clodronic acid has been researched along with Disease Exacerbation in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (12.90) | 18.2507 |
| 2000's | 11 (35.48) | 29.6817 |
| 2010's | 13 (41.94) | 24.3611 |
| 2020's | 3 (9.68) | 2.80 |
| Authors | Studies |
|---|---|
| Alikhanyan, K; Chen, Y; Kraut, S; Sotillo, R | 1 |
| Gong, FL; Guo, XL; Li, YS; Wang, L; Yang, XX; Yu, LG; Zhang, XK; Zhao, L | 1 |
| Adhikari, M; Amorim, T; Anderson, J; Bellido, T; Boeckman, RK; Cregor, M; Cuevas, PL; Delgado-Calle, J; Ebetino, FH; Ferrari, AJ; Helms, JA; Khan, S; Kurihara, N; Lehal, R; McAndrews, K; Roodman, GD; Sabol, HM; Srinivasan, V; Vigolo, M | 1 |
| Hasuike, S; Iwakiri, H; Kameda, T; Kamiunten, A; Kusumoto, K; Miike, T; Nagata, K; Nakamura, K; Ozono, Y; Sawaguchi, A; Shide, K; Shimoda, K; Takaishi, Y; Toyoshima, F; Tsuchimochi, M | 1 |
| Abais-Battad, JM; Dasinger, JH; Fehrenbach, DJ; Lund, H; Mattson, DL | 1 |
| Aronovich, R; Bina, H; Chapman, J; Katzav, A | 1 |
| Bascands, JL; Belliere, J; Buffin-Meyer, B; Casemayou, A; Chauveau, D; Ducasse, L; Guilbeau-Frugier, C; Iacovoni, JS; Martins, F; Pipy, B; Schanstra, JP; Zakaroff-Girard, A | 1 |
| He, X; Jin, X; Liu, M; Pan, L; Zhang, X; Zhao, Y | 1 |
| Dietrich, W; Gapp, B; Kagan, D; Kim, M; Ksiazek, I; Kueng, B; Piaia, A; Shenoy, N; Weber, D | 1 |
| Anselmo, A; Barbaglio, F; Bertilaccio, MTS; Caligaris-Cappio, F; Cittaro, D; Corti, A; De Palma, M; Galletti, G; Ghia, P; Klein, C; Lazarevic, D; Ponzoni, M; Ranghetti, P; Riba, M; Ries, CH; Rocchi, M; Rodriguez, TV; Scarfò, L; Scielzo, C; Simonetti, G; van Rooijen, N | 1 |
| Berry, G; Burt, BM; Engleman, E; Kheradmand, F; Lee, HS; Sugarbaker, DJ; Wang, DH; Wheeler, TM; Yoon, D | 1 |
| Duijvestijn, A; Gupta, S; Hofstra, L; Maessen, JG; Narula, J; Pinto, YM; Pokharel, S; Reutelingsperger, C; Sharma, UC; van Brakel, T; van den Borne, S; van Rooijen, N; Verjans, JW; Zandbergen, HR | 1 |
| Perlman, S; Van Rooijen, N; Zhao, J | 1 |
| Adib-Conquy, M; Brock, M; Cavaillon, JM; Droin-Bergère, S; Hohl, TM; Ibrahim-Granet, O; Jouvion, G; Kim, OY; Philippart, F; Schwendener, R | 1 |
| Lipton, A; Saad, F | 1 |
| Carmichael, MD; Davis, JM; Gangemi, JD; McClellan, JL; Murphy, EA; Rooijen, NV | 1 |
| Chen, X; Li, Q; Qin, L; Wang, B; Wang, J; Zhao, S | 1 |
| Allavena, P; Mantovani, A | 1 |
| Chi, K; Ding, K; Elliott, C; Ernst, DS; Moore, MJ; Parulekar, W; Reyno, L; Tannock, IF; Venner, PM; Winquist, EW | 1 |
| Egawa, S; Endo, Y; Matsuno, S; Mikami, Y; Qiu-Feng, H; Shibuya, K; Shimamura, H; Sunamura, M; Takeda, K; Yagi, H; Yamauchi, J | 1 |
| Forsea, AM; Geilen, CC; Müller, C; Orfanos, CE; Riebeling, C | 1 |
| Clemons, MJ; Cole, DE; Dranitsaris, G; Ooi, WS; Pritchard, KI; Sukovic, T; Trudeau, M; Verma, S; Wong, BY; Yogendran, G | 1 |
| Dearnaley, DP; Glaholm, J; Huddart, RA; James, ND; Langley, RE; Mason, MD; Parmar, MK; Robinson, AC; Sokal, M; Stott, M; Sydes, MR | 1 |
| Harker, J; Openshaw, PJ; Pribul, PK; Schwarze, J; Tregoning, JS; Wang, B; Wang, H | 1 |
| Hannuniemi, R; Kippo, K; Laurén, L; Osterman, T; Sellman, R | 1 |
| Elomaa, I; Laakso, M; Lahtinen, R; Virkkunen, P | 1 |
| Aaron, JE; Alcover, J; Carretero, P; Fernández-Conde, M; Ordi, J | 1 |
| Ejlertsen, B; Groenvold, M; Hein, S; Kristensen, B; Loft, H; Mouridsen, HT | 1 |
| Ahlström, H; Andréasson, I; Aström, G; Bergh, J; Ciray, I; Edekling, T; Hansen, J | 1 |
| Abbaszadegan, H; Adolphson, P; Bodén, H; Henriques, T; Salemyr, M | 1 |
| Clark, RE; Durham, BH; Flory, AJ; Fraser, WD; Ion, EM; Woodcock, BE | 1 |
2 review(s) available for clodronic acid and Disease Exacerbation
| Article | Year |
|---|---|
Bone-marker levels in patients with prostate cancer: potential correlations with outcomes.
Topics: Alkaline Phosphatase; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Biomarkers, Tumor; Bone Density Conservation Agents; Bone Neoplasms; Clodronic Acid; Collagen Type I; Denosumab; Diphosphonates; Disease Progression; Humans; Imidazoles; Male; Peptides; Prognosis; Prostatic Neoplasms; RANK Ligand; Risk Assessment; Treatment Outcome; Zoledronic Acid | 2010 |
Immunology in the clinic review series; focus on cancer: tumour-associated macrophages: undisputed stars of the inflammatory tumour microenvironment.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzenesulfonates; Chemotaxis; Clodronic Acid; Cytokines; Dioxoles; Disease Progression; Humans; Immunity, Innate; Inflammation; Liposomes; Macrophages; Mice; Molecular Targeted Therapy; Neoplasm Invasiveness; Neoplasm Proteins; Neoplasms; Neovascularization, Pathologic; Niacinamide; Phenylurea Compounds; Prognosis; Pyridines; Sorafenib; Tetrahydroisoquinolines; Trabectedin; Tumor Escape; Tumor Microenvironment | 2012 |
8 trial(s) available for clodronic acid and Disease Exacerbation
| Article | Year |
|---|---|
Randomized, double-blind, controlled trial of mitoxantrone/prednisone and clodronate versus mitoxantrone/prednisone and placebo in patients with hormone-refractory prostate cancer and pain.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Clodronic Acid; Disease Progression; Double-Blind Method; Humans; Male; Middle Aged; Mitoxantrone; Pain; Pain Measurement; Palliative Care; Prednisone; Prostatic Neoplasms; Quality of Life; Regression Analysis; Statistics, Nonparametric; Survival Analysis; Treatment Outcome | 2003 |
Phase II trial evaluating the palliative benefit of second-line zoledronic acid in breast cancer patients with either a skeletal-related event or progressive bone metastases despite first-line bisphosphonate therapy.
Topics: Adult; Aged; Aged, 80 and over; Bone and Bones; Bone Density Conservation Agents; Bone Neoplasms; Breast Neoplasms; Clodronic Acid; Diphosphonates; Disease Progression; Drug Resistance; Female; Humans; Imidazoles; Middle Aged; Pain; Palliative Care; Pamidronate; Prospective Studies; Treatment Outcome; Zoledronic Acid | 2006 |
Oral sodium clodronate for nonmetastatic prostate cancer--results of a randomized double-blind placebo-controlled trial: Medical Research Council PR04 (ISRCTN61384873).
Topics: Administration, Oral; Aged; Antineoplastic Agents; Bone Density Conservation Agents; Clodronic Acid; Combined Modality Therapy; Disease Progression; Double-Blind Method; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Prostatic Neoplasms; Radiotherapy | 2007 |
Subgroup and cost-benefit analysis of the Finnish multicentre trial of clodronate in multiple myeloma. Finnish Leukaemia Group.
Topics: Aged; Bone and Bones; Clodronic Acid; Cost-Benefit Analysis; Disease Progression; Double-Blind Method; Female; Health Care Costs; Humans; Male; Middle Aged; Multiple Myeloma; Osteolysis; Paraneoplastic Syndromes; Risk Factors | 1994 |
Skeletal response to clodronate in prostate cancer with bone metastases.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Androgen Antagonists; Antineoplastic Agents, Hormonal; Biopsy; Bone and Bones; Bone Matrix; Bone Neoplasms; Bone Resorption; Calcification, Physiologic; Clodronic Acid; Disease Progression; Follow-Up Studies; Gonadotropin-Releasing Hormone; Humans; Injections, Intravenous; Male; Middle Aged; Orchiectomy; Osteoblasts; Osteoclasts; Palliative Care; Prostatic Neoplasms; Quality of Life | 1997 |
Oral clodronate in breast cancer patients with bone metastases: a randomized study.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Bone Neoplasms; Breast Neoplasms; Clodronic Acid; Disease Progression; Female; Humans; Middle Aged; Prospective Studies; Quality of Life; Survival Analysis | 1999 |
Evaluation of new sclerotic bone metastases in breast cancer patients during treatment.
Topics: Adult; Aged; Bone Neoplasms; Breast Neoplasms; Clodronic Acid; Diagnosis, Differential; Disease Progression; Female; Humans; Middle Aged; Osteosclerosis; Radionuclide Imaging | 2000 |
Clodronate increases mineralization of callus after Colles' fracture: a randomized, double-blind, placebo-controlled, prospective trial in 32 patients.
Topics: Absorptiometry, Photon; Aged; Bone Density; Bone Diseases, Metabolic; Bony Callus; Clodronic Acid; Colles' Fracture; Diphosphonates; Disease Progression; Double-Blind Method; Female; Fracture Healing; Humans; Middle Aged; Postmenopause; Prospective Studies; Radionuclide Imaging; Range of Motion, Articular; Splints; Treatment Outcome | 2000 |
21 other study(ies) available for clodronic acid and Disease Exacerbation
| Article | Year |
|---|---|
Targeting alveolar macrophages shows better treatment response than deletion of interstitial macrophages in EGFR mutant lung adenocarcinoma.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Antineoplastic Agents, Immunological; Bronchoalveolar Lavage Fluid; CD8-Positive T-Lymphocytes; Clodronic Acid; Cytokines; Disease Progression; ErbB Receptors; Humans; Macrophage Activation; Macrophages, Alveolar; Mice; Mice, Transgenic; Mutation; Tumor Microenvironment | 2020 |
Galectin-3 expression and secretion by tumor-associated macrophages in hypoxia promotes breast cancer progression.
Topics: Adenocarcinoma; Animals; Bevacizumab; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Clodronic Acid; Coculture Techniques; Disease Progression; Female; Galectin 3; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Lymphatic Metastasis; Macrophages; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; NF-kappa B; Pectins; Signal Transduction; Sorafenib | 2020 |
Targeting Notch Inhibitors to the Myeloma Bone Marrow Niche Decreases Tumor Growth and Bone Destruction without Gut Toxicity.
Topics: Animals; Bone and Bones; Bone Density Conservation Agents; Bone Marrow Cells; Cell Line, Tumor; Clodronic Acid; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Humans; Mice; Multiple Myeloma; Osteolysis; Receptors, Notch; Signal Transduction; X-Ray Microtomography; Xenograft Model Antitumor Assays | 2021 |
Monocyte-derived fibrocytes elimination had little contribution on liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Clodronic Acid; Collagen Type I; Disease Progression; Female; Liver; Liver Cirrhosis, Experimental; Mice, Inbred C57BL; Monocytes; Time Factors; Up-Regulation | 2019 |
Salt-sensitive increase in macrophages in the kidneys of Dahl SS rats.
Topics: Albuminuria; Animals; B-Lymphocytes; Clodronic Acid; Disease Models, Animal; Disease Progression; Hypertension; Kidney; Kidney Diseases; Lipopolysaccharide Receptors; Lymphocyte Antigen 96; Macrophages; Phenotype; Rats, Inbred BN; Rats, Inbred Dahl; Rats, Sprague-Dawley; Signal Transduction; Sodium Chloride, Dietary; T-Lymphocytes; Toll-Like Receptor 4 | 2019 |
Treatment for experimental autoimmune neuritis with clodronate (Bonefos).
Topics: Animals; Autoimmune Diseases; Biomarkers; Clodronic Acid; Demyelinating Diseases; Disease Models, Animal; Disease Progression; Female; Humans; Macrophages; Matrix Metalloproteinase 9; Motor Activity; Myelin P2 Protein; Neuritis, Autoimmune, Experimental; Rats; Rats, Inbred Lew; Sciatic Nerve; Syndrome | 2013 |
Specific macrophage subtypes influence the progression of rhabdomyolysis-induced kidney injury.
Topics: Acute Kidney Injury; Animals; Cells, Cultured; Clodronic Acid; Disease Models, Animal; Disease Progression; Flow Cytometry; Glycerol; Humans; Macrophages; Male; Mice; Myoglobin; Random Allocation; Rhabdomyolysis; Risk Factors; Sensitivity and Specificity | 2015 |
Macrophages support splenic erythropoiesis in 4T1 tumor-bearing mice.
Topics: Anemia; Animals; Bone Morphogenetic Protein 4; Cell Line, Tumor; Clodronic Acid; Disease Progression; Erythropoiesis; Erythropoietin; Female; Granulocyte Colony-Stimulating Factor; Macrophages; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Spleen; Splenectomy | 2015 |
Progression of Alport Kidney Disease in Col4a3 Knock Out Mice Is Independent of Sex or Macrophage Depletion by Clodronate Treatment.
Topics: Animals; Apoptosis; Autoantigens; Clodronic Acid; Collagen Type IV; Disease Progression; Drug Evaluation, Preclinical; Female; Kidney; Kidney Failure, Chronic; Liposomes; Macrophages; Male; Mice; Mice, 129 Strain; Mice, Knockout; Models, Animal; Nephritis, Hereditary; Sex Characteristics | 2015 |
Targeting Macrophages Sensitizes Chronic Lymphocytic Leukemia to Apoptosis and Inhibits Disease Progression.
Topics: Animals; Antibodies, Monoclonal; Apoptosis; B-Lymphocytes; Cell Communication; Cell Line, Tumor; Clodronic Acid; Disease Progression; Gene Expression Regulation, Leukemic; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Liposomes; Macrophages; Mice; Mice, Transgenic; Neoplasm Transplantation; Primary Cell Culture; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Signal Transduction; Survival Analysis; Transplantation, Heterologous; Tumor Microenvironment | 2016 |
Progression of EGFR-Mutant Lung Adenocarcinoma is Driven By Alveolar Macrophages.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Immunological; Cetuximab; Clodronic Acid; Cytokines; Disease Progression; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Female; Gene Expression Regulation, Neoplastic; Genes, erbB-1; Genes, Synthetic; Humans; Lung Neoplasms; Macrophage Activation; Macrophages, Alveolar; Mice; Mice, Transgenic; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Protein Kinase Inhibitors; Recombinant Fusion Proteins; Smoking; Uteroglobin | 2017 |
Macrophage depletion in hypertensive rats accelerates development of cardiomyopathy.
Topics: Animals; Cardiomyopathies; CD4-Positive T-Lymphocytes; Clodronic Acid; Disease Models, Animal; Disease Progression; Hypertension; Injections, Intravenous; Liposomes; Macrophages; Male; Monocytes; Myocardium; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Renin; Stroke Volume; Time Factors; Ventricular Function, Left; Ventricular Remodeling | 2009 |
Evasion by stealth: inefficient immune activation underlies poor T cell response and severe disease in SARS-CoV-infected mice.
Topics: Animals; Clodronic Acid; Dendritic Cells; Disease Progression; Immune Evasion; Liposomes; Lymphocyte Activation; Macrophages, Alveolar; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Myeloablative Agonists; Severe Acute Respiratory Syndrome; Severe acute respiratory syndrome-related coronavirus; T-Lymphocytes; Virus Latency | 2009 |
In vivo bioluminescence imaging and histopathopathologic analysis reveal distinct roles for resident and recruited immune effector cells in defense against invasive aspergillosis.
Topics: Animals; Aspergillus fumigatus; Clodronic Acid; Cyclophosphamide; Disease Models, Animal; Disease Progression; DNA, Fungal; Histocytochemistry; Immunosuppression Therapy; Invasive Pulmonary Aspergillosis; Luminescent Measurements; Luminescent Proteins; Lung; Macrophages, Alveolar; Mice; Monocytes; Neutrophils; Organisms, Genetically Modified; Reverse Transcriptase Polymerase Chain Reaction; Whole Body Imaging | 2010 |
Susceptibility to infection and inflammatory response following influenza virus (H1N1, A/PR/8/34) challenge: role of macrophages.
Topics: Animals; Blood Component Removal; Clodronic Acid; Cytokines; Disease Models, Animal; Disease Progression; Disease Susceptibility; Humans; Inflammation Mediators; Influenza A Virus, H1N1 Subtype; Influenza, Human; Lung; Macrophages, Alveolar; Mice; Mice, Inbred ICR; Orthomyxoviridae Infections; RNA, Viral; Virus Replication | 2011 |
Transition of tumor-associated macrophages from MHC class II(hi) to MHC class II(low) mediates tumor progression in mice.
Topics: Adoptive Transfer; Animals; Cell Line, Tumor; Clodronic Acid; Cytokines; Disease Progression; Female; Histocompatibility Antigens Class II; Leukocyte Reduction Procedures; Liposomes; Lymphocyte Activation; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Invasiveness; Neoplasms; T-Lymphocytes; Tumor Microenvironment | 2011 |
Do peritoneal macrophages play an essential role in the progression of acute pancreatitis in rats?
Topics: Acute Disease; Animals; Ascites; Cell Count; Clodronic Acid; Cytokines; Disease Progression; Inflammation; Liposomes; Lung; Macrophages, Peritoneal; Male; Neutrophils; Oligopeptides; Pancreas; Pancreatitis; Peritoneal Cavity; Peritoneal Lavage; Peroxidase; Rats; Rats, Wistar | 2003 |
Nitrogen-containing bisphosphonates inhibit cell cycle progression in human melanoma cells.
Topics: Antimetabolites; Antineoplastic Agents; Cell Cycle; Clodronic Acid; Diphosphonates; Disease Progression; Humans; Imidazoles; Melanoma; Nitrogen; Pamidronate; Skin Neoplasms; Tumor Cells, Cultured; Zoledronic Acid | 2004 |
Alveolar macrophages are a major determinant of early responses to viral lung infection but do not influence subsequent disease development.
Topics: Animals; Chemokines; Clodronic Acid; Cytokines; Disease Models, Animal; Disease Progression; Lymphocytes; Macrophages, Alveolar; Mice; Respiratory Syncytial Virus Infections; Time Factors; Viral Load | 2008 |
Effect of clodronate on established adjuvant arthritis.
Topics: Animals; Arthritis, Experimental; Clodronic Acid; Disease Models, Animal; Disease Progression; Injections, Subcutaneous; Male; Rats; Rats, Inbred Lew; Severity of Illness Index | 1994 |
Biochemical markers of bone turnover following high-dose chemotherapy and autografting in multiple myeloma.
Topics: Adult; Aged; Alkaline Phosphatase; Amino Acids; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Bone Remodeling; Bone Resorption; Carmustine; Clodronic Acid; Combined Modality Therapy; Cytarabine; Disease Progression; Female; Hematopoietic Stem Cell Transplantation; Humans; Isoenzymes; Male; Melphalan; Middle Aged; Multiple Myeloma; Osteoclasts; Peptide Fragments; Podophyllotoxin; Procollagen; Transplantation Conditioning; Transplantation, Autologous; Treatment Outcome | 2000 |