
Topics: Animals; Antibodies, Monoclonal; Apoptosis; Bone Density Conservation Agents; Bronchoalveolar Lavage Fluid; Cell Line; Chemokine CXCL1; Clodronic Acid; Fas Ligand Protein; fas Receptor; Inflammation; Macrophages, Alveolar; Male; Mice; Respiratory Distress Syndrome; Respiratory Mucosa; Time Factors | 2008 |
The investigation of macrophage infiltration in the early phase of ischemic acute renal failure in mice.
Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; CD11b Antigen; Clodronic Acid; Creatinine; Fluorescent Antibody Technique; Inflammation; Ischemia; Kidney Medulla; Macrophages; Male; Mice; Mice, Inbred C57BL; Perfusion; Time Factors | 2008 |
Modulation of macrophage infiltration and inflammatory activity by the phosphatase SHP-1 in virus-induced demyelinating disease.
Topics: Animals; Antigens, Ly; CD11b Antigen; Central Nervous System; Clodronic Acid; Gene Expression Profiling; Immunologic Factors; Inflammation; Leukocyte Common Antigens; Leukocyte Reduction Procedures; Macrophages; Mice; Mice, Inbred C3H; Mice, Knockout; Poliomyelitis; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Spinal Cord; Theilovirus | 2009 |
Neurodegeneration induced by PVC-211 murine leukemia virus is associated with increased levels of vascular endothelial growth factor and macrophage inflammatory protein 1 alpha and is inhibited by blocking activation of microglia.
Topics: Animals; Capillaries; Cells, Cultured; Cerebellum; Chemokine CCL3; Clodronic Acid; Demyelinating Diseases; Endothelium, Vascular; Inflammation; Leukemia Virus, Murine; Leukemia, Experimental; Microglia; Muscular Atrophy; Nerve Degeneration; Rats; Rats, Inbred F344; Retroviridae Infections; Tumor Virus Infections; Vascular Endothelial Growth Factor A | 2009 |
Elevated endogenous surfactant reduces inflammation in an acute lung injury model.
Topics: Acute Lung Injury; Animals; Clodronic Acid; Cytokines; Disease Models, Animal; Inflammation; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Liposomes; Macrophages, Alveolar; Male; Mice; Pulmonary Surfactants | 2009 |
Brain perivascular macrophages and the sympathetic response to inflammation in rats after myocardial infarction.
Topics: Animals; Blood-Brain Barrier; Clodronic Acid; Cyclooxygenase 2; Dinoprostone; Heart Failure; Immunomodulation; Inflammation; Injections, Intraventricular; Interleukin-1beta; Liposomes; Macrophages; Male; Myocardial Infarction; Norepinephrine; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sympathetic Nervous System; Tumor Necrosis Factor-alpha | 2010 |
Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model.
Topics: Acid Phosphatase; Animals; Bone Matrix; Calcification, Physiologic; Clodronic Acid; Disease Models, Animal; Inflammation; Isoenzymes; Liposomes; Macrophage Colony-Stimulating Factor; Macrophages; Membranes; Mice; Mice, Inbred C57BL; Mice, Transgenic; Osteoblasts; Osteogenesis; Osteoprotegerin; Surface Properties; Tartrate-Resistant Acid Phosphatase; Tibia; Wound Healing | 2011 |
Kupffer cell depletion prevents but has no therapeutic effect on metabolic and inflammatory changes induced by a high-fat diet.
Topics: Adipose Tissue; Adiposity; Animals; Clodronic Acid; Diet, High-Fat; Fatty Liver; Inflammation; Insulin Resistance; Kupffer Cells; Liver; Male; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Obesity | 2011 |
RhoGDI2 suppresses lung metastasis in mice by reducing tumor versican expression and macrophage infiltration.
Topics: Animals; Carcinoma, Transitional Cell; Cell Line, Tumor; Chemokine CCL2; Clodronic Acid; Coculture Techniques; Female; Gene Expression Regulation, Neoplastic; Guanine Nucleotide Dissociation Inhibitors; Humans; Inflammation; Kaplan-Meier Estimate; Lung Neoplasms; Macrophages; Mice; Mice, Nude; Molecular Targeted Therapy; Neoplasm Proteins; Neoplasm Transplantation; Prognosis; Protein Isoforms; Tumor Microenvironment; U937 Cells; Urinary Bladder Neoplasms; Versicans | 2012 |
Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis.
Topics: Actins; Animals; Antigens, Differentiation; Caspase 1; Caspase 3; Choline Deficiency; Clodronic Acid; Collagen Type I; Fatty Liver; Hepatic Stellate Cells; Hepatocytes; Inflammation; Interleukin-1beta; Kupffer Cells; LIM Domain Proteins; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Proteins; Nuclear Proteins; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2012 |
The effect of clodronate on a mevalonate kinase deficiency cellular model.
Topics: Adolescent; Adult; Alendronate; Animals; Anti-Inflammatory Agents; Apoptosis; Cell Line; Cells, Cultured; Child; Clodronic Acid; Female; Humans; Inflammation; Lipopolysaccharides; Male; Mevalonate Kinase Deficiency; Mice; Models, Biological; Monocytes; Nitric Oxide; Young Adult | 2012 |
Monocytes/macrophages prevent healing defects and left ventricular thrombus formation after myocardial infarction.
Topics: Animals; Bone Density Conservation Agents; Clodronic Acid; Extracellular Matrix; Female; Heart Ventricles; Humans; Inflammation; Lipopolysaccharide Receptors; Liposomes; Macrophages; Mice; Monocytes; Myocardial Infarction; Receptors, IgG; Thrombosis | 2013 |
APCs in the liver and spleen recruit activated allogeneic CD8+ T cells to elicit hepatic graft-versus-host disease.
Topics: Acute Disease; Animals; Antigen-Presenting Cells; Bone Marrow Transplantation; CD8-Positive T-Lymphocytes; Cell Movement; Clodronic Acid; Dendritic Cells; Graft vs Host Disease; Immunosuppressive Agents; Inflammation; Injections, Intravenous; Liposomes; Liver; Lymphocyte Activation; Macrophages; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Organ Specificity; Spleen; Survival Rate | 2002 |
Do peritoneal macrophages play an essential role in the progression of acute pancreatitis in rats?
Topics: Acute Disease; Animals; Ascites; Cell Count; Clodronic Acid; Cytokines; Disease Progression; Inflammation; Liposomes; Lung; Macrophages, Peritoneal; Male; Neutrophils; Oligopeptides; Pancreas; Pancreatitis; Peritoneal Cavity; Peritoneal Lavage; Peroxidase; Rats; Rats, Wistar | 2003 |
Tissue monocytes/macrophages in inflammation: hyperalgesia versus opioid-mediated peripheral antinociception.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Clodronic Acid; Fentanyl; Flow Cytometry; Foot; Freund's Adjuvant; Hot Temperature; Hyperalgesia; Inflammation; Injections; Liposomes; Macrophages; Male; Monocytes; Pain Measurement; Pressure; Rats; Rats, Wistar | 2004 |
Inhibition of inflammatory and bone-resorption-inhibitory effects of alendronate by etidronate.
Topics: Alendronate; Animals; Anti-Inflammatory Agents; Antimetabolites; Bone and Bones; Bone Resorption; Clodronic Acid; Drug Interactions; Drug Therapy, Combination; Etidronic Acid; Histidine Decarboxylase; Inflammation; Male; Mice; Mice, Inbred BALB C | 2005 |
Comparative appraisal of clodronate, aspirin and dexamethasone as agents reducing alendronate-induced inflammation in a murine model.
Topics: Alendronate; Animals; Anti-Inflammatory Agents; Aspirin; Bone Density Conservation Agents; Clodronic Acid; Dexamethasone; Histidine Decarboxylase; Inflammation; Interleukin-1; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Organ Size; Radiography; Sclerosis; Spleen; Tibia | 2005 |
Mutation of mouse Mayp/Pstpip2 causes a macrophage autoinflammatory disease.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Substitution; Animals; Autoimmune Diseases; Bone Density Conservation Agents; Bone Marrow Transplantation; Cell Movement; Cells, Cultured; Clodronic Acid; Cytokines; Cytoskeletal Proteins; Gene Expression Regulation; Genes, Recessive; Granulocytes; Inflammation; Lipopolysaccharides; Lymphocytes; Macrophage-1 Antigen; Macrophages; Mice; Mice, Mutant Strains; Mutagenesis; Osteolysis; Point Mutation; Syndrome | 2006 |
Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation.
Topics: Animals; Clodronic Acid; Dendritic Cells; Disease Models, Animal; I-kappa B Kinase; Inflammation; Liposomes; Macrophages; Mice; Mice, Knockout; Phenotype; Psoriasis; Skin; T-Lymphocytes | 2006 |
Histidine decarboxylase-stimulating and inflammatory effects of alendronate in mice: involvement of mevalonate pathway, TNFalpha, macrophages, and T-cells.
Topics: Alendronate; Animals; Bone Density Conservation Agents; Clodronic Acid; Female; Histidine Decarboxylase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Interleukin-1alpha; Interleukin-1beta; Liposomes; Liver; Lung; Macrophages; Mevalonic Acid; Mice; Mice, Knockout; Peritoneal Cavity; Spleen; T-Lymphocytes; Tumor Necrosis Factor-alpha | 2007 |
Interaction between macrophages, TGF-beta1, and the COX-2 pathway during the inflammatory phase of skeletal muscle healing after injury.
Topics: Animals; Cardiotoxins; Cells, Cultured; Clodronic Acid; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Histocytochemistry; Inflammation; Liposomes; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; Regeneration; Transforming Growth Factor beta1 | 2008 |
Inflammatory stimuli from macrophages and cancer cells synergistically promote tumor growth and angiogenesis.
Topics: Animals; Cell Division; Cell Line, Tumor; Clodronic Acid; Drug Synergism; Humans; Inflammation; Interleukin-1beta; Lung Neoplasms; Macrophages; Male; Mice; Mice, Inbred C57BL; Neoplasms; Neovascularization, Pathologic; Transplantation, Heterologous; U937 Cells | 2007 |
Macrophage depletion diminishes implant-wear-induced inflammatory osteolysis in a mouse model.
Topics: Acid Phosphatase; Animals; Bone and Bones; Bone Resorption; Clodronic Acid; Collagen; Female; Implants, Experimental; Inflammation; Interleukin-1beta; Isoenzymes; Liposomes; Macrophages; Membranes; Mice; Mice, Inbred BALB C; Models, Animal; Molecular Weight; Osteoclasts; Osteolysis; Polyethylene; Protective Agents; Spleen; Tartrate-Resistant Acid Phosphatase; Tumor Necrosis Factor-alpha | 2008 |
Effects of depletion of neutrophils or macrophages on the inflammatory response induced by metalloelastase (MMP-12) in mice airways.
Topics: Animals; Bronchoalveolar Lavage Fluid; Clodronic Acid; Cytokines; Humans; Inflammation; Leukocyte Elastase; Liposomes; Macrophages, Alveolar; Matrix Metalloproteinase 12; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils | 2008 |
Clodronate inhibits angiogenesis in vitro and in vivo.
Topics: Angiogenesis Inhibitors; Animals; Bone Density Conservation Agents; Capillaries; Cell Proliferation; Chick Embryo; Chorioallantoic Membrane; Clodronic Acid; Collagen; Drug Combinations; Endothelium, Vascular; Fibroblast Growth Factor 2; In Vitro Techniques; Inflammation; Laminin; Microscopy, Phase-Contrast; Neoplasms; Neovascularization, Pathologic; Proteoglycans | 2008 |
Methods for assessing splenic macrophage depletion by liposome encapsulated clodronate.
Topics: Animals; Cell Count; Clodronic Acid; Complement C3b; Complement System Proteins; Erythrocytes; Inflammation; Liposomes; Macrophages; Male; Rats; Receptors, Fc; Spleen | 1995 |
Macrophage elimination increases bacterial translocation and gut-origin septicemia but attenuates symptoms and mortality rate in a model of systemic inflammation.
Topics: Animals; Bacterial Physiological Phenomena; Blood; Cell Movement; Clodronic Acid; Inflammation; Intestines; Liver; Lymph Nodes; Macrophages; Male; Mesentery; Mice; Sepsis; Spleen; Zymosan | 1993 |
The human chorionic gonadotrophin-induced inflammation-like response is enhanced in macrophage-depleted rat testes.
Topics: Animals; Chorionic Gonadotropin; Clodronic Acid; Inflammation; Liposomes; Macrophages; Male; Neutrophils; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Testis; Testosterone | 1993 |
Slow-release clodronate in prevention of inflammation and bone loss associated with adjuvant arthritis.
Topics: Alkaline Phosphatase; Analysis of Variance; Animals; Arthritis, Experimental; Bone and Bones; Bone Density; Bone Diseases, Metabolic; Calcium; Clodronic Acid; Delayed-Action Preparations; Drug Administration Schedule; Inflammation; Injections, Intravenous; Male; Osteocalcin; Rats; Rats, Inbred Lew | 1997 |
Role of passenger leukocytes in allograft rejection: effect of depletion of donor alveolar macrophages on the local production of TNF-alpha, T helper 1/T helper 2 cytokines, IgG subclasses, and pathology in a rat model of lung transplantation.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cell Movement; Clodronic Acid; Cytokines; Graft Rejection; Immunoglobulin G; Immunosuppression Therapy; Inflammation; Intubation, Intratracheal; Leukopenia; Liposomes; Lung Transplantation; Macrophages, Alveolar; Male; Models, Biological; Rats; Rats, Inbred BN; Rats, Inbred Lew; Th1 Cells; Th2 Cells; Tissue Donors; Tumor Necrosis Factor-alpha | 1997 |
Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury.
Topics: Animals; Axons; Clodronic Acid; Drug Carriers; Female; Hindlimb; Inflammation; Liposomes; Macrophages; Motor Activity; Nerve Degeneration; Rats; Rats, Inbred Lew; Spinal Cord; Spinal Cord Injuries | 1999 |
Th type 1-stimulating activity of lung macrophages inhibits Th2-mediated allergic airway inflammation by an IFN-gamma-dependent mechanism.
Topics: Administration, Intranasal; Adoptive Transfer; Allergens; Animals; Antigen Presentation; Antigen-Presenting Cells; Clodronic Acid; Cytokines; Eosinophilia; Female; Immunophenotyping; Inflammation; Interferon-gamma; Interleukin-12; Leukopenia; Liposomes; Lung; Macrophages, Alveolar; Mice; Mice, Inbred BALB C; Ovalbumin; Respiratory Hypersensitivity; Th1 Cells; Th2 Cells; Up-Regulation | 2001 |