clodronic acid has been researched along with Disease Models, Animal in 165 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (3.64) | 18.7374 |
| 1990's | 17 (10.30) | 18.2507 |
| 2000's | 52 (31.52) | 29.6817 |
| 2010's | 77 (46.67) | 24.3611 |
| 2020's | 13 (7.88) | 2.80 |
| Authors | Studies |
|---|---|
| Davis, AR; Gugala, Z; Mejia, J; Olmsted-Davis, E; Salisbury, E | 1 |
| Hanafy, KA; Islam, R; Vrionis, F | 1 |
| Fujimori, K; Fujiwara, Y; Hasegawa, Y; Kai, K; Kajiwara, S; Kameno, K; Kim-Mitsuyama, S; Mukasa, A; Uchikawa, H; Uekawa, K | 1 |
| Al-Bazaz, S; Angrisani, N; Bankstahl, JP; Ehlert, N; Harting, H; Herrmann, T; Meißner, J; Polyak, A; Reifenrath, J; Ross, TL; Willmann, M | 1 |
| Jang, JY; Kim, CH; Lee, HY; Roh, J; Seo, C; Shin, YS; Won, HR | 1 |
| Berta, T; Lee, SH; Shanahan, H; Strong, JA; Tonello, R; Xie, W; Zhang, J; Zhang, JM; Zhang, L | 1 |
| Hiraiwa, R; Iguma, Y; Imai, S; Iwamitsu, Y; Kawaguchi-Sakita, N; Kotake, T; Koyanagi, M; Matsubara, K; Matsumoto, M; Nagayasu, K; Nakagawa, S; Nakagawa, T; Ntogwa, M; Ogihara, T; Omura, T; Saigo, M; Yonezawa, A | 1 |
| Ashida, K; Hasuzawa, N; Kabashima, M; Moriyama, Y; Nagayama, A; Nomura, M; Ogawa, Y; Tatsushima, K; Tokubuchi, R; Wang, L | 1 |
| Gimigliano, F; Ilardi, W; Iolascon, G; Liguori, S; Moretti, A; Paoletta, M; Snichelotto, F; Toro, G | 1 |
| Duan, B; Hackfort, BT; Hu, W; Li, YL; Tu, H; Wadman, MC; Xiong, W; Zhang, D | 1 |
| Chen, T; Hua, Y; Keep, RF; Tan, X; Xi, G; Xia, F | 1 |
| Hoshi, T; Hwang, GW; Matsuzawa, A; Naganuma, A; Noguchi, T; Saito, Y; Toyama, T | 1 |
| Adhikari, M; Amorim, T; Anderson, J; Bellido, T; Boeckman, RK; Cregor, M; Cuevas, PL; Delgado-Calle, J; Ebetino, FH; Ferrari, AJ; Helms, JA; Khan, S; Kurihara, N; Lehal, R; McAndrews, K; Roodman, GD; Sabol, HM; Srinivasan, V; Vigolo, M | 1 |
| Bertin, FR; Blostein, MD; Ebrahimian, T; Kassim, Y; Laurance, S; Lehoux, S; Lemarié, CA; Rys, RN | 1 |
| Aikawa, J; Inoue, G; Iwabuchi, K; Iwase, D; Matsumoto, T; Minatani, A; Miyagi, M; Mukai, M; Satoh, M; Takano, S; Takaso, M; Uchida, K | 1 |
| Bridle, KR; Britton, LJ; Campbell, CM; Crawford, DHG; Damink, SWMO; Dejong, CHC; Fawcett, J; Jansen, PLM; Jaskowski, L; Reiling, J; Santrampurwala, N; Schaap, FG | 1 |
| Bader, JE; Carson, JA; Carson, MS; Chatzistamou, I; Davis, JM; Enos, RT; Murphy, EA; Nagarkatti, M; Nagarkatti, PS; Robinson, CM; Velázquez, KT | 1 |
| Geys, L; Hoylaerts, MF; Lijnen, HR; Roose, E; Rottensteiner, H; Scroyen, I; Tersteeg, C; Vanhoorelbeke, K | 1 |
| Abbassi, R; Blank, A; Gress, TM; Griesmann, H; Haybaeck, J; Hüttelmaier, S; Krug, S; Michl, P; Perren, A; Rexin, P; Rinke, A; Sipos, B; Wiese, D | 1 |
| Costello, A; Katikaneni, D; MacNamara, KC; Maloney, J; McCabe, A; Smith, JNP | 1 |
| Brignole, C; Di Paolo, D; Pastorino, F; Perri, P; Ponzoni, M | 1 |
| Aixinjueluo, W; Arai, S; Honda, A; Hosoi, M; Kataoka, K; Kobayashi, T; Kumano, K; Kurokawa, M; Miyauchi, M; Nakahata, T; Nakauchi, H; Niwa, A; Otsu, M; Taoka, K; Yamazaki, S; Yoshimi, A | 1 |
| Gielniewski, B; Gieryng, A; Kaminska, B; Rajan, WD; Wojtas, B; Zawadzka, M | 1 |
| Dimanche-Boitrel, MT; Dion, S; Farooq, M; Filliol, A; Jan, A; Le Seyec, J; Piquet-Pellorce, C; Raguenes-Nicol, C; Samson, M; Simoes Eugénio, M | 1 |
| Bewley, MA; Bingle, CD; Craig, RW; Cross, S; Dockrell, DH; Greaves, DR; Jubrail, J; Marriott, HM; McGarry Houghton, A; Mitchell, TJ; Mohasin, M; Morris, L; Preston, JA; Read, RC; Shapiro, SD; Stephenson, YL; van Rooijen, N; Whyte, MKB | 1 |
| Mert, T; Sahin, E; Sahin, M; Yaman, S | 1 |
| Beneke, A; Burzlaff, N; Daniel, C; Eckardt, KU; Goppelt-Struebe, M; Herrmann, M; Jantsch, J; Kalucka, J; Katschinski, DM; Klanke, B; Mayer, M; Palsson, R; Schatz, V; Schley, G; Thorsteinsdottir, M; Weidemann, A; Willam, C | 1 |
| Abais-Battad, JM; Dasinger, JH; Fehrenbach, DJ; Lund, H; Mattson, DL | 1 |
| Clark, KC; Coulter, EA; Croucher, PI; Evdokiou, A; Hewett, DR; Mrozik, KM; Noll, JE; Opperman, KS; Psaltis, PJ; Schwarz, N; Vandyke, K; Zannettino, AC | 1 |
| Bonorino, C; Borges, TJ; Campos, MM; Coutinho-Silva, R; da Silva, GL; Morrone, FB; Sperotto, ND; Takyia, CM; Zanin, RF | 1 |
| Abdel-Wahab, O; Breda, L; Casu, C; Crielaard, BJ; Ebert, BL; Gardenghi, S; Ghaffari, S; Giardina, PJ; Grady, RW; Gupta, R; Guy, E; Levine, RL; Marongiu, MF; Ramos, P; Rivella, S; Van Rooijen, N | 1 |
| Aronovich, R; Bina, H; Chapman, J; Katzav, A | 1 |
| Godai, K; Hasegawa-Moriyama, M; Kanmura, Y; Kojima, M; Kurimoto, T; Kuwaki, T; Nakama, M | 1 |
| Bousso, P; Breart, B; Celli, S; Deguine, J; Garcia, Z; Montalvao, F; Van Rooijen, N | 1 |
| Duque, JC; Faridi, MH; Gupta, V; Martinez, L; Mesa, A; Pena, A; Pham, SM; Rodriguez-Menocal, L; Shehadeh, LA; Vazquez-Padron, RI; Wei, Y | 1 |
| Fu, YC; Lu, SW; Luo, HM; Tang, SJ; Xu, MY; Zhang, XM | 1 |
| Braumüller, ST; Fröba, JS; Gebhard, F; Knöferl, MW; Niesler, U; Palmer, A; Seitz, DH; Zhou, S | 1 |
| Haribhai, D; Hwang, ST; Mackinnon, AC; Plaza, JA; Schulte, BC; Williams, CB; Wu, X; Zhou, Y | 1 |
| Clark, M; Grosso, MJ; Iannotti, CA; Matheus, V; Steinmetz, MP; van Rooijen, N | 1 |
| Moore, BB; Osterholzer, JJ; Peters-Golden, M; Przybranowski, S; Teitz-Tennenbaum, S; van Rooijen, N; Wilke, C; Wilkinson, JE; Zasłona, Z | 1 |
| Fischer, AJ; Milani-Nejad, N; Zelinka, C | 1 |
| Bando, K; Endo, Y; Kinbara, M; Kuroishi, T; Sasaki, K; Sugawara, S; Takahashi, H; Takano-Yamamoto, T; Tanaka, Y | 1 |
| Bascands, JL; Belliere, J; Buffin-Meyer, B; Casemayou, A; Chauveau, D; Ducasse, L; Guilbeau-Frugier, C; Iacovoni, JS; Martins, F; Pipy, B; Schanstra, JP; Zakaroff-Girard, A | 1 |
| Fu, CL; Hsieh, MH; Odegaard, JI | 1 |
| Chang, SH; Cho, HS; Jeon, DH; Jung, MH; Kim, JH; Lee, DW; Park, DJ | 1 |
| Kim, JY; Lee, JH; Park, JW; Sohn, JH | 1 |
| Chen, M; Chen, RF; Cui, L; Dang, SC; Gu, M; Jiang, DL; Qu, JG; Shen, XQ; Wang, H; Zhang, JX | 1 |
| Weber, GF | 1 |
| Handoko, HY; Khosrotehrani, K; Muller, HK; Rodero, MP; Walker, GJ | 1 |
| Dam, W; Hijmans, RS; Navis, G; Poosti, F; van den Born, J; van Goor, H; Yazdani, S | 1 |
| Hwang, ST; Wu, X | 1 |
| Fisher, PD; Horstmann, JK; Milbrandt, TA; Puleo, DA; Talwalkar, V; Zou, Y | 1 |
| Fujii, H; Hayashi, Y; Hiyama, S; Iijima, H; Inoue, T; Ishii, M; Kamada, Y; Kawai, S; Kuwahara, R; Miyoshi, E; Morii, E; Shinzaki, S; Shiraishi, E; Takamatsu, S; Takehara, T; Tsujii, M; Wakamatsu, K | 1 |
| Aikawa, J; Fujimaki, H; Inoue, G; Iwabuchi, K; Minatani, A; Miyagi, M; Sato, M; Takano, S; Takaso, M; Uchida, K | 1 |
| Benner, A; Dürr, C; Egle, A; Gribben, JG; Hanna, BS; Kalter, V; Lichter, P; McClanahan, F; Rößner, PM; Seiffert, M; Yazdanparast, H; Zaborsky, N | 1 |
| Barham, W; Khabele, D; Saskowski, J; Wilson, AJ; Yull, F | 1 |
| Amenduni, M; Cadamuro, M; De Matteis, M; Fabris, L; Fiorotto, R; Lecchi, S; Locatelli, L; Morell, CM; Pietrobattista, A; Popov, Y; Schuppan, D; Scirpo, R; Spirlì, C; Strazzabosco, M; Torre, G | 1 |
| Jiang, L; Jiang, Z; Li, Y; Ma, Y; Wang, L; Wang, Y; Yang, GY; Zhang, Z | 1 |
| Blanchard, E; Derugin, N; Faustino, J; Fernández-López, D; Klibanov, AL; Leib, SL; Simon, F; Vexler, ZS | 1 |
| Albrecht, PJ; de Carvalho-Barbosa, M; Dougherty, PM; Heijnen, CJ; Kavelaars, A; Li, Y; Zhang, H | 1 |
| Ding, J; Iwashina, T; Ma, Z; Tredget, EE; Zhu, Z | 1 |
| Hayashi, S; Kato, G; Kimura, S; Kurata, K; Sueoka-Aragane, N; Takahashi, K; Tashiro, H | 1 |
| Basu, S; Belanger, AM; Binder, RJ; Croix, CS; Franks, J; Gladwin, MT; Jessup, M; Kanias, T; Kim-Shapiro, DB; Lee, JS; M Novelli, E; Osei-Hwedieh, DO; Potoka, K; Sertorio, JT; Sinchar, D; Triulzi, D; Xiong, Z; Xu, Q | 1 |
| Horisawa, K; Matsuda-Ito, K; Miura, S; Ohkawa, Y; Sekiya, S; Suzuki, A; Takashima, Y; Terada, M | 1 |
| Busuttil, RW; Kupiec-Weglinski, JW; Wang, X; Yue, S; Zhai, Y; Zhou, H | 1 |
| Conzelmann, L; Henrich, D; Herzog, C; Lehnert, M; Marzi, I; Niederlaender, S; Relja, B | 1 |
| Anthony, DC; Bilgen, M; Campbell, SJ; Davis, AE; Jiang, Y; Law, S; Losey, P; Morsali, D; van Rooijen, N; Zahid, I | 1 |
| Fotovati, A; Hiraoka, K; Hosoi, F; Iguchi, H; Kimura, YN; Kuwano, M; Nagata, K; Ono, M; Osada, H; Shoda, T; Watari, K; Zenmyo, M | 1 |
| Busch, SA; Hawthorne, AL; Horn, KP; Silver, J; van Rooijen, N | 1 |
| Dawson, R; Forrester, JV; Lois, N; McKinnon, AD; Smith, GC; Townend, J; Van Rooijen, N; van't Hof, R | 1 |
| Atsu, N; Basaran, A; Basok, EK; Tokuc, R; Yildirim, A | 1 |
| Hu, J; Wang, Y; Xie, L | 1 |
| Duijvestijn, A; Gupta, S; Hofstra, L; Maessen, JG; Narula, J; Pinto, YM; Pokharel, S; Reutelingsperger, C; Sharma, UC; van Brakel, T; van den Borne, S; van Rooijen, N; Verjans, JW; Zandbergen, HR | 1 |
| Bergh, A; Halin, S; Rudolfsson, SH; Van Rooijen, N | 1 |
| O'Dea, KP; Shearman, AD; Takata, M; van Rooijen, N; Wilson, MR; Zhang, D | 1 |
| Hamaguchi, T; Inokuchi, C; Miyagawa, J; Namba, M; Okamura, H; Shinohara, M; Ueda, H | 1 |
| Bellamy, C; Devey, L; Harrison, EM; Henderson, N; Mohr, E; Ross, JA; Simpson, K; Wigmore, SJ | 1 |
| Clementi, AH; Gaudy, AM; Mooney, RA; Pierce, RH; van Rooijen, N | 1 |
| Lewis, JF; McCaig, L; Tessolini, JM; Veldhuizen, RA; Walker, MG; Yao, LJ | 1 |
| Christophi, GP; Massa, PT | 1 |
| Abshagen, K; Diedrich, S; Eipel, C; Heidecke, CD; Maier, S; Mikulcak, M; Traeger, T; Vollmar, B | 1 |
| Clark, M; Horn, KP; Iannotti, CA; Silver, J; Steinmetz, MP; van Rooijen, N | 1 |
| Cheng, L; Holt, MP; Ju, C; Yin, H; You, Q | 1 |
| Adib-Conquy, M; Brock, M; Cavaillon, JM; Droin-Bergère, S; Hohl, TM; Ibrahim-Granet, O; Jouvion, G; Kim, OY; Philippart, F; Schwendener, R | 1 |
| Amani, Z; Atkinson, C; Balish, E; Chavin, KD; Ellett, JD; Evans, ZP; Schmidt, MG; Schnellmann, RG; van Rooijen, N | 1 |
| Burnett, S; Ciavarra, RP; Kim, WK; Sanford, LD; Steel, CD; Van Rooijen, N; Wellman, LL | 1 |
| Baghat, A; Jager, MJ; Jordanova, ES; Luyten, GP; Ly, LV; van der Velden, PA; van Hall, T; van Rooijen, N; Versluis, M | 1 |
| Kachi, S; Kaneko, H; Kataoka, K; Nishiguchi, KM; Terasaki, H; van Rooijen, N | 1 |
| Bagnoud, N; Busso, N; Chobaz, V; Ea, HK; Holzinger, D; Kai-Lik So, A; Kolly, L; Lioté, F; Narayan, S; Pazar, B; Vogl, T | 1 |
| Alexander, KA; Chang, MK; Hume, DA; Kohler, T; Maylin, ER; Müller, R; Pettit, AR; Raggatt, LJ; Sweet, MJ; Van Rooijen, N; Wu, AC | 1 |
| Carmichael, MD; Davis, JM; Gangemi, JD; McClellan, JL; Murphy, EA; Rooijen, NV | 1 |
| Aiolfi, R; Bianchi, ME; Chisari, FV; Guidotti, LG; Iannacone, M; Isogawa, M; Scozzesi, C; Sitia, G; van Rooijen, N; von Andrian, UH | 1 |
| Dang, SC; Jiang, DL; Yin, K; Zhang, JX | 1 |
| Drabek, T; End, B; Jackson, EK; Janata, A; Janesko-Feldman, K; Kochanek, PM; Stezoski, J; Tisherman, SA; Vagni, VA; van Rooijen, N; Wilson, CD | 1 |
| Alvarez-Lindo, N; Arroba, AI; de la Rosa, EJ; van Rooijen, N | 1 |
| Eitzman, DT; Guo, C; Luo, W; Ohman, MK; Shi, K; Wang, H; Wang, J | 1 |
| An, J; Cha, CI; Cho, YJ; Joo, KM; Kim, SH; Lee, JC; Lee, SJ; Nam, DH; Seong, J | 1 |
| Brown, A; Dekaban, GA; Lu, WY; Mawhinney, LA; Rooijen, Nv; Thawer, SG; Weaver, LC | 1 |
| Béduneau, A; Lamprecht, A; Niebel, W; Pellequer, Y; Walkenbach, K | 1 |
| Davidson, DJ; Dhaliwal, K; Dorward, DA; Duffin, R; Ferenbach, D; Gibbons, M; Haslett, C; Hirani, N; Hughes, J; Humphries, D; Mack, M; MacKinnon, A; Morris, AC; Rossi, AG; Scholefield, E; Simpson, AJ; van Rooijen, N; Wallace, WA; Wilkinson, TS | 1 |
| Jeong, YB; Jung, YJ; Kang, KP; Kang, MJ; Kim, DH; Kim, HJ; Kim, W; Lee, AS; Lee, JE; Lee, S; Lee, SY; Moon, WS; Park, SK; Sung, MJ | 1 |
| Feng, Y; Fox, JG; Ge, Z; McCabe, A; Mobley, M; Muthupalani, S; Rickman, B; Van Rooijen, N | 1 |
| Endo, Y; Kim, S; Kuroishi, T; Okada, S; Seiryu, M; Sugawara, S; Takano-Yamamoto, T | 1 |
| Danenberg, HD; Fishbein, I; Gao, J; Gati, I; Golomb, G; Moerman, E; Mönkkönen, J; Reich, R | 1 |
| Beringue, V; Couvreur, P; Dormont, D | 1 |
| Chiba, T; Honjo, T; Ikuta, K; Kawanami, C; Matsuura, M; Nakase, H; Okazaki, K; Tabata, Y; Tamaki, H; Watanabe, N | 1 |
| Chiba, T; Nakase, H; Okazaki, K; Tabata, Y | 1 |
| Canninga-van Dijk, MR; de Weger, RA; Ebeling, SB; Hagenbeek, A; Hogenes, MC; Martens, AC; Rijkers, G; Simonetti, ER; Spits, H; Storm, G; van Bloois, L; van Rijn, RS; Weijer, K | 1 |
| Ambati, BK; Ambati, J; Anand, A; Sakurai, E; van Rooijen, N | 1 |
| Cousins, SW; Csaky, KG; Espinosa-Heidmann, DG; Hernandez, EP; Monroy, D; Suner, IJ | 1 |
| Bissonnette, EY; Careau, E | 1 |
| Kakiuchi, T; Miyazaki, S; Sumiyama, Y; Tanaka, H | 1 |
| Cote, CK; Norris, SL; Rea, KM; van Rooijen, N; Welkos, SL | 1 |
| Abu-Dahab, R; Lehr, CM; Menger, MD; Nakamura, T; Schäfer, U; Schäfers, HJ; Vollmar, B; Wada, H | 1 |
| Fukata, K; Fukushima, A; Ishida, W; Ozaki, A; Ueno, H; van Rooijen, N | 1 |
| Farley, KS; Law, C; McCormack, DG; Mehta, S; Razavi, HM; Rohan, M; Wang, LF | 1 |
| Bissonnette, EY; Careau, E; Pouliot, P; Proulx, LI; Spahr, A; Turmel, V | 1 |
| Frank, JA; Matthay, MA; McAuley, DF; Schwendener, R; Wray, CM | 1 |
| Haase, I; Hartmann, K; Krieg, T; Markur, D; Pasparakis, M; Peters, T; Rupec, RA; Scharffetter-Kochanek, K; Stratis, A; van Rooijen, N | 1 |
| Dow, S; Jordan, M; Mathes, M | 1 |
| Du Clos, TW; Hutt, JA; Kataranovski, M; Marnell, LL; Mold, C; Rodriguez, W; Verbeek, JS | 1 |
| Artamonova, GV; Ayala, VI; Carbonetti, NH; Van Rooijen, N | 1 |
| Gray, M; Gupta, R; Palispis, W; Popovich, PG; van Rooijen, N | 1 |
| Forbes, A; Foroughian, M; Lewis, J; Pickell, M; Veldhuizen, R; Yao, LJ | 1 |
| Eyal, FG; Hamm, CR; Parker, JC | 1 |
| Allen, J; Blanco, VG; Gonzalez, NC; Schmidt, EJ; van Rooijen, N; Wood, JG | 1 |
| Bakker, EN; Hardeman, MR; Pistea, A; Spaan, JA; van Rooijen, N; VanBavel, E | 1 |
| Honda, S; Imai, H; Nagai, T; Negi, A | 1 |
| Harker, J; Openshaw, PJ; Pribul, PK; Schwarze, J; Tregoning, JS; Wang, B; Wang, H | 1 |
| Hatano, M; Kobayashi, Y; Nagata, K; Ohata, S; Sasaki, S; Shiratsuchi, Y; Yamazaki, T | 1 |
| McClure, J | 1 |
| Doppelt, SH; Neer, RM; Potts, JT | 1 |
| Hannuniemi, R; Kippo, K; Laurén, L; Osterman, T; Sellman, R | 2 |
| Hanhijärvi, H; Hyvönen, PM; Karhi, T; Kosma, VM; Liimola-Luoma, L | 1 |
| Alizadeh, H; Jager, MJ; Niederkorn, JY; Taylor, WM; van Klink, F; van Rooijen, N | 1 |
| Dziedzic-Gocławska, N; Kamiński, A; Sotowski, R; Stachowicz, W; Wojtowicz, N | 1 |
| Antic, VN; Fleisch, H; Mühlbauer, RC | 1 |
| Hannuniemi, R; Jalovaara, P; Kippo, K; Laurén, L; Lepola, VT; Osterman, T; Sellman, R; Väänänen, HK; Virtamo, T | 1 |
| Gupta, M; Smith, AD; Tuncay, OL; Valderrama, E | 1 |
| Gao, T; Lindholm, TC; Lindholm, TS; Nyman, MT | 1 |
| Kaastad, TS; Madsen, JE; Narum, S; Nordsletten, L; Obrant, KJ; Reikerâs, O; Stromme, JH | 1 |
| Broekhuyse, RM; Huitinga, I; Kuhlmann, ED; Rooijen, NV; Winkens, HJ | 1 |
| Diel, IJ | 1 |
| Berg-Larsen, T; Falch, JA; Kirkeby, OJ; Madsen, JE; Nordsletten, L | 1 |
| Alves Rosa, MF; Isturiz, MA; Palermo, MS; Van Rooijen, N | 1 |
| Cocchi, D; Paganelli, C; Zaffe, D | 1 |
| Brück, W; Hopkins, SJ; Huitinga, I; Nau, R; Schmitz-Salue, M; Stuertz, K; Trostdorf, F; van Rooijen, N | 1 |
| Goodfellow, RM; Richards, PJ; Williams, AS; Williams, BD | 1 |
| Hernández, ER; Revilla, M; Rico, H; Sánchez-Atrio, A; Seco, C; Valencia, MJ; Villa, LF | 1 |
| Hori, Y; Kuroda, Y; Shinkai, M; Takase, K; Takeyama, Y; Ueda, T | 1 |
| Bain, S; Barnes, J; Golub, LM; Liang, CT; Liu, Y; Llavaneras, A; Puerner, D; Ramamurthy, N; Strachan, MJ | 1 |
| Aramaki, Y; Kakiuchi, T; Nakamura, Y | 1 |
| Bang, D; Kwon, HJ; Lee, ES; Lee, S; Lee, SI; Sohn, S | 1 |
| Bauer, I; Bauer, M; Pannen, BH; Paxian, M; Rensing, H; Rickauer, A; Schmeck, J; Schönhofen, S | 1 |
| Richards, PJ; Williams, AS; Williams, BD | 1 |
| Aspenberg, P; Astrand, J | 1 |
| Blackwell, TS; Christman, JW; Gao, X; Koay, MA; Parman, KS; Sadikot, RT; Washington, MK | 1 |
| Horiuchi, H; Mitsuta, T; Shinoda, H | 1 |
| Flora, L | 1 |
| Doyle, DV; Dunn, CJ; Willoughby, DA | 1 |
| Onge, MS; Parker, B; Wink, CS | 1 |
| Rowe, DJ; Schmidt, LJ | 1 |
| Braisted, J; Dranchak, P; Earnest, TW; Gu, X; Hoon, MA; Inglese, J; Oliphant, E; Solinski, HJ | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
5 review(s) available for clodronic acid and Disease Models, Animal
| Article | Year |
|---|---|
The Rationale for the Intra-Articular Administration of Clodronate in Osteoarthritis.
Topics: Animals; Clodronic Acid; Disease Models, Animal; Humans; Injections, Intra-Articular; Mice; Osteoarthritis; Rabbits | 2021 |
Targeting Macrophages as a Potential Therapeutic Intervention: Impact on Inflammatory Diseases and Cancer.
Topics: Animals; Clodronic Acid; Disease Models, Animal; Drug Delivery Systems; Humans; Inflammation; Liposomes; Macrophages; Mice; Nanotechnology; Neoplasms | 2018 |
Involvement of macrophages in the pathogenesis of transmissible spongiform encephalopathies.
Topics: Animals; Clodronic Acid; Disease Models, Animal; Humans; In Vitro Techniques; Liposomes; Macrophages; Macrophages, Peritoneal; Mice; Prion Diseases; PrPSc Proteins; Scrapie | 2002 |
Biodegradable microspheres targeting mucosal immune-regulating cells: new approach for treatment of inflammatory bowel disease.
Topics: Absorbable Implants; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Clodronic Acid; Dexamethasone; Disease Models, Animal; Drug Delivery Systems; Humans; Inflammatory Bowel Diseases; Interleukin-10; Intestinal Mucosa; Mice; Microspheres; Monocytes | 2003 |
[Bisphosphonates in the adjuvant therapy of breast cancer-- pathophysiology, animal models, and clinical experiences].
Topics: Administration, Oral; Animals; Antineoplastic Agents; Bone and Bones; Bone Density; Bone Neoplasms; Breast Neoplasms; Chemotherapy, Adjuvant; Clodronic Acid; Diphosphonates; Disease Models, Animal; Female; Humans; Mammary Neoplasms, Experimental; Pamidronate; Rats | 1998 |
1 trial(s) available for clodronic acid and Disease Models, Animal
| Article | Year |
|---|---|
[Bisphosphonates in the adjuvant therapy of breast cancer-- pathophysiology, animal models, and clinical experiences].
Topics: Administration, Oral; Animals; Antineoplastic Agents; Bone and Bones; Bone Density; Bone Neoplasms; Breast Neoplasms; Chemotherapy, Adjuvant; Clodronic Acid; Diphosphonates; Disease Models, Animal; Female; Humans; Mammary Neoplasms, Experimental; Pamidronate; Rats | 1998 |
160 other study(ies) available for clodronic acid and Disease Models, Animal
| Article | Year |
|---|---|
A Population of M2 Macrophages Associated With Bone Formation.
Topics: Adipocytes, Brown; Animals; Cell Plasticity; Cells, Cultured; Clodronic Acid; Disease Models, Animal; Femoral Fractures; Femur; Lipopolysaccharides; Macrophages; Mice, Transgenic; Ossification, Heterotopic; Osteogenesis; Phagocytosis; Phenotype; Receptors, Adrenergic, beta-3; Transcriptome | 2021 |
Microglial TLR4 is Critical for Neuronal Injury and Cognitive Dysfunction in Subarachnoid Hemorrhage.
Topics: Animals; Brain Injuries; Clodronic Acid; Cognitive Dysfunction; Disease Models, Animal; Female; Liposomes; Male; Mice; Mice, Inbred C57BL; Microglia; Neurons; Subarachnoid Hemorrhage; Toll-Like Receptor 4 | 2022 |
Pretreatment with Clodronate Improved Neurological Function by Preventing Reduction of Posthemorrhagic Cerebral Blood Flow in Experimental Subarachnoid Hemorrhage.
Topics: Animals; Brain; Cerebrovascular Circulation; Clodronic Acid; Disease Models, Animal; Male; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage | 2023 |
Preparation and PET/CT imaging of implant directed
Topics: Animals; Clodronic Acid; Disease Models, Animal; Gallium Radioisotopes; Magnetic Phenomena; Mice; Nanopores; Positron Emission Tomography Computed Tomography; Tissue Distribution; Titanium | 2023 |
An Important Role of Macrophages for Wound Margin Regeneration in a Murine Flap Model.
Topics: Animals; Cell Movement; Clodronic Acid; Coculture Techniques; Disease Models, Animal; Humans; Keratinocytes; Liposomes; Macrophages; Male; Mice; Mice, Inbred C57BL; Regeneration; Skin; Surgical Flaps; THP-1 Cells; Wound Healing | 2019 |
Key role of CCR2-expressing macrophages in a mouse model of low back pain and radiculopathy.
Topics: Animals; Chemokine CCL2; Clodronic Acid; Disease Models, Animal; Ganglia, Spinal; Low Back Pain; Macrophages; Mice; Radiculopathy; Receptors, CCR2 | 2021 |
Pronociceptive Roles of Schwann Cell-Derived Galectin-3 in Taxane-Induced Peripheral Neuropathy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Blood Proteins; Cell Movement; Chemotaxis; Clodronic Acid; Disease Models, Animal; Docetaxel; Female; Galectins; Humans; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Paclitaxel; Pain Perception; Peripheral Nervous System Diseases; Prospective Studies; Rats; Schwann Cells; Sciatic Nerve; Up-Regulation | 2021 |
Clodronate, an inhibitor of the vesicular nucleotide transporter, ameliorates steatohepatitis and acute liver injury.
Topics: Adenosine Triphosphate; Animals; Chemical and Drug Induced Liver Injury; Clodronic Acid; Diet; Disease Models, Animal; Fatty Liver; Humans; Inflammation; Lipopolysaccharides; Mice; Nucleotide Transport Proteins; Receptors, Purinergic | 2021 |
Macrophage depletion in stellate ganglia alleviates cardiac sympathetic overactivation and ventricular arrhythmogenesis by attenuating neuroinflammation in heart failure.
Topics: Action Potentials; Animals; Anti-Inflammatory Agents; Calcium Channels, N-Type; Calcium Signaling; Clodronic Acid; Disease Models, Animal; Heart; Heart Failure; Heart Rate; Inflammation Mediators; Interleukin-1beta; Liposomes; Macrophages; Male; Neuroinflammatory Diseases; Rats, Sprague-Dawley; Stellate Ganglion; Tachycardia, Ventricular; Tumor Necrosis Factor-alpha; Ventricular Fibrillation | 2021 |
Hydrocephalus Induced by Intraventricular Peroxiredoxin-2: The Role of Macrophages in the Choroid Plexus.
Topics: Animals; Antibodies, Monoclonal; Choroid Plexus; Clodronic Acid; Disease Models, Animal; Hydrocephalus; Infusions, Intraventricular; Liposomes; Macrophages; Magnetic Resonance Imaging; Male; Peroxiredoxins; Rats; Rats, Sprague-Dawley | 2021 |
Methylmercury induces neuronal cell death by inducing TNF-α expression through the ASK1/p38 signaling pathway in microglia.
Topics: Animals; Apoptosis; Brain; Cell Line; Clodronic Acid; Disease Models, Animal; Environmental Pollutants; Gene Knockdown Techniques; Humans; Imidazoles; Male; MAP Kinase Kinase Kinase 5; MAP Kinase Signaling System; Mercury Poisoning, Nervous System; Methylmercury Compounds; Mice; Microglia; Mitochondria; Neurons; p38 Mitogen-Activated Protein Kinases; Peptides, Cyclic; Phosphorylation; Primary Cell Culture; Pyridines; Tumor Necrosis Factor-alpha | 2021 |
Targeting Notch Inhibitors to the Myeloma Bone Marrow Niche Decreases Tumor Growth and Bone Destruction without Gut Toxicity.
Topics: Animals; Bone and Bones; Bone Density Conservation Agents; Bone Marrow Cells; Cell Line, Tumor; Clodronic Acid; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Humans; Mice; Multiple Myeloma; Osteolysis; Receptors, Notch; Signal Transduction; X-Ray Microtomography; Xenograft Model Antitumor Assays | 2021 |
Gas6 Promotes Inflammatory (CCR2
Topics: Animals; Cells, Cultured; Chemokine CCL2; Chemotaxis, Leukocyte; Clodronic Acid; CX3C Chemokine Receptor 1; Disease Models, Animal; Endothelial Cells; Genetic Predisposition to Disease; Inflammation; Intercellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Male; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Paracrine Communication; Phenotype; Receptors, CCR2; Receptors, Chemokine; Signal Transduction; Vena Cava, Inferior; Venous Thrombosis | 2017 |
Nerve growth factor regulation and production by macrophages in osteoarthritic synovium.
Topics: Aged; Aged, 80 and over; Animals; Cells, Cultured; Clodronic Acid; Disease Models, Animal; Female; Fibroblasts; Gene Expression Regulation; Humans; Interleukin-1beta; Lipopolysaccharide Receptors; Liposomes; Macrophages; Male; Mice; Nerve Growth Factor; Osteoarthritis; Osteoarthritis, Knee; Polymerase Chain Reaction; Synovial Membrane; Tumor Necrosis Factor-alpha | 2017 |
The role of macrophages in the development of biliary injury in a lipopolysaccharide-aggravated hepatic ischaemia-reperfusion model.
Topics: Animals; Bile; Bile Duct Diseases; Bile Ducts; Chemokine CCL2; Clodronic Acid; Disease Models, Animal; Epithelial Cells; Humans; Lipopolysaccharides; Liposomes; Liver; Macrophages; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2018 |
Macrophage depletion using clodronate liposomes decreases tumorigenesis and alters gut microbiota in the AOM/DSS mouse model of colon cancer.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Biomarkers, Tumor; Cell Transformation, Neoplastic; Clodronic Acid; Colon; Colonic Polyps; Colorectal Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Host-Pathogen Interactions; Inflammation Mediators; Liposomes; Macrophages; Male; Mice, Inbred C57BL; Signal Transduction; Time Factors; Tumor Burden | 2018 |
Platelet rescue by macrophage depletion in obese ADAMTS-13-deficient mice at risk of thrombotic thrombocytopenic purpura.
Topics: ADAMTS13 Protein; Animals; Blood Platelets; Cells, Cultured; Clodronic Acid; Disease Models, Animal; Kupffer Cells; Macrophages; Male; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Obesity; Phagocytosis; Purpura, Thrombotic Thrombocytopenic; Spleen; Time Factors; von Willebrand Factor | 2018 |
Therapeutic targeting of tumor-associated macrophages in pancreatic neuroendocrine tumors.
Topics: Adolescent; Adult; Aged; Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Cell Proliferation; Clodronic Acid; Disease Models, Animal; Drug Carriers; Drug Synergism; Female; Humans; Insulinoma; Liposomes; Macrophages; Male; Mice; Mice, Transgenic; Middle Aged; Neovascularization, Pathologic; Neuroendocrine Tumors; Pancreatic Neoplasms; Sunitinib; Young Adult | 2018 |
Hematopoietic stem cell loss and hematopoietic failure in severe aplastic anemia is driven by macrophages and aberrant podoplanin expression.
Topics: Anemia, Aplastic; Animals; Biomarkers; Bone Marrow; Cell Count; Clodronic Acid; Cytokines; Disease Models, Animal; Gene Expression Regulation; Hematopoiesis; Hematopoietic Stem Cells; Immunophenotyping; Liposomes; Lymphocyte Activation; Macrophages; Membrane Glycoproteins; Mice; Mice, Transgenic; Models, Biological; Phenotype; Severity of Illness Index; T-Lymphocytes; Thrombocytopenia | 2018 |
Using patient-derived iPSCs to develop humanized mouse models for chronic myelomonocytic leukemia and therapeutic drug identification, including liposomal clodronate.
Topics: Aged; Animals; Cell Differentiation; Clodronic Acid; Disease Models, Animal; Drug Repositioning; Enhancer of Zeste Homolog 2 Protein; Hematopoietic Stem Cells; Humans; Induced Pluripotent Stem Cells; Leukemia, Myelomonocytic, Chronic; Liposomes; Male; Mice; Neurofibromin 1; Phosphorylation; Protein Kinase Inhibitors; STAT5 Transcription Factor; Teratoma; Transplantation, Heterologous | 2018 |
Dissecting functional phenotypes of microglia and macrophages in the rat brain after transient cerebral ischemia.
Topics: Animals; Animals, Newborn; Antigens, CD; Arginase; Brain; Calcium-Binding Proteins; Cells, Cultured; Clodronic Acid; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Infarction, Middle Cerebral Artery; Laminin; Liposomes; Macrophages; Male; Microfilament Proteins; Microglia; Nitric Oxide Synthase Type II; Rats; Rats, Wistar | 2019 |
Depletion of RIPK1 in hepatocytes exacerbates liver damage in fulminant viral hepatitis.
Topics: Animals; Apoptosis; Cell Death; Cells, Cultured; Clodronic Acid; Disease Models, Animal; Gene Knockout Techniques; Hepatitis, Viral, Animal; Hepatocytes; Kupffer Cells; Liver Diseases; Massive Hepatic Necrosis; Mice; Mice, Inbred C57BL; Mice, Knockout; Murine hepatitis virus; Poly I-C; Receptor-Interacting Protein Serine-Threonine Kinases; Tumor Necrosis Factor-alpha | 2019 |
Alveolar Macrophage Apoptosis-associated Bacterial Killing Helps Prevent Murine Pneumonia.
Topics: Animals; Apoptosis; Bacteria; Biphenyl Compounds; Caspases; Clodronic Acid; Disease Models, Animal; Haemophilus influenzae; Humans; Macrophages, Alveolar; Mice; Mice, Transgenic; Mitochondria; Myeloid Cell Leukemia Sequence 1 Protein; Nitric Oxide; Nitrophenols; Phagocytosis; Phagosomes; Piperazines; Pneumonia, Bacterial; Reactive Oxygen Species; Staphylococcus aureus; Streptococcus pneumoniae; Sulfonamides | 2019 |
Anti-inflammatory properties of Liposome-encapsulated clodronate or Anti-Ly6G can be modulated by peripheral or central inflammatory markers in carrageenan-induced inflammation model.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Carrageenan; Clodronic Acid; Disease Models, Animal; Edema; Hyperalgesia; Inflammation; Liposomes; Macrophages; Male; Neutrophils; Pain; Rats; Rats, Wistar; Spinal Cord | 2019 |
Mononuclear phagocytes orchestrate prolyl hydroxylase inhibition-mediated renoprotection in chronic tubulointerstitial nephritis.
Topics: Adenine; Animals; Anti-Inflammatory Agents; Basic Helix-Loop-Helix Transcription Factors; Clodronic Acid; Complement C1q; Disease Models, Animal; Glycine; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Isoquinolines; Kidney Tubules; Male; Mice; Mice, Transgenic; Nephritis, Interstitial; Phagocytes; Prolyl Hydroxylases; Prolyl-Hydroxylase Inhibitors; Protective Agents; Renal Insufficiency, Chronic | 2019 |
Salt-sensitive increase in macrophages in the kidneys of Dahl SS rats.
Topics: Albuminuria; Animals; B-Lymphocytes; Clodronic Acid; Disease Models, Animal; Disease Progression; Hypertension; Kidney; Kidney Diseases; Lipopolysaccharide Receptors; Lymphocyte Antigen 96; Macrophages; Phenotype; Rats, Inbred BN; Rats, Inbred Dahl; Rats, Sprague-Dawley; Signal Transduction; Sodium Chloride, Dietary; T-Lymphocytes; Toll-Like Receptor 4 | 2019 |
Clodronate-Liposome Mediated Macrophage Depletion Abrogates Multiple Myeloma Tumor Establishment In Vivo.
Topics: Animals; Biomarkers; Bone Density Conservation Agents; Cell Count; Cell Line, Tumor; Cell Movement; Clodronic Acid; Disease Models, Animal; Disease Susceptibility; Immunophenotyping; Liposomes; Macrophages; Mice; Multiple Myeloma; Osteoblasts; Tumor Microenvironment | 2019 |
P2X7 receptor is required for neutrophil accumulation in a mouse model of irritant contact dermatitis.
Topics: Animals; Apoptosis; Cell Movement; Cells, Cultured; Clodronic Acid; Croton Oil; Dermatitis, Contact; Disease Models, Animal; In Vitro Techniques; Interleukin-1beta; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Purinergic P2X Receptor Antagonists; Pyridines; Receptors, Purinergic P2X7; Tetrazoles | 2013 |
Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia.
Topics: Animals; beta-Thalassemia; Clodronic Acid; Disease Models, Animal; Erythrocyte Count; Erythropoiesis; Female; Hematocrit; Hemoglobins; Humans; Macrophages; Male; Mice; Mice, Inbred C57BL; Polycythemia Vera; Reticulocytes; Stress, Physiological | 2013 |
Treatment for experimental autoimmune neuritis with clodronate (Bonefos).
Topics: Animals; Autoimmune Diseases; Biomarkers; Clodronic Acid; Demyelinating Diseases; Disease Models, Animal; Disease Progression; Female; Humans; Macrophages; Matrix Metalloproteinase 9; Motor Activity; Myelin P2 Protein; Neuritis, Autoimmune, Experimental; Rats; Rats, Inbred Lew; Sciatic Nerve; Syndrome | 2013 |
Peroxisome proliferator-activated receptor-gamma agonist rosiglitazone attenuates inflammatory pain through the induction of heme oxygenase-1 in macrophages.
Topics: Animals; Anti-Inflammatory Agents; Antigens, Differentiation; Clodronic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Freund's Adjuvant; Gene Expression Regulation; Heme Oxygenase-1; Hyperalgesia; Inflammation; Lectins, C-Type; Macrophages, Peritoneal; Male; Mannose Receptor; Mannose-Binding Lectins; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Pain; Pain Measurement; Pain Threshold; Receptors, Cell Surface; Rosiglitazone; Thiazolidinediones; Time Factors | 2013 |
The mechanism of anti-CD20-mediated B cell depletion revealed by intravital imaging.
Topics: Animals; Antibodies, Monoclonal; Antigens, CD20; B-Lymphocytes; Burkitt Lymphoma; Clodronic Acid; Disease Models, Animal; Fluorescent Dyes; Kupffer Cells; Liposomes; Liver; Liver Regeneration; Lymphocyte Depletion; Lymphoid Tissue; Lymphoma, B-Cell; Mice; Mice, Inbred C57BL; Mice, Transgenic; Optical Imaging; Phagocytosis | 2013 |
Macrophage-derived IL-18 and increased fibrinogen deposition are age-related inflammatory signatures of vascular remodeling.
Topics: Age Factors; Aging; Animals; Apoptosis; Cell Adhesion; Cells, Cultured; Chemotaxis; Clodronic Acid; Disease Models, Animal; Fibrinogen; Gene Expression Regulation; Hyperplasia; Inflammation Mediators; Interleukin-18; Macrophages; Male; Monocytes; Muscle, Smooth, Vascular; Neointima; Paracrine Communication; Rats; Rats, Inbred F344; Signal Transduction; Time Factors; Vascular System Injuries | 2014 |
Clodronate liposomes reduce excessive scar formation in a mouse model of burn injury by reducing collagen deposition and TGF-β1 expression.
Topics: Animals; Burns; Cicatrix; Clodronic Acid; Collagen; Collagen Type I; Disease Models, Animal; Liposomes; Macrophages; Mice; Time Factors; Transforming Growth Factor beta1; Wound Healing | 2014 |
Role of alveolar macrophages in the regulation of local and systemic inflammation after lung contusion.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cell Movement; Chemokine CCL5; Chemokines; Clodronic Acid; Contusions; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Inflammation Mediators; Interleukin-6; Leukocytes, Mononuclear; Lung Injury; Macrophages, Alveolar; Male; Mice; Mice, Inbred C3H; Random Allocation; Reference Values; Role; Sensitivity and Specificity; Systemic Inflammatory Response Syndrome; Wounds, Nonpenetrating | 2014 |
Depletion of M2-like tumor-associated macrophages delays cutaneous T-cell lymphoma development in vivo.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Bone Marrow Cells; Cell Line, Tumor; Clodronic Acid; Cytokines; Disease Models, Animal; Humans; Inflammation; Liposomes; Lymphoma, T-Cell, Cutaneous; Macrophages; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, SCID; Mycosis Fungoides; Neoplasm Transplantation; Phenotype; Platelet Endothelial Cell Adhesion Molecule-1; Receptors, Cell Surface; Skin Neoplasms | 2014 |
Effects of an immunomodulatory therapy and chondroitinase after spinal cord hemisection injury.
Topics: Animals; Bone Density Conservation Agents; Chondroitin ABC Lyase; Clodronic Acid; Combined Modality Therapy; Disease Models, Animal; Female; Immunomodulation; Immunotherapy; Liposomes; Male; Motor Activity; Phosphodiesterase 4 Inhibitors; Rats; Recovery of Function; Rolipram; Spinal Cord Injuries | 2014 |
Resident alveolar macrophages suppress, whereas recruited monocytes promote, allergic lung inflammation in murine models of asthma.
Topics: Allergens; Alveolitis, Extrinsic Allergic; Animals; Antigens, Ly; Asthma; Bronchoalveolar Lavage Fluid; CD11b Antigen; Cell Proliferation; Clodronic Acid; Cytokines; Disease Models, Animal; Eosinophils; Inflammation; Leukocyte Common Antigens; Lung; Macrophages, Alveolar; Mice; Mice, Inbred C57BL; Monocytes; Ovalbumin; Pneumonia; Pyroglyphidae | 2014 |
Reactive retinal microglia, neuronal survival, and the formation of retinal folds and detachments.
Topics: Age Factors; Animals; Animals, Newborn; Cell Death; Chickens; Clodronic Acid; Disease Models, Animal; Excitatory Amino Acid Agonists; In Situ Nick-End Labeling; Interleukin-6; Leukocyte Common Antigens; Liposomes; Macrophages; Microglia; N-Methylaspartate; Neurons; Plant Lectins; Retina; Retinal Detachment; SOX9 Transcription Factor | 2015 |
Resin monomers act as adjuvants in Ni-induced allergic dermatitis in vivo.
Topics: Adaptive Immunity; Adjuvants, Immunologic; Animals; Blood Component Removal; Cell Transplantation; Clodronic Acid; Dental Materials; Dermatitis, Allergic Contact; Disease Models, Animal; Female; Immunization; Inflammation Mediators; Injections, Intradermal; Injections, Intraperitoneal; Interleukin-1alpha; Interleukin-1beta; Liposomes; Macrophages; Methacrylates; Methylmethacrylate; Mice; Mice, Inbred BALB C; Mice, Knockout; Nickel; Spleen | 2014 |
Specific macrophage subtypes influence the progression of rhabdomyolysis-induced kidney injury.
Topics: Acute Kidney Injury; Animals; Cells, Cultured; Clodronic Acid; Disease Models, Animal; Disease Progression; Flow Cytometry; Glycerol; Humans; Macrophages; Male; Mice; Myoglobin; Random Allocation; Rhabdomyolysis; Risk Factors; Sensitivity and Specificity | 2015 |
Macrophages are required for host survival in experimental urogenital schistosomiasis.
Topics: Animals; Clodronic Acid; Cricetinae; Cytokines; Disease Models, Animal; Female; Fibrosis; Granuloma; Host-Pathogen Interactions; Liposomes; Macrophages; Mice; Mice, Inbred C57BL; Schistosomiasis haematobia; Urinary Bladder Diseases | 2015 |
Macrophage depletion ameliorates glycerol-induced acute kidney injury in mice.
Topics: Acute Kidney Injury; Administration, Intravenous; Animals; Apoptosis; Clodronic Acid; Cytokines; Disease Models, Animal; Epithelial Cells; Glycerol; Injections, Intramuscular; Kidney Tubules; Liposomes; Macrophages; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Rhabdomyolysis | 2014 |
Obesity increases airway hyperresponsiveness via the TNF-α pathway and treating obesity induces recovery.
Topics: Animals; Antibodies, Neutralizing; Body Weight; Clodronic Acid; Diet Therapy; Diet, High-Fat; Disease Models, Animal; Exercise Therapy; Macrophages, Alveolar; Mice; Obesity; Ovalbumin; Respiratory Hypersensitivity; Tumor Necrosis Factor-alpha | 2015 |
Are gastric mucosal macrophages responsible for gastric injury in acute pancreatitis?
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Clodronic Acid; Cytoprotection; Disease Models, Animal; Gastric Mucosa; Liposomes; Macrophages; Pancreatitis; Protective Agents; Rats, Sprague-Dawley; Stomach Diseases; Taurocholic Acid; Tumor Necrosis Factor-alpha | 2015 |
Immune targeting of the pleural space by intercostal approach.
Topics: Animals; B-Lymphocytes; Bone Density Conservation Agents; Cell Movement; Cellular Microenvironment; Clodronic Acid; Disease Models, Animal; Escherichia coli; Escherichia coli Infections; Flow Cytometry; Klebsiella Infections; Klebsiella pneumoniae; Leukocytes; Macrophages; Mice; Mice, Inbred C57BL; Pleura; Pneumonia, Bacterial | 2015 |
Lack of Evidence From a Transgenic Mouse Model that the Activation and Migration of Melanocytes to the Epidermis after Neonatal UVR Enhances Melanoma Development.
Topics: Animals; Animals, Newborn; Biopsy, Needle; Carcinogenesis; Cell Movement; Cells, Cultured; Clodronic Acid; Disease Models, Animal; Epidermal Cells; Immunohistochemistry; Injections, Intraperitoneal; Liposomes; Macrophages; Melanocytes; Melanoma, Experimental; Mice; Mice, Transgenic; Random Allocation; Sensitivity and Specificity; Ultraviolet Rays | 2015 |
Targeting tubulointerstitial remodeling in proteinuric nephropathy in rats.
Topics: Animals; Antibodies; Biomarkers; Clodronic Acid; Collagen Type III; Disease Models, Animal; Doxorubicin; Fibrosis; Fingolimod Hydrochloride; Inflammation; Kidney Diseases; Kidney Tubules; Leukocyte Count; Liposomes; Lymphangiogenesis; Lymphatic Vessels; Macrophages; Male; Myofibroblasts; Proteinuria; Rats, Wistar; RNA, Messenger; T-Lymphocytes; Vascular Endothelial Growth Factor Receptor-3 | 2015 |
Cutaneous T-Cell Lymphoma: The Yin and Yang of Inflammation and Neoplasia.
Topics: Adrenal Cortex Hormones; Animals; Cell Line, Tumor; Clodronic Acid; Dermatitis, Irritant; Dinitrofluorobenzene; Disease Models, Animal; Humans; Interleukin-1beta; Liposomes; Lymphoma, T-Cell, Cutaneous; Macrophages; Mice; Yin-Yang | 2015 |
Synergistic local drug delivery in a piglet model of ischemic osteonecrosis: a preliminary study.
Topics: Animals; Bone Density Conservation Agents; Clodronic Acid; Disease Models, Animal; Drug Delivery Systems; Drug Therapy, Combination; Femur Head; Femur Head Necrosis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemia; Male; Pilot Projects; Simvastatin; Swine; Swine, Miniature; Treatment Outcome; X-Ray Microtomography | 2015 |
N-Acetylglucosaminyltransferase V exacerbates murine colitis with macrophage dysfunction and enhances colitic tumorigenesis.
Topics: Animals; Clodronic Acid; Colitis; Colonic Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Flow Cytometry; Inflammation; Interleukin-10; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; N-Acetylglucosaminyltransferases; Severity of Illness Index; Trinitrobenzenesulfonic Acid | 2016 |
Synovial macrophage-derived IL-1β regulates the calcitonin receptor in osteoarthritic mice.
Topics: Animals; Antigens, Differentiation; Calcitonin Gene-Related Peptide; Calcitonin Receptor-Like Protein; Cells, Cultured; Clodronic Acid; Disease Models, Animal; Gene Expression Regulation; Humans; Interleukin-1beta; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Osteoarthritis; Receptor Activity-Modifying Protein 1; Receptors, Calcitonin; Signal Transduction; Synovial Membrane | 2016 |
Depletion of CLL-associated patrolling monocytes and macrophages controls disease development and repairs immune dysfunction in vivo.
Topics: Animals; Antigens, Ly; B7-H1 Antigen; Chemokine CXCL9; Clodronic Acid; Dendritic Cells; Disease Models, Animal; Gene Expression Regulation, Leukemic; Humans; Immunophenotyping; Interleukin-10; Leukemia, Lymphocytic, Chronic, B-Cell; Macrophages; Mice; Mice, Transgenic; Monocytes; Peritoneal Cavity; Phenotype; Receptors, CCR2; Signal Transduction; Spleen; T-Lymphocytes; Tumor Necrosis Factor-alpha | 2016 |
Microenvironmental effects limit efficacy of thymoquinone treatment in a mouse model of ovarian cancer.
Topics: Animals; Antinematodal Agents; Apoptosis; Benzoquinones; Cell Line, Tumor; Clodronic Acid; Disease Models, Animal; Female; Macrophages; Mice; Mice, Inbred C57BL; NF-kappa B; Ovarian Neoplasms | 2015 |
Macrophage recruitment by fibrocystin-defective biliary epithelial cells promotes portal fibrosis in congenital hepatic fibrosis.
Topics: Animals; Antigens, Neoplasm; Chemokines; Clodronic Acid; Collagen; Disease Models, Animal; Epithelial Cells; Genetic Diseases, Inborn; Integrins; Liver Cirrhosis; Macrophages; Mice; Myofibroblasts; Receptors, Cell Surface; Snail Family Transcription Factors; Transcription Factors; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha | 2016 |
Macrophage depletion reduced brain injury following middle cerebral artery occlusion in mice.
Topics: Analysis of Variance; Animals; Antigens, CD; Bone Density Conservation Agents; Brain; Brain Injuries; Calcium-Binding Proteins; Clodronic Acid; Disease Models, Animal; Flow Cytometry; Gene Expression Regulation; Infarction, Middle Cerebral Artery; Macrophages; Male; Mice; Mice, Inbred ICR; Microfilament Proteins; Microglia; Microvessels; Myelin Basic Protein; Time Factors | 2016 |
Microglial Cells Prevent Hemorrhage in Neonatal Focal Arterial Stroke.
Topics: Age Factors; Animals; Animals, Newborn; Benzamides; Bone Density Conservation Agents; Caspase 3; Clodronic Acid; Dioxoles; Disease Models, Animal; Endothelial Cells; Female; Gene Expression Regulation, Developmental; Infarction, Middle Cerebral Artery; Intracranial Hemorrhages; Male; Mice; Mice, Transgenic; Microglia; Rats; Signal Transduction; Smad2 Protein; Transforming Growth Factor beta1 | 2016 |
Dorsal Root Ganglion Infiltration by Macrophages Contributes to Paclitaxel Chemotherapy-Induced Peripheral Neuropathy.
Topics: Anesthetics; Animals; Antibodies; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antineoplastic Agents, Phytogenic; Bone Density Conservation Agents; Cell Movement; Chemokine CCL2; Clodronic Acid; Disease Models, Animal; Drug Administration Routes; Ganglia, Spinal; GAP-43 Protein; Hyperalgesia; Isoflurane; Lipopolysaccharides; Macrophages; Male; Paclitaxel; Pain Threshold; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Spinal Cord; Spleen; Time Factors; Tumor Necrosis Factor-alpha; Ubiquitin Thiolesterase | 2016 |
Systemic depletion of macrophages in the subacute phase of wound healing reduces hypertrophic scar formation.
Topics: Animals; Cell Differentiation; Cicatrix, Hypertrophic; Clodronic Acid; Collagen; Cytokines; Disease Models, Animal; Female; Fibroblasts; Humans; Liposomes; Macrophages; Male; Mast Cells; Mice; Mice, Nude; Skin Transplantation; Spleen; Wound Healing; Wounds and Injuries | 2016 |
Interleukin-33 from Monocytes Recruited to the Lung Contributes to House Dust Mite-Induced Airway Inflammation in a Mouse Model.
Topics: Allergens; Animals; Antigens, Ly; Asthma; Bronchoalveolar Lavage Fluid; CD11b Antigen; CD11c Antigen; Cell Movement; Clodronic Acid; Cytokines; Disease Models, Animal; Female; Gene Expression Regulation; Humans; Interleukin-33; Interleukins; Leukocyte Reduction Procedures; Liposomes; Lung; Mice; Mice, Inbred BALB C; Monocytes; Pyroglyphidae; Respiratory Mucosa; Signal Transduction; Thymic Stromal Lymphopoietin | 2016 |
Sickle Cell Trait Increases Red Blood Cell Storage Hemolysis and Post-Transfusion Clearance in Mice.
Topics: Animals; Blood Preservation; Clodronic Acid; Disease Models, Animal; Erythrocyte Transfusion; Erythrocytes; Erythrocytes, Abnormal; Female; Hemoglobin A; Hemolysis; Humans; Male; Mice; Mice, Transgenic; Osmotic Fragility; Sickle Cell Trait; Splenectomy | 2016 |
Kupffer cells induce Notch-mediated hepatocyte conversion in a common mouse model of intrahepatic cholangiocarcinoma.
Topics: Animals; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Carcinogens; Cell Communication; Cell Dedifferentiation; Cholangiocarcinoma; Clodronic Acid; Disease Models, Animal; Gene Expression Regulation; Hepatocytes; Humans; Jagged-1 Protein; Kupffer Cells; Mice; Mice, Inbred C57BL; Pyridines; Receptor, Notch1; Signal Transduction; Survival Analysis; Thioacetamide | 2016 |
Prolonged Ischemia Triggers Necrotic Depletion of Tissue-Resident Macrophages To Facilitate Inflammatory Immune Activation in Liver Ischemia Reperfusion Injury.
Topics: Animals; Cells, Cultured; Clodronic Acid; Disease Models, Animal; GTPase-Activating Proteins; Humans; Imidazoles; Immunity; Indoles; Inflammation; Kupffer Cells; Liver; Male; Mice; Mice, Inbred C57BL; Necrosis; Reperfusion Injury; Signal Transduction | 2017 |
Differential effects of GdCl3- or MDP treatment on rat liver microcirculation and gene expression in the hepatic non-parenchymal cell fraction in LPS shock.
Topics: Animals; Anti-Inflammatory Agents; Blood Flow Velocity; Bone Density Conservation Agents; Clodronic Acid; Disease Models, Animal; Gadolinium; Gene Expression Regulation; Kupffer Cells; Lipopolysaccharides; Liver; Male; Microcirculation; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Shock, Septic; Tumor Necrosis Factor-alpha | 2008 |
Liver Kupffer cells control the magnitude of the inflammatory response in the injured brain and spinal cord.
Topics: Analysis of Variance; Animals; Bone Density Conservation Agents; Brain Injuries; Chemokines; Clodronic Acid; Disease Models, Animal; Encephalitis; Interleukin-1beta; Kupffer Cells; Liposomes; Male; Myelitis; Rats; Rats, Wistar; RNA, Messenger; Spinal Cord Injuries; Time Factors | 2008 |
Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages.
Topics: Animals; Bone Density Conservation Agents; Bone Neoplasms; Clodronic Acid; Disease Models, Animal; Female; Humans; Lung Neoplasms; Macrophages; Mice; Mice, Inbred BALB C; Monocytes; Muscle Neoplasms; Neoplasm Invasiveness; Pyrans; Spiro Compounds | 2008 |
Another barrier to regeneration in the CNS: activated macrophages induce extensive retraction of dystrophic axons through direct physical interactions.
Topics: Animals; Animals, Newborn; Axons; Bone Density Conservation Agents; Cell Communication; Cell Movement; Cells, Cultured; Cicatrix; Clodronic Acid; Disease Models, Animal; Female; Ganglia, Spinal; Growth Cones; Liposomes; Macrophages; Nerve Regeneration; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries; Wallerian Degeneration | 2008 |
Effect of short-term macrophage depletion in the development of posterior capsule opacification in rodents.
Topics: Animals; Cataract; Clodronic Acid; Disease Models, Animal; Epithelial Cells; Lens Capsule, Crystalline; Liposomes; Macrophages; Male; Phacoemulsification; Rats; Rats, Sprague-Dawley; Sodium Chloride | 2008 |
Are new-generation bisphosphonates effective for the inhibition of calcium oxalate stone formation in a rat model?
Topics: Animals; Calcium; Calcium Oxalate; Clodronic Acid; Creatinine; Diphosphonates; Disease Models, Animal; Imidazoles; Injections, Intraperitoneal; Male; Rats; Rats, Sprague-Dawley; Urinary Bladder Calculi; Zinc; Zoledronic Acid | 2008 |
Potential role of macrophages in experimental keratomycosis.
Topics: Animals; Candida albicans; Candidiasis; Clodronic Acid; Colony Count, Microbial; Cytokines; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Eye Infections, Fungal; Female; Fluorescent Antibody Technique, Indirect; Fusarium; Keratitis; Liposomes; Macrophages; Male; Mice; Mice, Inbred BALB C; Mycoses; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Th1 Cells; Th2 Cells; Toll-Like Receptor 4 | 2009 |
Macrophage depletion in hypertensive rats accelerates development of cardiomyopathy.
Topics: Animals; Cardiomyopathies; CD4-Positive T-Lymphocytes; Clodronic Acid; Disease Models, Animal; Disease Progression; Hypertension; Injections, Intravenous; Liposomes; Macrophages; Male; Monocytes; Myocardium; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Renin; Stroke Volume; Time Factors; Ventricular Function, Left; Ventricular Remodeling | 2009 |
Extratumoral macrophages promote tumor and vascular growth in an orthotopic rat prostate tumor model.
Topics: Angiogenic Proteins; Animals; Cell Proliferation; Chemokines; Clodronic Acid; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Liposomes; Macrophages; Male; Neoplasm Transplantation; Neovascularization, Pathologic; Prostatic Neoplasms; Rats; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured | 2009 |
Role of lung-marginated monocytes in an in vivo mouse model of ventilator-induced lung injury.
Topics: Animals; Clodronic Acid; Disease Models, Animal; Lipopolysaccharides; Liposomes; Lung; Male; Mice; Mice, Inbred C57BL; Monocytes; Pulmonary Edema; Receptors, Chemokine; Ventilator-Induced Lung Injury | 2009 |
Role of macrophages in the development of pancreatic islet injury in spontaneously diabetic torii rats.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Bone Density Conservation Agents; Cell Count; Cell Separation; Cells, Cultured; Clodronic Acid; Diabetes Mellitus, Type 2; Disease Models, Animal; Flow Cytometry; Insulin-Secreting Cells; Interferon-gamma; Interleukin-18; Islets of Langerhans; Liposomes; Macrophages; Male; Monocytes; Nitrates; Nitrites; Rats; Rats, Sprague-Dawley; Spleen | 2009 |
c-Jun terminal kinase-2 gene deleted mice overexpress hemeoxygenase-1 and are protected from hepatic ischemia reperfusion injury.
Topics: Alanine Transaminase; Animals; Apoptosis; Cell Survival; Cells, Cultured; Clodronic Acid; Disease Models, Animal; Enzyme Inhibitors; Female; Hematopoietic Stem Cells; Heme Oxygenase-1; Ischemia; Kupffer Cells; Lipopolysaccharides; Liver; Membrane Proteins; Mesoporphyrins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 9; Monocytes; Reperfusion Injury; Severity of Illness Index; Time Factors; Tumor Necrosis Factor-alpha; Up-Regulation | 2009 |
Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling.
Topics: Adipose Tissue; Animals; Bone Density Conservation Agents; Clodronic Acid; Diet; Disease Models, Animal; Fatty Liver; Gene Expression Regulation; Inflammation Mediators; Insulin; Insulin Resistance; Interleukin-10; Interleukin-6; Kupffer Cells; Liposomes; Macrophages; Male; Mice; Obesity; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptor, Insulin; RNA, Messenger; Signal Transduction; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Triglycerides | 2009 |
Elevated endogenous surfactant reduces inflammation in an acute lung injury model.
Topics: Acute Lung Injury; Animals; Clodronic Acid; Cytokines; Disease Models, Animal; Inflammation; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Liposomes; Macrophages, Alveolar; Male; Mice; Pulmonary Surfactants | 2009 |
Central neuroinvasion and demyelination by inflammatory macrophages after peripheral virus infection is controlled by SHP-1.
Topics: Animals; Cardiovirus Infections; Central Nervous System; Chemokine CCL2; Chemokines; Chemotaxis, Leukocyte; Clodronic Acid; Cytokines; Demyelinating Diseases; Disease Models, Animal; Gene Expression Profiling; Injections, Intraperitoneal; Macrophages; Mice; Mice, Inbred C3H; Mice, Knockout; Mice, Mutant Strains; Paralysis; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Theilovirus; Viral Load; Virus Replication | 2009 |
Kupffer cell depletion reduces hepatic inflammation and apoptosis but decreases survival in abdominal sepsis.
Topics: Animals; Apoptosis; Clodronic Acid; Colon; Cytokines; Disease Models, Animal; Female; Hepatitis; Kupffer Cells; Liposomes; Liver; Mice; Mice, Inbred C57BL; Microcirculation; Peritonitis; Sepsis; Stents; Survival Rate | 2010 |
A combination immunomodulatory treatment promotes neuroprotection and locomotor recovery after contusion SCI.
Topics: Analysis of Variance; Animals; Axons; Brain Stem; Clodronic Acid; Contusions; Disease Models, Animal; Drug Therapy, Combination; Ectodysplasins; Exploratory Behavior; Female; Glial Fibrillary Acidic Protein; Hindlimb; Immunologic Factors; Liposomes; Locomotion; Macrophages; Motor Cortex; Myelin Basic Protein; Myelin Sheath; Neural Pathways; Neurofilament Proteins; Neuroprotective Agents; Phosphodiesterase 4 Inhibitors; Psychomotor Performance; Rats; Recovery of Function; Rolipram; Spinal Cord Injuries; Stilbamidines; Vimentin | 2011 |
Involvement of natural killer T cells in halothane-induced liver injury in mice.
Topics: Anesthetics, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Clodronic Acid; Disease Models, Animal; Female; Halothane; Killer Cells, Natural; Kupffer Cells; Liver; Lymphocyte Depletion; Mice; Mice, Inbred BALB C; Mice, Knockout; Neutrophils | 2010 |
In vivo bioluminescence imaging and histopathopathologic analysis reveal distinct roles for resident and recruited immune effector cells in defense against invasive aspergillosis.
Topics: Animals; Aspergillus fumigatus; Clodronic Acid; Cyclophosphamide; Disease Models, Animal; Disease Progression; DNA, Fungal; Histocytochemistry; Immunosuppression Therapy; Invasive Pulmonary Aspergillosis; Luminescent Measurements; Luminescent Proteins; Lung; Macrophages, Alveolar; Mice; Monocytes; Neutrophils; Organisms, Genetically Modified; Reverse Transcriptase Polymerase Chain Reaction; Whole Body Imaging | 2010 |
Murine Kupffer cells are protective in total hepatic ischemia/reperfusion injury with bowel congestion through IL-10.
Topics: Animals; Biological Transport; Cell Death; Clodronic Acid; Disease Models, Animal; Dose-Response Relationship, Immunologic; Endothelium, Vascular; Interleukin-10; Intestinal Mucosa; Ischemia; Kupffer Cells; Lipopolysaccharides; Liposomes; Liver Transplantation; Male; Mice; Mice, Inbred C57BL; Reperfusion Injury; Survival Analysis | 2010 |
Distinct macrophage subpopulations regulate viral encephalitis but not viral clearance in the CNS.
Topics: Animals; Apoptosis; Bone Density Conservation Agents; Central Nervous System; Clodronic Acid; Disease Models, Animal; Encephalitis, Viral; Flow Cytometry; Granulocytes; Green Fluorescent Proteins; Macrophages; Mice; Mice, Nude; Mice, Transgenic; Peritoneum; Tacrolimus; Vesiculovirus | 2010 |
In aged mice, outgrowth of intraocular melanoma depends on proangiogenic M2-type macrophages.
Topics: Aging; Animals; Cell Line, Tumor; Cell Polarity; Cell Proliferation; Clodronic Acid; Conjunctiva; Disease Models, Animal; Eye Neoplasms; Growth Inhibitors; Liposomes; Macrophages; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic | 2010 |
The roles of vitreal macrophages and circulating leukocytes in retinal neovascularization.
Topics: Animals; Bone Marrow Transplantation; Calcium-Binding Proteins; Cell Movement; Clodronic Acid; Disease Models, Animal; Green Fluorescent Proteins; Intravitreal Injections; Leukocytes; Lymphocyte Depletion; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Microglia; Oxygen; Phagocytosis; Retinal Neovascularization; Retinal Vessels; Vitreous Body | 2011 |
Octacalcium phosphate crystals induce inflammation in vivo through interleukin-1 but independent of the NLRP3 inflammasome in mice.
Topics: Animals; Bone Density Conservation Agents; Bone Substitutes; Calcium Phosphates; Carrier Proteins; Cell Survival; Clodronic Acid; Crystallization; Disease Models, Animal; Female; Injections, Intraperitoneal; Interleukin-1; Macrophages, Peritoneal; Male; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; NLR Family, Pyrin Domain-Containing 3 Protein; p-Methoxy-N-methylphenethylamine; Peritoneum; Peritonitis | 2011 |
Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model.
Topics: Acid Phosphatase; Animals; Bone Matrix; Calcification, Physiologic; Clodronic Acid; Disease Models, Animal; Inflammation; Isoenzymes; Liposomes; Macrophage Colony-Stimulating Factor; Macrophages; Membranes; Mice; Mice, Inbred C57BL; Mice, Transgenic; Osteoblasts; Osteogenesis; Osteoprotegerin; Surface Properties; Tartrate-Resistant Acid Phosphatase; Tibia; Wound Healing | 2011 |
Susceptibility to infection and inflammatory response following influenza virus (H1N1, A/PR/8/34) challenge: role of macrophages.
Topics: Animals; Blood Component Removal; Clodronic Acid; Cytokines; Disease Models, Animal; Disease Progression; Disease Susceptibility; Humans; Inflammation Mediators; Influenza A Virus, H1N1 Subtype; Influenza, Human; Lung; Macrophages, Alveolar; Mice; Mice, Inbred ICR; Orthomyxoviridae Infections; RNA, Viral; Virus Replication | 2011 |
Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Bone Density Conservation Agents; CD8-Positive T-Lymphocytes; Clodronic Acid; Disease Models, Animal; Gadolinium; Hepatitis B; Hepatitis B virus; Hepatocytes; HMGB Proteins; Kupffer Cells; Liposomes; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neutrophils; Receptors, Scavenger; RNA, Messenger; Time Factors | 2011 |
Protective effect of clodronate-containing liposomes on intestinal mucosal injury in rats with severe acute pancreatitis.
Topics: Acute Disease; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Apoptosis; Clodronic Acid; Disease Models, Animal; Immunohistochemistry; In Situ Nick-End Labeling; Interleukin-12; Intestinal Mucosa; Liposomes; Macrophages; Pancreas; Pancreatitis; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Taurocholic Acid; Time Factors; Tumor Necrosis Factor-alpha | 2011 |
Microglial depletion using intrahippocampal injection of liposome-encapsulated clodronate in prolonged hypothermic cardiac arrest in rats.
Topics: Animals; Cardiopulmonary Resuscitation; Cell Proliferation; Clodronic Acid; Disease Models, Animal; Heart Arrest; Hippocampus; Hypothermia, Induced; Injections, Intralesional; Liposomes; Male; Microglia; Nerve Degeneration; Random Allocation; Rats; Rats, Sprague-Dawley; Reference Values; Risk Assessment; Survival Rate | 2012 |
Microglia-mediated IGF-I neuroprotection in the rd10 mouse model of retinitis pigmentosa.
Topics: Animals; Apoptosis; Calcium-Binding Proteins; CD11b Antigen; Clodronic Acid; Cyclic Nucleotide Phosphodiesterases, Type 6; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique, Indirect; In Situ Nick-End Labeling; Insulin-Like Growth Factor I; Intravitreal Injections; Mice; Mice, Inbred C57BL; Microfilament Proteins; Microglia; Microscopy, Confocal; Mutation, Missense; Neuroprotective Agents; Photoreceptor Cells, Vertebrate; Retinitis Pigmentosa | 2011 |
P-selectin glycoprotein ligand-1 deficiency leads to cytokine resistance and protection against atherosclerosis in apolipoprotein E deficient mice.
Topics: Adoptive Transfer; Animals; Antibodies; Apolipoproteins E; Atherosclerosis; Bone Marrow Transplantation; Clodronic Acid; Cytokines; Disease Models, Animal; E-Selectin; Endothelial Cells; Interleukin-1beta; Leukocyte Rolling; Leukocytes; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocytes; P-Selectin; Time Factors | 2012 |
Replacement of microglial cells using Clodronate liposome and bone marrow transplantation in the central nervous system of SOD1(G93A) transgenic mice as an in vivo model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Bone Marrow Transplantation; Central Nervous System; Clodronic Acid; Disease Models, Animal; Injections, Intraventricular; Liposomes; Mice; Mice, Transgenic; Microglia; Mutation; Superoxide Dismutase; Superoxide Dismutase-1 | 2012 |
Differential detection and distribution of microglial and hematogenous macrophage populations in the injured spinal cord of lys-EGFP-ki transgenic mice.
Topics: Animals; Antigens, CD1; Antigens, Differentiation; Antigens, Ly; Clodronic Acid; Disease Models, Animal; Female; Flow Cytometry; Gene Expression Regulation; Green Fluorescent Proteins; Liposomes; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Muramidase; Neutrophils; Peroxidase; Spinal Cord Injuries; Time Factors | 2012 |
Nanoparticle-based clodronate delivery mitigates murine experimental colitis.
Topics: Animals; Anti-Inflammatory Agents; Caco-2 Cells; Cell Line; Cell Survival; Clodronic Acid; Colitis; Disease Models, Animal; Humans; Mice; Nanoparticles; Oxazolone; Polymers; Trinitrobenzenesulfonic Acid | 2012 |
Monocytes control second-phase neutrophil emigration in established lipopolysaccharide-induced murine lung injury.
Topics: Acute Lung Injury; Analysis of Variance; Animals; Bronchoalveolar Lavage Fluid; Cell Movement; Clodronic Acid; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Immunohistochemistry; Leukocytes, Mononuclear; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Monocytes; Neutrophils; Random Allocation; Statistics, Nonparametric | 2012 |
Vascular endothelial growth factor-C and -D are involved in lymphangiogenesis in mouse unilateral ureteral obstruction.
Topics: Animals; Cell Proliferation; Clodronic Acid; Disease Models, Animal; Endothelium, Lymphatic; Fibrosis; Kidney; Lymphangiogenesis; Macrophages; Male; Mice; Mice, Inbred C57BL; Signal Transduction; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha; Ureteral Obstruction; Vascular Endothelial Growth Factor C; Vascular Endothelial Growth Factor D | 2013 |
Systemic macrophage depletion inhibits Helicobacter bilis-induced proinflammatory cytokine-mediated typhlocolitis and impairs bacterial colonization dynamics in a BALB/c Rag2-/- mouse model of inflammatory bowel disease.
Topics: Animals; Cecum; Clodronic Acid; Colitis; Cytokines; Disease Models, Animal; DNA-Binding Proteins; Helicobacter; Helicobacter Infections; Humans; Inflammation Mediators; Inflammatory Bowel Diseases; Interleukin-10; Macrophages; Mice; Mice, Inbred BALB C | 2012 |
Analgesic effects of the non-nitrogen-containing bisphosphonates etidronate and clodronate, independent of anti-resorptive effects on bone.
Topics: Acetic Acid; Analgesics; Animals; Capsaicin; Clodronic Acid; Corticosterone; Diphosphonates; Disease Models, Animal; Dose-Response Relationship, Drug; Etidronic Acid; Gene Expression Regulation; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Pain; Proto-Oncogene Proteins c-fos | 2013 |
Macrophage depletion by clodronate-containing liposomes reduces neointimal formation after balloon injury in rats and rabbits.
Topics: Animals; Carotid Arteries; Carotid Stenosis; Catheterization; Cell Division; Clodronic Acid; Disease Models, Animal; Flow Cytometry; Immunohistochemistry; Interleukin-1; Lipopolysaccharide Receptors; Liposomes; Liver; Macrophages; Male; Matrix Metalloproteinase 2; Monocytes; Proliferating Cell Nuclear Antigen; Rabbits; Rats; Rats, Inbred Strains; Spleen; Tunica Intima | 2002 |
Elimination of local macrophages in intestine prevents chronic colitis in interleukin-10-deficient mice.
Topics: Animals; Biopsy, Needle; Chronic Disease; Clodronic Acid; Colitis; Disease Models, Animal; Female; Flow Cytometry; Immunohistochemistry; Inflammatory Bowel Diseases; Interleukin-10; Macrophages; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Microspheres; Reference Values; Sensitivity and Specificity | 2003 |
A new xenograft model for graft-versus-host disease by intravenous transfer of human peripheral blood mononuclear cells in RAG2-/- gammac-/- double-mutant mice.
Topics: Animals; Antimetabolites; CD4-CD8 Ratio; Clodronic Acid; Cytokines; Disease Models, Animal; DNA-Binding Proteins; Female; Gene Rearrangement, T-Lymphocyte; Graft vs Host Disease; Humans; Immunoglobulin G; Immunoglobulin M; Injections, Intravenous; Kidney; Leukocytes, Mononuclear; Liver; Lung; Macrophages; Male; Mice; Mice, Mutant Strains; Nuclear Proteins; Phenotype; Skin; Spleen; T-Lymphocytes; Titrimetry; Transplantation Chimera; Transplantation, Heterologous; Transplants | 2003 |
Macrophage depletion inhibits experimental choroidal neovascularization.
Topics: Animals; Antigens, Differentiation; Antimetabolites; Cell Movement; Choroidal Neovascularization; Clodronic Acid; Disease Models, Animal; Endothelial Growth Factors; Enzyme-Linked Immunosorbent Assay; Fluorescein Angiography; Intercellular Signaling Peptides and Proteins; Liposomes; Lymphokines; Macrophages; Male; Mice; Mice, Inbred C57BL; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
Macrophage depletion diminishes lesion size and severity in experimental choroidal neovascularization.
Topics: Animals; Antimetabolites; Cell Count; Choroid; Choroidal Neovascularization; Clodronic Acid; Dextrans; Disease Models, Animal; Female; Flow Cytometry; Fluoresceins; Liposomes; Macrophages; Mice; Mice, Inbred C57BL | 2003 |
Adoptive transfer of alveolar macrophages abrogates bronchial hyperresponsiveness.
Topics: Adoptive Transfer; Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Clodronic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance; Genetic Predisposition to Disease; Immunoglobulin E; Immunoglobulin G; Liposomes; Macrophages, Alveolar; Male; Methacholine Chloride; Ovalbumin; Rats; Rats, Sprague-Dawley; Reaction Time | 2004 |
Role of macrophages in a mouse model of postoperative MRSA enteritis.
Topics: Animals; Antimetabolites; Clodronic Acid; Cyclophosphamide; Disease Models, Animal; Enteritis; Immunosuppressive Agents; Lipopolysaccharides; Macrophages, Peritoneal; Male; Methicillin Resistance; Mice; Mice, Inbred BALB C; Phagocytosis; Postoperative Complications; Specific Pathogen-Free Organisms; Staphylococcal Infections; Teichoic Acids | 2004 |
The use of a model of in vivo macrophage depletion to study the role of macrophages during infection with Bacillus anthracis spores.
Topics: Animals; Anthrax; Bacillus anthracis; Clodronic Acid; Disease Models, Animal; Immunity, Innate; Liposomes; Liver; Macrophages, Alveolar; Macrophages, Peritoneal; Mice; Silicon Dioxide; Spleen; Spores, Bacterial | 2004 |
Depletion of alveolar macrophages by clodronate-liposomes aggravates ischemia-reperfusion injury of the lung.
Topics: Animals; Bone Density Conservation Agents; Bronchoalveolar Lavage Fluid; Chemokine CXCL2; Clodronic Acid; Disease Models, Animal; Liposomes; Lung; Lung Compliance; Macrophages, Alveolar; Male; Models, Cardiovascular; Monokines; Neutrophils; Rats; Rats, Inbred Lew; Reperfusion Injury; Vascular Resistance | 2005 |
Suppression of macrophage infiltration into the conjunctiva by clodronate liposomes in experimental immune-mediated blepharoconjunctivitis.
Topics: Animals; Clodronic Acid; Conjunctivitis, Allergic; Disease Models, Animal; Liposomes; Macrophages; Male; Rats | 2005 |
Effects of macrophage inducible nitric oxide synthase in murine septic lung injury.
Topics: Animals; Base Sequence; Clodronic Acid; Disease Models, Animal; DNA Primers; Gene Expression Regulation, Enzymologic; Lung Diseases; Macrophages, Alveolar; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Proteins; Pulmonary Circulation; RNA, Messenger; Sepsis | 2006 |
Antigen sensitization modulates alveolar macrophage functions in an asthma model.
Topics: Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Clodronic Acid; Disease Models, Animal; Lung; Macrophages, Alveolar; Male; Methacholine Chloride; Ovalbumin; Rats; Rats, Inbred BN; Tumor Necrosis Factor-alpha | 2006 |
Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury.
Topics: Animals; Bronchoalveolar Lavage Fluid; Clodronic Acid; Disease Models, Animal; Humans; Liposomes; Macrophages, Alveolar; Pulmonary Alveoli; Pulmonary Edema; Rats; Respiratory Distress Syndrome; Tidal Volume | 2006 |
Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation.
Topics: Animals; Clodronic Acid; Dendritic Cells; Disease Models, Animal; I-kappa B Kinase; Inflammation; Liposomes; Macrophages; Mice; Mice, Knockout; Phenotype; Psoriasis; Skin; T-Lymphocytes | 2006 |
Evaluation of liposomal clodronate in experimental spontaneous autoimmune hemolytic anemia in dogs.
Topics: Anemia, Hemolytic, Autoimmune; Animals; Bone Density Conservation Agents; Clodronic Acid; Dendritic Cells; Disease Models, Animal; Dog Diseases; Dogs; Humans; Infusions, Intravenous; Liposomes; Macrophages; Phagocytosis; Rabbits; Spleen; Treatment Outcome | 2006 |
C-reactive protein-mediated suppression of nephrotoxic nephritis: role of macrophages, complement, and Fcgamma receptors.
Topics: Animals; C-Reactive Protein; Chemokines; Clodronic Acid; Complement C3; Complement System Proteins; Disease Models, Animal; Elapid Venoms; Gene Expression Profiling; Glomerulonephritis, Membranous; Immunosuppression Therapy; Interleukin-10; Macrophages; Mice; Mice, Knockout; Proteinuria; Receptors, IgG; RNA, Messenger | 2007 |
Pertussis toxin targets airway macrophages to promote Bordetella pertussis infection of the respiratory tract.
Topics: Adenosine Diphosphate Ribose; Animals; Bordetella pertussis; Clodronic Acid; Colony Count, Microbial; Disease Models, Animal; Female; GTP-Binding Proteins; Immunologic Factors; Leukocyte Reduction Procedures; Lung; Macrophages; Mice; Mice, Inbred BALB C; Neutrophils; Pertussis Toxin; Respiratory System; Trachea; Whooping Cough | 2007 |
Macrophage depletion alters the blood-nerve barrier without affecting Schwann cell function after neural injury.
Topics: Analysis of Variance; Animals; Blood-Nerve Barrier; Bone Density Conservation Agents; Cell Count; Clodronic Acid; Disease Models, Animal; Ectodysplasins; Indoles; Macrophages; Rats; Rats, Sprague-Dawley; S100 Proteins; Schwann Cells; Sciatic Neuropathy; Time Factors | 2007 |
Alveolar macrophage depletion is associated with increased surfactant pool sizes in adult rats.
Topics: Animals; Apoptosis; Cell Proliferation; Clodronic Acid; Disease Models, Animal; Homeostasis; Liposomes; Lung; Macrophages, Alveolar; Male; Pulmonary Alveolar Proteinosis; Pulmonary Surfactants; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome | 2007 |
Reduction in alveolar macrophages attenuates acute ventilator induced lung injury in rats.
Topics: Acute Disease; Animals; Bronchoalveolar Lavage Fluid; Carbon Dioxide; Clodronic Acid; Disease Models, Animal; Lung; Lung Compliance; Macrophages, Alveolar; Organ Size; Oxygen; Partial Pressure; Pneumonia, Ventilator-Associated; Random Allocation; Rats; Rats, Sprague-Dawley; Tidal Volume; Ventilators, Mechanical | 2007 |
Alveolar macrophages are necessary for the systemic inflammation of acute alveolar hypoxia.
Topics: Acute Disease; Animals; Brain; Cell Adhesion; Cells, Cultured; Clodronic Acid; Disease Models, Animal; Endothelium, Vascular; Hypoxia; Leukocytes; Lung Diseases, Interstitial; Macrophages, Alveolar; Male; Mast Cells; Mesentery; Microcirculation; Muscle, Skeletal; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley; Vasculitis | 2007 |
Small artery remodeling and erythrocyte deformability in L-NAME-induced hypertension: role of transglutaminases.
Topics: Animals; Blood Pressure; Clodronic Acid; Disease Models, Animal; Enzyme Inhibitors; Erythrocyte Deformability; Factor XIII; GTP-Binding Proteins; Hematocrit; Hypertension; Macrophages; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Protein Glutamine gamma Glutamyltransferase 2; Research Design; Stress, Mechanical; Time Factors; Transglutaminases | 2008 |
Antiangiogenic effects of bisphosphonates on laser-induced choroidal neovascularization in mice.
Topics: Alendronate; Angiogenesis Inhibitors; Animals; Cell Culture Techniques; Choroid; Choroidal Neovascularization; Clodronic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Fluorescein Angiography; Injections, Intraperitoneal; Integrin alphaV; Integrin beta1; Integrin beta3; Laser Coagulation; Male; Mice; Mice, Inbred C57BL; Pigment Epithelium of Eye; Reverse Transcriptase Polymerase Chain Reaction; Vascular Endothelial Growth Factor A | 2007 |
Alveolar macrophages are a major determinant of early responses to viral lung infection but do not influence subsequent disease development.
Topics: Animals; Chemokines; Clodronic Acid; Cytokines; Disease Models, Animal; Disease Progression; Lymphocytes; Macrophages, Alveolar; Mice; Respiratory Syncytial Virus Infections; Time Factors; Viral Load | 2008 |
Effects of Kupffer cell-depletion on Concanavalin A-induced hepatitis.
Topics: Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Clodronic Acid; Concanavalin A; Cytokines; Disease Models, Animal; Immunohistochemistry; Kupffer Cells; Liposomes; Male; Mice | 2008 |
The effects of disodium ethane-hydroxy-1,1-diphosphonate and disodium dichloromethylene diphosphonate on lanthanide-induced calcergy.
Topics: Animals; Calcinosis; Clodronic Acid; Diphosphonates; Disease Models, Animal; Etidronic Acid; Hydrocarbons, Chlorinated; Male; Metals, Rare Earth; Methylene Chloride; Mice; Time Factors | 1982 |
Human parathyroid hormone 1-34-mediated hypercalcemia in a rat model, and its inhibition by dichloromethane diphosphonate.
Topics: Animals; Calcium; Clodronic Acid; Diphosphonates; Disease Models, Animal; Hypercalcemia; Kinetics; Parathyroid Glands; Parathyroid Hormone; Peptide Fragments; Phosphates; Rats; Teriparatide; Thyroidectomy | 1981 |
Effect of clodronate on established collagen-induced arthritis in rats.
Topics: Analgesics, Non-Narcotic; Analysis of Variance; Animals; Arthritis, Experimental; Biomarkers; Blood Specimen Collection; Bone and Bones; Calcium; Cartilage, Articular; Clodronic Acid; Collagen; Disease Models, Animal; Female; Injections, Subcutaneous; Joints; Rats | 1995 |
Effect of clodronate on established adjuvant arthritis.
Topics: Animals; Arthritis, Experimental; Clodronic Acid; Disease Models, Animal; Disease Progression; Injections, Subcutaneous; Male; Rats; Rats, Inbred Lew; Severity of Illness Index | 1994 |
The influence of dichloromethylene bisphosphonate on the healing of a long bone fracture, composition of bone mineral and histology of bone in the rat.
Topics: Animals; Body Weight; Bone Density; Calcium; Clodronic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking; Female; Femoral Fractures; Femur; Fluorides; Fracture Healing; Humans; Injections, Subcutaneous; Magnesium; Osteocalcin; Osteoporosis, Postmenopausal; Phosphorus; Rats; Rats, Sprague-Dawley | 1994 |
The role of macrophages in Acanthamoeba keratitis.
Topics: Acanthamoeba Keratitis; Analgesics, Non-Narcotic; Animals; Chronic Disease; Clodronic Acid; Conjunctiva; Cornea; Cricetinae; Cricetulus; Disease Models, Animal; Drug Carriers; Incidence; Liposomes; Macrophages | 1996 |
[Effect of bisphosphonates (HEBP, CL2MBP) on the process of biological mineralization in fresh bone and bone tissue de novo as a result of experimental osteogenesis induction in guinea pigs].
Topics: Animals; Bone Transplantation; Calcification, Physiologic; Clodronic Acid; Disease Models, Animal; Etidronic Acid; Guinea Pigs; Ossification, Heterotopic; Osteogenesis; Transplantation, Heterotopic; Urinary Bladder | 1995 |
Effect of bisphosphonates on the increase in bone resorption induced by a low calcium diet.
Topics: Alendronate; Animals; Bone Resorption; Calcium; Calcium, Dietary; Clodronic Acid; Diphosphonates; Disease Models, Animal; Homeostasis; Ibandronic Acid; Male; Rats; Rats, Wistar; Tetracycline | 1996 |
Bisphosphonates clodronate and etidronate in the prevention of ovariectomy-induced osteopenia in growing rats.
Topics: Analysis of Variance; Animals; Bone Diseases, Metabolic; Clodronic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Etidronic Acid; Female; Femur Neck; Injections, Subcutaneous; Lumbar Vertebrae; Ovariectomy; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Tibia | 1996 |
Inhibition of calcium oxalate urolithiasis in a rat model of lithogenesis using bisphosphonates.
Topics: Analgesics, Non-Narcotic; Animals; Calcium; Calcium Oxalate; Clodronic Acid; Creatinine; Diphosphonates; Disease Models, Animal; Dose-Response Relationship, Drug; Follow-Up Studies; Injections, Intraperitoneal; Male; Pamidronate; Rats; Rats, Sprague-Dawley; Urinary Bladder Calculi; Zinc | 1997 |
Healing of a tibial double osteotomy is modified by clodronate administration.
Topics: Administration, Cutaneous; Animals; Calcification, Physiologic; Clodronic Acid; Disease Models, Animal; Fracture Healing; Fractures, Open; Male; Osteotomy; Radiography; Rats; Rats, Inbred Strains | 1996 |
Effects of clodronate on cortical and trabecular bone in ovariectomized rats on a low calcium diet.
Topics: Animals; Calcium, Dietary; Clodronic Acid; Disease Models, Animal; Female; Femur; Osteoporosis; Ovariectomy; Rats; Rats, Wistar; Strontium Radioisotopes; Tibia | 1997 |
Differential effect of macrophage depletion on two forms of experimental uveitis evoked by pigment epithelial membrane protein (EAPU), and by melanin-protein (EMIU).
Topics: Animals; Autoimmune Diseases; Choroid; Clodronic Acid; Disease Models, Animal; Eye Proteins; Female; Immunization; Liposomes; Macrophages; Melanins; Nerve Growth Factors; Phagocytosis; Proteins; Rats; Rats, Inbred Lew; Retina; Serpins; Uveitis | 1997 |
No adverse effects of clodronate on fracture healing in rats.
Topics: Absorptiometry, Photon; Animals; Biomechanical Phenomena; Bone Density; Bone Resorption; Clodronic Acid; Disease Models, Animal; Drug Evaluation, Preclinical; Fracture Healing; Male; Premedication; Radionuclide Imaging; Rats; Rats, Wistar; Tibial Fractures | 1998 |
Depletion of liver and splenic macrophages reduces the lethality of Shiga toxin-2 in a mouse model.
Topics: Animals; Bacterial Toxins; Clodronic Acid; Disease Models, Animal; Escherichia coli; Escherichia coli Infections; Female; Hemolytic-Uremic Syndrome; Humans; Lipopolysaccharides; Liposomes; Liver; Macrophages; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Shiga Toxins; Spleen | 1999 |
Induction and pharmacological treatment of oral osteopenia in rats.
Topics: Animals; Bone Diseases, Metabolic; Clodronic Acid; Disease Models, Animal; Estradiol; Female; Fractures, Bone; Male; Mandibular Fractures; Maxillary Fractures; Osteoporosis; Placebos; Rats; Rats, Sprague-Dawley | 1999 |
Reduction of meningeal macrophages does not decrease migration of granulocytes into the CSF and brain parenchyma in experimental pneumococcal meningitis.
Topics: Analgesics, Non-Narcotic; Animals; Carboxylic Ester Hydrolases; Cell Count; Cell Movement; Cerebrospinal Fluid; Choroid Plexus; Clodronic Acid; Disease Models, Animal; Granulocytes; Interleukin-1; Lactic Acid; Liposomes; Macrophages; Meninges; Meningitis, Pneumococcal; Phagocytosis; Phosphopyruvate Hydratase; Rabbits; Tumor Necrosis Factor-alpha | 1999 |
Liposomal clodronate eliminates synovial macrophages, reduces inflammation and ameliorates joint destruction in antigen-induced arthritis.
Topics: Analgesics, Non-Narcotic; Animals; Arthritis, Experimental; Clodronic Acid; Disease Models, Animal; Drug Carriers; Liposomes; Macrophages; Male; Mononuclear Phagocyte System; Rats; Rats, Inbred Lew; Synovial Membrane | 1999 |
Calcitonin versus clodronate in the prevention of ovariectomy-induced osteopenia in rats.
Topics: Absorptiometry, Photon; Animals; Bone Density; Bone Diseases, Metabolic; Calcitonin; Clodronic Acid; Disease Models, Animal; Female; Femur; Injections, Subcutaneous; Ovariectomy; Rats; Rats, Wistar; Spine; Treatment Outcome | 2000 |
Macrophage-derived transforming growth factor-beta1 induces hepatocellular injury via apoptosis in rat severe acute pancreatitis.
Topics: Acute Disease; Animals; Apoptosis; Clodronic Acid; Deoxycholic Acid; Disease Models, Animal; DNA Fragmentation; Immunohistochemistry; Kupffer Cells; Liposomes; Liver; Macrophages, Peritoneal; Male; Neutralization Tests; Pancreatitis; Rats; Rats, Wistar; Transforming Growth Factor beta | 2000 |
A combination of subtherapeutic doses of chemically modified doxycycline (CMT-8) and a bisphosphonate (clodronate) inhibits bone loss in the ovariectomized rat: a dynamic histomorphometric and gene expression study.
Topics: Animals; Bone and Bones; Bone Density; Clodronic Acid; Collagen; Collagenases; Disease Models, Animal; Doxycycline; Drug Therapy, Combination; Female; Femur; Gene Expression Regulation; Osteopontin; Osteoporosis; Ovariectomy; Protease Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sialoglycoproteins; Tetracyclines; Transcription, Genetic | 2001 |
A mouse model for postoperative fatal enteritis due to Staphylococcus infection.
Topics: Analgesics, Non-Narcotic; Animals; Bacterial Translocation; Clodronic Acid; Cyclophosphamide; Disease Models, Animal; Endotoxins; Enterocolitis; Escherichia coli; Immunosuppressive Agents; Jejunum; Macrophages; Male; Methicillin Resistance; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Postoperative Complications; Staphylococcal Infections | 2001 |
Expression of Th2 cytokines decreases the development of and improves Behçet's disease-like symptoms induced by herpes simplex virus in mice.
Topics: Animals; Behcet Syndrome; Clodronic Acid; Disease Models, Animal; Drug Carriers; Herpes Simplex; Herpesvirus 1, Human; Humans; Interleukin-4; Liposomes; Macrophages; Male; Mice; Mice, Inbred ICR; Ovalbumin; Spleen; Th2 Cells | 2001 |
Kupffer cells and neutrophils as paracrine regulators of the heme oxygenase-1 gene in hepatocytes after hemorrhagic shock.
Topics: Acetylcysteine; Animals; Antioxidants; Blood Pressure; Cells, Cultured; Chromans; Clodronic Acid; Deferoxamine; Disease Models, Animal; Gadolinium; Gene Expression Regulation, Enzymologic; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hepatocytes; Kupffer Cells; Male; Neutrophils; Rats; Rats, Sprague-Dawley; Resuscitation; Shock, Hemorrhagic; Time Factors; Vinblastine | 2001 |
Suppression of chronic streptococcal cell wall-induced arthritis in Lewis rats by liposomal clodronate.
Topics: Animals; Ankle Joint; Arthritis, Experimental; Clodronic Acid; Disease Models, Animal; Drug Carriers; Female; Image Processing, Computer-Assisted; Immunoenzyme Techniques; Injections, Intravenous; Interleukin-1; Interleukin-6; Liposomes; Macrophages; Matrix Metalloproteinase 9; Rats; Rats, Inbred Lew; Tumor Necrosis Factor-alpha | 2001 |
Reduction of instability-induced bone resorption using bisphosphonates: high doses are needed in rats.
Topics: Alendronate; Animals; Bone Plates; Bone Resorption; Clodronic Acid; Diphosphonates; Disease Models, Animal; Dose-Response Relationship, Drug; Immunohistochemistry; Joint Instability; Male; Osseointegration; Preoperative Care; Probability; Prostheses and Implants; Rats; Rats, Wistar; Reference Values; Sensitivity and Specificity; Statistics, Nonparametric; Tibia | 2002 |
Macrophages are necessary for maximal nuclear factor-kappa B activation in response to endotoxin.
Topics: Administration, Inhalation; Animals; Bronchoalveolar Lavage Fluid; Cell Count; Clodronic Acid; Cytokines; Disease Models, Animal; Endotoxins; Injections, Intraperitoneal; Injections, Intravenous; Instillation, Drug; Intubation, Intratracheal; Lipopolysaccharides; Lung; Macrophages, Alveolar; Mice; Mice, Inbred C57BL; Neutrophils; NF-kappa B; Pneumonia | 2002 |
Effects of topical administration of clodronate on alveolar bone resorption in rats with experimental periodontitis.
Topics: Acid Phosphatase; Administration, Topical; Alveolar Bone Loss; Analysis of Variance; Animals; Antimetabolites; Azo Compounds; Biomarkers; Bone Density; Bone Resorption; Cell Count; Clodronic Acid; Coloring Agents; Disease Models, Animal; Eosine Yellowish-(YS); Fluorescent Dyes; Injections; Isoenzymes; Male; Maxillary Diseases; Methyl Green; Molar; Osteoclasts; Periodontitis; Radiography; Rats; Rats, Wistar; Statistics as Topic; Tartrate-Resistant Acid Phosphatase | 2002 |
Comparative antiinflammatory and bone protective effects of two diphosphonates in adjuvant arthritis.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Body Weight; Bone and Bones; Bone Resorption; Clodronic Acid; Diphosphonates; Disease Models, Animal; Drug Evaluation, Preclinical; Etidronic Acid; Hindlimb; Injections, Subcutaneous; Male; Radiography; Rats | 1979 |
Potassium permanganate induced calcergy: a model to study the effects of drugs on hydroxyapatite crystal deposition.
Topics: Animals; Calcinosis; Clodronic Acid; Dexamethasone; Disease Models, Animal; Etidronic Acid; Hydroxyapatites; Indomethacin; Male; Osteoarthritis; Potassium Permanganate; Rats; Spectrophotometry, Infrared; Time Factors | 1979 |
The effects of dichloromethylene biphosphonate on osteoporotic femora of adult castrate male rats.
Topics: Animals; Clodronic Acid; Diphosphonates; Disease Models, Animal; Male; Orchiectomy; Osteolysis; Osteoporosis; Rats | 1985 |
The effects of diphosphonates on alveolar bone loss.
Topics: Animals; Bone Resorption; Clodronic Acid; Diphosphonates; Disease Models, Animal; Female; Male; Periodontitis; Rats | 1987 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |